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Entry version 142 (22 Apr 2020)
Sequence version 3 (18 May 2010)
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Protein

Ankyrin repeat domain-containing protein 11

Gene

ANKRD11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 11
Alternative name(s):
Ankyrin repeat-containing cofactor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD11
Synonyms:ANCO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21316 ANKRD11

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611192 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UB99

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

KBG syndrome (KBGS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by macrodontia of the upper central incisors, distinctive craniofacial findings, short stature, skeletal anomalies, and neurologic involvement that includes global developmental delay, seizures, and intellectual disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0758702512R → Q in KBGS; unknown pathological significance. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
29123

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ANKRD11

MalaCards human disease database

More...
MalaCardsi
ANKRD11
MIMi148050 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167522

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
261250 16q24.3 microdeletion syndrome
2332 KBG syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134861925

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6UB99 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD11

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439440

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669071 – 2663Ankyrin repeat domain-containing protein 11Add BLAST2663

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei276PhosphoserineCombined sources1
Modified residuei408PhosphoserineCombined sources1
Modified residuei410PhosphothreonineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei834PhosphoserineCombined sources1
Modified residuei1079PhosphoserineBy similarity1
Modified residuei1120PhosphothreonineCombined sources1
Modified residuei1123PhosphoserineCombined sources1
Modified residuei1419PhosphothreonineCombined sources1
Modified residuei1509PhosphoserineCombined sources1
Modified residuei1692PhosphoserineBy similarity1
Modified residuei1792PhosphoserineCombined sources1
Modified residuei1847PhosphoserineCombined sources1
Modified residuei1850PhosphotyrosineBy similarity1
Modified residuei1851PhosphotyrosineBy similarity1
Modified residuei1852PhosphoserineBy similarity1
Modified residuei1859PhosphoserineCombined sources1
Modified residuei1990PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Subject to proteasomal degradation which is probably essential to regulate its activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6UB99

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6UB99

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6UB99

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UB99

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UB99

PeptideAtlas

More...
PeptideAtlasi
Q6UB99

PRoteomics IDEntifications database

More...
PRIDEi
Q6UB99

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
67406

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6UB99

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6UB99

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UB99

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression levels are regulated during the cell cycle, reaching maximal levels at M phase and then rapidly declining after late M phase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167522 Expressed in tendon of biceps brachii and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UB99 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UB99 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167522 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PAS region of the p160 coactivators.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
118888, 35 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q6UB99

Protein interaction database and analysis system

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IntActi
Q6UB99, 19 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301030

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6UB99 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6UB99

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati167 – 196ANK 1Add BLAST30
Repeati200 – 229ANK 2Add BLAST30
Repeati233 – 262ANK 3Add BLAST30
Repeati266 – 292ANK 4Add BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2369 – 2663Important for protein degradation1 PublicationAdd BLAST295

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi478 – 588Ser-richAdd BLAST111
Compositional biasi621 – 1655Lys-richAdd BLAST1035
Compositional biasi1824 – 2365Pro-richAdd BLAST542

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ47 Eukaryota
ENOG4110UQU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155966

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_229338_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UB99

KEGG Orthology (KO)

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KOi
K21436

Identification of Orthologs from Complete Genome Data

More...
OMAi
KSLEPWE

Database of Orthologous Groups

More...
OrthoDBi
854133at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UB99

TreeFam database of animal gene trees

More...
TreeFami
TF326440

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042636 ANKRD11
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24145 PTHR24145, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.Show allAlign All

Q6UB99-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGGCPKAP QQEELPLSSD MVEKQTGKKD KDKVSLTKTP KLERGDGGKE
60 70 80 90 100
VRERASKRKL PFTAGANGEQ KDSDTEKQGP ERKRIKKEPV TRKAGLLFGM
110 120 130 140 150
GLSGIRAGYP LSERQQVALL MQMTAEESAN SPVDTTPKHP SQSTVCQKGT
160 170 180 190 200
PNSASKTKDK VNKRNERGET RLHRAAIRGD ARRIKELISE GADVNVKDFA
210 220 230 240 250
GWTALHEACN RGYYDVAKQL LAAGAEVNTK GLDDDTPLHD AANNGHYKVV
260 270 280 290 300
KLLLRYGGNP QQSNRKGETP LKVANSPTMV NLLLGKGTYT SSEESSTESS
310 320 330 340 350
EEEDAPSFAP SSSVDGNNTD SEFEKGLKHK AKNPEPQKAT APVKDEYEFD
360 370 380 390 400
EDDEQDRVPP VDDKHLLKKD YRKETKSNSF ISIPKMEVKS YTKNNTIAPK
410 420 430 440 450
KASHRILSDT SDEEDASVTV GTGEKLRLSA HTILPGSKTR EPSNAKQQKE
460 470 480 490 500
KNKVKKKRKK ETKGREVRFG KRSDKFCSSE SESESSESGE DDRDSLGSSG
510 520 530 540 550
CLKGSPLVLK DPSLFSSLSA SSTSSHGSSA AQKQNPSHTD QHTKHWRTDN
560 570 580 590 600
WKTISSPAWS EVSSLSDSTR TRLTSESDYS SEGSSVESLK PVRKRQEHRK
610 620 630 640 650
RASLSEKKSP FLSSAEGAVP KLDKEGKVVK KHKTKHKHKN KEKGQCSISQ
660 670 680 690 700
ELKLKSFTYE YEDSKQKSDK AILLENDLST ENKLKVLKHD RDHFKKEEKL
710 720 730 740 750
SKMKLEEKEW LFKDEKSLKR IKDTNKDISR SFREEKDRSN KAEKERSLKE
760 770 780 790 800
KSPKEEKLRL YKEERKKKSK DRPSKLEKKN DLKEDKISKE KEKIFKEDKE
810 820 830 840 850
KLKKEKVYRE DSAFDEYCNK NQFLENEDTK FSLSDDQRDR WFSDLSDSSF
860 870 880 890 900
DFKGEDSWDS PVTDYRDMKS DSVAKLILET VKEDSKERRR DSRAREKRDY
910 920 930 940 950
REPFFRKKDR DYLDKNSEKR KEQTEKHKSV PGYLSEKDKK RRESAEAGRD
960 970 980 990 1000
RKDALESCKE RRDGRAKPEE AHREELKECG CESGFKDKSD GDFGKGLEPW
1010 1020 1030 1040 1050
ERHHPAREKE KKDGPDKERK EKTKPERYKE KSSDKDKSEK SILEKCQKDK
1060 1070 1080 1090 1100
EFDKCFKEKK DTKEKHKDTH GKDKERKASL DQGKEKKEKA FPGIISEDFS
1110 1120 1130 1140 1150
EKKDDKKGKE KSWYIADIFT DESEDDRDSC MGSGFKMGEA SDLPRTDGLQ
1160 1170 1180 1190 1200
EKEEGREAYA SDRHRKSSDK QHPERQKDKE PRDRRKDRGA ADAGRDKKEK
1210 1220 1230 1240 1250
VFEKHKEKKD KESTEKYKDR KDRASVDSTQ DKKNKQKLPE KAEKKHAAED
1260 1270 1280 1290 1300
KAKSKHKEKS DKEHSKERKS SRSADAEKSL LEKLEEEALH EYREDSNDKI
1310 1320 1330 1340 1350
SEVSSDSFTD RGQEPGLTAF LEVSFTEPPG DDKPRESACL PEKLKEKERH
1360 1370 1380 1390 1400
RHSSSSSKKS HDRERAKKEK AEKKEKGEDY KEGGSRKDSG QYEKDFLEAD
1410 1420 1430 1440 1450
AYGVSYNMKA DIEDELDKTI ELFSTEKKDK NDSEREPSKK IEKELKPYGS
1460 1470 1480 1490 1500
SAINILKEKK KREKHREKWR DEKERHRDRH ADGLLRHHRD ELLRHHRDEQ
1510 1520 1530 1540 1550
KPATRDKDSP PRVLKDKSRD EGPRLGDAKL KEKFKDGAEK EKGDPVKMSN
1560 1570 1580 1590 1600
GNDKVAPSKD PGKKDARPRE KLLGDGDLMM TSFERMLSQK DLEIEERHKR
1610 1620 1630 1640 1650
HKERMKQMEK LRHRSGDPKL KEKAKPADDG RKKGLDIPAK KPPGLDPPFK
1660 1670 1680 1690 1700
DKKLKESTPI PPAAENKLHP ASGADSKDWL AGPHMKEVLP ASPRPDQSRP
1710 1720 1730 1740 1750
TGVPTPTSVL SCPSYEEVMH TPRTPSCSAD DYADLVFDCA DSQHSTPVPT
1760 1770 1780 1790 1800
APTSACSPSF FDRFSVASSG LSENASQAPA RPLSTNLYRS VSVDIRRTPE
1810 1820 1830 1840 1850
EEFSVGDKLF RQQSVPAASS YDSPMPPSME DRAPLPPVPA EKFACLSPGY
1860 1870 1880 1890 1900
YSPDYGLPSP KVDALHCPPA AVVTVTPSPE GVFSSLQAKP SPSPRAELLV
1910 1920 1930 1940 1950
PSLEGALPPD LDTSEDQQAT AAIIPPEPSY LEPLDEGPFS AVITEEPVEW
1960 1970 1980 1990 2000
AHPSEQALAS SLIGGTSENP VSWPVGSDLL LKSPQRFPES PKRFCPADPL
2010 2020 2030 2040 2050
HSAAPGPFSA SEAPYPAPPA SPAPYALPVA EPGLEDVKDG VDAVPAAIST
2060 2070 2080 2090 2100
SEAAPYAPPS GLESFFSNCK SLPEAPLDVA PEPACVAAVA QVEALGPLEN
2110 2120 2130 2140 2150
SFLDGSRGLS HLGQVEPVPW ADAFAGPEDD LDLGPFSLPE LPLQTKDAAD
2160 2170 2180 2190 2200
GEAEPVEESL APPEEMPPGA PGVINGGDVS TVVAEEPPAL PPDQASTRLP
2210 2220 2230 2240 2250
AELEPEPSGE PKLDVALEAA VEAETVPEER ARGDPDSSVE PAPVPPEQRP
2260 2270 2280 2290 2300
LGSGDQGAEA EGPPAASLCA PDGPAPNTVA QAQAADGAGP EDDTEASRAA
2310 2320 2330 2340 2350
APAEGPPGGI QPEAAEPKPT AEAPKAPRVE EIPQRMTRNR AQMLANQSKQ
2360 2370 2380 2390 2400
GPPPSEKECA PTPAPVTRAK ARGSEDDDAQ AQHPRKRRFQ RSTQQLQQQL
2410 2420 2430 2440 2450
NTSTQQTREV IQQTLAAIVD AIKLDAIEPY HSDRANPYFE YLQIRKKIEE
2460 2470 2480 2490 2500
KRKILCCITP QAPQCYAEYV TYTGSYLLDG KPLSKLHIPV IAPPPSLAEP
2510 2520 2530 2540 2550
LKELFRQQEA VRGKLRLQHS IEREKLIVSC EQEILRVHCR AARTIANQAV
2560 2570 2580 2590 2600
PFSACTMLLD SEVYNMPLES QGDENKSVRD RFNARQFISW LQDVDDKYDR
2610 2620 2630 2640 2650
MKTCLLMRQQ HEAAALNAVQ RMEWQLKVQE LDPAGHKSLC VNEVPSFYVP
2660
MVDVNDDFVL LPA
Length:2,663
Mass (Da):297,913
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i845B04094AF37CFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WTN8A0A087WTN8_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
366Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X5D778X5D778_HUMAN
Ankyrin repeat domain 11 isoform A
ANKRD11
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YEI0A0A2R8YEI0_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
272Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y438A0A2R8Y438_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
944Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YE03A0A2R8YE03_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNU4H3BNU4_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2U4H0Y2U4_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4T9A0A2R8Y4T9_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7Z1A0A2R8Y7Z1_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y5V1A0A2R8Y5V1_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD11
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69013 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76E → EE in AAR25661 (Ref. 1) Curated1
Sequence conflicti971A → V in AAR25661 (Ref. 1) Curated1
Sequence conflicti971A → V in AAS45544 (PubMed:15184363).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0758702512R → Q in KBGS; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY373756 mRNA Translation: AAR25661.1
AY533563 mRNA Translation: AAS45544.1
AC137932 Genomic DNA No translation available.
BC069013 mRNA Translation: AAH69013.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS32513.1

NCBI Reference Sequences

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RefSeqi
NP_001243111.1, NM_001256182.1
NP_001243112.1, NM_001256183.1
NP_037407.4, NM_013275.5
XP_011521353.1, XM_011523051.2
XP_011521355.1, XM_011523053.2
XP_016878671.1, XM_017023182.1
XP_016878672.1, XM_017023183.1
XP_016878673.1, XM_017023184.1
XP_016878674.1, XM_017023185.1
XP_016878675.1, XM_017023186.1
XP_016878676.1, XM_017023187.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000301030; ENSP00000301030; ENSG00000167522
ENST00000378330; ENSP00000367581; ENSG00000167522
ENST00000642600; ENSP00000495226; ENSG00000167522

Database of genes from NCBI RefSeq genomes

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GeneIDi
29123

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:29123

UCSC genome browser

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UCSCi
uc002fmx.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY373756 mRNA Translation: AAR25661.1
AY533563 mRNA Translation: AAS45544.1
AC137932 Genomic DNA No translation available.
BC069013 mRNA Translation: AAH69013.1 Sequence problems.
CCDSiCCDS32513.1
RefSeqiNP_001243111.1, NM_001256182.1
NP_001243112.1, NM_001256183.1
NP_037407.4, NM_013275.5
XP_011521353.1, XM_011523051.2
XP_011521355.1, XM_011523053.2
XP_016878671.1, XM_017023182.1
XP_016878672.1, XM_017023183.1
XP_016878673.1, XM_017023184.1
XP_016878674.1, XM_017023185.1
XP_016878675.1, XM_017023186.1
XP_016878676.1, XM_017023187.1

3D structure databases

SMRiQ6UB99
ModBaseiSearch...

Protein-protein interaction databases

BioGridi118888, 35 interactors
CORUMiQ6UB99
IntActiQ6UB99, 19 interactors
STRINGi9606.ENSP00000301030

PTM databases

CarbonylDBiQ6UB99
iPTMnetiQ6UB99
PhosphoSitePlusiQ6UB99

Polymorphism and mutation databases

BioMutaiANKRD11
DMDMi296439440

Proteomic databases

EPDiQ6UB99
jPOSTiQ6UB99
MassIVEiQ6UB99
MaxQBiQ6UB99
PaxDbiQ6UB99
PeptideAtlasiQ6UB99
PRIDEiQ6UB99
ProteomicsDBi67406

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4516 129 antibodies

Genome annotation databases

EnsembliENST00000301030; ENSP00000301030; ENSG00000167522
ENST00000378330; ENSP00000367581; ENSG00000167522
ENST00000642600; ENSP00000495226; ENSG00000167522
GeneIDi29123
KEGGihsa:29123
UCSCiuc002fmx.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29123
DisGeNETi29123

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ANKRD11
GeneReviewsiANKRD11
HGNCiHGNC:21316 ANKRD11
HPAiENSG00000167522 Low tissue specificity
MalaCardsiANKRD11
MIMi148050 phenotype
611192 gene
neXtProtiNX_Q6UB99
OpenTargetsiENSG00000167522
Orphaneti261250 16q24.3 microdeletion syndrome
2332 KBG syndrome
PharmGKBiPA134861925

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ47 Eukaryota
ENOG4110UQU LUCA
GeneTreeiENSGT00940000155966
HOGENOMiCLU_229338_0_0_1
InParanoidiQ6UB99
KOiK21436
OMAiKSLEPWE
OrthoDBi854133at2759
PhylomeDBiQ6UB99
TreeFamiTF326440

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ANKRD11 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
29123
PharosiQ6UB99 Tbio

Protein Ontology

More...
PROi
PR:Q6UB99
RNActiQ6UB99 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167522 Expressed in tendon of biceps brachii and 215 other tissues
ExpressionAtlasiQ6UB99 baseline and differential
GenevisibleiQ6UB99 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR042636 ANKRD11
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR24145 PTHR24145, 3 hits
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR11_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UB99
Secondary accession number(s): Q6NTG1, Q6QMF8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
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