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Protein

Epigen

Gene

EPGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.1 Publication

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: HGNC
  • growth factor activity Source: HGNC

GO - Biological processi

  • activation of MAPK activity Source: HGNC
  • angiogenesis Source: HGNC
  • MAPK cascade Source: Ensembl
  • positive regulation of cell proliferation Source: HGNC
  • positive regulation of epidermal growth factor-activated receptor activity Source: HGNC
  • positive regulation of epithelial cell proliferation Source: HGNC
  • positive regulation of MAP kinase activity Source: HGNC
  • positive regulation of mitotic nuclear division Source: HGNC

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

SIGNORiQ6UW88

Names & Taxonomyi

Protein namesi
Recommended name:
Epigen
Alternative name(s):
Epithelial mitogen
Short name:
EPG
Gene namesi
Name:EPGN
ORF Names:UNQ3072/PRO9904
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000182585.9
HGNCiHGNC:17470 EPGN
neXtProtiNX_Q6UW88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 110ExtracellularSequence analysisAdd BLAST88
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi255324
OpenTargetsiENSG00000182585
PharmGKBiPA162385143

Polymorphism and mutation databases

DMDMi229464464

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000004546223 – 154EpigenAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
Disulfide bondi86 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiQ6UW88
PRIDEiQ6UW88
ProteomicsDBi67455
67456 [Q6UW88-2]
67457 [Q6UW88-3]
67458 [Q6UW88-4]
67459 [Q6UW88-5]
67460 [Q6UW88-6]
67461 [Q6UW88-7]
TopDownProteomicsiQ6UW88-2 [Q6UW88-2]

PTM databases

PhosphoSitePlusiQ6UW88

Expressioni

Gene expression databases

BgeeiENSG00000182585
CleanExiHS_EPGN
ExpressionAtlasiQ6UW88 baseline and differential

Organism-specific databases

HPAiHPA014369

Interactioni

GO - Molecular functioni

  • epidermal growth factor receptor binding Source: HGNC
  • growth factor activity Source: HGNC

Protein-protein interaction databases

IntActiQ6UW88, 1 interactor

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi66 – 68Combined sources3
Beta strandi74 – 76Combined sources3
Turni77 – 80Combined sources4
Beta strandi81 – 83Combined sources3
Turni92 – 95Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WB8X-ray3.00B/C49-108[»]
ProteinModelPortaliQ6UW88
SMRiQ6UW88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 96EGF-likePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00510000048556
HOVERGENiHBG079616
InParanoidiQ6UW88
OMAiYCYVRKR
OrthoDBiEOG091G0RK4
PhylomeDBiQ6UW88
TreeFamiTF335931

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015497 EGF_rcpt_ligand
PANTHERiPTHR10740 PTHR10740, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6UW88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG
60 70 80 90 100
PIALKFSHLC LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL
110 120 130 140 150
TSYAVDSYEK YIAIGIGVGL LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE

RRPL
Length:154
Mass (Da):17,091
Last modified:March 24, 2009 - v2
Checksum:iBC78016BE3026474
GO
Isoform 2 (identifier: Q6UW88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     137-154: CLKLKSPYNVCSGERRPL → YEKDKI

Show »
Length:133
Mass (Da):14,792
Checksum:i7A5B3257D0484182
GO
Isoform 3 (identifier: Q6UW88-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     96-137: Missing.

Show »
Length:112
Mass (Da):12,319
Checksum:i8D0EE50785FA2891
GO
Isoform 4 (identifier: Q6UW88-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     87-137: Missing.

Show »
Length:103
Mass (Da):11,304
Checksum:i062973EAC9EA4570
GO
Isoform 5 (identifier: Q6UW88-5) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     96-137: Missing.

Show »
Length:103
Mass (Da):11,289
Checksum:i1C1FB863C2FE3419
GO
Isoform 6 (identifier: Q6UW88-6) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     87-137: Missing.

Show »
Length:94
Mass (Da):10,274
Checksum:i13193DA6BF249099
GO
Isoform 7 (identifier: Q6UW88-7) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     15-44: Missing.
     87-137: Missing.

Show »
Length:73
Mass (Da):8,149
Checksum:i860BFE12C853D368
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → A in ABB60048 (Ref. 1) Curated1
Sequence conflicti62E → G in ABB60047 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03665415 – 44Missing in isoform 7. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_03665536 – 44Missing in isoform 2, isoform 5 and isoform 6. 2 Publications9
Alternative sequenceiVSP_03665687 – 137Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_03665796 – 137Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_036658137 – 154CLKLK…ERRPL → YEKDKI in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ235264 mRNA Translation: ABB60043.1
DQ235265 mRNA Translation: ABB60044.1
DQ235266 mRNA Translation: ABB60045.1
DQ235267 mRNA Translation: ABB60046.1
DQ235268 mRNA Translation: ABB60047.1
DQ235269 mRNA Translation: ABB60048.1
AY358920 mRNA Translation: AAQ89279.1
AK289455 mRNA Translation: BAF82144.1
CCDSiCCDS59475.1 [Q6UW88-5]
CCDS59476.1 [Q6UW88-6]
CCDS59477.1 [Q6UW88-3]
CCDS59478.1 [Q6UW88-1]
CCDS59479.1 [Q6UW88-4]
RefSeqiNP_001257918.1, NM_001270989.1 [Q6UW88-1]
NP_001257919.1, NM_001270990.1 [Q6UW88-3]
NP_001257920.1, NM_001270991.1 [Q6UW88-5]
NP_001257921.1, NM_001270992.1 [Q6UW88-4]
NP_001257922.1, NM_001270993.1 [Q6UW88-6]
XP_005265723.1, XM_005265666.4 [Q6UW88-2]
UniGeneiHs.401237

Genome annotation databases

EnsembliENST00000332112; ENSP00000330375; ENSG00000182585 [Q6UW88-2]
ENST00000413830; ENSP00000411898; ENSG00000182585 [Q6UW88-1]
ENST00000502358; ENSP00000426678; ENSG00000182585 [Q6UW88-4]
ENST00000503098; ENSP00000425890; ENSG00000182585 [Q6UW88-3]
ENST00000505212; ENSP00000424392; ENSG00000182585 [Q6UW88-6]
ENST00000509145; ENSP00000426630; ENSG00000182585 [Q6UW88-7]
ENST00000514968; ENSP00000426550; ENSG00000182585 [Q6UW88-5]
GeneIDi255324
KEGGihsa:255324
UCSCiuc003hhw.5 human [Q6UW88-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiEPGN_HUMAN
AccessioniPrimary (citable) accession number: Q6UW88
Secondary accession number(s): A1BMM3
, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8, A8K090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 24, 2009
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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