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Protein

Ankyrin repeat domain-containing protein 12

Gene

ANKRD12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 12
Alternative name(s):
Ankyrin repeat-containing cofactor 2
GAC-1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANKRD12
Synonyms:ANCO2, KIAA0874
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000101745.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29135 ANKRD12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610616 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6UB98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23253

Open Targets

More...
OpenTargetsi
ENSG00000101745

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134899860

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANKRD12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160358772

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000669081 – 2062Ankyrin repeat domain-containing protein 12Add BLAST2062

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei149PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1
Modified residuei861PhosphoserineCombined sources1
Modified residuei1401PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6UB98

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6UB98

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6UB98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6UB98

PeptideAtlas

More...
PeptideAtlasi
Q6UB98

PRoteomics IDEntifications database

More...
PRIDEi
Q6UB98

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67404
67405 [Q6UB98-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6UB98

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6UB98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6UB98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000101745 Expressed in 231 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_ANKRD12

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6UB98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6UB98 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA040705

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the PAS region of the p160 coactivators.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116857, 17 interactors

Protein interaction database and analysis system

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IntActi
Q6UB98, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262126

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6UB98

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6UB98

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati184 – 213ANK 1Add BLAST30
Repeati217 – 246ANK 2Add BLAST30
Repeati250 – 280ANK 3Add BLAST31

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJ47 Eukaryota
ENOG4110UQU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154742

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033954

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106885

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6UB98

KEGG Orthology (KO)

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KOi
K21436

Identification of Orthologs from Complete Genome Data

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OMAi
DSSVQGF

Database of Orthologous Groups

More...
OrthoDBi
854133at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6UB98

TreeFam database of animal gene trees

More...
TreeFami
TF326440

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00204 ANK, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415 ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6UB98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPKSGFTKPI QSENSDSDSN MVEKPYGRKS KDKIASYSKT PKIERSDVSK
60 70 80 90 100
EMKEKSSMKR KLPFTISPSR NEERDSDTDS DPGHTSENWG ERLISSYRTY
110 120 130 140 150
SEKEGPEKKK TKKEAGNKKS TPVSILFGYP LSERKQMALL MQMTARDNSP
160 170 180 190 200
DSTPNHPSQT TPAQKKTPSS SSRQKDKVNK RNERGETPLH MAAIRGDVKQ
210 220 230 240 250
VKELISLGAN VNVKDFAGWT PLHEACNVGY YDVAKILIAA GADVNTQGLD
260 270 280 290 300
DDTPLHDSAS SGHRDIVKLL LRHGGNPFQA NKHGERPVDV AETEELELLL
310 320 330 340 350
KREVPLSDDD ESYTDSEEAQ SVNPSSVDEN IDSETEKDSL ICESKQILPS
360 370 380 390 400
KTPLPSALDE YEFKDDDDEE INKMIDDRHI LRKEQRKENE PEAEKTHLFA
410 420 430 440 450
KQEKAFYPKS FKSKKQKPSR VLYSSTESSD EEALQNKKIS TSCSVIPETS
460 470 480 490 500
NSDMQTKKEY VVSGEHKQKG KVKRKLKNQN KNKENQELKQ EKEGKENTRI
510 520 530 540 550
TNLTVNTGLD CSEKTREEGN FRKSFSPKDD TSLHLFHIST GKSPKHSCGL
560 570 580 590 600
SEKQSTPLKQ EHTKTCLSPG SSEMSLQPDL VRYDNTESEF LPESSSVKSC
610 620 630 640 650
KHKEKSKHQK DFHLEFGEKS NAKIKDEDHS PTFENSDCTL KKMDKEGKTL
660 670 680 690 700
KKHKLKHKER EKEKHKKEIE GEKEKYKTKD SAKELQRSVE FDREFWKENF
710 720 730 740 750
FKSDETEDLF LNMEHESLTL EKKSKLEKNI KDDKSTKEKH VSKERNFKEE
760 770 780 790 800
RDKIKKESEK SFREEKIKDL KEERENIPTD KDSEFTSLGM SAIEESIGLH
810 820 830 840 850
LVEKEIDIEK QEKHIKESKE KPEKRSQIKE KDIEKMERKT FEKEKKIKHE
860 870 880 890 900
HKSEKDKLDL SECVDKIKEK DKLYSHHTEK CHKEGEKSKN TAAIKKTDDR
910 920 930 940 950
EKSREKMDRK HDKEKPEKER HLAESKEKHL MEKKNKQSDN SEYSKSEKGK
960 970 980 990 1000
NKEKDRELDK KEKSRDKESI NITNSKHIQE EKKSSIVDGN KAQHEKPLSL
1010 1020 1030 1040 1050
KEKTKDEPLK TPDGKEKDKK DKDIDRYKER DKHKDKIQIN SLLKLKSEAD
1060 1070 1080 1090 1100
KPKPKSSPAS KDTRPKEKRL VNDDLMQTSF ERMLSLKDLE IEQWHKKHKE
1110 1120 1130 1140 1150
KIKQKEKERL RNRNCLELKI KDKEKTKHTP TESKNKELTR SKSSEVTDAY
1160 1170 1180 1190 1200
TKEKQPKDAV SNRSQSVDTK NVMTLGKSSF VSDNSLNRSP RSENEKPGLS
1210 1220 1230 1240 1250
SRSVSMISVA SSEDSCHTTV TTPRPPVEYD SDFMLESSES QMSFSQSPFL
1260 1270 1280 1290 1300
SIAKSPALHE RELDSLADLP ERIKPPYANR LSTSHLRSSS VEDVKLIISE
1310 1320 1330 1340 1350
GRPTIEVRRC SMPSVICEHT KQFQTISEES NQGSLLTVPG DTSPSPKPEV
1360 1370 1380 1390 1400
FSNVPERDLS NVSNIHSSFA TSPTGASNSK YVSADRNLIK NTAPVNTVMD
1410 1420 1430 1440 1450
SPVHLEPSSQ VGVIQNKSWE MPVDRLETLS TRDFICPNSN IPDQESSLQS
1460 1470 1480 1490 1500
FCNSENKVLK ENADFLSLRQ TELPGNSCAQ DPASFMPPQQ PCSFPSQSLS
1510 1520 1530 1540 1550
DAESISKHMS LSYVANQEPG ILQQKNAVQI ISSALDTDNE STKDTENTFV
1560 1570 1580 1590 1600
LGDVQKTDAF VPVYSDSTIQ EASPNFEKAY TLPVLPSEKD FNGSDASTQL
1610 1620 1630 1640 1650
NTHYAFSKLT YKSSSGHEVE NSTTDTQVIS HEKENKLESL VLTHLSRCDS
1660 1670 1680 1690 1700
DLCEMNAGMP KGNLNEQDPK HCPESEKCLL SIEDEESQQS ILSSLENHSQ
1710 1720 1730 1740 1750
QSTQPEMHKY GQLVKVELEE NAEDDKTENQ IPQRMTRNKA NTMANQSKQI
1760 1770 1780 1790 1800
LASCTLLSEK DSESSSPRGR IRLTEDDDPQ IHHPRKRKVS RVPQPVQVSP
1810 1820 1830 1840 1850
SLLQAKEKTQ QSLAAIVDSL KLDEIQPYSS ERANPYFEYL HIRKKIEEKR
1860 1870 1880 1890 1900
KLLCSVIPQA PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK
1910 1920 1930 1940 1950
ELFRQQEVVR MKLRLQHSIE REKLIVSNEQ EVLRVHYRAA RTLANQTLPF
1960 1970 1980 1990 2000
SACTVLLDAE VYNVPLDSQS DDSKTSVRDR FNARQFMSWL QDVDDKFDKL
2010 2020 2030 2040 2050
KTCLLMRQQH EAAALNAVQR LEWQLKLQEL DPATYKSISI YEIQEFYVPL
2060
VDVNDDFELT PI
Length:2,062
Mass (Da):235,652
Last modified:October 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3CAFAA05E4AA1753
GO
Isoform 2 (identifier: Q6UB98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-101: Missing.

Show »
Length:2,039
Mass (Da):233,012
Checksum:i70841CCC1DA4CECA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYX2F5GYX2_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD12
310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B5MEA4B5MEA4_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD12
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSU9J3KSU9_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD12
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRX3J3QRX3_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD12
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS53J3KS53_HUMAN
Ankyrin repeat domain-containing pr...
ANKRD12
12Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15014 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti604E → K in CAH56382 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019425171S → T2 Publications1
Natural variantiVAR_026042277P → A. Corresponds to variant dbSNP:rs2298548Ensembl.1
Natural variantiVAR_048271390E → D. Corresponds to variant dbSNP:rs35101529Ensembl.1
Natural variantiVAR_048272507T → I. Corresponds to variant dbSNP:rs17498752Ensembl.1
Natural variantiVAR_048273531T → S. Corresponds to variant dbSNP:rs7243088Ensembl.1
Natural variantiVAR_022088818S → N. Corresponds to variant dbSNP:rs2298546Ensembl.1
Natural variantiVAR_024173906K → R1 PublicationCorresponds to variant dbSNP:rs4798791Ensembl.1
Natural variantiVAR_048274998L → S. Corresponds to variant dbSNP:rs34996750Ensembl.1
Natural variantiVAR_0482751758S → P. Corresponds to variant dbSNP:rs3744822Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01090179 – 101Missing in isoform 2. 2 PublicationsAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF317425 mRNA Translation: AAG38609.1
AY373757 mRNA Translation: AAR25662.1
AY533564 mRNA Translation: AAS45545.2
AL834204 mRNA Translation: CAH56382.1
AK024808 mRNA Translation: BAB15014.1 Sequence problems.
AB020681 mRNA Translation: BAA74897.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11843.1 [Q6UB98-1]
CCDS42411.1 [Q6UB98-2]

NCBI Reference Sequences

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RefSeqi
NP_001077094.1, NM_001083625.2 [Q6UB98-2]
NP_001190985.1, NM_001204056.1 [Q6UB98-2]
NP_056023.3, NM_015208.4 [Q6UB98-1]
XP_005258149.1, XM_005258092.3 [Q6UB98-1]
XP_005258150.1, XM_005258093.3 [Q6UB98-1]
XP_016881152.1, XM_017025663.1 [Q6UB98-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.464585

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000262126; ENSP00000262126; ENSG00000101745 [Q6UB98-1]
ENST00000400020; ENSP00000382897; ENSG00000101745 [Q6UB98-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23253

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23253

UCSC genome browser

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UCSCi
uc002knv.4 human [Q6UB98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF317425 mRNA Translation: AAG38609.1
AY373757 mRNA Translation: AAR25662.1
AY533564 mRNA Translation: AAS45545.2
AL834204 mRNA Translation: CAH56382.1
AK024808 mRNA Translation: BAB15014.1 Sequence problems.
AB020681 mRNA Translation: BAA74897.1
CCDSiCCDS11843.1 [Q6UB98-1]
CCDS42411.1 [Q6UB98-2]
RefSeqiNP_001077094.1, NM_001083625.2 [Q6UB98-2]
NP_001190985.1, NM_001204056.1 [Q6UB98-2]
NP_056023.3, NM_015208.4 [Q6UB98-1]
XP_005258149.1, XM_005258092.3 [Q6UB98-1]
XP_005258150.1, XM_005258093.3 [Q6UB98-1]
XP_016881152.1, XM_017025663.1 [Q6UB98-2]
UniGeneiHs.464585

3D structure databases

ProteinModelPortaliQ6UB98
SMRiQ6UB98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116857, 17 interactors
IntActiQ6UB98, 12 interactors
STRINGi9606.ENSP00000262126

PTM databases

CarbonylDBiQ6UB98
iPTMnetiQ6UB98
PhosphoSitePlusiQ6UB98

Polymorphism and mutation databases

BioMutaiANKRD12
DMDMi160358772

Proteomic databases

EPDiQ6UB98
jPOSTiQ6UB98
MaxQBiQ6UB98
PaxDbiQ6UB98
PeptideAtlasiQ6UB98
PRIDEiQ6UB98
ProteomicsDBi67404
67405 [Q6UB98-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23253
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262126; ENSP00000262126; ENSG00000101745 [Q6UB98-1]
ENST00000400020; ENSP00000382897; ENSG00000101745 [Q6UB98-2]
GeneIDi23253
KEGGihsa:23253
UCSCiuc002knv.4 human [Q6UB98-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23253
DisGeNETi23253
EuPathDBiHostDB:ENSG00000101745.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ANKRD12

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0014323
HGNCiHGNC:29135 ANKRD12
HPAiHPA040705
MIMi610616 gene
neXtProtiNX_Q6UB98
OpenTargetsiENSG00000101745
PharmGKBiPA134899860

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ47 Eukaryota
ENOG4110UQU LUCA
GeneTreeiENSGT00940000154742
HOGENOMiHOG000033954
HOVERGENiHBG106885
InParanoidiQ6UB98
KOiK21436
OMAiDSSVQGF
OrthoDBi854133at2759
PhylomeDBiQ6UB98
TreeFamiTF326440

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANKRD12 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23253

Protein Ontology

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PROi
PR:Q6UB98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000101745 Expressed in 231 organ(s), highest expression level in testis
CleanExiHS_ANKRD12
ExpressionAtlasiQ6UB98 baseline and differential
GenevisibleiQ6UB98 HS

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PfamiView protein in Pfam
PF00023 Ank, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 3 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANR12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UB98
Secondary accession number(s): O94951
, Q658K1, Q6QMF7, Q9H231, Q9H784
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 23, 2007
Last modified: January 16, 2019
This is version 132 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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