UniProtKB - Q6UUV9 (CRTC1_HUMAN)
CREB-regulated transcription coactivator 1
CRTC1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 575 | Required for ubiquitination and degradationBy similarity | 1 |
GO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
GO - Biological processi
- energy homeostasis Source: Ensembl
- entrainment of circadian clock by photoperiod Source: UniProtKB
- memory Source: Ensembl
- negative regulation of membrane hyperpolarization Source: Ensembl
- positive regulation of CREB transcription factor activity Source: UniProtKB
- positive regulation of dendrite development Source: Ensembl
- positive regulation of long-term synaptic potentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- protein homotetramerization Source: InterPro
- rhythmic process Source: UniProtKB-KW
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator |
Biological process | Biological rhythms, Host-virus interaction, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6UUV9 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-400253, Circadian Clock |
SIGNORi | Q6UUV9 |
Names & Taxonomyi
Protein namesi | Recommended name: CREB-regulated transcription coactivator 1Alternative name(s): Mucoepidermoid carcinoma translocated protein 1 Transducer of regulated cAMP response element-binding protein 1 Short name: TORC-1 Short name: Transducer of CREB protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105662.15 |
HGNCi | HGNC:16062, CRTC1 |
MIMi | 607536, gene |
neXtProti | NX_Q6UUV9 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
Note: Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity).By similarity2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: GO_Central
- dendrite Source: Ensembl
- glutamatergic synapse Source: Ensembl
- neuronal cell body Source: Ensembl
- postsynaptic density Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 42 – 43 | Breakpoint for translocation to form the MECT1-MAML2 and MAML2-MECT1 fusion proteins2 Publications | 2 |
Organism-specific databases
DisGeNETi | 23373 |
OpenTargetsi | ENSG00000105662 |
PharmGKBi | PA30730 |
Miscellaneous databases
Pharosi | Q6UUV9, Tbio |
Polymorphism and mutation databases
BioMutai | CRTC1 |
DMDMi | 68565585 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096354 | 1 – 634 | CREB-regulated transcription coactivator 1Add BLAST | 634 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 64 | PhosphoserineBy similarity | 1 | |
Modified residuei | 113 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 151 | Phosphoserine; by SIK1 and SIK21 Publication | 1 | |
Modified residuei | 161 | PhosphothreonineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6UUV9 |
jPOSTi | Q6UUV9 |
MassIVEi | Q6UUV9 |
MaxQBi | Q6UUV9 |
PaxDbi | Q6UUV9 |
PeptideAtlasi | Q6UUV9 |
PRIDEi | Q6UUV9 |
ProteomicsDBi | 67426 [Q6UUV9-1] 67427 [Q6UUV9-2] 67428 [Q6UUV9-3] |
PTM databases
iPTMneti | Q6UUV9 |
PhosphoSitePlusi | Q6UUV9 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105662, Expressed in dorsal plus ventral thalamus and 202 other tissues |
ExpressionAtlasi | Q6UUV9, baseline and differential |
Genevisiblei | Q6UUV9, HS |
Organism-specific databases
HPAi | ENSG00000105662, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:14536081). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:14536081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:14536081).
Interacts with 14-3-3 proteins, including YWHAE/14-3-3 epsilon (PubMed:30611118).
Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:30611118).
2 Publications(Microbial infection) Interacts with HTLV1 Tax.
1 PublicationBinary interactionsi
Q6UUV9
With | #Exp. | IntAct |
---|---|---|
CREB1 [P16220] | 6 | EBI-1644259,EBI-711855 |
GO - Molecular functioni
- cAMP response element binding protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116952, 12 interactors |
IntActi | Q6UUV9, 10 interactors |
STRINGi | 9606.ENSP00000345001 |
Miscellaneous databases
RNActi | Q6UUV9, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 242 – 258 | Nuclear export signalBy similarityAdd BLAST | 17 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 299 – 366 | Ser-richAdd BLAST | 68 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502QU41, Eukaryota |
GeneTreei | ENSGT00390000010652 |
HOGENOMi | CLU_019357_2_0_1 |
InParanoidi | Q6UUV9 |
OMAi | AWDAKKT |
OrthoDBi | 1118500at2759 |
PhylomeDBi | Q6UUV9 |
TreeFami | TF321571 |
Family and domain databases
InterProi | View protein in InterPro IPR024786, TORC IPR024785, TORC_C IPR024784, TORC_M IPR024783, TORC_N |
PANTHERi | PTHR13589, PTHR13589, 1 hit |
Pfami | View protein in Pfam PF12886, TORC_C, 1 hit PF12885, TORC_M, 1 hit PF12884, TORC_N, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY
60 70 80 90 100
LQLGPSRGQY YGGSLPNVNQ IGSGTMDLPF QTPFQSSGLD TSRTTRHHGL
110 120 130 140 150
VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTMYLSP PADTSWRRTN
160 170 180 190 200
SDSALHQSTM TPTQPESFSS GSQDVHQKRV LLLTVPGMEE TTSEADKNLS
210 220 230 240 250
KQAWDTKKTG SRPKSCEVPG INIFPSADQE NTTALIPATH NTGGSLPDLT
260 270 280 290 300
NIHFPSPLPT PLDPEEPTFP ALSSSSSTGN LAANLTHLGI GGAGQGMSTP
310 320 330 340 350
GSSPQHRPAG VSPLSLSTEA RRQQASPTLS PLSPITQAVA MDALSLEQQL
360 370 380 390 400
PYAFFTQAGS QQPPPQPQPP PPPPPASQQP PPPPPPQAPV RLPPGGPLLP
410 420 430 440 450
SASLTRGPQP PPLAVTVPSS LPQSPPENPG QPSMGIDIAS APALQQYRTS
460 470 480 490 500
AGSPANQSPT SPVSNQGFSP GSSPQHTSTL GSVFGDAYYE QQMAARQANA
510 520 530 540 550
LSHQLEQFNM MENAISSSSL YSPGSTLNYS QAAMMGLTGS HGSLPDSQQL
560 570 580 590 600
GYASHSGIPN IILTVTGESP PSLSKELTSS LAGVGDVSFD SDSQFPLDEL
610 620 630
KIDPLTLDGL HMLNDPDMVL ADPATEDTFR MDRL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QXN6 | M0QXN6_HUMAN | CREB-regulated transcription coacti... | CRTC1 | 392 | Annotation score: | ||
M0QX46 | M0QX46_HUMAN | CREB-regulated transcription coacti... | CRTC1 | 593 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 84 | F → S in BAB14822 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 384 | P → S in BAB14822 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 556 | S → G in BAB14822 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053934 | 286 | T → A. Corresponds to variant dbSNP:rs3746266Ensembl. | 1 | |
Natural variantiVAR_053935 | 311 | V → I1 PublicationCorresponds to variant dbSNP:rs36070283Ensembl. | 1 | |
Natural variantiVAR_053936 | 328 | T → A1 PublicationCorresponds to variant dbSNP:rs3746266Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051749 | 81 | Q → QPSGFLGEALAAAPVSL in isoform 2. 2 Publications | 1 | |
Alternative sequenceiVSP_051750 | 475 – 503 | Missing in isoform 3. 3 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_051751 | 580 – 634 | SLAGV…RMDRL → HRGHLPDGPPVSGHAGTLPL SRPDGASPARGRPCSVPRQR PSL in isoform 3. 3 PublicationsAdd BLAST | 55 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY360171 mRNA Translation: AAQ98856.1 AY040323 mRNA Translation: AAK93832.1 AY040324 mRNA Translation: AAK93833.1 Different termination. AK024089 mRNA Translation: BAB14822.1 AC003107 Genomic DNA No translation available. AC004476 Genomic DNA No translation available. AC006123 Genomic DNA Translation: AAC97072.1 CH471106 Genomic DNA Translation: EAW84730.1 BC017075 mRNA Translation: AAH17075.3 Different initiation. BC023614 mRNA Translation: AAH23614.2 Different initiation. BC028050 mRNA Translation: AAH28050.1 AB014516 mRNA Translation: BAA31591.1 AY186997 mRNA Translation: AAP12462.1 Different termination. AY186998 mRNA Translation: AAP12463.1 Different initiation. |
CCDSi | CCDS32963.1 [Q6UUV9-1] CCDS42525.1 [Q6UUV9-2] |
PIRi | T00388 |
RefSeqi | NP_001091952.1, NM_001098482.1 [Q6UUV9-2] NP_056136.2, NM_015321.2 [Q6UUV9-1] |
Genome annotation databases
Ensembli | ENST00000321949; ENSP00000323332; ENSG00000105662 [Q6UUV9-1] ENST00000338797; ENSP00000345001; ENSG00000105662 [Q6UUV9-2] |
GeneIDi | 23373 |
KEGGi | hsa:23373 |
UCSCi | uc002nkb.5, human [Q6UUV9-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangement, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY360171 mRNA Translation: AAQ98856.1 AY040323 mRNA Translation: AAK93832.1 AY040324 mRNA Translation: AAK93833.1 Different termination. AK024089 mRNA Translation: BAB14822.1 AC003107 Genomic DNA No translation available. AC004476 Genomic DNA No translation available. AC006123 Genomic DNA Translation: AAC97072.1 CH471106 Genomic DNA Translation: EAW84730.1 BC017075 mRNA Translation: AAH17075.3 Different initiation. BC023614 mRNA Translation: AAH23614.2 Different initiation. BC028050 mRNA Translation: AAH28050.1 AB014516 mRNA Translation: BAA31591.1 AY186997 mRNA Translation: AAP12462.1 Different termination. AY186998 mRNA Translation: AAP12463.1 Different initiation. |
CCDSi | CCDS32963.1 [Q6UUV9-1] CCDS42525.1 [Q6UUV9-2] |
PIRi | T00388 |
RefSeqi | NP_001091952.1, NM_001098482.1 [Q6UUV9-2] NP_056136.2, NM_015321.2 [Q6UUV9-1] |
3D structure databases
SMRi | Q6UUV9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116952, 12 interactors |
IntActi | Q6UUV9, 10 interactors |
STRINGi | 9606.ENSP00000345001 |
PTM databases
iPTMneti | Q6UUV9 |
PhosphoSitePlusi | Q6UUV9 |
Polymorphism and mutation databases
BioMutai | CRTC1 |
DMDMi | 68565585 |
Proteomic databases
EPDi | Q6UUV9 |
jPOSTi | Q6UUV9 |
MassIVEi | Q6UUV9 |
MaxQBi | Q6UUV9 |
PaxDbi | Q6UUV9 |
PeptideAtlasi | Q6UUV9 |
PRIDEi | Q6UUV9 |
ProteomicsDBi | 67426 [Q6UUV9-1] 67427 [Q6UUV9-2] 67428 [Q6UUV9-3] |
Protocols and materials databases
Antibodypediai | 15141, 352 antibodies |
DNASUi | 23373 |
Genome annotation databases
Ensembli | ENST00000321949; ENSP00000323332; ENSG00000105662 [Q6UUV9-1] ENST00000338797; ENSP00000345001; ENSG00000105662 [Q6UUV9-2] |
GeneIDi | 23373 |
KEGGi | hsa:23373 |
UCSCi | uc002nkb.5, human [Q6UUV9-1] |
Organism-specific databases
CTDi | 23373 |
DisGeNETi | 23373 |
EuPathDBi | HostDB:ENSG00000105662.15 |
GeneCardsi | CRTC1 |
HGNCi | HGNC:16062, CRTC1 |
HPAi | ENSG00000105662, Tissue enhanced (brain) |
MIMi | 607536, gene |
neXtProti | NX_Q6UUV9 |
OpenTargetsi | ENSG00000105662 |
PharmGKBi | PA30730 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QU41, Eukaryota |
GeneTreei | ENSGT00390000010652 |
HOGENOMi | CLU_019357_2_0_1 |
InParanoidi | Q6UUV9 |
OMAi | AWDAKKT |
OrthoDBi | 1118500at2759 |
PhylomeDBi | Q6UUV9 |
TreeFami | TF321571 |
Enzyme and pathway databases
PathwayCommonsi | Q6UUV9 |
Reactomei | R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-400253, Circadian Clock |
SIGNORi | Q6UUV9 |
Miscellaneous databases
BioGRID-ORCSi | 23373, 11 hits in 850 CRISPR screens |
ChiTaRSi | CRTC1, human |
GeneWikii | CRTC1 |
GenomeRNAii | 23373 |
Pharosi | Q6UUV9, Tbio |
PROi | PR:Q6UUV9 |
RNActi | Q6UUV9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105662, Expressed in dorsal plus ventral thalamus and 202 other tissues |
ExpressionAtlasi | Q6UUV9, baseline and differential |
Genevisiblei | Q6UUV9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR024786, TORC IPR024785, TORC_C IPR024784, TORC_M IPR024783, TORC_N |
PANTHERi | PTHR13589, PTHR13589, 1 hit |
Pfami | View protein in Pfam PF12886, TORC_C, 1 hit PF12885, TORC_M, 1 hit PF12884, TORC_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRTC1_HUMAN | |
Accessioni | Q6UUV9Primary (citable) accession number: Q6UUV9 Secondary accession number(s): A6NMG5 Q9H801 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations