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UniProtKB - Q6UVM3 (KCNT2_HUMAN)

Entry version 143 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Potassium channel subfamily T member 2

Gene

KCNT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Outward rectifying potassium channel. Produces rapidly activating outward rectifier K+ currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1025 – 1032ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandATP-binding, Nucleotide-binding, Potassium

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.1.3.6 the voltage-gated ion channel (vic) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium channel subfamily T member 2
Alternative name(s):
Sequence like an intermediate conductance potassium channel subunit
Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNT2
Synonyms:SLICK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18866 KCNT2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610044 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UVM3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 63CytoplasmicSequence analysisAdd BLAST63
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei64 – 84Helical; Name=Segment S1Sequence analysisAdd BLAST21
Topological domaini85 – 101ExtracellularSequence analysisAdd BLAST17
Transmembranei102 – 122Helical; Name=Segment S2Sequence analysisAdd BLAST21
Topological domaini123 – 137CytoplasmicSequence analysisAdd BLAST15
Transmembranei138 – 158Helical; Name=Segment S3Sequence analysisAdd BLAST21
Topological domaini159 – 164ExtracellularSequence analysis6
Transmembranei165 – 185Helical; Name=Segment S4Sequence analysisAdd BLAST21
Topological domaini186 – 198CytoplasmicSequence analysisAdd BLAST13
Transmembranei199 – 219Helical; Name=Segment S5Sequence analysisAdd BLAST21
Topological domaini220 – 228ExtracellularSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei229 – 249Pore-formingSequence analysisAdd BLAST21
Topological domaini250 – 256ExtracellularSequence analysis7
Transmembranei257 – 277Helical; Name=Segment S6Sequence analysisAdd BLAST21
Topological domaini278 – 1135CytoplasmicSequence analysisAdd BLAST858

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epileptic encephalopathy, early infantile, 57 (EIEE57)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE57 is an autosomal dominant condition.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_080867240F → L in EIEE57; decreased protein abundance; loss of chloride-activated potassium channel activity; loss of potassium selectivity. 1 PublicationCorresponds to variant dbSNP:rs1060499537EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy

Organism-specific databases

DisGeNET

More...DisGeNETi		343450

MalaCards human disease database

More...MalaCardsi		KCNT2
MIMi617771 phenotype

Open Targets

More...OpenTargetsi		ENSG00000162687

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38726

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6UVM3

Chemistry databases

DrugCentral

More...DrugCentrali		Q6UVM3

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		386

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KCNT2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749370

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003125031 – 1135Potassium channel subfamily T member 2Add BLAST1135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6UVM3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6UVM3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6UVM3

PeptideAtlas

More...PeptideAtlasi		Q6UVM3

PRoteomics IDEntifications database

More...PRIDEi		Q6UVM3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67432 [Q6UVM3-1]
67433 [Q6UVM3-2]
67434 [Q6UVM3-3]
67435 [Q6UVM3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UVM3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UVM3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000162687 Expressed in 151 organ(s), highest expression level in parietal pleura

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UVM3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6UVM3 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA051218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		131252, 11 interactors

Protein interaction database and analysis system

More...IntActi		Q6UVM3, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000294725

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6UVM3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini422 – 543RCK N-terminalAdd BLAST122

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.2/KCNT2 sub-subfamily. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3193 Eukaryota
ENOG410XSMA LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158746

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231460

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6UVM3

KEGG Orthology (KO)

More...KOi		K04947

Identification of Orthologs from Complete Genome Data

More...OMAi		VEDWEDT

Database of Orthologous Groups

More...OrthoDBi		858812at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UVM3

TreeFam database of animal gene trees

More...TreeFami		TF314283

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UVM3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDLESEVPP LPPRYRFRDL LLGDQGWQND DRVQVEFYMN ENTFKERLKL 
        60         70         80         90        100
FFIKNQRSSL RIRLFNFSLK LLSCLLYIIR VLLENPSQGN EWSHIFWVNR 
       110        120        130        140        150
SLPLWGLQVS VALISLFETI LLGYLSYKGN IWEQILRIPF ILEIINAVPF 
       160        170        180        190        200
IISIFWPSLR NLFVPVFLNC WLAKHALENM INDLHRAIQR TQSAMFNQVL 
       210        220        230        240        250
ILISTLLCLI FTCICGIQHL ERIGKKLNLF DSLYFCIVTF STVGFGDVTP 
       260        270        280        290        300
ETWSSKLFVV AMICVALVVL PIQFEQLAYL WMERQKSGGN YSRHRAQTEK 
       310        320        330        340        350
HVVLCVSSLK IDLLMDFLNE FYAHPRLQDY YVVILCPTEM DVQVRRVLQI 
       360        370        380        390        400
PMWSQRVIYL QGSALKDQDL LRAKMDDAEA CFILSSRCEV DRTSSDHQTI 
       410        420        430        440        450
LRAWAVKDFA PNCPLYVQIL KPENKFHIKF ADHVVCEEEF KYAMLALNCI 
       460        470        480        490        500
CPATSTLITL LVHTSRGQEG QQSPEQWQKM YGRCSGNEVY HIVLEESTFF 
       510        520        530        540        550
AEYEGKSFTY ASFHAHKKFG VCLIGVRRED NKNILLNPGP RYIMNSTDIC 
       560        570        580        590        600
FYINITKEEN SAFKNQDQQR KSNVSRSFYH GPSRLPVHSI IASMGTVAID 
       610        620        630        640        650
LQDTSCRSAS GPTLSLPTEG SKEIRRPSIA PVLEVADTSS IQTCDLLSDQ 
       660        670        680        690        700
SEDETTPDEE MSSNLEYAKG YPPYSPYIGS SPTFCHLLHE KVPFCCLRLD 
       710        720        730        740        750
KSCQHNYYED AKAYGFKNKL IIVAAETAGN GLYNFIVPLR AYYRPKKELN 
       760        770        780        790        800
PIVLLLDNPP DMHFLDAICW FPMVYYMVGS IDNLDDLLRC GVTFAANMVV 
       810        820        830        840        850
VDKESTMSAE EDYMADAKTI VNVQTLFRLF SSLSIITELT HPANMRFMQF 
       860        870        880        890        900
RAKDCYSLAL SKLEKKERER GSNLAFMFRL PFAAGRVFSI SMLDTLLYQS 
       910        920        930        940        950
FVKDYMISIT RLLLGLDTTP GSGFLCSMKI TADDLWIRTY ARLYQKLCSS 
       960        970        980        990       1000
TGDVPIGIYR TESQKLTTSE SQISISVEEW EDTKDSKEQG HHRSNHRNST 
      1010       1020       1030       1040       1050
SSDQSDHPLL RRKSMQWARR LSRKGPKHSG KTAEKITQQR LNLYRRSERQ 
      1060       1070       1080       1090       1100
ELAELVKNRM KHLGLSTVGY DEMNDHQSTL SYILINPSPD TRIELNDVVY 
      1110       1120       1130 
LIRPDPLAYL PNSEPSRRNS ICNVTGQDSR EETQL
Length:1,135
Mass (Da):130,501
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4957C6DAB1E030CF
GO
Isoform 2 (identifier: Q6UVM3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     760-783: Missing.

Show »
Length:1,111
Mass (Da):127,654
Checksum:iDE4D70DA9B495A9C
GO
Isoform 3 (identifier: Q6UVM3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     469-518: Missing.
     760-783: Missing.
     970-970: E → ESRKIASQ

Show »
Length:1,068
Mass (Da):122,551
Checksum:i1E86C928DE0F5F3A
GO
Isoform 4 (identifier: Q6UVM3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-153: Missing.
     468-468: Q → QCVCLCCR
     760-783: Missing.
     970-970: E → ESRKIASQ
     1071-1135: DEMNDHQSTL...GQDSREETQL → GMLFKNYCIYGLVISCH

Show »
Length:1,052
Mass (Da):120,830
Checksum:i50C3939611E2F3DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3IRL4A0A3B3IRL4_HUMAN
Potassium channel subfamily T membe...
KCNT2
771Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3SY61Q3SY61_HUMAN
KCNT2 protein
KCNT2
370Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GZ63V9GZ63_HUMAN
Potassium channel subfamily T membe...
KCNT2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03752733V → I in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_080867240F → L in EIEE57; decreased protein abundance; loss of chloride-activated potassium channel activity; loss of potassium selectivity. 1 PublicationCorresponds to variant dbSNP:rs1060499537EnsemblClinVar.1
Natural variantiVAR_037528413C → W. Corresponds to variant dbSNP:rs12738104Ensembl.1
Natural variantiVAR_037529429K → N. Corresponds to variant dbSNP:rs12742082Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029852129 – 153Missing in isoform 4. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_029853468Q → QCVCLCCR in isoform 4. 2 Publications1
Alternative sequenceiVSP_029854469 – 518Missing in isoform 3. CuratedAdd BLAST50
Alternative sequenceiVSP_029855760 – 783Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST24
Alternative sequenceiVSP_029856970E → ESRKIASQ in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0298571071 – 1135DEMND…EETQL → GMLFKNYCIYGLVISCH in isoform 4. 2 PublicationsAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY359444 mRNA Translation: AAR06170.1
AK131498 mRNA Translation: BAD18642.1
BX647852 mRNA Translation: CAI46099.1
AL138931 Genomic DNA No translation available.
AL139137 Genomic DNA No translation available.
AL358853 Genomic DNA No translation available.
AL591604 Genomic DNA No translation available.
BC103948 mRNA Translation: AAI03949.1
BC103949 mRNA Translation: AAI03950.1
BC103950 mRNA Translation: AAI03951.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1384.1 [Q6UVM3-1]
CCDS72994.1 [Q6UVM3-3]
CCDS72995.1 [Q6UVM3-2]

NCBI Reference Sequences

More...RefSeqi		NP_001274748.1, NM_001287819.1 [Q6UVM3-2]
NP_001274749.1, NM_001287820.1 [Q6UVM3-3]
NP_940905.2, NM_198503.3 [Q6UVM3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000294725; ENSP00000294725; ENSG00000162687 [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687 [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687 [Q6UVM3-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		343450

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:343450

UCSC genome browser

More...UCSCi		uc001gtd.3 human [Q6UVM3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359444 mRNA Translation: AAR06170.1
AK131498 mRNA Translation: BAD18642.1
BX647852 mRNA Translation: CAI46099.1
AL138931 Genomic DNA No translation available.
AL139137 Genomic DNA No translation available.
AL358853 Genomic DNA No translation available.
AL591604 Genomic DNA No translation available.
BC103948 mRNA Translation: AAI03949.1
BC103949 mRNA Translation: AAI03950.1
BC103950 mRNA Translation: AAI03951.1
CCDSiCCDS1384.1 [Q6UVM3-1]
CCDS72994.1 [Q6UVM3-3]
CCDS72995.1 [Q6UVM3-2]
RefSeqiNP_001274748.1, NM_001287819.1 [Q6UVM3-2]
NP_001274749.1, NM_001287820.1 [Q6UVM3-3]
NP_940905.2, NM_198503.3 [Q6UVM3-1]

3D structure databases

SMRiQ6UVM3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi131252, 11 interactors
IntActiQ6UVM3, 8 interactors
STRINGi9606.ENSP00000294725

Chemistry databases

DrugCentraliQ6UVM3
GuidetoPHARMACOLOGYi386

Protein family/group databases

TCDBi1.A.1.3.6 the voltage-gated ion channel (vic) superfamily

PTM databases

iPTMnetiQ6UVM3
PhosphoSitePlusiQ6UVM3

Polymorphism and mutation databases

BioMutaiKCNT2
DMDMi74749370

Proteomic databases

jPOSTiQ6UVM3
MassIVEiQ6UVM3
PaxDbiQ6UVM3
PeptideAtlasiQ6UVM3
PRIDEiQ6UVM3
ProteomicsDBi67432 [Q6UVM3-1]
67433 [Q6UVM3-2]
67434 [Q6UVM3-3]
67435 [Q6UVM3-4]

Genome annotation databases

EnsembliENST00000294725; ENSP00000294725; ENSG00000162687 [Q6UVM3-1]
ENST00000367433; ENSP00000356403; ENSG00000162687 [Q6UVM3-2]
ENST00000609185; ENSP00000476657; ENSG00000162687 [Q6UVM3-3]
GeneIDi343450
KEGGihsa:343450
UCSCiuc001gtd.3 human [Q6UVM3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		343450
DisGeNETi343450

GeneCards: human genes, protein and diseases

More...GeneCardsi		KCNT2
HGNCiHGNC:18866 KCNT2
HPAiHPA051218
MalaCardsiKCNT2
MIMi610044 gene
617771 phenotype
neXtProtiNX_Q6UVM3
OpenTargetsiENSG00000162687
PharmGKBiPA38726

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3193 Eukaryota
ENOG410XSMA LUCA
GeneTreeiENSGT00940000158746
HOGENOMiHOG000231460
InParanoidiQ6UVM3
KOiK04947
OMAiVEDWEDT
OrthoDBi858812at2759
PhylomeDBiQ6UVM3
TreeFamiTF314283

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KCNT2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KCNT2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		343450
PharosiQ6UVM3

Protein Ontology

More...PROi		PR:Q6UVM3

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000162687 Expressed in 151 organ(s), highest expression level in parietal pleura
ExpressionAtlasiQ6UVM3 baseline and differential
GenevisibleiQ6UVM3 HS

Family and domain databases

InterProiView protein in InterPro
IPR003929 K_chnl_BK_asu
IPR013099 K_chnl_dom
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF03493 BK_channel_a, 1 hit
PF07885 Ion_trans_2, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNT2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UVM3
Secondary accession number(s): Q3SY59, Q5VTN1, Q6ZMT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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