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UniProtKB - Q6UW88 (EPGN_HUMAN)

Entry version 143 (10 Feb 2021)
Sequence version 2 (24 Mar 2009)
Previous versions | rss
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Protein

Epigen

Gene

EPGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6UW88

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-177929, Signaling by EGFR
R-HSA-179812, GRB2 events in EGFR signaling
R-HSA-180292, GAB1 signalosome
R-HSA-180336, SHC1 events in EGFR signaling
R-HSA-182971, EGFR downregulation
R-HSA-212718, EGFR interacts with phospholipase C-gamma
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6UW88

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epigen
Alternative name(s):
Epithelial mitogen
Short name:
EPG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPGN
ORF Names:UNQ3072/PRO9904
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17470, EPGN

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618717, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UW88

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182585.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 110ExtracellularSequence analysisAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		255324

Open Targets

More...OpenTargetsi		ENSG00000182585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162385143

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6UW88, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EPGN

Domain mapping of disease mutations (DMDM)

More...DMDMi		229464464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004546223 – 154EpigenAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
Disulfide bondi86 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6UW88

PeptideAtlas

More...PeptideAtlasi		Q6UW88

PRoteomics IDEntifications database

More...PRIDEi		Q6UW88

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67455 [Q6UW88-1]
67456 [Q6UW88-2]
67457 [Q6UW88-3]
67458 [Q6UW88-4]
67459 [Q6UW88-5]
67460 [Q6UW88-6]
67461 [Q6UW88-7]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q6UW88-2 [Q6UW88-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6UW88, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UW88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UW88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182585, Expressed in esophagus and 87 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UW88, baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182585, Tissue enhanced (epididymis, esophagus, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		129094, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q6UW88, 7 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000411898

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6UW88, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6UW88

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 96EGF-likePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S4QW, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00510000048556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_144237_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6UW88

Identification of Orthologs from Complete Genome Data

More...OMAi		YNICSGG

Database of Orthologous Groups

More...OrthoDBi		1425022at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UW88

TreeFam database of animal gene trees

More...TreeFami		TF335931

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000742, EGF-like_dom
IPR015497, EGF_rcpt_ligand

The PANTHER Classification System

More...PANTHERi		PTHR10740, PTHR10740, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UW88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG 
        60         70         80         90        100
PIALKFSHLC LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL 
       110        120        130        140        150
TSYAVDSYEK YIAIGIGVGL LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE 

RRPL
Length:154
Mass (Da):17,091
Last modified:March 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC78016BE3026474
GO
Isoform 2 (identifier: Q6UW88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     137-154: CLKLKSPYNVCSGERRPL → YEKDKI

Show »
Length:133
Mass (Da):14,792
Checksum:i7A5B3257D0484182
GO
Isoform 3 (identifier: Q6UW88-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     96-137: Missing.

Show »
Length:112
Mass (Da):12,319
Checksum:i8D0EE50785FA2891
GO
Isoform 4 (identifier: Q6UW88-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     87-137: Missing.

Show »
Length:103
Mass (Da):11,304
Checksum:i062973EAC9EA4570
GO
Isoform 5 (identifier: Q6UW88-5) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     96-137: Missing.

Show »
Length:103
Mass (Da):11,289
Checksum:i1C1FB863C2FE3419
GO
Isoform 6 (identifier: Q6UW88-6) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     87-137: Missing.

Show »
Length:94
Mass (Da):10,274
Checksum:i13193DA6BF249099
GO
Isoform 7 (identifier: Q6UW88-7) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     15-44: Missing.
     87-137: Missing.

Show »
Length:73
Mass (Da):8,149
Checksum:i860BFE12C853D368
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM13H3BM13_HUMAN
Epigen
EPGN
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0PK19A0PK19_HUMAN
EPGN protein
EPGN
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9V → A in ABB60048 (Ref. 1) Curated1
Sequence conflicti62E → G in ABB60047 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03665415 – 44Missing in isoform 7. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_03665536 – 44Missing in isoform 2, isoform 5 and isoform 6. 2 Publications9
Alternative sequenceiVSP_03665687 – 137Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_03665796 – 137Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_036658137 – 154CLKLK…ERRPL → YEKDKI in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ235264 mRNA Translation: ABB60043.1
DQ235265 mRNA Translation: ABB60044.1
DQ235266 mRNA Translation: ABB60045.1
DQ235267 mRNA Translation: ABB60046.1
DQ235268 mRNA Translation: ABB60047.1
DQ235269 mRNA Translation: ABB60048.1
AY358920 mRNA Translation: AAQ89279.1
AK289455 mRNA Translation: BAF82144.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59475.1 [Q6UW88-5]
CCDS59476.1 [Q6UW88-6]
CCDS59477.1 [Q6UW88-3]
CCDS59478.1 [Q6UW88-1]
CCDS59479.1 [Q6UW88-4]

NCBI Reference Sequences

More...RefSeqi		NP_001257918.1, NM_001270989.1 [Q6UW88-1]
NP_001257919.1, NM_001270990.1 [Q6UW88-3]
NP_001257920.1, NM_001270991.1 [Q6UW88-5]
NP_001257921.1, NM_001270992.1 [Q6UW88-4]
NP_001257922.1, NM_001270993.1 [Q6UW88-6]
XP_005265723.1, XM_005265666.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000332112; ENSP00000330375; ENSG00000182585 [Q6UW88-2]
ENST00000413830; ENSP00000411898; ENSG00000182585 [Q6UW88-1]
ENST00000502358; ENSP00000426678; ENSG00000182585 [Q6UW88-4]
ENST00000503098; ENSP00000425890; ENSG00000182585 [Q6UW88-3]
ENST00000505212; ENSP00000424392; ENSG00000182585 [Q6UW88-6]
ENST00000509145; ENSP00000426630; ENSG00000182585 [Q6UW88-7]
ENST00000514968; ENSP00000426550; ENSG00000182585 [Q6UW88-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		255324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:255324

UCSC genome browser

More...UCSCi		uc003hhw.5, human [Q6UW88-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ235264 mRNA Translation: ABB60043.1
DQ235265 mRNA Translation: ABB60044.1
DQ235266 mRNA Translation: ABB60045.1
DQ235267 mRNA Translation: ABB60046.1
DQ235268 mRNA Translation: ABB60047.1
DQ235269 mRNA Translation: ABB60048.1
AY358920 mRNA Translation: AAQ89279.1
AK289455 mRNA Translation: BAF82144.1
CCDSiCCDS59475.1 [Q6UW88-5]
CCDS59476.1 [Q6UW88-6]
CCDS59477.1 [Q6UW88-3]
CCDS59478.1 [Q6UW88-1]
CCDS59479.1 [Q6UW88-4]
RefSeqiNP_001257918.1, NM_001270989.1 [Q6UW88-1]
NP_001257919.1, NM_001270990.1 [Q6UW88-3]
NP_001257920.1, NM_001270991.1 [Q6UW88-5]
NP_001257921.1, NM_001270992.1 [Q6UW88-4]
NP_001257922.1, NM_001270993.1 [Q6UW88-6]
XP_005265723.1, XM_005265666.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WB8X-ray3.00B/C49-108[»]
SMRiQ6UW88
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi129094, 4 interactors
IntActiQ6UW88, 7 interactors
STRINGi9606.ENSP00000411898

PTM databases

GlyGeniQ6UW88, 2 sites
iPTMnetiQ6UW88
PhosphoSitePlusiQ6UW88

Genetic variation databases

BioMutaiEPGN
DMDMi229464464

Proteomic databases

MassIVEiQ6UW88
PeptideAtlasiQ6UW88
PRIDEiQ6UW88
ProteomicsDBi67455 [Q6UW88-1]
67456 [Q6UW88-2]
67457 [Q6UW88-3]
67458 [Q6UW88-4]
67459 [Q6UW88-5]
67460 [Q6UW88-6]
67461 [Q6UW88-7]
TopDownProteomicsiQ6UW88-2 [Q6UW88-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24613, 169 antibodies

The DNASU plasmid repository

More...DNASUi		255324

Genome annotation databases

EnsembliENST00000332112; ENSP00000330375; ENSG00000182585 [Q6UW88-2]
ENST00000413830; ENSP00000411898; ENSG00000182585 [Q6UW88-1]
ENST00000502358; ENSP00000426678; ENSG00000182585 [Q6UW88-4]
ENST00000503098; ENSP00000425890; ENSG00000182585 [Q6UW88-3]
ENST00000505212; ENSP00000424392; ENSG00000182585 [Q6UW88-6]
ENST00000509145; ENSP00000426630; ENSG00000182585 [Q6UW88-7]
ENST00000514968; ENSP00000426550; ENSG00000182585 [Q6UW88-5]
GeneIDi255324
KEGGihsa:255324
UCSCiuc003hhw.5, human [Q6UW88-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		255324
DisGeNETi255324

GeneCards: human genes, protein and diseases

More...GeneCardsi		EPGN
HGNCiHGNC:17470, EPGN
HPAiENSG00000182585, Tissue enhanced (epididymis, esophagus, tongue)
MIMi618717, gene
neXtProtiNX_Q6UW88
OpenTargetsiENSG00000182585
PharmGKBiPA162385143
VEuPathDBiHostDB:ENSG00000182585.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S4QW, Eukaryota
GeneTreeiENSGT00510000048556
HOGENOMiCLU_144237_1_0_1
InParanoidiQ6UW88
OMAiYNICSGG
OrthoDBi1425022at2759
PhylomeDBiQ6UW88
TreeFamiTF335931

Enzyme and pathway databases

PathwayCommonsiQ6UW88
ReactomeiR-HSA-1257604, PIP3 activates AKT signaling
R-HSA-177929, Signaling by EGFR
R-HSA-179812, GRB2 events in EGFR signaling
R-HSA-180292, GAB1 signalosome
R-HSA-180336, SHC1 events in EGFR signaling
R-HSA-182971, EGFR downregulation
R-HSA-212718, EGFR interacts with phospholipase C-gamma
R-HSA-2219530, Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303, Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828, Clathrin-mediated endocytosis
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SIGNORiQ6UW88

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		255324, 6 hits in 842 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		255324
PharosiQ6UW88, Tbio

Protein Ontology

More...PROi		PR:Q6UW88
RNActiQ6UW88, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182585, Expressed in esophagus and 87 other tissues
ExpressionAtlasiQ6UW88, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR015497, EGF_rcpt_ligand
PANTHERiPTHR10740, PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPGN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UW88
Secondary accession number(s): A1BMM3
, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8, A8K090
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 24, 2009
Last modified: February 10, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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