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Protein

KDEL motif-containing protein 1

Gene

KDELC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

CAZyiGT90 Glycosyltransferase Family 90

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL motif-containing protein 1
Alternative name(s):
Endoplasmic reticulum resident protein 58
Short name:
ER protein 58
Short name:
ERp58
Gene namesi
Name:KDELC1
Synonyms:EP58
ORF Names:UNQ1910/PRO4357
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000134901.12
HGNCiHGNC:19350 KDELC1
MIMi611613 gene
neXtProtiNX_Q6UW63

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi79070
OpenTargetsiENSG00000134901
PharmGKBiPA134974174

Polymorphism and mutation databases

BioMutaiKDELC1
DMDMi74749382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024716320 – 502KDEL motif-containing protein 1Add BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6UW63
MaxQBiQ6UW63
PaxDbiQ6UW63
PeptideAtlasiQ6UW63
PRIDEiQ6UW63
ProteomicsDBi67452

PTM databases

iPTMnetiQ6UW63
PhosphoSitePlusiQ6UW63

Expressioni

Gene expression databases

BgeeiENSG00000134901
CleanExiHS_KDELC1
GenevisibleiQ6UW63 HS

Organism-specific databases

HPAiCAB020780
HPA043946
HPA064398

Interactioni

Protein-protein interaction databases

BioGridi122521, 12 interactors
IntActiQ6UW63, 1 interactor
STRINGi9606.ENSP00000365172

Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni29 – 31Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi72 – 76Combined sources5
Beta strandi88 – 90Combined sources3
Beta strandi93 – 95Combined sources3
Beta strandi98 – 100Combined sources3
Beta strandi111 – 118Combined sources8
Beta strandi125 – 127Combined sources3

3D structure databases

ProteinModelPortaliQ6UW63
SMRiQ6UW63
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6UW63

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 130FilaminAdd BLAST107

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi499 – 502Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the KDELC family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2458 Eukaryota
ENOG410XT5U LUCA
GeneTreeiENSGT00530000063132
HOGENOMiHOG000286007
HOVERGENiHBG081852
InParanoidiQ6UW63
OMAiPEKSEIW
OrthoDBiEOG091G04SJ
PhylomeDBiQ6UW63
TreeFamiTF323280

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR017868 Filamin/ABP280_repeat-like
IPR001298 Filamin/ABP280_rpt
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR006598 LipoPS_modifying
PfamiView protein in Pfam
PF00630 Filamin, 1 hit
PF05686 Glyco_transf_90, 1 hit
SMARTiView protein in SMART
SM00672 CAP10, 1 hit
SM00557 IG_FLMN, 1 hit
SUPFAMiSSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50194 FILAMIN_REPEAT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UW63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGTLLLYCF FLATVPALAE TGGERQLSPE KSEIWGPGLK ADVVLPARYF
60 70 80 90 100
YIQAVDTSGN KFTSSPGEKV FQVKVSAPEE QFTRVGVQVL DRKDGSFIVR
110 120 130 140 150
YRMYASYKNL KVEIKFQGQH VAKSPYILKG PVYHENCDCP LQDSAAWLRE
160 170 180 190 200
MNCPETIAQI QRDLAHFPAV DPEKIAVEIP KRFGQRQSLC HYTLKDNKVY
210 220 230 240 250
IKTHGEHVGF RIFMDAILLS LTRKVKMPDV ELFVNLGDWP LEKKKSNSNI
260 270 280 290 300
HPIFSWCGST DSKDIVMPTY DLTDSVLETM GRVSLDMMSV QANTGPPWES
310 320 330 340 350
KNSTAVWRGR DSRKERLELV KLSRKHPELI DAAFTNFFFF KHDENLYGPI
360 370 380 390 400
VKHISFFDFF KHKYQINIDG TVAAYRLPYL LVGDSVVLKQ DSIYYEHFYN
410 420 430 440 450
ELQPWKHYIP VKSNLSDLLE KLKWAKDHDE EAKKIAKAGQ EFARNNLMGD
460 470 480 490 500
DIFCYYFKLF QEYANLQVSE PQIREGMKRV EPQTEDDLFP CTCHRKKTKD

EL
Length:502
Mass (Da):58,043
Last modified:July 5, 2004 - v1
Checksum:i82633729E373E116
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109N → S in BAD96287 (Ref. 2) Curated1
Sequence conflicti163D → G in BAD96287 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027080114I → V1 PublicationCorresponds to variant dbSNP:rs1047740Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358959 mRNA Translation: AAQ89318.1
AK222567 mRNA Translation: BAD96287.1
AL157769 Genomic DNA No translation available.
BC001297 mRNA Translation: AAH01297.1
CCDSiCCDS9504.1
RefSeqiNP_001305661.1, NM_001318732.1
NP_076994.2, NM_024089.2
UniGeneiHs.408629

Genome annotation databases

EnsembliENST00000376004; ENSP00000365172; ENSG00000134901
GeneIDi79070
KEGGihsa:79070
UCSCiuc001vpq.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKDEL1_HUMAN
AccessioniPrimary (citable) accession number: Q6UW63
Secondary accession number(s): Q53HL3, Q9BVD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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