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Entry version 137 (26 Feb. 2020)
Sequence version 2 (24 Mar. 2009)
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Protein

Epigen

Gene

EPGN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-177929 Signaling by EGFR
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180292 GAB1 signalosome
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-182971 EGFR downregulation
R-HSA-212718 EGFR interacts with phospholipase C-gamma
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6UW88

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epigen
Alternative name(s):
Epithelial mitogen
Short name:
EPG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPGN
ORF Names:UNQ3072/PRO9904
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17470 EPGN

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UW88

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 110ExtracellularSequence analysisAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 154CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
255324

Open Targets

More...
OpenTargetsi
ENSG00000182585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385143

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UW88 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EPGN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
229464464

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 221 PublicationAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004546223 – 154EpigenAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi37N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi41N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi60 ↔ 73PROSITE-ProRule annotation
Disulfide bondi68 ↔ 84PROSITE-ProRule annotation
Disulfide bondi86 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UW88

PeptideAtlas

More...
PeptideAtlasi
Q6UW88

PRoteomics IDEntifications database

More...
PRIDEi
Q6UW88

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67455 [Q6UW88-1]
67456 [Q6UW88-2]
67457 [Q6UW88-3]
67458 [Q6UW88-4]
67459 [Q6UW88-5]
67460 [Q6UW88-6]
67461 [Q6UW88-7]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q6UW88-2 [Q6UW88-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UW88

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UW88

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182585 Expressed in esophagus mucosa and 70 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UW88 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014420

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6UW88, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000411898

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UW88 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6UW88

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 96EGF-likePROSITE-ProRule annotationAdd BLAST41

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048556

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_144237_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UW88

Identification of Orthologs from Complete Genome Data

More...
OMAi
HSYCING

Database of Orthologous Groups

More...
OrthoDBi
1425022at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UW88

TreeFam database of animal gene trees

More...
TreeFami
TF335931

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UW88-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG
60 70 80 90 100
PIALKFSHLC LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL
110 120 130 140 150
TSYAVDSYEK YIAIGIGVGL LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE

RRPL
Length:154
Mass (Da):17,091
Last modified:March 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC78016BE3026474
GO
Isoform 2 (identifier: Q6UW88-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     137-154: CLKLKSPYNVCSGERRPL → YEKDKI

Show »
Length:133
Mass (Da):14,792
Checksum:i7A5B3257D0484182
GO
Isoform 3 (identifier: Q6UW88-3) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     96-137: Missing.

Show »
Length:112
Mass (Da):12,319
Checksum:i8D0EE50785FA2891
GO
Isoform 4 (identifier: Q6UW88-4) [UniParc]FASTAAdd to basket
Also known as: E

The sequence of this isoform differs from the canonical sequence as follows:
     87-137: Missing.

Show »
Length:103
Mass (Da):11,304
Checksum:i062973EAC9EA4570
GO
Isoform 5 (identifier: Q6UW88-5) [UniParc]FASTAAdd to basket
Also known as: F

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     96-137: Missing.

Show »
Length:103
Mass (Da):11,289
Checksum:i1C1FB863C2FE3419
GO
Isoform 6 (identifier: Q6UW88-6) [UniParc]FASTAAdd to basket
Also known as: G

The sequence of this isoform differs from the canonical sequence as follows:
     36-44: Missing.
     87-137: Missing.

Show »
Length:94
Mass (Da):10,274
Checksum:i13193DA6BF249099
GO
Isoform 7 (identifier: Q6UW88-7) [UniParc]FASTAAdd to basket
Also known as: D

The sequence of this isoform differs from the canonical sequence as follows:
     15-44: Missing.
     87-137: Missing.

Show »
Length:73
Mass (Da):8,149
Checksum:i860BFE12C853D368
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BM13H3BM13_HUMAN
Epigen
EPGN
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0PK19A0PK19_HUMAN
EPGN protein
EPGN
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9V → A in ABB60048 (Ref. 1) Curated1
Sequence conflicti62E → G in ABB60047 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03665415 – 44Missing in isoform 7. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_03665536 – 44Missing in isoform 2, isoform 5 and isoform 6. 2 Publications9
Alternative sequenceiVSP_03665687 – 137Missing in isoform 4, isoform 6 and isoform 7. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_03665796 – 137Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_036658137 – 154CLKLK…ERRPL → YEKDKI in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ235264 mRNA Translation: ABB60043.1
DQ235265 mRNA Translation: ABB60044.1
DQ235266 mRNA Translation: ABB60045.1
DQ235267 mRNA Translation: ABB60046.1
DQ235268 mRNA Translation: ABB60047.1
DQ235269 mRNA Translation: ABB60048.1
AY358920 mRNA Translation: AAQ89279.1
AK289455 mRNA Translation: BAF82144.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59475.1 [Q6UW88-5]
CCDS59476.1 [Q6UW88-6]
CCDS59477.1 [Q6UW88-3]
CCDS59478.1 [Q6UW88-1]
CCDS59479.1 [Q6UW88-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001257918.1, NM_001270989.1 [Q6UW88-1]
NP_001257919.1, NM_001270990.1 [Q6UW88-3]
NP_001257920.1, NM_001270991.1 [Q6UW88-5]
NP_001257921.1, NM_001270992.1 [Q6UW88-4]
NP_001257922.1, NM_001270993.1 [Q6UW88-6]
XP_005265723.1, XM_005265666.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000332112; ENSP00000330375; ENSG00000182585 [Q6UW88-2]
ENST00000413830; ENSP00000411898; ENSG00000182585 [Q6UW88-1]
ENST00000502358; ENSP00000426678; ENSG00000182585 [Q6UW88-4]
ENST00000503098; ENSP00000425890; ENSG00000182585 [Q6UW88-3]
ENST00000505212; ENSP00000424392; ENSG00000182585 [Q6UW88-6]
ENST00000509145; ENSP00000426630; ENSG00000182585 [Q6UW88-7]
ENST00000514968; ENSP00000426550; ENSG00000182585 [Q6UW88-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
255324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:255324

UCSC genome browser

More...
UCSCi
uc003hhw.5 human [Q6UW88-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ235264 mRNA Translation: ABB60043.1
DQ235265 mRNA Translation: ABB60044.1
DQ235266 mRNA Translation: ABB60045.1
DQ235267 mRNA Translation: ABB60046.1
DQ235268 mRNA Translation: ABB60047.1
DQ235269 mRNA Translation: ABB60048.1
AY358920 mRNA Translation: AAQ89279.1
AK289455 mRNA Translation: BAF82144.1
CCDSiCCDS59475.1 [Q6UW88-5]
CCDS59476.1 [Q6UW88-6]
CCDS59477.1 [Q6UW88-3]
CCDS59478.1 [Q6UW88-1]
CCDS59479.1 [Q6UW88-4]
RefSeqiNP_001257918.1, NM_001270989.1 [Q6UW88-1]
NP_001257919.1, NM_001270990.1 [Q6UW88-3]
NP_001257920.1, NM_001270991.1 [Q6UW88-5]
NP_001257921.1, NM_001270992.1 [Q6UW88-4]
NP_001257922.1, NM_001270993.1 [Q6UW88-6]
XP_005265723.1, XM_005265666.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WB8X-ray3.00B/C49-108[»]
SMRiQ6UW88
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ6UW88, 4 interactors
STRINGi9606.ENSP00000411898

PTM databases

iPTMnetiQ6UW88
PhosphoSitePlusiQ6UW88

Polymorphism and mutation databases

BioMutaiEPGN
DMDMi229464464

Proteomic databases

MassIVEiQ6UW88
PeptideAtlasiQ6UW88
PRIDEiQ6UW88
ProteomicsDBi67455 [Q6UW88-1]
67456 [Q6UW88-2]
67457 [Q6UW88-3]
67458 [Q6UW88-4]
67459 [Q6UW88-5]
67460 [Q6UW88-6]
67461 [Q6UW88-7]
TopDownProteomicsiQ6UW88-2 [Q6UW88-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
255324

Genome annotation databases

EnsembliENST00000332112; ENSP00000330375; ENSG00000182585 [Q6UW88-2]
ENST00000413830; ENSP00000411898; ENSG00000182585 [Q6UW88-1]
ENST00000502358; ENSP00000426678; ENSG00000182585 [Q6UW88-4]
ENST00000503098; ENSP00000425890; ENSG00000182585 [Q6UW88-3]
ENST00000505212; ENSP00000424392; ENSG00000182585 [Q6UW88-6]
ENST00000509145; ENSP00000426630; ENSG00000182585 [Q6UW88-7]
ENST00000514968; ENSP00000426550; ENSG00000182585 [Q6UW88-5]
GeneIDi255324
KEGGihsa:255324
UCSCiuc003hhw.5 human [Q6UW88-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
255324
DisGeNETi255324

GeneCards: human genes, protein and diseases

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GeneCardsi
EPGN
HGNCiHGNC:17470 EPGN
HPAiHPA014420
neXtProtiNX_Q6UW88
OpenTargetsiENSG00000182585
PharmGKBiPA162385143

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00510000048556
HOGENOMiCLU_144237_1_0_1
InParanoidiQ6UW88
OMAiHSYCING
OrthoDBi1425022at2759
PhylomeDBiQ6UW88
TreeFamiTF335931

Enzyme and pathway databases

ReactomeiR-HSA-1257604 PIP3 activates AKT signaling
R-HSA-177929 Signaling by EGFR
R-HSA-179812 GRB2 events in EGFR signaling
R-HSA-180292 GAB1 signalosome
R-HSA-180336 SHC1 events in EGFR signaling
R-HSA-182971 EGFR downregulation
R-HSA-212718 EGFR interacts with phospholipase C-gamma
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5638303 Inhibition of Signaling by Overexpressed EGFR
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis
R-HSA-9009391 Extra-nuclear estrogen signaling
R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SIGNORiQ6UW88

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
255324
PharosiQ6UW88 Tbio

Protein Ontology

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PROi
PR:Q6UW88
RNActiQ6UW88 protein

Gene expression databases

BgeeiENSG00000182585 Expressed in esophagus mucosa and 70 other tissues
ExpressionAtlasiQ6UW88 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEPGN_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UW88
Secondary accession number(s): A1BMM3
, A1BMM4, A1BMM5, A1BMM6, A1BMM7, A1BMM8, A8K090
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: March 24, 2009
Last modified: February 26, 2020
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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