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UniProtKB - Q6UN15 (FIP1_HUMAN)

Entry version 155 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Pre-mRNA 3'-end-processing factor FIP1

Gene

FIP1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei339 – 340Breakpoint for interstitial deletion to form the FIP1L1-PDGFRA fusion protein2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6UN15

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-77595, Processing of Intronless Pre-mRNAs
R-HSA-9673766, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6UN15

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA 3'-end-processing factor FIP1
Short name:
hFip1
Alternative name(s):
FIP1-like 1 protein
Factor interacting with PAP
Rearranged in hypereosinophilia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FIP1L1
Synonyms:FIP1, RHE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19124, FIP1L1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607686, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6UN15

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000145216.15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving FIP1L1 is found in some cases of hypereosinophilic syndrome. Interstitial chromosomal deletion del(4)(q12q12) causes the fusion of FIP1L1 and PDGFRA (FIP1L1-PDGFRA).2 Publications

Organism-specific databases

DisGeNET

More...DisGeNETi		81608

MalaCards human disease database

More...MalaCardsi		FIP1L1
MIMi607685, phenotype

Open Targets

More...OpenTargetsi		ENSG00000145216

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		520, Acute promyelocytic leukemia
168940, Chronic eosinophilic leukemia
314950, Primary hypereosinophilic syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134875694

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6UN15, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FIP1L1

Domain mapping of disease mutations (DMDM)

More...DMDMi		74749365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002150371 – 594Pre-mRNA 3'-end-processing factor FIP1Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei85PhosphoserineBy similarity1
Modified residuei87PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei426PhosphotyrosineCombined sources1
Modified residuei492PhosphoserineCombined sources1
Modified residuei494PhosphothreonineCombined sources1
Modified residuei496PhosphoserineCombined sources1
Modified residuei500PhosphoserineCombined sources1
Modified residuei554PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6UN15

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6UN15

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6UN15

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6UN15

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6UN15

PeptideAtlas

More...PeptideAtlasi		Q6UN15

PRoteomics IDEntifications database

More...PRIDEi		Q6UN15

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33719
67417 [Q6UN15-1]
67418 [Q6UN15-3]
67419 [Q6UN15-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6UN15, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6UN15

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6UN15

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6UN15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000145216, Expressed in tendon of biceps brachii and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6UN15, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6UN15, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000145216, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1.

Found in a complex with CPSF1, FIP1L1 and PAPOLA.

Interacts with CPSF1, CPSF4, CSTF2 and CSTF3 (PubMed:14749727).

Interacts with AHCYL1 (when phosphorylated); the interaction is direct and associates AHCYL1 with the CPSF complex and RNA (PubMed:19224921).

Interacts with NUDT21/CPSF5; this interaction occurs in a RNA sequence-specific manner (PubMed:15937220).

Interacts (preferentially via unphosphorylated form and Arg/Glu/Asp-rich domain) with CPSF6 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF6 hyper-phosphorylation (PubMed:29276085).

Interacts (preferentially via unphosphorylated form and Arg/Asp/Glu-rich domain) with CPSF7 (via Arg/Ser-rich domain); this interaction mediates, at least in part, the interaction between the CFIm and CPSF complexes and may be inhibited by CPSF7 hyper-phosphorylation (PubMed:29276085).

Interacts with PAPOLA; the interaction seems to be increased by the interaction with AHCYL1 (By similarity).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123545, 128 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6UN15

Database of interacting proteins

More...DIPi		DIP-42503N

Protein interaction database and analysis system

More...IntActi		Q6UN15, 69 interactors

Molecular INTeraction database

More...MINTi		Q6UN15

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000336752

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6UN15, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6UN15

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 356Necessary for stimulating PAPOLA activityAdd BLAST356
Regioni1 – 111Sufficient for interaction with PAPOLAAdd BLAST111
Regioni137 – 243Sufficient for interaction with CPSF41 PublicationAdd BLAST107
Regioni443 – 594Sufficient for interaction with CPSF1 and CSTF31 PublicationAdd BLAST152
Regioni457 – 490Arg/Asp/Glu-rich domain1 PublicationAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi356 – 406Pro-richAdd BLAST51
Compositional biasi456 – 562Arg-richAdd BLAST107
Compositional biasi478 – 594Glu-richAdd BLAST117

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FIP1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1049, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_035577_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		MAMFGGR

Database of Orthologous Groups

More...OrthoDBi		929913at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6UN15

TreeFam database of animal gene trees

More...TreeFami		TF318610

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007854, Fip1_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05182, Fip1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UN15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSAGEVERLV SELSGGTGGD EEEEWLYGGP WDVHVHSDLA KDLDENEVER 
        60         70         80         90        100
PEEENASANP PSGIEDETAE NGVPKPKVTE TEDDSDSDSD DDEDDVHVTI 
       110        120        130        140        150
GDIKTGAPQY GSYGTAPVNL NIKTGGRVYG TTGTKVKGVD LDAPGSINGV 
       160        170        180        190        200
PLLEVDLDSF EDKPWRKPGA DLSDYFNYGF NEDTWKAYCE KQKRIRMGLE 
       210        220        230        240        250
VIPVTSTTNK ITAEDCTMEV TPGAEIQDGR FNLFKVQQGR TGNSEKETAL 
       260        270        280        290        300
PSTKAEFTSP PSLFKTGLPP SRNSTSSQSQ TSTASRKANS SVGKWQDRYG 
       310        320        330        340        350
RAESPDLRRL PGAIDVIGQT ITISRVEGRR RANENSNIQV LSERSATEVD 
       360        370        380        390        400
NNFSKPPPFF PPGAPPTHLP PPPFLPPPPT VSTAPPLIPP PGFPPPPGAP 
       410        420        430        440        450
PPSLIPTIES GHSSGYDSRS ARAFPYGNVA FPHLPGSAPS WPSLVDTSKQ 
       460        470        480        490        500
WDYYARREKD RDRERDRDRE RDRDRDRERE RTRERERERD HSPTPSVFNS 
       510        520        530        540        550
DEERYRYREY AERGYERHRA SREKEERHRE RRHREKEETR HKSSRSNSRR 
       560        570        580        590 
RHESEEGDSH RRHKHKKSKR SKEGKEAGSE PAPEQESTEA TPAE
Length:594
Mass (Da):66,526
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB391D142419ED061
GO
Isoform 3 (identifier: Q6UN15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     213-235: Missing.
     272-307: Missing.

Show »
Length:520
Mass (Da):58,376
Checksum:i55D48285A046A783
GO
Isoform 4 (identifier: Q6UN15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     393-393: F → K
     394-594: Missing.

Show »
Length:378
Mass (Da):40,835
Checksum:i1B699B114C9560D4
GO
Isoform 5 (identifier: Q6UN15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-43: Missing.
     389-389: P → PPPGIPITVP

Show »
Length:588
Mass (Da):65,728
Checksum:i0E9D598DEAF3C752
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8P7H0Y8P7_HUMAN
Pre-mRNA 3'-end-processing factor F...
FIP1L1
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8J4H0Y8J4_HUMAN
Pre-mRNA 3'-end-processing factor F...
FIP1L1
26Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH24016 differs from that shown. Intron retention.Curated
The sequence AAH52959 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118V → I in BAG58575 (PubMed:14702039).Curated1
Sequence conflicti312G → R in AAH24016 (PubMed:15489334).Curated1
Sequence conflicti312G → R in AAH52959 (PubMed:15489334).Curated1
Sequence conflicti524K → R in AAH52959 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01672829 – 43Missing in isoform 3, isoform 4 and isoform 5. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_016729213 – 235Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_016730272 – 307Missing in isoform 3. 1 PublicationAdd BLAST36
Alternative sequenceiVSP_046213389P → PPPGIPITVP in isoform 5. 1 Publication1
Alternative sequenceiVSP_016731393F → K in isoform 4. 1 Publication1
Alternative sequenceiVSP_016732394 – 594Missing in isoform 4. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY366510 mRNA Translation: AAQ88277.1
AL136910 mRNA Translation: CAB66844.1
AK295737 mRNA Translation: BAG58575.1
AC058822 Genomic DNA No translation available.
AC095040 Genomic DNA No translation available.
AC098587 Genomic DNA No translation available.
AC098821 Genomic DNA No translation available.
AC105384 Genomic DNA No translation available.
AC110298 Genomic DNA No translation available.
AC110792 Genomic DNA No translation available.
AC124017 Genomic DNA No translation available.
AC138607 Genomic DNA No translation available.
AC138779 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05448.1
BC011543 mRNA Translation: AAH11543.1
BC017724 mRNA Translation: AAH17724.1
BC024016 mRNA Translation: AAH24016.1 Sequence problems.
BC052959 mRNA Translation: AAH52959.1 Sequence problems.
BC110383 mRNA Translation: AAI10384.1
AY229892 mRNA Translation: AAP69563.1 Different termination.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3491.1 [Q6UN15-1]
CCDS47055.1 [Q6UN15-5]
CCDS47056.1 [Q6UN15-3]

NCBI Reference Sequences

More...RefSeqi		NP_001128409.1, NM_001134937.1 [Q6UN15-5]
NP_001128410.1, NM_001134938.1 [Q6UN15-3]
NP_112179.2, NM_030917.3 [Q6UN15-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3]
ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1]
ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5]
ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81608

UCSC genome browser

More...UCSCi		uc003gzx.5, human [Q6UN15-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY366510 mRNA Translation: AAQ88277.1
AL136910 mRNA Translation: CAB66844.1
AK295737 mRNA Translation: BAG58575.1
AC058822 Genomic DNA No translation available.
AC095040 Genomic DNA No translation available.
AC098587 Genomic DNA No translation available.
AC098821 Genomic DNA No translation available.
AC105384 Genomic DNA No translation available.
AC110298 Genomic DNA No translation available.
AC110792 Genomic DNA No translation available.
AC124017 Genomic DNA No translation available.
AC138607 Genomic DNA No translation available.
AC138779 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05448.1
BC011543 mRNA Translation: AAH11543.1
BC017724 mRNA Translation: AAH17724.1
BC024016 mRNA Translation: AAH24016.1 Sequence problems.
BC052959 mRNA Translation: AAH52959.1 Sequence problems.
BC110383 mRNA Translation: AAI10384.1
AY229892 mRNA Translation: AAP69563.1 Different termination.
CCDSiCCDS3491.1 [Q6UN15-1]
CCDS47055.1 [Q6UN15-5]
CCDS47056.1 [Q6UN15-3]
RefSeqiNP_001128409.1, NM_001134937.1 [Q6UN15-5]
NP_001128410.1, NM_001134938.1 [Q6UN15-3]
NP_112179.2, NM_030917.3 [Q6UN15-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7K95X-ray1.90B/C159-200[»]
SMRiQ6UN15
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123545, 128 interactors
CORUMiQ6UN15
DIPiDIP-42503N
IntActiQ6UN15, 69 interactors
MINTiQ6UN15
STRINGi9606.ENSP00000336752

PTM databases

GlyGeniQ6UN15, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ6UN15
MetOSiteiQ6UN15
PhosphoSitePlusiQ6UN15

Genetic variation databases

BioMutaiFIP1L1
DMDMi74749365

Proteomic databases

EPDiQ6UN15
jPOSTiQ6UN15
MassIVEiQ6UN15
MaxQBiQ6UN15
PaxDbiQ6UN15
PeptideAtlasiQ6UN15
PRIDEiQ6UN15
ProteomicsDBi33719
67417 [Q6UN15-1]
67418 [Q6UN15-3]
67419 [Q6UN15-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		12232, 151 antibodies

The DNASU plasmid repository

More...DNASUi		81608

Genome annotation databases

EnsembliENST00000306932; ENSP00000302993; ENSG00000145216 [Q6UN15-3]
ENST00000337488; ENSP00000336752; ENSG00000145216 [Q6UN15-1]
ENST00000358575; ENSP00000351383; ENSG00000145216 [Q6UN15-5]
ENST00000507922; ENSP00000425456; ENSG00000145216 [Q6UN15-4]
GeneIDi81608
KEGGihsa:81608
UCSCiuc003gzx.5, human [Q6UN15-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81608
DisGeNETi81608

GeneCards: human genes, protein and diseases

More...GeneCardsi		FIP1L1
HGNCiHGNC:19124, FIP1L1
HPAiENSG00000145216, Low tissue specificity
MalaCardsiFIP1L1
MIMi607685, phenotype
607686, gene
neXtProtiNX_Q6UN15
OpenTargetsiENSG00000145216
Orphaneti520, Acute promyelocytic leukemia
168940, Chronic eosinophilic leukemia
314950, Primary hypereosinophilic syndrome
PharmGKBiPA134875694
VEuPathDBiHostDB:ENSG00000145216.15

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1049, Eukaryota
GeneTreeiENSGT01000000214759
HOGENOMiCLU_035577_0_0_1
OMAiMAMFGGR
OrthoDBi929913at2759
PhylomeDBiQ6UN15
TreeFamiTF318610

Enzyme and pathway databases

PathwayCommonsiQ6UN15
ReactomeiR-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-72163, mRNA Splicing - Major Pathway
R-HSA-72187, mRNA 3'-end processing
R-HSA-73856, RNA Polymerase II Transcription Termination
R-HSA-77595, Processing of Intronless Pre-mRNAs
R-HSA-9673766, Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
SIGNORiQ6UN15

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81608, 681 hits in 1004 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FIP1L1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FIP1L1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81608
PharosiQ6UN15, Tbio

Protein Ontology

More...PROi		PR:Q6UN15
RNActiQ6UN15, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000145216, Expressed in tendon of biceps brachii and 230 other tissues
ExpressionAtlasiQ6UN15, baseline and differential
GenevisibleiQ6UN15, HS

Family and domain databases

InterProiView protein in InterPro
IPR007854, Fip1_dom
PfamiView protein in Pfam
PF05182, Fip1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFIP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UN15
Secondary accession number(s): B4DIR3
, G3XAD6, Q0VGE0, Q499Y4, Q49AU3, Q7Z608, Q8WVN3, Q96F80, Q9H077
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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