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Protein

Sodium/hydrogen exchanger 10

Gene

Slc9c1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC).2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi890 – 1026cNMPAdd BLAST137

GO - Molecular functioni

  • potassium:proton antiporter activity Source: GO_Central
  • sodium:proton antiporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processAntiport, Differentiation, Ion transport, Sodium transport, Spermatogenesis, Transport
LigandSodium

Protein family/group databases

TCDBi2.A.36.7.7 the monovalent cation:proton antiporter-1 (cpa1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/hydrogen exchanger 10
Alternative name(s):
Na(+)/H(+) exchanger 10
Short name:
NHE-10
Solute carrier family 10 member 10
Solute carrier family 9 member C1
Sperm-specific Na(+)/H(+) exchanger
Short name:
sNHE
Gene namesi
Name:Slc9c1
Synonyms:Gm610, Slc9a10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2685456 Slc9c1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei125 – 145HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei633 – 653HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Transmembranei693 – 713HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Flagellum, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are normal but males are sterile. Male sterility is due to defects in sperm motility inability to fertilize intact eggs. Moreover, spermatozoa fail to develop the cAMP-dependent protein tyrosine phosphorylation that coincides with the functional maturation occurring upon incubation in capacitating conditions in vitro. cAMP analogs almost completely rescue the motility and infertility phenotypes.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002957051 – 1175Sodium/hydrogen exchanger 10Add BLAST1175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6UJY2
PaxDbiQ6UJY2
PRIDEiQ6UJY2

PTM databases

iPTMnetiQ6UJY2
PhosphoSitePlusiQ6UJY2

Expressioni

Tissue specificityi

Testis-specific. Specifically present in the principal piece of sperm tail (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000033210 Expressed in 8 organ(s), highest expression level in testis
CleanExiMM_SLC9A10
ExpressionAtlasiQ6UJY2 baseline and differential

Interactioni

Subunit structurei

Interacts with soluble adenylyl cyclase (sAC).1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Adcy10Q8C0T92EBI-15639080,EBI-15639026

Protein-protein interaction databases

DIPiDIP-60951N
IntActiQ6UJY2, 1 interactor
STRINGi10090.ENSMUSP00000124969

Structurei

3D structure databases

ProteinModelPortaliQ6UJY2
SMRiQ6UJY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni618 – 698Ion transport-likeAdd BLAST81

Domaini

The ion transport-like region is related to the membrane segments of voltage-gated ion channels. Its function is unknown.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00530000063840
HOGENOMiHOG000169764
HOVERGENiHBG071202
InParanoidiQ6UJY2
KOiK14726
OrthoDBiEOG091G031U
PhylomeDBiQ6UJY2
TreeFamiTF328865

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR028483 N/H_exchanger_10
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10110 PTHR10110, 1 hit
PTHR10110:SF87 PTHR10110:SF87, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00999 Na_H_Exchanger, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6UJY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMEEISENL TASHSIKLTN MWLELLKSVF LSTPQDLPEI ILILSLICTV
60 70 80 90 100
GAFLNMHLKD FPIPLPVILF LIGCCFEILS FASTQIQIYA DAIQWMDPDI
110 120 130 140 150
FFGIFTPVII FNVAFDMDIY MLQKLFWQIL VITIPGFLIN YTLILWYLQS
160 170 180 190 200
VNKLSLKTVP WLLFSAVLIS SDPMLTSASI RDLGLSRSLT NLINGESLLT
210 220 230 240 250
SVLSLVIYSG VVHIRFKSKS VNHTLAHKVM STAWSYIVES FITGIVFTKV
260 270 280 290 300
IQLWMATIFG DDVNHITLIF SVLYLIFYVC ELVGMSGIFT LATIGLFLNS
310 320 330 340 350
TSFKPGVEAF LLEFWNCLSF IGFLMVFTFI GLLIPAHTYL HISFSDVYYS
360 370 380 390 400
LNIYFTLIVL RLLVFLLMSP ILSRLGHGFS WRWAFIMVWS EMKGTPNINM
410 420 430 440 450
ALLLAYSDIS LGSERERSQI LFHGVSVCVI TLIVNRFILP MAVTKLGLRD
460 470 480 490 500
VTSTKYKSVY YTFQHFQELT KSTAMALKFD KDLANADWNM VDNAIILQNP
510 520 530 540 550
YAMNQEEITE HQKVKCPDCN KEIDETLNIE AMELTNRRLL SAQIASYQRQ
560 570 580 590 600
YRNEVLSQSA VQVLVGAAGS FGEKKGEYMS PENIKNFSES KKLLSFLRKL
610 620 630 640 650
LLNWVYNTKK DKGVPSRYMF LHACHRIVFT NEFEYTGYLV VLMSTYPMII
660 670 680 690 700
CWISRLKDIY DNEIKCANYY FLAFYILEAL LKVAAMRKEF FSHTWLLFEL
710 720 730 740 750
GITLVGVLDI ILIETDSISY NFDLTETVVF MNVIRLLRIL RILKLVTPKL
760 770 780 790 800
LQIIDKRMSQ QISFRYSILK GYVQGEMDVL NIIDQIASSK QTKQILLKRV
810 820 830 840 850
MRNMEHAMKE LGYLEYDHPE IAVTMKTKEE INVMLNMARE IVKAFRSKGI
860 870 880 890 900
IHKVEGTEIN KLIMAKKIQV LDLQSVIQPF NVEEAPCNIP WLSEDPEAIT
910 920 930 940 950
FIQEKAKVVT FDCGNNIFEE GDEPEGIYVI ISGMVKLKRS KPHLEMERVS
960 970 980 990 1000
AESEIKIHPL PHTEYLLSGE IIGELNCLTK ERMQYSATCK TVVETYFIPI
1010 1020 1030 1040 1050
SHLYEGFEKR CPNMKHKMWQ KIGLAITAQK IREHLSFEDW NYKLQLKLCN
1060 1070 1080 1090 1100
AFIRDIPKSM KTDIYDETVT HVVLIHGSAE DCQLRKIYKA PFLIPVTCHQ
1110 1120 1130 1140 1150
IQGMEDFTKV MIIQTSIAVR KFRWNVRKYI PPRRISMKPD SERESFETLD
1160 1170
ETSEEDNGKK ENQENEELIE ENINI
Length:1,175
Mass (Da):135,545
Last modified:July 27, 2011 - v3
Checksum:i4D65DAE082BF517F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QW97M0QW97_MOUSE
Sodium/hydrogen exchanger 10
Slc9c1
520Annotation score:
M0QWN6M0QWN6_MOUSE
Sodium/hydrogen exchanger 10
Slc9c1
163Annotation score:

Sequence cautioni

The sequence AAQ88278 differs from that shown. Reason: Frameshift at position 29.Curated
The sequence DAA01464 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3M → T in AAQ88278 (PubMed:14634667).Curated1
Sequence conflicti503M → L in AAQ88278 (PubMed:14634667).Curated1
Sequence conflicti520N → T in AAQ88278 (PubMed:14634667).Curated1
Sequence conflicti707V → I in AAQ88278 (PubMed:14634667).Curated1
Sequence conflicti844A → T in AAQ88278 (PubMed:14634667).Curated1
Sequence conflicti1129Y → F in AAQ88278 (PubMed:14634667).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368685 mRNA Translation: AAQ88278.1 Frameshift.
AC124636 Genomic DNA No translation available.
BK001330 mRNA Translation: DAA01464.1 Sequence problems.
CCDSiCCDS28198.2
RefSeqiNP_932774.3, NM_198106.4
UniGeneiMm.277437

Genome annotation databases

EnsembliENSMUST00000159945; ENSMUSP00000124969; ENSMUSG00000033210
GeneIDi208169
KEGGimmu:208169
UCSCiuc007ziq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY368685 mRNA Translation: AAQ88278.1 Frameshift.
AC124636 Genomic DNA No translation available.
BK001330 mRNA Translation: DAA01464.1 Sequence problems.
CCDSiCCDS28198.2
RefSeqiNP_932774.3, NM_198106.4
UniGeneiMm.277437

3D structure databases

ProteinModelPortaliQ6UJY2
SMRiQ6UJY2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60951N
IntActiQ6UJY2, 1 interactor
STRINGi10090.ENSMUSP00000124969

Protein family/group databases

TCDBi2.A.36.7.7 the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ6UJY2
PhosphoSitePlusiQ6UJY2

Proteomic databases

MaxQBiQ6UJY2
PaxDbiQ6UJY2
PRIDEiQ6UJY2

Protocols and materials databases

DNASUi208169
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000159945; ENSMUSP00000124969; ENSMUSG00000033210
GeneIDi208169
KEGGimmu:208169
UCSCiuc007ziq.2 mouse

Organism-specific databases

CTDi285335
MGIiMGI:2685456 Slc9c1

Phylogenomic databases

eggNOGiKOG1965 Eukaryota
COG0025 LUCA
GeneTreeiENSGT00530000063840
HOGENOMiHOG000169764
HOVERGENiHBG071202
InParanoidiQ6UJY2
KOiK14726
OrthoDBiEOG091G031U
PhylomeDBiQ6UJY2
TreeFamiTF328865

Miscellaneous databases

PROiPR:Q6UJY2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033210 Expressed in 8 organ(s), highest expression level in testis
CleanExiMM_SLC9A10
ExpressionAtlasiQ6UJY2 baseline and differential

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR006153 Cation/H_exchanger
IPR018422 Cation/H_exchanger_CPA1
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR028483 N/H_exchanger_10
IPR014710 RmlC-like_jellyroll
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10110 PTHR10110, 1 hit
PTHR10110:SF87 PTHR10110:SF87, 1 hit
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00999 Na_H_Exchanger, 1 hit
SUPFAMiSSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSL9C1_MOUSE
AccessioniPrimary (citable) accession number: Q6UJY2
Secondary accession number(s): E0CX34, Q7M6Y7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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