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Protein

Pre-mRNA 3'-end-processing factor FIP1

Gene

FIP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei339 – 340Breakpoint for interstitial deletion to form the FIP1L1-PDGFRA fusion protein2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-77595 Processing of Intronless Pre-mRNAs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6UN15

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA 3'-end-processing factor FIP1
Short name:
hFip1
Alternative name(s):
FIP1-like 1 protein
Factor interacting with PAP
Rearranged in hypereosinophilia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FIP1L1
Synonyms:FIP1, RHE
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000145216.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19124 FIP1L1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607686 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UN15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).2 Publications

Organism-specific databases

DisGeNET

More...
DisGeNETi
81608

MalaCards human disease database

More...
MalaCardsi
FIP1L1
MIMi607685 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145216

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
520 Acute promyelocytic leukemia
168940 Chronic eosinophilic leukemia
314950 Primary hypereosinophilic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134875694

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FIP1L1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002150371 – 594Pre-mRNA 3'-end-processing factor FIP1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei426PhosphotyrosineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6UN15

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6UN15

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6UN15

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UN15

PeptideAtlas

More...
PeptideAtlasi
Q6UN15

PRoteomics IDEntifications database

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PRIDEi
Q6UN15

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67417
67418 [Q6UN15-3]
67419 [Q6UN15-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UN15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UN15

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q6UN15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000145216 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii

CleanEx database of gene expression profiles

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CleanExi
HS_FIP1L1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UN15 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UN15 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037475
HPA058202

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (PubMed:14749727). Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921). Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220). Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085). Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085). Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
123545, 91 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6UN15

Database of interacting proteins

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DIPi
DIP-42503N

Protein interaction database and analysis system

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IntActi
Q6UN15, 55 interactors

Molecular INTeraction database

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MINTi
Q6UN15

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336752

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6UN15

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 356Necessary for stimulating PAPOLA activityAdd BLAST356
Regioni1 – 111Sufficient for interaction with PAPOLAAdd BLAST111
Regioni137 – 243Sufficient for interaction with CPSF41 PublicationAdd BLAST107
Regioni443 – 594Sufficient for interaction with CPSF1 and CSTF31 PublicationAdd BLAST152
Regioni457 – 490Arg/Asp/Glu-rich domain1 PublicationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 406Pro-richAdd BLAST51
Compositional biasi456 – 562Arg-richAdd BLAST107
Compositional biasi478 – 594Glu-richAdd BLAST117

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FIP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1049 Eukaryota
COG5213 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164253

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000004854

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059889

KEGG Orthology (KO)

More...
KOi
K14405

Identification of Orthologs from Complete Genome Data

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OMAi
QENQEAM

Database of Orthologous Groups

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OrthoDBi
929913at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6UN15

TreeFam database of animal gene trees

More...
TreeFami
TF318610

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039849 Fip1-like
IPR007854 Fip1_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13484 PTHR13484, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05182 Fip1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UN15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER
60 70 80 90 100
PEEENASANP PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI
110 120 130 140 150
GDIKTGAPQY GSYGTAPVNL NIKTGGRVYG TTGTKVKGVD LDAPGSINGV
160 170 180 190 200
PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF NEDTWKAYCE KQKRIRMGLE
210 220 230 240 250
VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR TGNSEKETAL
260 270 280 290 300
PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD
360 370 380 390 400
NNFSKPPPFF PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP
410 420 430 440 450
PPSLIPTIES GHSSGYDSRS ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ
460 470 480 490 500
WDYYARREKD RDRERDRDRE RDRDRDRERE RTRERERERD HSPTPSVFNS
510 520 530 540 550
DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR HKSSRSNSRR
560 570 580 590
RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
Length:594
Mass (Da):66,526
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB391D142419ED061
GO
Isoform 3 (identifier: Q6UN15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     213-235: Missing.
     272-307: Missing.

Show »
Length:520
Mass (Da):58,376
Checksum:i55D48285A046A783
GO
Isoform 4 (identifier: Q6UN15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     393-393: F → K
     394-594: Missing.

Show »
Length:378
Mass (Da):40,835
Checksum:i1B699B114C9560D4
GO
Isoform 5 (identifier: Q6UN15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     389-389: P → PPPGIPITVP

Note: No experimental confirmation available.
Show »
Length:588
Mass (Da):65,728
Checksum:i0E9D598DEAF3C752
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8P7H0Y8P7_HUMAN
Pre-mRNA 3'-end-processing factor F...
FIP1L1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8J4H0Y8J4_HUMAN
Pre-mRNA 3'-end-processing factor F...
FIP1L1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24016 differs from that shown. Intron retention.Curated
The sequence AAH52959 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118V → I in BAG58575 (PubMed:14702039).Curated1
Sequence conflicti312G → R in AAH24016 (PubMed:15489334).Curated1
Sequence conflicti312G → R in AAH52959 (PubMed:15489334).Curated1
Sequence conflicti524K → R in AAH52959 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01672829 – 43Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_016729213 – 235Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016730272 – 307Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_046213389P → PPPGIPITVP in isoform 5. 1 Publication1
Alternative sequenceiVSP_016731393F → K in isoform 4. 1 Publication1
Alternative sequenceiVSP_016732394 – 594Missing in isoform 4. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY366510 mRNA Translation: AAQ88277.1
AL136910 mRNA Translation: CAB66844.1
AK295737 mRNA Translation: BAG58575.1
AC058822 Genomic DNA No translation available.
AC095040 Genomic DNA No translation available.
AC098587 Genomic DNA No translation available.
AC098821 Genomic DNA No translation available.
AC105384 Genomic DNA No translation available.
AC110298 Genomic DNA No translation available.
AC110792 Genomic DNA No translation available.
AC124017 Genomic DNA No translation available.
AC138607 Genomic DNA No translation available.
AC138779 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05448.1
BC011543 mRNA Translation: AAH11543.1
BC017724 mRNA Translation: AAH17724.1
BC024016 mRNA Translation: AAH24016.1 Sequence problems.
BC052959 mRNA Translation: AAH52959.1 Sequence problems.
BC110383 mRNA Translation: AAI10384.1
AY229892 mRNA Translation: AAP69563.1 Different termination.

The Consensus CDS (CCDS) project

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CCDSi
CCDS3491.1 [Q6UN15-1]
CCDS47055.1 [Q6UN15-5]
CCDS47056.1 [Q6UN15-3]

NCBI Reference Sequences

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RefSeqi
NP_001128409.1, NM_001134937.1 [Q6UN15-5]
NP_001128410.1, NM_001134938.1 [Q6UN15-3]
NP_112179.2, NM_030917.3 [Q6UN15-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.555109
Hs.624245

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3]
ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1]
ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5]
ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81608

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81608

UCSC genome browser

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UCSCi
uc003gzx.5 human [Q6UN15-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366510 mRNA Translation: AAQ88277.1
AL136910 mRNA Translation: CAB66844.1
AK295737 mRNA Translation: BAG58575.1
AC058822 Genomic DNA No translation available.
AC095040 Genomic DNA No translation available.
AC098587 Genomic DNA No translation available.
AC098821 Genomic DNA No translation available.
AC105384 Genomic DNA No translation available.
AC110298 Genomic DNA No translation available.
AC110792 Genomic DNA No translation available.
AC124017 Genomic DNA No translation available.
AC138607 Genomic DNA No translation available.
AC138779 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05448.1
BC011543 mRNA Translation: AAH11543.1
BC017724 mRNA Translation: AAH17724.1
BC024016 mRNA Translation: AAH24016.1 Sequence problems.
BC052959 mRNA Translation: AAH52959.1 Sequence problems.
BC110383 mRNA Translation: AAI10384.1
AY229892 mRNA Translation: AAP69563.1 Different termination.
CCDSiCCDS3491.1 [Q6UN15-1]
CCDS47055.1 [Q6UN15-5]
CCDS47056.1 [Q6UN15-3]
RefSeqiNP_001128409.1, NM_001134937.1 [Q6UN15-5]
NP_001128410.1, NM_001134938.1 [Q6UN15-3]
NP_112179.2, NM_030917.3 [Q6UN15-1]
UniGeneiHs.555109
Hs.624245

3D structure databases

ProteinModelPortaliQ6UN15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123545, 91 interactors
CORUMiQ6UN15
DIPiDIP-42503N
IntActiQ6UN15, 55 interactors
MINTiQ6UN15
STRINGi9606.ENSP00000336752

PTM databases

iPTMnetiQ6UN15
PhosphoSitePlusiQ6UN15

Polymorphism and mutation databases

BioMutaiFIP1L1
DMDMi74749365

Proteomic databases

EPDiQ6UN15
jPOSTiQ6UN15
MaxQBiQ6UN15
PaxDbiQ6UN15
PeptideAtlasiQ6UN15
PRIDEiQ6UN15
ProteomicsDBi67417
67418 [Q6UN15-3]
67419 [Q6UN15-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
81608
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3]
ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1]
ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5]
ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4]
GeneIDi81608
KEGGihsa:81608
UCSCiuc003gzx.5 human [Q6UN15-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81608
DisGeNETi81608
EuPathDBiHostDB:ENSG00000145216.15

GeneCards: human genes, protein and diseases

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GeneCardsi
FIP1L1
HGNCiHGNC:19124 FIP1L1
HPAiHPA037475
HPA058202
MalaCardsiFIP1L1
MIMi607685 phenotype
607686 gene
neXtProtiNX_Q6UN15
OpenTargetsiENSG00000145216
Orphaneti520 Acute promyelocytic leukemia
168940 Chronic eosinophilic leukemia
314950 Primary hypereosinophilic syndrome
PharmGKBiPA134875694

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1049 Eukaryota
COG5213 LUCA
GeneTreeiENSGT00940000164253
HOGENOMiHOG000004854
HOVERGENiHBG059889
KOiK14405
OMAiQENQEAM
OrthoDBi929913at2759
PhylomeDBiQ6UN15
TreeFamiTF318610

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-77595 Processing of Intronless Pre-mRNAs
SIGNORiQ6UN15

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FIP1L1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FIP1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81608
PMAP-CutDBiQ6UN15

Protein Ontology

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PROi
PR:Q6UN15

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000145216 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii
CleanExiHS_FIP1L1
ExpressionAtlasiQ6UN15 baseline and differential
GenevisibleiQ6UN15 HS

Family and domain databases

InterProiView protein in InterPro
IPR039849 Fip1-like
IPR007854 Fip1_dom
PANTHERiPTHR13484 PTHR13484, 1 hit
PfamiView protein in Pfam
PF05182 Fip1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UN15
Secondary accession number(s): B4DIR3
, G3XAD6, Q0VGE0, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: January 16, 2019
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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