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UniProtKB - Q6URC4 (Q6URC4_HUMAN)
Protein
Submitted name:
Diaphanous 1
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- small GTPase binding Source: InterPro
GO - Biological processi
- actin filament polymerization Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Diaphanous 1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- small GTPase binding Source: InterPro
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 84 – 449 | GBD/FH3InterPro annotationAdd BLAST | 366 | |
Domaini | 769 – 1171 | FH2InterPro annotationAdd BLAST | 403 | |
Domaini | 1194 – 1222 | DADInterPro annotationAdd BLAST | 29 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 84 | DisorderedSequence analysisAdd BLAST | 84 | |
Regioni | 573 – 754 | DisorderedSequence analysisAdd BLAST | 182 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 495 – 568 | Sequence analysisAdd BLAST | 74 | |
Coiled coili | 1045 – 1072 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 1094 – 1114 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 1148 – 1192 | Sequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 36 – 67 | Basic and acidic residuesSequence analysisAdd BLAST | 32 | |
Compositional biasi | 68 – 84 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 576 – 627 | Pro residuesSequence analysisAdd BLAST | 52 | |
Compositional biasi | 635 – 663 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 670 – 754 | Pro residuesSequence analysisAdd BLAST | 85 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisARBA annotationPhylogenomic databases
OrthoDBi | 1204639at2759 |
Family and domain databases
Gene3Di | 1.10.20.40, 1 hit 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR044933, DIA_GBD_sf IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR027653, Formin_Diaph1 IPR014768, GBD/FH3_dom IPR010473, GTPase-bd |
PANTHERi | PTHR45691:SF4, PTHR45691:SF4, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6URC4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEPPGGSLGP GRGTRDKKKG RSPDELPSAG GDGGKSKKFT LKRLMADELE
60 70 80 90 100
RFTSMRIKKE KEKPNSAHRN SSASYGDDPT AQSLQDVSDE QVLVLFEQML
110 120 130 140 150
LDMNLNEEKQ QPLREKDIII KREMVSQYLY TSKAGMSQKE SSKSAMMYIQ
160 170 180 190 200
ELRSGLRDMP LLSCLESLRV SLNNNPVSWV QTFGAEGLAS LLDILKRLHD
210 220 230 240 250
EKEETAGSYD SRNKHEIIRC LKAFMNNKFG IKTMLETEEG ILLLVRAMDP
260 270 280 290 300
AVPNMMIDAA KLLSALCILP QPEDMNERVL EAMTERAEMD EVERFQPLLD
310 320 330 340 350
GLKSGTTIAL KVGCLQLINA LITPAEELDF RVHIRSELMR LGLHQVLQDL
360 370 380 390 400
REIENEDMRV QLNVFDEQGE EDSYDLKGRL DDIRMEMDDF NEVFQILLNT
410 420 430 440 450
VKDSKAEPHF LSILQHLLLV RNDYEARPQY YKLIEECISQ IVLHKNGADP
460 470 480 490 500
DFKCRHLQIE IEGLIDQMID KTKVEKSEAK AAELGKKLDS ELTARHELQV
510 520 530 540 550
EMKKMESDFE QKLQDLQGEK DALHSEKQQI ATEKQDLEAE VSQLTGEVAK
560 570 580 590 600
LTKELEDAKK EMASLSAAAI TVPPSVPSRA PVPPAPPLPG DSGTIIPPPP
610 620 630 640 650
APGDSTTPPP PPPPPPPPPP LPGGVCISSP PSLPGGTAIS PPPPLSGDAT
660 670 680 690 700
IPPPPPLPEG VGIPSPSSLP GGTAIPPPPP LPGSARIPPP PPPLPGSAGI
710 720 730 740 750
PPPPPPLPGE AGMPPPPPPL PGGPGIPPPP PFPGGPGIPP PPPGMGMPPP
760 770 780 790 800
PPFGFGVPAA PVLPFGLTPK KLYKPEVQLR RPNWSKLVAE DLSQDCFWTK
810 820 830 840 850
VKEDRFENNE LFAKLTLTFS AQTKTSKAKK DQEGGEEKKS VQKKKVKELK
860 870 880 890 900
VLDSKTAQNL SIFLGSFRMP YQEIKNVILE VNEAVLTESM IQNLIKQMPE
910 920 930 940 950
PEQLKMLSEL KDEYDDLAES EQFGVVMGTV PRLRPRLNAI LFKLQFSEQV
960 970 980 990 1000
ENIKPEIVSV TAACEELRKS ESFSNLLEIT LLVGNYMNAG SRNAGAFGFN
1010 1020 1030 1040 1050
ISFLCKLRDT KSTDQKMTLL HFLAELCEND YPDVLKFPDE LAHVEKASRV
1060 1070 1080 1090 1100
SAENLQKNLD QMKKRISDVE RDVQNFPAAT DEKDKFVEKM TSFVKDAQEQ
1110 1120 1130 1140 1150
YNKLRMMHSN METLYKELGE YFLFDPKKLS VEEFFMDLHN FRNMFLQAVK
1160 1170 1180 1190 1200
ENQKRRETEE KMRRAKLAKE KAEKERLEKQ QKREQLIDMN AEGDETGVMD
1210 1220 1230 1240 1250
SLLEALQSGA AFRRKRGPRQ ANRKAGCAVT SLLASELTKD DAMAAVPAKV
1260 1270
SKNSETFPTI LEEAKELVGR AS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY363395 mRNA Translation: AAQ63049.1 |
RefSeqi | NP_005210.3, NM_005219.4 |
Genome annotation databases
GeneIDi | 1729 |
KEGGi | hsa:1729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY363395 mRNA Translation: AAQ63049.1 |
RefSeqi | NP_005210.3, NM_005219.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q6URC4 |
Protocols and materials databases
DNASUi | 1729 |
Genome annotation databases
GeneIDi | 1729 |
KEGGi | hsa:1729 |
Organism-specific databases
CTDi | 1729 |
PharmGKBi | PA27333 |
Phylogenomic databases
OrthoDBi | 1204639at2759 |
Miscellaneous databases
BioGRID-ORCSi | 1729, 32 hits in 1078 CRISPR screens |
GenomeRNAii | 1729 |
Gene expression databases
Genevisiblei | Q6URC4, HS |
Family and domain databases
Gene3Di | 1.10.20.40, 1 hit 1.20.58.2220, 1 hit 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR014767, DAD_dom IPR044933, DIA_GBD_sf IPR015425, FH2_Formin IPR042201, FH2_Formin_sf IPR010472, FH3_dom IPR027653, Formin_Diaph1 IPR014768, GBD/FH3_dom IPR010473, GTPase-bd |
PANTHERi | PTHR45691:SF4, PTHR45691:SF4, 2 hits |
Pfami | View protein in Pfam PF06367, Drf_FH3, 1 hit PF06371, Drf_GBD, 1 hit PF02181, FH2, 1 hit |
SMARTi | View protein in SMART SM01139, Drf_FH3, 1 hit SM01140, Drf_GBD, 1 hit SM00498, FH2, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51231, DAD, 1 hit PS51444, FH2, 1 hit PS51232, GBD_FH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6URC4_HUMAN | |
Accessioni | Q6URC4Primary (citable) accession number: Q6URC4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |