Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

All-trans retinoic acid-induced differentiation factor

Gene

ATRAID

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.1 Publication

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
All-trans retinoic acid-induced differentiation factor
Alternative name(s):
Apoptosis-related protein 3
Short name:
APR-3
p18
Gene namesi
Name:ATRAID
Synonyms:APR3, C2orf28
ORF Names:HSPC013, UNQ214/PRO240
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138085.16
HGNCiHGNC:24090 ATRAID
neXtProtiNX_Q6UW56

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 199ExtracellularSequence analysisAdd BLAST169
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Topological domaini221 – 229CytoplasmicSequence analysis9

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51374
OpenTargetsiENSG00000138085
PharmGKBiPA134964154

Polymorphism and mutation databases

BioMutaiATRAID
DMDMi239938597

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 301 PublicationAdd BLAST30
ChainiPRO_000002075231 – 229All-trans retinoic acid-induced differentiation factorAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 171PROSITE-ProRule annotation
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 181PROSITE-ProRule annotation
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi183 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6UW56
PaxDbiQ6UW56
PeptideAtlasiQ6UW56
PRIDEiQ6UW56
ProteomicsDBi67447
67448 [Q6UW56-2]
67449 [Q6UW56-3]

PTM databases

GlyConnecti1000
iPTMnetiQ6UW56
PhosphoSitePlusiQ6UW56

Expressioni

Tissue specificityi

Weakly expressed in hematopoietic cell lines.1 Publication

Inductioni

Up-regulated by all-trans-retinoic acid (ATRA) in several tumor cell lines.1 Publication

Gene expression databases

BgeeiENSG00000138085 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_C2orf28
ExpressionAtlasiQ6UW56 baseline and differential
GenevisibleiQ6UW56 HS

Organism-specific databases

HPAiHPA051353

Interactioni

Subunit structurei

Interacts with NELL1; the interaction promotes osteoblastic differentiation and mineralization.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi119507, 4 interactors
IntActiQ6UW56, 5 interactors
MINTiQ6UW56
STRINGi9606.ENSP00000369518

Structurei

3D structure databases

ProteinModelPortaliQ6UW56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 193EGF-likePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYNU Eukaryota
ENOG4111PJW LUCA
GeneTreeiENSGT00390000017252
HOVERGENiHBG054041
InParanoidiQ6UW56
OMAiPGGINAW
OrthoDBiEOG091G0PFL
PhylomeDBiQ6UW56
TreeFamiTF335766

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UW56-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF
60 70 80 90 100
YCKTTRELML HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL
110 120 130 140 150
QANPLKGDLA NTFRGFTQLQ TLILPQHVNC PGGINAWNTI TSYIDNQICQ
160 170 180 190 200
GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ CVCADGFHGY KCMRQGSFSL
210 220
LMFFGILGAT TLSVSILLWA TQRRKAKTS
Length:229
Mass (Da):24,747
Last modified:June 16, 2009 - v2
Checksum:iCF051C5E886BCFF1
GO
Isoform 2 (identifier: Q6UW56-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: Missing.

Note: Produced by alternative splicing of isoform 1. No experimental confirmation available.
Show »
Length:171
Mass (Da):18,597
Checksum:i91A42CD2B2CB0883
GO
Isoform 3 (identifier: Q6UW56-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MKTSAELHEQEKPPSSPRATGPGRLGHARGRGPDALRGGAAGPGRASSGAPRERKM

Note: Produced by alternative promoter usage.
Show »
Length:284
Mass (Da):30,342
Checksum:iF7F1A5CEC82ABB39
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA62C9JA62_HUMAN
All-trans retinoic acid-induced dif...
ATRAID
75Annotation score:

Sequence cautioni

The sequence AAD27770 differs from that shown. Reason: Frameshift at position 19.Curated
The sequence AAD31317 differs from that shown. Reason: Frameshift at position 189.Curated
The sequence AAD31317 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH02846 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH11006 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH35850 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAX93173 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5D → G in BAF80618 (Ref. 1) Curated1
Sequence conflicti5D → G in AAD27770 (PubMed:11042152).Curated1
Sequence conflicti5D → G in AAQ89327 (PubMed:12975309).Curated1
Sequence conflicti5D → G in AAH02846 (PubMed:15489334).Curated1
Sequence conflicti5D → G in AAH11006 (PubMed:15489334).Curated1
Sequence conflicti5D → G in AAH35850 (PubMed:15489334).Curated1
Sequence conflicti33E → EP in AAK69412 (Ref. 3) Curated1
Sequence conflicti219W → S in BAF80618 (Ref. 1) Curated1
Sequence conflicti221T → A in AAK69412 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057991209A → S1 PublicationCorresponds to variant dbSNP:rs7437Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0141081 – 58Missing in isoform 2. 4 PublicationsAdd BLAST58
Alternative sequenceiVSP_0375211M → MKTSAELHEQEKPPSSPRAT GPGRLGHARGRGPDALRGGA AGPGRASSGAPRERKM in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009017 mRNA Translation: BAF80618.1
AF144055 mRNA Translation: AAD31317.2 Sequence problems.
AF275744 mRNA Translation: AAK69412.1
AF077037 mRNA Translation: AAD27770.1 Frameshift.
AY358968 mRNA Translation: AAQ89327.1
AK291894 mRNA Translation: BAF84583.1
CR600041 mRNA No translation available.
AC013403 Genomic DNA Translation: AAX93173.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00617.1
BC002846 mRNA Translation: AAH02846.2 Different initiation.
BC011006 mRNA Translation: AAH11006.3 Different initiation.
BC021237 mRNA Translation: AAH21237.1
BC035850 mRNA Translation: AAH35850.1 Different initiation.
CCDSiCCDS1741.1 [Q6UW56-3]
CCDS46243.1 [Q6UW56-2]
CCDS62877.1 [Q6UW56-1]
RefSeqiNP_001164266.1, NM_001170795.1 [Q6UW56-1]
NP_057169.2, NM_016085.4 [Q6UW56-2]
NP_542159.3, NM_080592.3 [Q6UW56-3]
UniGeneiHs.9527

Genome annotation databases

EnsembliENST00000380171; ENSP00000369518; ENSG00000138085 [Q6UW56-3]
ENST00000405489; ENSP00000384033; ENSG00000138085 [Q6UW56-2]
ENST00000606999; ENSP00000476080; ENSG00000138085 [Q6UW56-1]
ENST00000611786; ENSP00000484228; ENSG00000138085 [Q6UW56-3]
GeneIDi51374
KEGGihsa:51374
UCSCiuc002rjf.5 human [Q6UW56-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009017 mRNA Translation: BAF80618.1
AF144055 mRNA Translation: AAD31317.2 Sequence problems.
AF275744 mRNA Translation: AAK69412.1
AF077037 mRNA Translation: AAD27770.1 Frameshift.
AY358968 mRNA Translation: AAQ89327.1
AK291894 mRNA Translation: BAF84583.1
CR600041 mRNA No translation available.
AC013403 Genomic DNA Translation: AAX93173.1 Sequence problems.
CH471053 Genomic DNA Translation: EAX00617.1
BC002846 mRNA Translation: AAH02846.2 Different initiation.
BC011006 mRNA Translation: AAH11006.3 Different initiation.
BC021237 mRNA Translation: AAH21237.1
BC035850 mRNA Translation: AAH35850.1 Different initiation.
CCDSiCCDS1741.1 [Q6UW56-3]
CCDS46243.1 [Q6UW56-2]
CCDS62877.1 [Q6UW56-1]
RefSeqiNP_001164266.1, NM_001170795.1 [Q6UW56-1]
NP_057169.2, NM_016085.4 [Q6UW56-2]
NP_542159.3, NM_080592.3 [Q6UW56-3]
UniGeneiHs.9527

3D structure databases

ProteinModelPortaliQ6UW56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119507, 4 interactors
IntActiQ6UW56, 5 interactors
MINTiQ6UW56
STRINGi9606.ENSP00000369518

PTM databases

GlyConnecti1000
iPTMnetiQ6UW56
PhosphoSitePlusiQ6UW56

Polymorphism and mutation databases

BioMutaiATRAID
DMDMi239938597

Proteomic databases

MaxQBiQ6UW56
PaxDbiQ6UW56
PeptideAtlasiQ6UW56
PRIDEiQ6UW56
ProteomicsDBi67447
67448 [Q6UW56-2]
67449 [Q6UW56-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380171; ENSP00000369518; ENSG00000138085 [Q6UW56-3]
ENST00000405489; ENSP00000384033; ENSG00000138085 [Q6UW56-2]
ENST00000606999; ENSP00000476080; ENSG00000138085 [Q6UW56-1]
ENST00000611786; ENSP00000484228; ENSG00000138085 [Q6UW56-3]
GeneIDi51374
KEGGihsa:51374
UCSCiuc002rjf.5 human [Q6UW56-1]

Organism-specific databases

CTDi51374
DisGeNETi51374
EuPathDBiHostDB:ENSG00000138085.16
GeneCardsiATRAID
HGNCiHGNC:24090 ATRAID
HPAiHPA051353
neXtProtiNX_Q6UW56
OpenTargetsiENSG00000138085
PharmGKBiPA134964154
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYNU Eukaryota
ENOG4111PJW LUCA
GeneTreeiENSGT00390000017252
HOVERGENiHBG054041
InParanoidiQ6UW56
OMAiPGGINAW
OrthoDBiEOG091G0PFL
PhylomeDBiQ6UW56
TreeFamiTF335766

Miscellaneous databases

ChiTaRSiATRAID human
GeneWikiiC2orf28
GenomeRNAii51374
PROiPR:Q6UW56

Gene expression databases

BgeeiENSG00000138085 Expressed in 225 organ(s), highest expression level in testis
CleanExiHS_C2orf28
ExpressionAtlasiQ6UW56 baseline and differential
GenevisibleiQ6UW56 HS

Family and domain databases

InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARAID_HUMAN
AccessioniPrimary (citable) accession number: Q6UW56
Secondary accession number(s): A8C1S2
, A8K779, Q96FF6, Q96RT2, Q9Y2R7, Q9Y5L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again