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Entry version 69 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

RNA2 polyprotein

Gene
N/A
Organism
Tobacco ringspot virus (TobRV) (TRSV)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

implicated in RNA2 replication. Could also be required for nematode transmission of the virus (By similarity).

By similarity

transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).

By similarity

Miscellaneous

Virions are comprised of 60 copies of the coat protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionViral movement protein
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
P2
Cleaved into the following 3 chains:
Protein 2A
Short name:
P2A
Alternative name(s):
2B-MP
Alternative name(s):
2C-CP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTobacco ringspot virus (TobRV) (TRSV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12282 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeComovirinaeNepovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiAnemone [TaxID: 22868]
Bacopa [TaxID: 90645]
Capsicum annuum (Capsicum pepper) [TaxID: 4072]
Carica papaya (Papaya) [TaxID: 3649]
Citrullus lanatus (Watermelon) (Citrullus vulgaris) [TaxID: 3654]
Cornus [TaxID: 4281]
Cucumis melo (Muskmelon) [TaxID: 3656]
Cucumis sativus (Cucumber) [TaxID: 3659]
Daphne [TaxID: 66679]
Fraxinus (ash trees) [TaxID: 38871]
Gladiolus [TaxID: 49747]
Glycine max (Soybean) (Glycine hispida) [TaxID: 3847]
Hemerocallis [TaxID: 16107]
Hydrangea [TaxID: 23109]
Impatiens walleriana [TaxID: 127142]
Iris [TaxID: 26378]
Lobelia [TaxID: 4382]
Lupinus [TaxID: 3869]
Malus domestica (Apple) (Pyrus malus) [TaxID: 3750]
Malus pumila (Paradise apple) [TaxID: 283210]
Mentha [TaxID: 21819]
Narcissus pseudonarcissus (Daffodil) [TaxID: 39639]
Nicotiana tabacum (Common tobacco) [TaxID: 4097]
Pelargonium [TaxID: 4030]
Petunia [TaxID: 4101]
Phaseolus vulgaris (Kidney bean) (French bean) [TaxID: 3885]
Phlox subulata [TaxID: 103544]
Portulaca [TaxID: 3582]
Prunus avium (Cherry) (Cerasus avium) [TaxID: 42229]
Prunus incisa [TaxID: 137206]
Prunus persica (Peach) (Amygdalus persica) [TaxID: 3760]
Prunus serrula [TaxID: 1358727]
Prunus serrulata [TaxID: 97321]
Pueraria montana [TaxID: 132459]
Rubus (bramble) [TaxID: 23216]
Rubus plicatus [TaxID: 211815]
Solanum lycopersicum (Tomato) (Lycopersicon esculentum) [TaxID: 4081]
Solanum melongena (Eggplant) (Aubergine) [TaxID: 4111]
Vaccinium corymbosum (Highbush blueberry) [TaxID: 69266]
Vigna unguiculata (Cowpea) [TaxID: 3917]
Vitis vinifera (Grape) [TaxID: 29760]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000201113 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host plasmodesma By similarity
  • Note: Assembles in tubules that are embedded within modified plasmodesmata.By similarity

Keywords - Cellular componenti

Capsid protein, Host cell junction, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000371121 – 228Protein 2ABy similarityAdd BLAST228
ChainiPRO_0000037113229 – 588Movement proteinBy similarityAdd BLAST360
ChainiPRO_0000037114589 – 1101Coat proteinBy similarityAdd BLAST513

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by the P1 encoded 3C-like protease yield mature proteins.By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005054, Nepo_coat
IPR005305, Nepo_coat_C
IPR005306, Nepo_coat_N
IPR029053, Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03391, Nepo_coat, 1 hit
PF03688, Nepo_coat_C, 1 hit
PF03689, Nepo_coat_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q6UR06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPLLWHVDA TTPSHIQALQ SGSLPPASPA AALTRVQRAL SFFRTAARKY
60 70 80 90 100
CKQADAPDLF ALAMTRVAEH NDIAVDARNV EQLFHFVGQH VANTAERKAL
110 120 130 140 150
RAALREQRAL FKASLPGACF PAPAPPGWGI PKPPPLPPPF VWKGCRYNVV
160 170 180 190 200
APPPRIPQPP PLPKFAPFVR NNFRVVAPPP LGEVYQPVGA PFPQTRASAA
210 220 230 240 250
LSFFRTASTC RQVLVESCIQ QPAFMTCCAS TGEVQEMTSM LTEARQTGKI
260 270 280 290 300
LTPKEVSQAL AQKRKEIKGA EENRISFDEG VHLTEADVFH RLSLAKRFMA
310 320 330 340 350
HKRDRTLVDV LMPTEHEVVR YPGTRPDGTL QMCVSALPRM SEEAARKLLE
360 370 380 390 400
KGWKNSKNVS LDIGVTSYMP YGAPIVAFMT IMDGRTDDPQ EAALCANYMD
410 420 430 440 450
LGREKSKVLS LPLVTIPLSE IEHDQGILDC LYIVTYFHGV QSYQPGTLMM
460 470 480 490 500
SYGTLEFQEY SNNSFTTATR VRESWDQILK RNENLGKRVH AGIGVLGTIE
510 520 530 540 550
KEMDQQLEDF PAINLETRPR PVVRTFQNAH QPLHKTRSMR IGTTSFTGNT
560 570 580 590 600
GRTVLPPVVK TYEEGNANFD SLQSKPRHSS ASTAHLMCAV TVVPDPTCCG
610 620 630 640 650
TLSFKVPKDA KKGKHLGTFD IRQAIMEYGG LHSQEWCAKG IVNPTFTVRM
660 670 680 690 700
HAPRNAFAGL SIACTFDDYK RIDLPALGNE CPPSEMFELP TKVFMLKDAD
710 720 730 740 750
VHEWQFNYGE LTGHGLCNWA NVVTQPTLYF FVASTNQVTM AADWQCIVTM
760 770 780 790 800
HVDMGPVIDR FELVPTMTWP IQLGDTFAID RYYEAKEIKL DGSTSMLSIS
810 820 830 840 850
YNFGGPVKHS KKHAISYSRA VMSRNLGWSG TISGSVKSVS SLFCTASFVI
860 870 880 890 900
FPWEHEAPPT LRQVLWGPHQ IMHGDGQFEI AIKTRLHSAA TTEEGFGRLG
910 920 930 940 950
ILPLSGPIAP DAHVGSYEFI VHIDTWRPDS QVHPPMFSSA ELYNWFTLTN
960 970 980 990 1000
LKPDANTGVV NFDIPGYIHD FASKDATVTL ASNPLSWLVA ATGWHYGEVD
1010 1020 1030 1040 1050
LCISWPRSKQ AQAQEGSVSI TTNYRDWGAY WQGQARIYDL RRTEAEIPIF
1060 1070 1080 1090 1100
LGSYAGATPS GALGKQNYVR ISIVNAKDIV ALRVCLRPKS IKFWGRSATL

F
Length:1,101
Mass (Da):122,235
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i792DE76C871CDF9E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY363727 Genomic RNA Translation: AAQ63694.1

NCBI Reference Sequences

More...
RefSeqi
NP_919039.1, NC_005096.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2943106

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:2943106

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY363727 Genomic RNA Translation: AAQ63694.1
RefSeqiNP_919039.1, NC_005096.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi2943106
KEGGivg:2943106

Family and domain databases

Gene3Di2.60.120.20, 2 hits
InterProiView protein in InterPro
IPR005054, Nepo_coat
IPR005305, Nepo_coat_C
IPR005306, Nepo_coat_N
IPR029053, Viral_coat
PfamiView protein in Pfam
PF03391, Nepo_coat, 1 hit
PF03688, Nepo_coat_C, 1 hit
PF03689, Nepo_coat_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL2_TRSV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UR06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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