UniProtKB - Q6UW68 (TM205_HUMAN)
Protein
Transmembrane protein 205
Gene
TMEM205
Organism
Homo sapiens (Human)
Status
Functioni
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.1 Publication
Enzyme and pathway databases
PathwayCommonsi | Q6UW68 |
Protein family/group databases
TCDBi | 9.A.55.1.1, the tmem205 (tmem205) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 205 |
Gene namesi | Name:TMEM205 ORF Names:UNQ501/PRO1018 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29631, TMEM205 |
MIMi | 613771, gene |
neXtProti | NX_Q6UW68 |
VEuPathDBi | HostDB:ENSG00000105518.13 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 53 – 73 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 374882 |
OpenTargetsi | ENSG00000105518 |
PharmGKBi | PA162406385 |
Miscellaneous databases
Pharosi | Q6UW68, Tdark |
Genetic variation databases
BioMutai | TMEM205 |
DMDMi | 74749383 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317501 | 1 – 189 | Transmembrane protein 205Add BLAST | 189 |
Proteomic databases
EPDi | Q6UW68 |
jPOSTi | Q6UW68 |
MassIVEi | Q6UW68 |
MaxQBi | Q6UW68 |
PaxDbi | Q6UW68 |
PeptideAtlasi | Q6UW68 |
PRIDEi | Q6UW68 |
ProteomicsDBi | 67453 |
TopDownProteomicsi | Q6UW68 |
PTM databases
iPTMneti | Q6UW68 |
PhosphoSitePlusi | Q6UW68 |
SwissPalmi | Q6UW68 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000105518, Expressed in right lobe of liver and 211 other tissues |
ExpressionAtlasi | Q6UW68, baseline and differential |
Genevisiblei | Q6UW68, HS |
Organism-specific databases
HPAi | ENSG00000105518, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6UW68
Protein-protein interaction databases
BioGRIDi | 131930, 63 interactors |
IntActi | Q6UW68, 28 interactors |
MINTi | Q6UW68 |
STRINGi | 9606.ENSP00000346954 |
Miscellaneous databases
RNActi | Q6UW68, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the TMEM205 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2886, Eukaryota |
GeneTreei | ENSGT00390000016298 |
InParanoidi | Q6UW68 |
OMAi | WEASQLC |
OrthoDBi | 1785664at2759 |
PhylomeDBi | Q6UW68 |
TreeFami | TF323838 |
Family and domain databases
InterProi | View protein in InterPro IPR025423, DUF4149 IPR042623, TMEM205 |
PANTHERi | PTHR46916, PTHR46916, 1 hit |
Pfami | View protein in Pfam PF13664, DUF4149, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
Q6UW68-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEEGGNLGGL IKMVHLLVLS GAWGMQMWVT FVSGFLLFRS LPRHTFGLVQ
60 70 80 90 100
SKLFPFYFHI SMGCAFINLC ILASQHAWAQ LTFWEASQLY LLFLSLTLAT
110 120 130 140 150
VNARWLEPRT TAAMWALQTV EKERGLGGEV PGSHQGPDPY RQLREKDPKY
160 170 180
SALRQNFFRY HGLSSLCNLG CVLSNGLCLA GLALEIRSL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7ELQ9 | K7ELQ9_HUMAN | Transmembrane protein 205 | TMEM205 | 170 | Annotation score: | ||
K7EJQ9 | K7EJQ9_HUMAN | Transmembrane protein 205 | TMEM205 | 107 | Annotation score: | ||
K7ER05 | K7ER05_HUMAN | Transmembrane protein 205 | TMEM205 | 88 | Annotation score: | ||
K7EM09 | K7EM09_HUMAN | Transmembrane protein 205 | TMEM205 | 120 | Annotation score: | ||
K7EPR0 | K7EPR0_HUMAN | Transmembrane protein 205 | TMEM205 | 128 | Annotation score: | ||
K7EMV9 | K7EMV9_HUMAN | Transmembrane protein 205 | TMEM205 | 123 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358949 mRNA Translation: AAQ89308.1 AK291979 mRNA Translation: BAF84668.1 CH471106 Genomic DNA Translation: EAW84191.1 BC064948 mRNA Translation: AAH64948.1 BC091472 mRNA Translation: AAH91472.1 |
CCDSi | CCDS32909.1 |
RefSeqi | NP_001138888.1, NM_001145416.1 NP_001308041.1, NM_001321112.1 NP_001308042.1, NM_001321113.1 NP_001308043.1, NM_001321114.1 NP_212133.1, NM_033408.3 NP_940938.1, NM_198536.2 XP_005259956.1, XM_005259899.2 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358949 mRNA Translation: AAQ89308.1 AK291979 mRNA Translation: BAF84668.1 CH471106 Genomic DNA Translation: EAW84191.1 BC064948 mRNA Translation: AAH64948.1 BC091472 mRNA Translation: AAH91472.1 |
CCDSi | CCDS32909.1 |
RefSeqi | NP_001138888.1, NM_001145416.1 NP_001308041.1, NM_001321112.1 NP_001308042.1, NM_001321113.1 NP_001308043.1, NM_001321114.1 NP_212133.1, NM_033408.3 NP_940938.1, NM_198536.2 XP_005259956.1, XM_005259899.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131930, 63 interactors |
IntActi | Q6UW68, 28 interactors |
MINTi | Q6UW68 |
STRINGi | 9606.ENSP00000346954 |
Protein family/group databases
TCDBi | 9.A.55.1.1, the tmem205 (tmem205) family |
PTM databases
iPTMneti | Q6UW68 |
PhosphoSitePlusi | Q6UW68 |
SwissPalmi | Q6UW68 |
Genetic variation databases
BioMutai | TMEM205 |
DMDMi | 74749383 |
Proteomic databases
EPDi | Q6UW68 |
jPOSTi | Q6UW68 |
MassIVEi | Q6UW68 |
MaxQBi | Q6UW68 |
PaxDbi | Q6UW68 |
PeptideAtlasi | Q6UW68 |
PRIDEi | Q6UW68 |
ProteomicsDBi | 67453 |
TopDownProteomicsi | Q6UW68 |
Protocols and materials databases
Antibodypediai | 52091, 110 antibodies |
DNASUi | 374882 |
Genome annotation databases
Organism-specific databases
CTDi | 374882 |
DisGeNETi | 374882 |
GeneCardsi | TMEM205 |
HGNCi | HGNC:29631, TMEM205 |
HPAi | ENSG00000105518, Low tissue specificity |
MIMi | 613771, gene |
neXtProti | NX_Q6UW68 |
OpenTargetsi | ENSG00000105518 |
PharmGKBi | PA162406385 |
VEuPathDBi | HostDB:ENSG00000105518.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2886, Eukaryota |
GeneTreei | ENSGT00390000016298 |
InParanoidi | Q6UW68 |
OMAi | WEASQLC |
OrthoDBi | 1785664at2759 |
PhylomeDBi | Q6UW68 |
TreeFami | TF323838 |
Enzyme and pathway databases
PathwayCommonsi | Q6UW68 |
Miscellaneous databases
BioGRID-ORCSi | 374882, 8 hits in 1001 CRISPR screens |
ChiTaRSi | TMEM205, human |
GenomeRNAii | 374882 |
Pharosi | Q6UW68, Tdark |
PROi | PR:Q6UW68 |
RNActi | Q6UW68, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105518, Expressed in right lobe of liver and 211 other tissues |
ExpressionAtlasi | Q6UW68, baseline and differential |
Genevisiblei | Q6UW68, HS |
Family and domain databases
InterProi | View protein in InterPro IPR025423, DUF4149 IPR042623, TMEM205 |
PANTHERi | PTHR46916, PTHR46916, 1 hit |
Pfami | View protein in Pfam PF13664, DUF4149, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM205_HUMAN | |
Accessioni | Q6UW68Primary (citable) accession number: Q6UW68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families