Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regenerating islet-derived protein 3-gamma

Gene

REG3G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and differentiation after skin injury.1 Publication

GO - Molecular functioni

  • oligosaccharide binding Source: UniProtKB
  • peptidoglycan binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processAcute phase, Inflammatory response
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Names & Taxonomyi

Protein namesi
Recommended name:
Regenerating islet-derived protein 3-gamma
Short name:
REG-3-gamma
Alternative name(s):
Pancreatitis-associated protein 1B
Short name:
PAP-1B
Pancreatitis-associated protein IB
Short name:
PAP IB
Regenerating islet-derived protein III-gamma
Short name:
REG III
Short name:
Reg III-gamma
Cleaved into the following 2 chains:
Gene namesi
Name:REG3G
Synonyms:PAP1B
ORF Names:UNQ429/PRO162
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000143954.12
HGNCiHGNC:29595 REG3G
MIMi609933 gene
neXtProtiNX_Q6UW15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi130120
OpenTargetsiENSG00000143954
PharmGKBiPA142671087

Polymorphism and mutation databases

BioMutaiREG3G
DMDMi68565895

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000001743427 – 175Regenerating islet-derived protein 3-gamma 16.5 kDa formAdd BLAST149
PropeptideiPRO_000042275127 – 371 PublicationAdd BLAST11
ChainiPRO_000042275238 – 175Regenerating islet-derived protein 3-gamma 15 kDa formAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 51PROSITE-ProRule annotation
Disulfide bondi68 ↔ 171PROSITE-ProRule annotation
Disulfide bondi146 ↔ 163PROSITE-ProRule annotation

Post-translational modificationi

Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ6UW15
PaxDbiQ6UW15
PeptideAtlasiQ6UW15
PRIDEiQ6UW15
ProteomicsDBi67443

Expressioni

Tissue specificityi

Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta.2 Publications

Gene expression databases

BgeeiENSG00000143954 Expressed in 86 organ(s), highest expression level in duodenum
CleanExiHS_REG3G
GenevisibleiQ6UW15 HS

Organism-specific databases

HPAiHPA047894
HPA048334
HPA060705

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000272324

Structurei

3D structure databases

ProteinModelPortaliQ6UW15
SMRiQ6UW15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 172C-type lectinPROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi114 – 116EPNBy similarity3

Domaini

The EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ6UW15
OMAiQKRPSGK
OrthoDBiEOG091G0MDY
PhylomeDBiQ6UW15

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6UW15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPPMALPSV SWMLLSCLIL LCQVQGEETQ KELPSPRISC PKGSKAYGSP
60 70 80 90 100
CYALFLSPKS WMDADLACQK RPSGKLVSVL SGAEGSFVSS LVRSISNSYS
110 120 130 140 150
YIWIGLHDPT QGSEPDGDGW EWSSTDVMNY FAWEKNPSTI LNPGHCGSLS
160 170
RSTGFLKWKD YNCDAKLPYV CKFKD
Length:175
Mass (Da):19,330
Last modified:July 5, 2004 - v1
Checksum:iAF0F5FC59ACB90F5
GO
Isoform 2 (identifier: Q6UW15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: Missing.

Show »
Length:129
Mass (Da):14,409
Checksum:iB5047BC23CFB243D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174K → T in CAG46736 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04516966 – 111Missing in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161037 mRNA Translation: BAD51394.1
AB161038 mRNA Translation: BAD51396.1
AY428734 mRNA Translation: AAR88147.1
AY359047 mRNA Translation: AAQ89406.1
CR541938 mRNA Translation: CAG46736.1
AB161039 Genomic DNA Translation: BAD51395.1
AK292595 mRNA Translation: BAF85284.1
AC017004 Genomic DNA Translation: AAX88840.1
CH471053 Genomic DNA Translation: EAW99580.1
CH471053 Genomic DNA Translation: EAW99581.1
BC103852 mRNA Translation: AAI03853.1
BC103853 mRNA Translation: AAI03854.1
BC103854 mRNA Translation: AAI03855.1
CCDSiCCDS1962.1 [Q6UW15-1]
CCDS58714.1 [Q6UW15-2]
RefSeqiNP_001008388.1, NM_001008387.2 [Q6UW15-1]
NP_001256969.1, NM_001270040.1 [Q6UW15-2]
NP_940850.1, NM_198448.3 [Q6UW15-1]
XP_005264192.1, XM_005264135.2 [Q6UW15-1]
UniGeneiHs.447084

Genome annotation databases

EnsembliENST00000272324; ENSP00000272324; ENSG00000143954 [Q6UW15-1]
ENST00000393897; ENSP00000377475; ENSG00000143954 [Q6UW15-1]
ENST00000409471; ENSP00000387105; ENSG00000143954 [Q6UW15-2]
GeneIDi130120
KEGGihsa:130120
UCSCiuc002snw.5 human [Q6UW15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB161037 mRNA Translation: BAD51394.1
AB161038 mRNA Translation: BAD51396.1
AY428734 mRNA Translation: AAR88147.1
AY359047 mRNA Translation: AAQ89406.1
CR541938 mRNA Translation: CAG46736.1
AB161039 Genomic DNA Translation: BAD51395.1
AK292595 mRNA Translation: BAF85284.1
AC017004 Genomic DNA Translation: AAX88840.1
CH471053 Genomic DNA Translation: EAW99580.1
CH471053 Genomic DNA Translation: EAW99581.1
BC103852 mRNA Translation: AAI03853.1
BC103853 mRNA Translation: AAI03854.1
BC103854 mRNA Translation: AAI03855.1
CCDSiCCDS1962.1 [Q6UW15-1]
CCDS58714.1 [Q6UW15-2]
RefSeqiNP_001008388.1, NM_001008387.2 [Q6UW15-1]
NP_001256969.1, NM_001270040.1 [Q6UW15-2]
NP_940850.1, NM_198448.3 [Q6UW15-1]
XP_005264192.1, XM_005264135.2 [Q6UW15-1]
UniGeneiHs.447084

3D structure databases

ProteinModelPortaliQ6UW15
SMRiQ6UW15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000272324

Polymorphism and mutation databases

BioMutaiREG3G
DMDMi68565895

Proteomic databases

EPDiQ6UW15
PaxDbiQ6UW15
PeptideAtlasiQ6UW15
PRIDEiQ6UW15
ProteomicsDBi67443

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272324; ENSP00000272324; ENSG00000143954 [Q6UW15-1]
ENST00000393897; ENSP00000377475; ENSG00000143954 [Q6UW15-1]
ENST00000409471; ENSP00000387105; ENSG00000143954 [Q6UW15-2]
GeneIDi130120
KEGGihsa:130120
UCSCiuc002snw.5 human [Q6UW15-1]

Organism-specific databases

CTDi130120
DisGeNETi130120
EuPathDBiHostDB:ENSG00000143954.12
GeneCardsiREG3G
HGNCiHGNC:29595 REG3G
HPAiHPA047894
HPA048334
HPA060705
MIMi609933 gene
neXtProtiNX_Q6UW15
OpenTargetsiENSG00000143954
PharmGKBiPA142671087
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiQ6UW15
OMAiQKRPSGK
OrthoDBiEOG091G0MDY
PhylomeDBiQ6UW15

Enzyme and pathway databases

ReactomeiR-HSA-6803157 Antimicrobial peptides

Miscellaneous databases

GeneWikiiREG3G
GenomeRNAii130120
PROiPR:Q6UW15
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143954 Expressed in 86 organ(s), highest expression level in duodenum
CleanExiHS_REG3G
GenevisibleiQ6UW15 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG3G_HUMAN
AccessioniPrimary (citable) accession number: Q6UW15
Secondary accession number(s): A8K980
, D6W5J6, Q3SYE4, Q3SYE6, Q6FH18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again