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Entry version 148 (11 Dec 2019)
Sequence version 2 (18 May 2010)
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Protein

Chondroitin sulfate proteoglycan 4

Gene

CSPG4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.3 Publications

Miscellaneous

Valuable marker for several incompletely differentiated precursor cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Transducer
Biological processAngiogenesis, Differentiation, Tissue remodeling

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6UVK1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chondroitin sulfate proteoglycan 4
Alternative name(s):
Chondroitin sulfate proteoglycan NG2
Melanoma chondroitin sulfate proteoglycan
Melanoma-associated chondroitin sulfate proteoglycan
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSPG4
Synonyms:MCSP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173546.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2466 CSPG4

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601172 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UVK1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 2224ExtracellularBy similarityAdd BLAST2195
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2225 – 2245HelicalSequence analysisAdd BLAST21
Topological domaini2246 – 2322CytoplasmicBy similarityAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1464

Open Targets

More...
OpenTargetsi
ENSG00000173546

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26963

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UVK1 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CSPG4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434468

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004196230 – 2322Chondroitin sulfate proteoglycan 4Add BLAST2293

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi169 ↔ 192PROSITE-ProRule annotation
Glycosylationi348N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi354 ↔ 380PROSITE-ProRule annotation
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi685N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi995O-linked (Xyl...) (chondroitin sulfate) serineBy similarity1
Glycosylationi1131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1202N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1645N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1909N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2016N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2034N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2040N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2075N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2252Phosphothreonine; by PKC/PRKCABy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation (By similarity). Involved in interaction with MMP16 and ITGA4.By similarity1 Publication
Phosphorylation by PRKCA regulates its subcellular location and function in cell motility.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UVK1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6UVK1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6UVK1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6UVK1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6UVK1

PeptideAtlas

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PeptideAtlasi
Q6UVK1

PRoteomics IDEntifications database

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PRIDEi
Q6UVK1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
67431

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
2028

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UVK1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UVK1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected only in malignant melanoma cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173546 Expressed in 166 organ(s), highest expression level in tendon

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6UVK1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB016189
HPA001933
HPA002951
HPA042785
HPA050008

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the first PDZ domain of MPDZ.

Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2.

Interacts with PLG and angiostatin. Binds FGF2 and PDGFA.

Interacts with GRIP1, GRIP2 and GRIA2.

Forms a ternary complex with GRIP1 and GRIA2 (By similarity).

Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3.

Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan.

Interacts with BCAR1, CDC42 and ACK1.

Interacts with MMP16.

By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107846, 19 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6UVK1

Protein interaction database and analysis system

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IntActi
Q6UVK1, 23 interactors

Molecular INTeraction database

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MINTi
Q6UVK1

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312506

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UVK1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6UVK1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 192Laminin G-like 1PROSITE-ProRule annotationAdd BLAST163
Domaini202 – 380Laminin G-like 2PROSITE-ProRule annotationAdd BLAST179
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati428 – 523CSPG 1PROSITE-ProRule annotation1 PublicationAdd BLAST96
Repeati553 – 645CSPG 2PROSITE-ProRule annotation1 PublicationAdd BLAST93
Repeati662 – 764CSPG 3PROSITE-ProRule annotation1 PublicationAdd BLAST103
Repeati783 – 878CSPG 4PROSITE-ProRule annotation1 PublicationAdd BLAST96
Repeati898 – 989CSPG 5PROSITE-ProRule annotation1 PublicationAdd BLAST92
Repeati1018 – 1110CSPG 6PROSITE-ProRule annotation1 PublicationAdd BLAST93
Repeati1126 – 1216CSPG 7PROSITE-ProRule annotation1 PublicationAdd BLAST91
Repeati1238 – 1337CSPG 8PROSITE-ProRule annotation1 PublicationAdd BLAST100
Repeati1356 – 1449CSPG 9PROSITE-ProRule annotation1 PublicationAdd BLAST94
Repeati1473 – 1563CSPG 10PROSITE-ProRule annotation1 PublicationAdd BLAST91
Repeati1581 – 1679CSPG 11PROSITE-ProRule annotation1 PublicationAdd BLAST99
Repeati1704 – 1803CSPG 12PROSITE-ProRule annotation1 PublicationAdd BLAST100
Repeati1832 – 1924CSPG 13PROSITE-ProRule annotation1 PublicationAdd BLAST93
Repeati1941 – 2029CSPG 14PROSITE-ProRule annotation1 PublicationAdd BLAST89
Repeati2038 – 2147CSPG 15PROSITE-ProRule annotation1 PublicationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 639Globular or compact configuration stabilized by disulfide bondsAdd BLAST610
Regioni30 – 639Neurite growth inhibitionBy similarityAdd BLAST610
Regioni574 – 1040Interaction with COL6A2By similarityAdd BLAST467
Regioni631 – 1446Interaction with COL5A1By similarityAdd BLAST816
Regioni1586 – 2221Neurite growth inhibitionBy similarityAdd BLAST636
Regioni1587 – 2221Cysteine-containingAdd BLAST635

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2320 – 2322PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi639 – 1586Gly/Ser-rich (glycosaminoglycan attachment domain)Add BLAST948

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3597 Eukaryota
ENOG410XQ29 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154091

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000170195

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6UVK1

KEGG Orthology (KO)

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KOi
K08115

Identification of Orthologs from Complete Genome Data

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OMAi
HVARGGQ

Database of Orthologous Groups

More...
OrthoDBi
219190at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UVK1

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UVK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSGPRPPLP APGLALALTL TMLARLASAA SFFGENHLEV PVATALTDID
60 70 80 90 100
LQLQFSTSQP EALLLLAAGP ADHLLLQLYS GRLQVRLVLG QEELRLQTPA
110 120 130 140 150
ETLLSDSIPH TVVLTVVEGW ATLSVDGFLN ASSAVPGAPL EVPYGLFVGG
160 170 180 190 200
TGTLGLPYLR GTSRPLRGCL HAATLNGRSL LRPLTPDVHE GCAEEFSASD
210 220 230 240 250
DVALGFSGPH SLAAFPAWGT QDEGTLEFTL TTQSRQAPLA FQAGGRRGDF
260 270 280 290 300
IYVDIFEGHL RAVVEKGQGT VLLHNSVPVA DGQPHEVSVH INAHRLEISV
310 320 330 340 350
DQYPTHTSNR GVLSYLEPRG SLLLGGLDAE ASRHLQEHRL GLTPEATNAS
360 370 380 390 400
LLGCMEDLSV NGQRRGLREA LLTRNMAAGC RLEEEEYEDD AYGHYEAFST
410 420 430 440 450
LAPEAWPAME LPEPCVPEPG LPPVFANFTQ LLTISPLVVA EGGTAWLEWR
460 470 480 490 500
HVQPTLDLME AELRKSQVLF SVTRGARHGE LELDIPGAQA RKMFTLLDVV
510 520 530 540 550
NRKARFIHDG SEDTSDQLVL EVSVTARVPM PSCLRRGQTY LLPIQVNPVN
560 570 580 590 600
DPPHIIFPHG SLMVILEHTQ KPLGPEVFQA YDPDSACEGL TFQVLGTSSG
610 620 630 640 650
LPVERRDQPG EPATEFSCRE LEAGSLVYVH RGGPAQDLTF RVSDGLQASP
660 670 680 690 700
PATLKVVAIR PAIQIHRSTG LRLAQGSAMP ILPANLSVET NAVGQDVSVL
710 720 730 740 750
FRVTGALQFG ELQKQGAGGV EGAEWWATQA FHQRDVEQGR VRYLSTDPQH
760 770 780 790 800
HAYDTVENLA LEVQVGQEIL SNLSFPVTIQ RATVWMLRLE PLHTQNTQQE
810 820 830 840 850
TLTTAHLEAT LEEAGPSPPT FHYEVVQAPR KGNLQLQGTR LSDGQGFTQD
860 870 880 890 900
DIQAGRVTYG ATARASEAVE DTFRFRVTAP PYFSPLYTFP IHIGGDPDAP
910 920 930 940 950
VLTNVLLVVP EGGEGVLSAD HLFVKSLNSA SYLYEVMERP RHGRLAWRGT
960 970 980 990 1000
QDKTTMVTSF TNEDLLRGRL VYQHDDSETT EDDIPFVATR QGESSGDMAW
1010 1020 1030 1040 1050
EEVRGVFRVA IQPVNDHAPV QTISRIFHVA RGGRRLLTTD DVAFSDADSG
1060 1070 1080 1090 1100
FADAQLVLTR KDLLFGSIVA VDEPTRPIYR FTQEDLRKRR VLFVHSGADR
1110 1120 1130 1140 1150
GWIQLQVSDG QHQATALLEV QASEPYLRVA NGSSLVVPQG GQGTIDTAVL
1160 1170 1180 1190 1200
HLDTNLDIRS GDEVHYHVTA GPRWGQLVRA GQPATAFSQQ DLLDGAVLYS
1210 1220 1230 1240 1250
HNGSLSPRDT MAFSVEAGPV HTDATLQVTI ALEGPLAPLK LVRHKKIYVF
1260 1270 1280 1290 1300
QGEAAEIRRD QLEAAQEAVP PADIVFSVKS PPSAGYLVMV SRGALADEPP
1310 1320 1330 1340 1350
SLDPVQSFSQ EAVDTGRVLY LHSRPEAWSD AFSLDVASGL GAPLEGVLVE
1360 1370 1380 1390 1400
LEVLPAAIPL EAQNFSVPEG GSLTLAPPLL RVSGPYFPTL LGLSLQVLEP
1410 1420 1430 1440 1450
PQHGALQKED GPQARTLSAF SWRMVEEQLI RYVHDGSETL TDSFVLMANA
1460 1470 1480 1490 1500
SEMDRQSHPV AFTVTVLPVN DQPPILTTNT GLQMWEGATA PIPAEALRST
1510 1520 1530 1540 1550
DGDSGSEDLV YTIEQPSNGR VVLRGAPGTE VRSFTQAQLD GGLVLFSHRG
1560 1570 1580 1590 1600
TLDGGFRFRL SDGEHTSPGH FFRVTAQKQV LLSLKGSQTL TVCPGSVQPL
1610 1620 1630 1640 1650
SSQTLRASSS AGTDPQLLLY RVVRGPQLGR LFHAQQDSTG EALVNFTQAE
1660 1670 1680 1690 1700
VYAGNILYEH EMPPEPFWEA HDTLELQLSS PPARDVAATL AVAVSFEAAC
1710 1720 1730 1740 1750
PQRPSHLWKN KGLWVPEGQR ARITVAALDA SNLLASVPSP QRSEHDVLFQ
1760 1770 1780 1790 1800
VTQFPSRGQL LVSEEPLHAG QPHFLQSQLA AGQLVYAHGG GGTQQDGFHF
1810 1820 1830 1840 1850
RAHLQGPAGA SVAGPQTSEA FAITVRDVNE RPPQPQASVP LRLTRGSRAP
1860 1870 1880 1890 1900
ISRAQLSVVD PDSAPGEIEY EVQRAPHNGF LSLVGGGLGP VTRFTQADVD
1910 1920 1930 1940 1950
SGRLAFVANG SSVAGIFQLS MSDGASPPLP MSLAVDILPS AIEVQLRAPL
1960 1970 1980 1990 2000
EVPQALGRSS LSQQQLRVVS DREEPEAAYR LIQGPQYGHL LVGGRPTSAF
2010 2020 2030 2040 2050
SQFQIDQGEV VFAFTNFSSS HDHFRVLALA RGVNASAVVN VTVRALLHVW
2060 2070 2080 2090 2100
AGGPWPQGAT LRLDPTVLDA GELANRTGSV PRFRLLEGPR HGRVVRVPRA
2110 2120 2130 2140 2150
RTEPGGSQLV EQFTQQDLED GRLGLEVGRP EGRAPGPAGD SLTLELWAQG
2160 2170 2180 2190 2200
VPPAVASLDF ATEPYNAARP YSVALLSVPE AARTEAGKPE SSTPTGEPGP
2210 2220 2230 2240 2250
MASSPEPAVA KGGFLSFLEA NMFSVIIPMC LVLLLLALIL PLLFYLRKRN
2260 2270 2280 2290 2300
KTGKHDVQVL TAKPRNGLAG DTETFRKVEP GQAIPLTAVP GQGPPPGGQP
2310 2320
DPELLQFCRT PNPALKNGQY WV
Length:2,322
Mass (Da):250,537
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B4F39AFC5ADD3CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5 – 6PR → RG in CAA65529 (PubMed:8790396).Curated2
Sequence conflicti5 – 6PR → RG in AAQ62842 (PubMed:15210734).Curated2
Sequence conflicti477 – 478RH → HY in CAA65529 (PubMed:8790396).Curated2
Sequence conflicti486P → L in CAA65529 (PubMed:8790396).Curated1
Sequence conflicti631R → C in CAA65529 (PubMed:8790396).Curated1
Sequence conflicti715 – 717QGA → HST in CAA65529 (PubMed:8790396).Curated3
Sequence conflicti942H → L in CAA65529 (PubMed:8790396).Curated1
Sequence conflicti1208R → E in CAA65529 (PubMed:8790396).Curated1
Sequence conflicti1405A → P in CAA65529 (PubMed:8790396).Curated1
Sequence conflicti1557R → P in CAA65529 (PubMed:8790396).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0617331703R → H. Corresponds to variant dbSNP:rs8023621Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X96753 mRNA Translation: CAA65529.1
AY359468 mRNA Translation: AAQ62842.1
AC105020 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99239.1
CH471136 Genomic DNA Translation: EAW99240.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10284.1

NCBI Reference Sequences

More...
RefSeqi
NP_001888.2, NM_001897.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000308508; ENSP00000312506; ENSG00000173546

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1464

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1464

UCSC genome browser

More...
UCSCi
uc002baw.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96753 mRNA Translation: CAA65529.1
AY359468 mRNA Translation: AAQ62842.1
AC105020 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99239.1
CH471136 Genomic DNA Translation: EAW99240.1
CCDSiCCDS10284.1
RefSeqiNP_001888.2, NM_001897.4

3D structure databases

SMRiQ6UVK1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi107846, 19 interactors
CORUMiQ6UVK1
IntActiQ6UVK1, 23 interactors
MINTiQ6UVK1
STRINGi9606.ENSP00000312506

PTM databases

GlyConnecti2028
iPTMnetiQ6UVK1
PhosphoSitePlusiQ6UVK1

Polymorphism and mutation databases

BioMutaiCSPG4
DMDMi296434468

Proteomic databases

EPDiQ6UVK1
jPOSTiQ6UVK1
MassIVEiQ6UVK1
MaxQBiQ6UVK1
PaxDbiQ6UVK1
PeptideAtlasiQ6UVK1
PRIDEiQ6UVK1
ProteomicsDBi67431

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q6UVK1

Genome annotation databases

EnsembliENST00000308508; ENSP00000312506; ENSG00000173546
GeneIDi1464
KEGGihsa:1464
UCSCiuc002baw.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1464
DisGeNETi1464
EuPathDBiHostDB:ENSG00000173546.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CSPG4
HGNCiHGNC:2466 CSPG4
HPAiCAB016189
HPA001933
HPA002951
HPA042785
HPA050008
MIMi601172 gene
neXtProtiNX_Q6UVK1
OpenTargetsiENSG00000173546
PharmGKBiPA26963

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3597 Eukaryota
ENOG410XQ29 LUCA
GeneTreeiENSGT00940000154091
HOGENOMiHOG000170195
InParanoidiQ6UVK1
KOiK08115
OMAiHVARGGQ
OrthoDBi219190at2759
PhylomeDBiQ6UVK1
TreeFamiTF316876

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-2022923 Dermatan sulfate biosynthesis
R-HSA-2024101 CS/DS degradation
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3595172 Defective CHST3 causes SEDCJD
R-HSA-3595174 Defective CHST14 causes EDS, musculocontractural type
R-HSA-3595177 Defective CHSY1 causes TPBS
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
SignaLinkiQ6UVK1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CSPG4 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CSPG4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1464
PharosiQ6UVK1 Tbio

Protein Ontology

More...
PROi
PR:Q6UVK1
RNActiQ6UVK1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173546 Expressed in 166 organ(s), highest expression level in tendon
GenevisibleiQ6UVK1 HS

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR039005 CSPG_rpt
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00054 Laminin_G_1, 1 hit
PF02210 Laminin_G_2, 1 hit
SMARTiView protein in SMART
SM00282 LamG, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51854 CSPG, 15 hits
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSPG4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UVK1
Secondary accession number(s): D3DW77, Q92675
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: May 18, 2010
Last modified: December 11, 2019
This is version 148 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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