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Entry version 130 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Myosin-14

Gene

Myh14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi194 – 201ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5627123 RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-14
Alternative name(s):
Myosin heavy chain 14
Myosin heavy chain, non-muscle IIc
Non-muscle myosin heavy chain IIc
Short name:
NMHC II-C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myh14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1919210 Myh14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Survival to adulthood with no obvious defects in brain structure, lung and heart development and no evidence for defective cell division. Deletion in animals expressing only 12% of wild-type amounts of Myh10 results in an increase in cardiac myocyte hypertrophy and interstitial fibrosis compared with the Myh10 hypomorphic animal.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234322 – 2000Myosin-14Add BLAST1999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei33PhosphothreonineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei925PhosphoserineCombined sources1
Modified residuei1198PhosphothreonineBy similarity1
Modified residuei1249PhosphoserineCombined sources1
Modified residuei1280PhosphoserineCombined sources1
Modified residuei1973PhosphoserineCombined sources1
Modified residuei1985PhosphoserineBy similarity1
Modified residuei1998PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6URW6

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6URW6

PeptideAtlas

More...
PeptideAtlasi
Q6URW6

PRoteomics IDEntifications database

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PRIDEi
Q6URW6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6URW6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6URW6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6URW6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in lung, kidney, brain and colon, very low levels in liver and bladder and no expression in spleen or seminal vesicle (at protein level). Isoform 1 is expressed in liver, kidney and testis with low levels in skeletal muscle and heart. Isoform 1 and isoform 2 are expressed in brain and lung. Isoform 2 is the main isoform expressed in skeletal muscle and heart. Isoform 3 is limited to brain stem, cerebellum and spinal cord.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed throughout the embryo at 11.5 dpc. Enhanced expression in the developing pituitary at 11.5 dpc. Expressed in developing lung from 13.5 dpc. At 16.5 dpc, confined to airway epithelial cells, developing sensory area of the cochlea and intestinal epithelial cells, particularly concentrated at their apical border.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000030739 Expressed in 243 organ(s), highest expression level in ileum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6URW6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6URW6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
215057, 1 interactor

Protein interaction database and analysis system

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IntActi
Q6URW6, 2 interactors

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000103531

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6URW6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 97Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini101 – 804Myosin motorPROSITE-ProRule annotationAdd BLAST704
Domaini807 – 836IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni682 – 704Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili866 – 1951Sequence analysisAdd BLAST1086

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158808

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000173958

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6URW6

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
DAIMDLE

Database of Orthologous Groups

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OrthoDBi
47111at2759

TreeFam database of animal gene trees

More...
TreeFami
TF333601

Family and domain databases

Database of protein disorder

More...
DisProti
DP01022

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6URW6-1) [UniParc]FASTAAdd to basket
Also known as: NM II-C1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAVTMSVSG RKVASRPGPV PEAAQSFLYA PRTPNVGGPG GPQVEWTARR
60 70 80 90 100
MVWVPSELHG FEAAALRDEG EEEAEVELAE SGRRLRLPRD QIQRMNPPKF
110 120 130 140 150
SKAEDMAELT CLNEASVLHN LRERYYSGLI YTYSGLFCVV INPYKQLPIY
160 170 180 190 200
TEAIVEMYRG KKRHEVPPHV YAVTEGAYRS MLQDREDQSI LCTGESGAGK
210 220 230 240 250
TENTKKVIQY LAHVASSPKG RKEPGVPASV STMSYGELER QLLQANPILE
260 270 280 290 300
AFGNAKTVKN DNSSRFGKFI RINFDIAGYI VGANIETYLL EKSRAIRQAK
310 320 330 340 350
DECSFHIFYQ LLGGAGEQLK ADLLLEPCSH YRFLTNGPSS SPGQERELFQ
360 370 380 390 400
ETLESLRVLG LLPEEITAML RTVSAVLQFG NIVLKKERNT DQATMPDNTA
410 420 430 440 450
AQKLCRLLGL GVTDFSRALL TPRIKVGRDY VQKAQTKEQA DFALEALAKA
460 470 480 490 500
TYERLFRWLV LRLNRALDRS PRQGASFLGI LDIAGFEIFQ LNSFEQLCIN
510 520 530 540 550
YTNEKLQQLF NHTMFVLEQE EYQREGIPWT FLDFGLDLQP CIDLIERPAN
560 570 580 590 600
PPGLLALLDE ECWFPKATDK SFVEKVAQEQ GSHPKFQRPR NLRDQADFSV
610 620 630 640 650
LHYAGKVDYK ASEWLMKNMD PLNDNVAALL HQSTDRLTAE IWKDVEGIVG
660 670 680 690 700
LEQVSSLGDG PPGGRPRRGM FRTVGQLYKE SLSRLMATLS NTNPSFVRCI
710 720 730 740 750
VPNHEKRAGK LEPRLVLDQL RCNGVLEGIR ICRQGFPNRI LFQEFRQRYE
760 770 780 790 800
ILTPNAIPKG FMDGKQACEK MIQALELDPN LYRVGQSKIF FRAGVLAQLE
810 820 830 840 850
EERDLKVTDI IVSFQAAARG YLARRAFQRR QQQQSALRVM QRNCAAYLKL
860 870 880 890 900
RNWQWWRLFI KVKPLLQVTR QDEVLQARAQ ELQKVQELQQ QSAREVGELQ
910 920 930 940 950
GRVAQLEEER TRLAEQLRAE AELCSEAEET RARLAARKQE LELVVTELEA
960 970 980 990 1000
RVGEEEECSR QLQSEKKRLQ QHIQELESHL EAEEGARQKL QLEKVTTEAK
1010 1020 1030 1040 1050
MKKFEEDLLL LEDQNSKLSK ERRLLEERLA EFSSQAAEEE EKVKSLNKLR
1060 1070 1080 1090 1100
LKYEATISDM EDRLKKEEKG RQELEKLKRR LDGESSELQE QMVEQKQRAE
1110 1120 1130 1140 1150
ELLAQLGRKE DELQAALLRA EEEGGARAQL LKSLREAQAG LAEAQEDLEA
1160 1170 1180 1190 1200
ERVARAKAEK QRRDLGEELE ALRGELEDTL DSTNAQQELR SKREQEVTEL
1210 1220 1230 1240 1250
KKALEEESRA HEVSMQELRQ RHSQALVEMA EQLEQARRGK GVWEKTRLSL
1260 1270 1280 1290 1300
EAEVSELKAE LSSLQTSRQE GEQKRRRLES QLQEVQGRSS DSERARSEAA
1310 1320 1330 1340 1350
EKLQRAQAEL ESVSTALSEA ESKAIRLGKE LSSAESQLHD TQELLQEETR
1360 1370 1380 1390 1400
AKLALGSRVR ALEAEAAGLR EQMEEEVVAR ERAGRELQST QAQLSEWRRR
1410 1420 1430 1440 1450
QEEEAAVLEA GEEARRRAAR EAETLTQRLA EKTEAVERLE RARRRLQQEL
1460 1470 1480 1490 1500
DDATVDLGQQ KQLLSTLEKK QRKFDQLLAE EKAAVLRAVE DRERIEAEGR
1510 1520 1530 1540 1550
EREARALSLT RALEEEQEAR EELERQNRAL RAELEALLSS KDDVGKNVHE
1560 1570 1580 1590 1600
LERARKAAEQ AASDLRTQVT ELEDELTAAE DAKLRLEVTV QALKAQHERD
1610 1620 1630 1640 1650
LQGRDDAGEE RRRQLAKQLR DAEVERDEER KQRALAMAAR KKLELELEEL
1660 1670 1680 1690 1700
KAQTSAAGQG KEEAVKQLKK MQVQMKELWR EVEETRSSRD EMFTLSRENE
1710 1720 1730 1740 1750
KKLKGLEAEV LRLQEELAAS DRARRQAQQD RDEMAEEVAS GNLSKAATLE
1760 1770 1780 1790 1800
EKRQLEGRLS QLEEELEEEQ NNSELLKDHY RKLVLQVESL TTELSAERSF
1810 1820 1830 1840 1850
SAKAESGRQQ LERQIQELRA RLGEEDAGAR ARQKMLIAAL ESKLAQAEEQ
1860 1870 1880 1890 1900
LEQESRERIL SGKLVRRAEK RLKEVVLQVD EERRVADQVR DQLEKSNLRL
1910 1920 1930 1940 1950
KQLKRQLEEA EEEASRAQAG RRRLQRELED VTESAESMNR EVTTLRNRLR
1960 1970 1980 1990 2000
RGPLTFTTRT VRQVFRLEEG VASDEEEAEG AEPGSAPGQE PEAPPPATPQ
Note: Requires phosphorylation of the myosin regulatory light chain for activity.
Length:2,000
Mass (Da):228,586
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1957C1A42EF2A21A
GO
Isoform 2 (identifier: Q6URW6-2) [UniParc]FASTAAdd to basket
Also known as: NM II-C0

The sequence of this isoform differs from the canonical sequence as follows:
     228-235: Missing.

Note: Requires phosphorylation of the myosin regulatory light chain for activity.
Show »
Length:1,992
Mass (Da):227,759
Checksum:i871EF7B8752D6614
GO
Isoform 3 (identifier: Q6URW6-3) [UniParc]FASTAAdd to basket
Also known as: NM II-C2

The sequence of this isoform differs from the canonical sequence as follows:
     228-235: Missing.
     644-644: D → DEQGGLQQFTLLGSFPSPSPGPAGRLGSGASPPGVGSLCAPT

Note: Constitutively active isoform which does not require phosphorylation of the regulatory myosin light chain for activity.
Show »
Length:2,033
Mass (Da):231,622
Checksum:i2362751C95BFB052
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4R2K3W4R2_MOUSE
Myosin-14
Myh14
2,000Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LI60A0A140LI60_MOUSE
Myosin-14
Myh14
1,245Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LHX1A0A140LHX1_MOUSE
Myosin-14
Myh14
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014633228 – 235Missing in isoform 2 and isoform 3. 2 Publications8
Alternative sequenceiVSP_044759644D → DEQGGLQQFTLLGSFPSPSP GPAGRLGSGASPPGVGSLCA PT in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY363100 mRNA Translation: AAQ24173.1
AY205605 mRNA Translation: AAO47092.1
EF602040 mRNA Translation: ABR10605.1
AC150895 Genomic DNA No translation available.
AC157653 Genomic DNA No translation available.
BC041796 mRNA Translation: AAH41796.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS39943.1 [Q6URW6-2]
CCDS71951.1 [Q6URW6-1]

NCBI Reference Sequences

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RefSeqi
NP_001258467.1, NM_001271538.1 [Q6URW6-3]
NP_001258469.1, NM_001271540.1 [Q6URW6-1]
NP_082297.1, NM_028021.3 [Q6URW6-2]
XP_011249204.1, XM_011250902.2 [Q6URW6-2]
XP_011249205.1, XM_011250903.2 [Q6URW6-1]
XP_017167802.1, XM_017312313.1 [Q6URW6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000048102; ENSMUSP00000046059; ENSMUSG00000030739 [Q6URW6-1]
ENSMUST00000107899; ENSMUSP00000103531; ENSMUSG00000030739 [Q6URW6-2]
ENSMUST00000207775; ENSMUSP00000147115; ENSMUSG00000030739 [Q6URW6-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
71960

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:71960

UCSC genome browser

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UCSCi
uc009gqi.2 mouse [Q6URW6-2]
uc009gqj.2 mouse [Q6URW6-1]
uc012fjt.2 mouse [Q6URW6-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363100 mRNA Translation: AAQ24173.1
AY205605 mRNA Translation: AAO47092.1
EF602040 mRNA Translation: ABR10605.1
AC150895 Genomic DNA No translation available.
AC157653 Genomic DNA No translation available.
BC041796 mRNA Translation: AAH41796.1
CCDSiCCDS39943.1 [Q6URW6-2]
CCDS71951.1 [Q6URW6-1]
RefSeqiNP_001258467.1, NM_001271538.1 [Q6URW6-3]
NP_001258469.1, NM_001271540.1 [Q6URW6-1]
NP_082297.1, NM_028021.3 [Q6URW6-2]
XP_011249204.1, XM_011250902.2 [Q6URW6-2]
XP_011249205.1, XM_011250903.2 [Q6URW6-1]
XP_017167802.1, XM_017312313.1 [Q6URW6-1]

3D structure databases

SMRiQ6URW6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi215057, 1 interactor
IntActiQ6URW6, 2 interactors
STRINGi10090.ENSMUSP00000103531

PTM databases

iPTMnetiQ6URW6
PhosphoSitePlusiQ6URW6
SwissPalmiQ6URW6

Proteomic databases

jPOSTiQ6URW6
PaxDbiQ6URW6
PeptideAtlasiQ6URW6
PRIDEiQ6URW6

Genome annotation databases

EnsembliENSMUST00000048102; ENSMUSP00000046059; ENSMUSG00000030739 [Q6URW6-1]
ENSMUST00000107899; ENSMUSP00000103531; ENSMUSG00000030739 [Q6URW6-2]
ENSMUST00000207775; ENSMUSP00000147115; ENSMUSG00000030739 [Q6URW6-3]
GeneIDi71960
KEGGimmu:71960
UCSCiuc009gqi.2 mouse [Q6URW6-2]
uc009gqj.2 mouse [Q6URW6-1]
uc012fjt.2 mouse [Q6URW6-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
79784
MGIiMGI:1919210 Myh14

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000158808
HOGENOMiHOG000173958
InParanoidiQ6URW6
KOiK10352
OMAiDAIMDLE
OrthoDBi47111at2759
TreeFamiTF333601

Enzyme and pathway databases

ReactomeiR-MMU-5627123 RHO GTPases activate PAKs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myh14 mouse

Protein Ontology

More...
PROi
PR:Q6URW6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000030739 Expressed in 243 organ(s), highest expression level in ileum
ExpressionAtlasiQ6URW6 baseline and differential
GenevisibleiQ6URW6 MM

Family and domain databases

DisProtiDP01022
Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH14_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6URW6
Secondary accession number(s): B3F3T1, Q80V64, Q80ZE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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