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UniProtKB - Q6UUV9 (CRTC1_HUMAN)

Entry version 149 (02 Dec 2020)
Sequence version 2 (05 Jul 2005)
Previous versions | rss
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Protein

CREB-regulated transcription coactivator 1

Gene

CRTC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.By similarity1 Publication
(Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei575Required for ubiquitination and degradationBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processBiological rhythms, Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6UUV9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-400253, Circadian Clock

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6UUV9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CREB-regulated transcription coactivator 1
Alternative name(s):
Mucoepidermoid carcinoma translocated protein 1
Transducer of regulated cAMP response element-binding protein 1
Short name:
TORC-1
Short name:
Transducer of CREB protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRTC1Imported
Synonyms:KIAA0616Imported, MECT1Imported, TORC1Imported, WAMTP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000105662.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:16062, CRTC1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607536, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UUV9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei42 – 43Breakpoint for translocation to form the MECT1-MAML2 and MAML2-MECT1 fusion proteins2 Publications2

Organism-specific databases

DisGeNET

More...DisGeNETi		23373

Open Targets

More...OpenTargetsi		ENSG00000105662

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30730

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6UUV9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CRTC1

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565585

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000963541 – 634CREB-regulated transcription coactivator 1Add BLAST634

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineBy similarity1
Modified residuei113PhosphoserineCombined sources1
Modified residuei149PhosphothreonineBy similarity1
Modified residuei151Phosphoserine; by SIK1 and SIK21 Publication1
Modified residuei161PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6UUV9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6UUV9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6UUV9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6UUV9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6UUV9

PeptideAtlas

More...PeptideAtlasi		Q6UUV9

PRoteomics IDEntifications database

More...PRIDEi		Q6UUV9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		67426 [Q6UUV9-1]
67427 [Q6UUV9-2]
67428 [Q6UUV9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UUV9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UUV9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105662, Expressed in dorsal plus ventral thalamus and 202 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UUV9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6UUV9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105662, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:14536081). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:14536081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:14536081).

Interacts with 14-3-3 proteins, including YWHAE/14-3-3 epsilon (PubMed:30611118).

Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118).

2 Publications

(Microbial infection) Interacts with HTLV1 Tax.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116952, 12 interactors

Protein interaction database and analysis system

More...IntActi		Q6UUV9, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345001

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6UUV9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6UUV9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi242 – 258Nuclear export signalBy similarityAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi299 – 366Ser-richAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TORC family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QU41, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000010652

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019357_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6UUV9

Identification of Orthologs from Complete Genome Data

More...OMAi		AWDAKKT

Database of Orthologous Groups

More...OrthoDBi		1118500at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UUV9

TreeFam database of animal gene trees

More...TreeFami		TF321571

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024786, TORC
IPR024785, TORC_C
IPR024784, TORC_M
IPR024783, TORC_N

The PANTHER Classification System

More...PANTHERi		PTHR13589, PTHR13589, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12886, TORC_C, 1 hit
PF12885, TORC_M, 1 hit
PF12884, TORC_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6UUV9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY 
        60         70         80         90        100
LQLGPSRGQY YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL 
       110        120        130        140        150
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTMYLSP PADTSWRRTN 
       160        170        180        190        200
SDSALHQSTM TPTQPESFSS GSQDVHQKRV LLLTVPGMEE TTSEADKNLS 
       210        220        230        240        250
KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT 
       260        270        280        290        300
NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP 
       310        320        330        340        350
GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL 
       360        370        380        390        400
PYAFFTQAGS QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP 
       410        420        430        440        450
SASLTRGPQP PPLAVTVPSS LPQSPPENPG QPSMGIDIAS APALQQYRTS 
       460        470        480        490        500
AGSPANQSPT SPVSNQGFSP GSSPQHTSTL GSVFGDAYYE QQMAARQANA 
       510        520        530        540        550
LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS HGSLPDSQQL 
       560        570        580        590        600
GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL 
       610        620        630 
KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL
Length:634
Mass (Da):67,300
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECDC427FF9D6920B
GO
Isoform 2Curated (identifier: Q6UUV9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-81: Q → QPSGFLGEALAAAPVSL

Show »
Length:650
Mass (Da):68,782
Checksum:i0458940C57945F4A
GO
Isoform 31 Publication (identifier: Q6UUV9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-503: Missing.
     580-634: SLAGVGDVSF...TEDTFRMDRL → HRGHLPDGPP...CSVPRQRPSL

Show »
Length:593
Mass (Da):62,530
Checksum:iB7D8709B0C731D29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXN6M0QXN6_HUMAN
CREB-regulated transcription coacti...
CRTC1
392Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX46M0QX46_HUMAN
CREB-regulated transcription coacti...
CRTC1
593Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17075 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH23614 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP12463 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84F → S in BAB14822 (PubMed:14702039).Curated1
Sequence conflicti384P → S in BAB14822 (PubMed:14702039).Curated1
Sequence conflicti556S → G in BAB14822 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053934286T → A. Corresponds to variant dbSNP:rs3746266Ensembl.1
Natural variantiVAR_053935311V → I1 PublicationCorresponds to variant dbSNP:rs36070283Ensembl.1
Natural variantiVAR_053936328T → A1 PublicationCorresponds to variant dbSNP:rs3746266Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05174981Q → QPSGFLGEALAAAPVSL in isoform 2. 2 Publications1
Alternative sequenceiVSP_051750475 – 503Missing in isoform 3. 3 PublicationsAdd BLAST29
Alternative sequenceiVSP_051751580 – 634SLAGV…RMDRL → HRGHLPDGPPVSGHAGTLPL SRPDGASPARGRPCSVPRQR PSL in isoform 3. 3 PublicationsAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY360171 mRNA Translation: AAQ98856.1
AY040323 mRNA Translation: AAK93832.1
AY040324 mRNA Translation: AAK93833.1 Different termination.
AK024089 mRNA Translation: BAB14822.1
AC003107 Genomic DNA No translation available.
AC004476 Genomic DNA No translation available.
AC006123 Genomic DNA Translation: AAC97072.1
CH471106 Genomic DNA Translation: EAW84730.1
BC017075 mRNA Translation: AAH17075.3 Different initiation.
BC023614 mRNA Translation: AAH23614.2 Different initiation.
BC028050 mRNA Translation: AAH28050.1
AB014516 mRNA Translation: BAA31591.1
AY186997 mRNA Translation: AAP12462.1 Different termination.
AY186998 mRNA Translation: AAP12463.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32963.1 [Q6UUV9-1]
CCDS42525.1 [Q6UUV9-2]

Protein sequence database of the Protein Information Resource

More...PIRi		T00388

NCBI Reference Sequences

More...RefSeqi		NP_001091952.1, NM_001098482.1 [Q6UUV9-2]
NP_056136.2, NM_015321.2 [Q6UUV9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000321949; ENSP00000323332; ENSG00000105662 [Q6UUV9-1]
ENST00000338797; ENSP00000345001; ENSG00000105662 [Q6UUV9-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23373

UCSC genome browser

More...UCSCi		uc002nkb.5, human [Q6UUV9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY360171 mRNA Translation: AAQ98856.1
AY040323 mRNA Translation: AAK93832.1
AY040324 mRNA Translation: AAK93833.1 Different termination.
AK024089 mRNA Translation: BAB14822.1
AC003107 Genomic DNA No translation available.
AC004476 Genomic DNA No translation available.
AC006123 Genomic DNA Translation: AAC97072.1
CH471106 Genomic DNA Translation: EAW84730.1
BC017075 mRNA Translation: AAH17075.3 Different initiation.
BC023614 mRNA Translation: AAH23614.2 Different initiation.
BC028050 mRNA Translation: AAH28050.1
AB014516 mRNA Translation: BAA31591.1
AY186997 mRNA Translation: AAP12462.1 Different termination.
AY186998 mRNA Translation: AAP12463.1 Different initiation.
CCDSiCCDS32963.1 [Q6UUV9-1]
CCDS42525.1 [Q6UUV9-2]
PIRiT00388
RefSeqiNP_001091952.1, NM_001098482.1 [Q6UUV9-2]
NP_056136.2, NM_015321.2 [Q6UUV9-1]

3D structure databases

SMRiQ6UUV9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116952, 12 interactors
IntActiQ6UUV9, 10 interactors
STRINGi9606.ENSP00000345001

PTM databases

iPTMnetiQ6UUV9
PhosphoSitePlusiQ6UUV9

Polymorphism and mutation databases

BioMutaiCRTC1
DMDMi68565585

Proteomic databases

EPDiQ6UUV9
jPOSTiQ6UUV9
MassIVEiQ6UUV9
MaxQBiQ6UUV9
PaxDbiQ6UUV9
PeptideAtlasiQ6UUV9
PRIDEiQ6UUV9
ProteomicsDBi67426 [Q6UUV9-1]
67427 [Q6UUV9-2]
67428 [Q6UUV9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15141, 352 antibodies

The DNASU plasmid repository

More...DNASUi		23373

Genome annotation databases

EnsembliENST00000321949; ENSP00000323332; ENSG00000105662 [Q6UUV9-1]
ENST00000338797; ENSP00000345001; ENSG00000105662 [Q6UUV9-2]
GeneIDi23373
KEGGihsa:23373
UCSCiuc002nkb.5, human [Q6UUV9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23373
DisGeNETi23373
EuPathDBiHostDB:ENSG00000105662.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRTC1
HGNCiHGNC:16062, CRTC1
HPAiENSG00000105662, Tissue enhanced (brain)
MIMi607536, gene
neXtProtiNX_Q6UUV9
OpenTargetsiENSG00000105662
PharmGKBiPA30730

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QU41, Eukaryota
GeneTreeiENSGT00390000010652
HOGENOMiCLU_019357_2_0_1
InParanoidiQ6UUV9
OMAiAWDAKKT
OrthoDBi1118500at2759
PhylomeDBiQ6UUV9
TreeFamiTF321571

Enzyme and pathway databases

PathwayCommonsiQ6UUV9
ReactomeiR-HSA-2151201, Transcriptional activation of mitochondrial biogenesis
R-HSA-400253, Circadian Clock
SIGNORiQ6UUV9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23373, 11 hits in 850 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CRTC1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CRTC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23373
PharosiQ6UUV9, Tbio

Protein Ontology

More...PROi		PR:Q6UUV9
RNActiQ6UUV9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105662, Expressed in dorsal plus ventral thalamus and 202 other tissues
ExpressionAtlasiQ6UUV9, baseline and differential
GenevisibleiQ6UUV9, HS

Family and domain databases

InterProiView protein in InterPro
IPR024786, TORC
IPR024785, TORC_C
IPR024784, TORC_M
IPR024783, TORC_N
PANTHERiPTHR13589, PTHR13589, 1 hit
PfamiView protein in Pfam
PF12886, TORC_C, 1 hit
PF12885, TORC_M, 1 hit
PF12884, TORC_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRTC1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UUV9
Secondary accession number(s): A6NMG5
, O75114, Q6Y3A3, Q7LDZ2, Q8IUL3, Q8IZ34, Q8IZL1, Q8N6W3, Q96AI8, Q9H801
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: December 2, 2020
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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