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Entry version 146 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

DBH-like monooxygenase protein 1

Gene

MOXD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu2+By similarityNote: Binds 2 copper ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei203Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi235Copper ABy similarity1
Metal bindingi236Copper ABy similarity1
Metal bindingi307Copper ABy similarity1
Active sitei389Sequence analysis1
Metal bindingi389Copper BBy similarity1
Metal bindingi391Copper BBy similarity1
Metal bindingi464Copper BBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandCopper, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6UVY6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6UVY6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DBH-like monooxygenase protein 1 (EC:1.14.17.-)
Alternative name(s):
Monooxygenase X
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOXD1
Synonyms:MOX
ORF Names:UNQ2493/PRO5780
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000079931.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21063, MOXD1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609000, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UVY6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 592LumenalSequence analysisAdd BLAST573
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei593 – 613HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
26002

Open Targets

More...
OpenTargetsi
ENSG00000079931

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134979178

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UVY6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MOXD1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749373

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030521720 – 613DBH-like monooxygenase protein 1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi205 ↔ 257By similarity
Disulfide bondi242 ↔ 269By similarity
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi364 ↔ 480By similarity
Disulfide bondi368 ↔ 550By similarity
Disulfide bondi443 ↔ 465By similarity
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi517N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UVY6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6UVY6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6UVY6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UVY6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UVY6

PeptideAtlas

More...
PeptideAtlasi
Q6UVY6

PRoteomics IDEntifications database

More...
PRIDEi
Q6UVY6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67438 [Q6UVY6-1]
67439 [Q6UVY6-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6UVY6, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UVY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UVY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lung, kidney, brain and spinal cord.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal liver and fetal brain.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By replicative senescence.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000079931, Expressed in kidney and 184 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UVY6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UVY6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000079931, Tissue enhanced (endometrium, smooth muscle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
117478, 37 interactors

Protein interaction database and analysis system

More...
IntActi
Q6UVY6, 19 interactors

Molecular INTeraction database

More...
MINTi
Q6UVY6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UVY6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 148DOMONPROSITE-ProRule annotationAdd BLAST114

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3568, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063085

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017939_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UVY6

Identification of Orthologs from Complete Genome Data

More...
OMAi
YFTNANK

Database of Orthologous Groups

More...
OrthoDBi
1472750at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UVY6

TreeFam database of animal gene trees

More...
TreeFami
TF320698

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.230, 1 hit
2.60.120.310, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014784, Cu2_ascorb_mOase-like_C
IPR000323, Cu2_ascorb_mOase_N
IPR036939, Cu2_ascorb_mOase_N_sf
IPR024548, Cu2_monoox_C
IPR000945, DBH-like
IPR005018, DOMON_domain
IPR028463, MOXD1
IPR008977, PHM/PNGase_F_dom_sf
IPR028460, Tbh/DBH

The PANTHER Classification System

More...
PANTHERi
PTHR10157, PTHR10157, 1 hit
PTHR10157:SF28, PTHR10157:SF28, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03712, Cu2_monoox_C, 1 hit
PF01082, Cu2_monooxygen, 1 hit
PF03351, DOMON, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00767, DBMONOXGNASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00664, DoH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49742, SSF49742, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50836, DOMON, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UVY6-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCCWPLLLLW GLLPGTAAGG SGRTYPHRTL LDSEGKYWLG WSQRGSQIAF
60 70 80 90 100
RLQVRTAGYV GFGFSPTGAM ASADIVVGGV AHGRPYLQDY FTNANRELKK
110 120 130 140 150
DAQQDYHLEY AMENSTHTII EFTRELHTCD INDKSITDST VRVIWAYHHE
160 170 180 190 200
DAGEAGPKYH DSNRGTKSLR LLNPEKTSVL STALPYFDLV NQDVPIPNKD
210 220 230 240 250
TTYWCQMFKI PVFQEKHHVI KVEPVIQRGH ESLVHHILLY QCSNNFNDSV
260 270 280 290 300
LESGHECYHP NMPDAFLTCE TVIFAWAIGG EGFSYPPHVG LSLGTPLDPH
310 320 330 340 350
YVLLEVHYDN PTYEEGLIDN SGLRLFYTMD IRKYDAGVIE AGLWVSLFHT
360 370 380 390 400
IPPGMPEFQS EGHCTLECLE EALEAEKPSG IHVFAVLLHA HLAGRGIRLR
410 420 430 440 450
HFRKGKEMKL LAYDDDFDFN FQEFQYLKEE QTILPGDNLI TECRYNTKDR
460 470 480 490 500
AEMTWGGLST RSEMCLSYLL YYPRINLTRC ASIPDIMEQL QFIGVKEIYR
510 520 530 540 550
PVTTWPFIIK SPKQYKNLSF MDAMNKFKWT KKEGLSFNKL VLSLPVNVRC
560 570 580 590 600
SKTDNAEWSI QGMTALPPDI ERPYKAEPLV CGTSSSSSLH RDFSINLLVC
610
LLLLSCTLST KSL
Note: Major.
Length:613
Mass (Da):69,652
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57B407655A8294BB
GO
Isoform 2 (identifier: Q6UVY6-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: Missing.
     27-87: HRTLLDSEGK...GGVAHGRPYL → MNSFLSVFRYPDFSFPYFP

Show »
Length:545
Mass (Da):62,700
Checksum:iB0E23E7DE2B03CD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PVS1A6PVS1_HUMAN
DBH-like monooxygenase protein 1
MOXD1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11263 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti148H → Y in BAC11263 (PubMed:14702039).Curated1
Sequence conflicti438N → Y in CAB45692 (PubMed:17974005).Curated1
Sequence conflicti512P → L in AAG09636 (PubMed:9751809).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035185488E → Q. Corresponds to variant dbSNP:rs36075540Ensembl.1
Natural variantiVAR_035186539K → E1 PublicationCorresponds to variant dbSNP:rs17851680Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0282881 – 26Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_02828927 – 87HRTLL…GRPYL → MNSFLSVFRYPDFSFPYFP in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY007239 mRNA Translation: AAG09636.1
AY359094 mRNA Translation: AAQ89452.1
AL357034 Genomic DNA No translation available.
AL023578 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48033.1
CH471051 Genomic DNA Translation: EAW48034.1
BC018756 mRNA Translation: AAH18756.1
AK074879 mRNA Translation: BAC11263.1 Different initiation.
AL080058 mRNA Translation: CAB45692.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5152.2 [Q6UVY6-1]

Protein sequence database of the Protein Information Resource

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PIRi
T12460

NCBI Reference Sequences

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RefSeqi
NP_056344.2, NM_015529.3 [Q6UVY6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000336749; ENSP00000336998; ENSG00000079931 [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931 [Q6UVY6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
26002

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:26002

UCSC genome browser

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UCSCi
uc003qde.4, human [Q6UVY6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007239 mRNA Translation: AAG09636.1
AY359094 mRNA Translation: AAQ89452.1
AL357034 Genomic DNA No translation available.
AL023578 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48033.1
CH471051 Genomic DNA Translation: EAW48034.1
BC018756 mRNA Translation: AAH18756.1
AK074879 mRNA Translation: BAC11263.1 Different initiation.
AL080058 mRNA Translation: CAB45692.1
CCDSiCCDS5152.2 [Q6UVY6-1]
PIRiT12460
RefSeqiNP_056344.2, NM_015529.3 [Q6UVY6-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi117478, 37 interactors
IntActiQ6UVY6, 19 interactors
MINTiQ6UVY6
STRINGi9606.ENSP00000356940

PTM databases

GlyGeniQ6UVY6, 4 sites
iPTMnetiQ6UVY6
PhosphoSitePlusiQ6UVY6

Polymorphism and mutation databases

BioMutaiMOXD1
DMDMi74749373

Proteomic databases

EPDiQ6UVY6
jPOSTiQ6UVY6
MassIVEiQ6UVY6
MaxQBiQ6UVY6
PaxDbiQ6UVY6
PeptideAtlasiQ6UVY6
PRIDEiQ6UVY6
ProteomicsDBi67438 [Q6UVY6-1]
67439 [Q6UVY6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
32922, 138 antibodies

The DNASU plasmid repository

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DNASUi
26002

Genome annotation databases

EnsembliENST00000336749; ENSP00000336998; ENSG00000079931 [Q6UVY6-2]
ENST00000367963; ENSP00000356940; ENSG00000079931 [Q6UVY6-1]
GeneIDi26002
KEGGihsa:26002
UCSCiuc003qde.4, human [Q6UVY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
26002
DisGeNETi26002
EuPathDBiHostDB:ENSG00000079931.14

GeneCards: human genes, protein and diseases

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GeneCardsi
MOXD1
HGNCiHGNC:21063, MOXD1
HPAiENSG00000079931, Tissue enhanced (endometrium, smooth muscle)
MIMi609000, gene
neXtProtiNX_Q6UVY6
OpenTargetsiENSG00000079931
PharmGKBiPA134979178

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3568, Eukaryota
GeneTreeiENSGT00530000063085
HOGENOMiCLU_017939_4_1_1
InParanoidiQ6UVY6
OMAiYFTNANK
OrthoDBi1472750at2759
PhylomeDBiQ6UVY6
TreeFamiTF320698

Enzyme and pathway databases

PathwayCommonsiQ6UVY6
SignaLinkiQ6UVY6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
26002, 5 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MOXD1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Monooxygenase_DBH-like_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
26002
PharosiQ6UVY6, Tbio

Protein Ontology

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PROi
PR:Q6UVY6
RNActiQ6UVY6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000079931, Expressed in kidney and 184 other tissues
ExpressionAtlasiQ6UVY6, baseline and differential
GenevisibleiQ6UVY6, HS

Family and domain databases

Gene3Di2.60.120.230, 1 hit
2.60.120.310, 1 hit
InterProiView protein in InterPro
IPR014784, Cu2_ascorb_mOase-like_C
IPR000323, Cu2_ascorb_mOase_N
IPR036939, Cu2_ascorb_mOase_N_sf
IPR024548, Cu2_monoox_C
IPR000945, DBH-like
IPR005018, DOMON_domain
IPR028463, MOXD1
IPR008977, PHM/PNGase_F_dom_sf
IPR028460, Tbh/DBH
PANTHERiPTHR10157, PTHR10157, 1 hit
PTHR10157:SF28, PTHR10157:SF28, 1 hit
PfamiView protein in Pfam
PF03712, Cu2_monoox_C, 1 hit
PF01082, Cu2_monooxygen, 1 hit
PF03351, DOMON, 1 hit
PRINTSiPR00767, DBMONOXGNASE
SMARTiView protein in SMART
SM00664, DoH, 1 hit
SUPFAMiSSF49742, SSF49742, 2 hits
PROSITEiView protein in PROSITE
PS50836, DOMON, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOXD1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UVY6
Secondary accession number(s): Q5THU6
, Q8NC97, Q8WV49, Q9H4M6, Q9Y4U3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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