UniProtKB - Q6UN15 (FIP1_HUMAN)
Pre-mRNA 3'-end-processing factor FIP1
FIP1L1
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 339 – 340 | Breakpoint for interstitial deletion to form the FIP1L1-PDGFRA fusion protein | 2 |
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- mRNA 3'-end processing Source: Reactome
- mRNA export from nucleus Source: Reactome
- mRNA polyadenylation Source: GO_Central
- mRNA splicing, via spliceosome Source: Reactome
- pre-mRNA cleavage required for polyadenylation Source: GO_Central
- termination of RNA polymerase II transcription Source: Reactome
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing |
Enzyme and pathway databases
Reactomei | R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-77595 Processing of Intronless Pre-mRNAs |
SIGNORi | Q6UN15 |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-mRNA 3'-end-processing factor FIP1Short name: hFip1 Alternative name(s): FIP1-like 1 protein Factor interacting with PAP Rearranged in hypereosinophilia |
Gene namesi | Name:FIP1L1 Synonyms:FIP1, RHE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19124 FIP1L1 |
MIMi | 607686 gene |
neXtProti | NX_Q6UN15 |
Subcellular locationi
Nucleus
Nucleus
- mRNA cleavage and polyadenylation specificity factor complex Source: GO_Central
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Organism-specific databases
DisGeNETi | 81608 |
MalaCardsi | FIP1L1 |
MIMi | 607685 phenotype |
OpenTargetsi | ENSG00000145216 |
Orphaneti | 520 Acute promyelocytic leukemia 168940 Chronic eosinophilic leukemia 314950 Primary hypereosinophilic syndrome |
PharmGKBi | PA134875694 |
Miscellaneous databases
Pharosi | Q6UN15 |
Polymorphism and mutation databases
BioMutai | FIP1L1 |
DMDMi | 74749365 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215037 | 1 – 594 | Pre-mRNA 3'-end-processing factor FIP1Add BLAST | 594 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 85 | PhosphoserineBy similarity | 1 | |
Modified residuei | 87 | PhosphoserineBy similarity | 1 | |
Modified residuei | 89 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 | |
Modified residuei | 426 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 492 | PhosphoserineCombined sources | 1 | |
Modified residuei | 494 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 496 | PhosphoserineCombined sources | 1 | |
Modified residuei | 500 | PhosphoserineCombined sources | 1 | |
Modified residuei | 554 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6UN15 |
jPOSTi | Q6UN15 |
MassIVEi | Q6UN15 |
MaxQBi | Q6UN15 |
PaxDbi | Q6UN15 |
PeptideAtlasi | Q6UN15 |
PRIDEi | Q6UN15 |
ProteomicsDBi | 33719 67417 [Q6UN15-1] 67418 [Q6UN15-3] 67419 [Q6UN15-4] |
PTM databases
iPTMneti | Q6UN15 |
PhosphoSitePlusi | Q6UN15 |
Miscellaneous databases
PMAP-CutDBi | Q6UN15 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145216 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii |
ExpressionAtlasi | Q6UN15 baseline and differential |
Genevisiblei | Q6UN15 HS |
Organism-specific databases
HPAi | HPA037475 HPA058202 |
Interactioni
Subunit structurei
Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1.
Found in a complex with CPSF1, FIP1L1 and PAPOLA.
Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (PubMed:14749727).
Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921).
Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220).
Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085).
Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085).
Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).
By similarity4 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGridi | 123545, 101 interactors |
CORUMi | Q6UN15 |
DIPi | DIP-42503N |
IntActi | Q6UN15, 58 interactors |
MINTi | Q6UN15 |
STRINGi | 9606.ENSP00000336752 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 356 | Necessary for stimulating PAPOLA activityAdd BLAST | 356 | |
Regioni | 1 – 111 | Sufficient for interaction with PAPOLAAdd BLAST | 111 | |
Regioni | 137 – 243 | Sufficient for interaction with CPSF41 PublicationAdd BLAST | 107 | |
Regioni | 443 – 594 | Sufficient for interaction with CPSF1 and CSTF31 PublicationAdd BLAST | 152 | |
Regioni | 457 – 490 | Arg/Asp/Glu-rich domain1 PublicationAdd BLAST | 34 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 356 – 406 | Pro-richAdd BLAST | 51 | |
Compositional biasi | 456 – 562 | Arg-richAdd BLAST | 107 | |
Compositional biasi | 478 – 594 | Glu-richAdd BLAST | 117 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1049 Eukaryota COG5213 LUCA |
GeneTreei | ENSGT00970000193444 |
HOGENOMi | HOG000004854 |
KOi | K14405 |
OMAi | LNKQPGK |
OrthoDBi | 929913at2759 |
PhylomeDBi | Q6UN15 |
TreeFami | TF318610 |
Family and domain databases
InterProi | View protein in InterPro IPR039849 Fip1 IPR007854 Fip1_dom |
PANTHERi | PTHR13484:SF5 PTHR13484:SF5, 1 hit |
Pfami | View protein in Pfam PF05182 Fip1, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER
60 70 80 90 100
PEEENASANP PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI
110 120 130 140 150
GDIKTGAPQY GSYGTAPVNL NIKTGGRVYG TTGTKVKGVD LDAPGSINGV
160 170 180 190 200
PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF NEDTWKAYCE KQKRIRMGLE
210 220 230 240 250
VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR TGNSEKETAL
260 270 280 290 300
PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG
310 320 330 340 350
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD
360 370 380 390 400
NNFSKPPPFF PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP
410 420 430 440 450
PPSLIPTIES GHSSGYDSRS ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ
460 470 480 490 500
WDYYARREKD RDRERDRDRE RDRDRDRERE RTRERERERD HSPTPSVFNS
510 520 530 540 550
DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR HKSSRSNSRR
560 570 580 590
RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y8P7 | H0Y8P7_HUMAN | Pre-mRNA 3'-end-processing factor F... | FIP1L1 | 254 | Annotation score: | ||
H0Y8J4 | H0Y8J4_HUMAN | Pre-mRNA 3'-end-processing factor F... | FIP1L1 | 26 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | V → I in BAG58575 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 312 | G → R in AAH24016 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 312 | G → R in AAH52959 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 524 | K → R in AAH52959 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016728 | 29 – 43 | Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST | 15 | |
Alternative sequenceiVSP_016729 | 213 – 235 | Missing in isoform 3. 1 PublicationAdd BLAST | 23 | |
Alternative sequenceiVSP_016730 | 272 – 307 | Missing in isoform 3. 1 PublicationAdd BLAST | 36 | |
Alternative sequenceiVSP_046213 | 389 | P → PPPGIPITVP in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_016731 | 393 | F → K in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_016732 | 394 – 594 | Missing in isoform 4. 1 PublicationAdd BLAST | 201 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY366510 mRNA Translation: AAQ88277.1 AL136910 mRNA Translation: CAB66844.1 AK295737 mRNA Translation: BAG58575.1 AC058822 Genomic DNA No translation available. AC095040 Genomic DNA No translation available. AC098587 Genomic DNA No translation available. AC098821 Genomic DNA No translation available. AC105384 Genomic DNA No translation available. AC110298 Genomic DNA No translation available. AC110792 Genomic DNA No translation available. AC124017 Genomic DNA No translation available. AC138607 Genomic DNA No translation available. AC138779 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05448.1 BC011543 mRNA Translation: AAH11543.1 BC017724 mRNA Translation: AAH17724.1 BC024016 mRNA Translation: AAH24016.1 Sequence problems. BC052959 mRNA Translation: AAH52959.1 Sequence problems. BC110383 mRNA Translation: AAI10384.1 AY229892 mRNA Translation: AAP69563.1 Different termination. |
CCDSi | CCDS3491.1 [Q6UN15-1] CCDS47055.1 [Q6UN15-5] CCDS47056.1 [Q6UN15-3] |
RefSeqi | NP_001128409.1, NM_001134937.1 [Q6UN15-5] NP_001128410.1, NM_001134938.1 [Q6UN15-3] NP_112179.2, NM_030917.3 [Q6UN15-1] |
Genome annotation databases
Ensembli | ENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3] ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1] ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5] ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4] |
GeneIDi | 81608 |
KEGGi | hsa:81608 |
UCSCi | uc003gzx.5 human [Q6UN15-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY366510 mRNA Translation: AAQ88277.1 AL136910 mRNA Translation: CAB66844.1 AK295737 mRNA Translation: BAG58575.1 AC058822 Genomic DNA No translation available. AC095040 Genomic DNA No translation available. AC098587 Genomic DNA No translation available. AC098821 Genomic DNA No translation available. AC105384 Genomic DNA No translation available. AC110298 Genomic DNA No translation available. AC110792 Genomic DNA No translation available. AC124017 Genomic DNA No translation available. AC138607 Genomic DNA No translation available. AC138779 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05448.1 BC011543 mRNA Translation: AAH11543.1 BC017724 mRNA Translation: AAH17724.1 BC024016 mRNA Translation: AAH24016.1 Sequence problems. BC052959 mRNA Translation: AAH52959.1 Sequence problems. BC110383 mRNA Translation: AAI10384.1 AY229892 mRNA Translation: AAP69563.1 Different termination. |
CCDSi | CCDS3491.1 [Q6UN15-1] CCDS47055.1 [Q6UN15-5] CCDS47056.1 [Q6UN15-3] |
RefSeqi | NP_001128409.1, NM_001134937.1 [Q6UN15-5] NP_001128410.1, NM_001134938.1 [Q6UN15-3] NP_112179.2, NM_030917.3 [Q6UN15-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 123545, 101 interactors |
CORUMi | Q6UN15 |
DIPi | DIP-42503N |
IntActi | Q6UN15, 58 interactors |
MINTi | Q6UN15 |
STRINGi | 9606.ENSP00000336752 |
PTM databases
iPTMneti | Q6UN15 |
PhosphoSitePlusi | Q6UN15 |
Polymorphism and mutation databases
BioMutai | FIP1L1 |
DMDMi | 74749365 |
Proteomic databases
EPDi | Q6UN15 |
jPOSTi | Q6UN15 |
MassIVEi | Q6UN15 |
MaxQBi | Q6UN15 |
PaxDbi | Q6UN15 |
PeptideAtlasi | Q6UN15 |
PRIDEi | Q6UN15 |
ProteomicsDBi | 33719 67417 [Q6UN15-1] 67418 [Q6UN15-3] 67419 [Q6UN15-4] |
Protocols and materials databases
DNASUi | 81608 |
Genome annotation databases
Ensembli | ENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3] ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1] ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5] ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4] |
GeneIDi | 81608 |
KEGGi | hsa:81608 |
UCSCi | uc003gzx.5 human [Q6UN15-1] |
Organism-specific databases
CTDi | 81608 |
DisGeNETi | 81608 |
GeneCardsi | FIP1L1 |
HGNCi | HGNC:19124 FIP1L1 |
HPAi | HPA037475 HPA058202 |
MalaCardsi | FIP1L1 |
MIMi | 607685 phenotype 607686 gene |
neXtProti | NX_Q6UN15 |
OpenTargetsi | ENSG00000145216 |
Orphaneti | 520 Acute promyelocytic leukemia 168940 Chronic eosinophilic leukemia 314950 Primary hypereosinophilic syndrome |
PharmGKBi | PA134875694 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1049 Eukaryota COG5213 LUCA |
GeneTreei | ENSGT00970000193444 |
HOGENOMi | HOG000004854 |
KOi | K14405 |
OMAi | LNKQPGK |
OrthoDBi | 929913at2759 |
PhylomeDBi | Q6UN15 |
TreeFami | TF318610 |
Enzyme and pathway databases
Reactomei | R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-77595 Processing of Intronless Pre-mRNAs |
SIGNORi | Q6UN15 |
Miscellaneous databases
ChiTaRSi | FIP1L1 human |
GeneWikii | FIP1L1 |
GenomeRNAii | 81608 |
Pharosi | Q6UN15 |
PMAP-CutDBi | Q6UN15 |
PROi | PR:Q6UN15 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145216 Expressed in 221 organ(s), highest expression level in tendon of biceps brachii |
ExpressionAtlasi | Q6UN15 baseline and differential |
Genevisiblei | Q6UN15 HS |
Family and domain databases
InterProi | View protein in InterPro IPR039849 Fip1 IPR007854 Fip1_dom |
PANTHERi | PTHR13484:SF5 PTHR13484:SF5, 1 hit |
Pfami | View protein in Pfam PF05182 Fip1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FIP1_HUMAN | |
Accessioni | Q6UN15Primary (citable) accession number: Q6UN15 Secondary accession number(s): B4DIR3 Q9H077 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 16, 2019 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot