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Entry version 132 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Methionine aminopeptidase 1D, mitochondrial

Gene

METAP1D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.UniRule annotation1 Publication

Caution

It is uncertain whether Met-1 or a Met upstream of this sequence is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation EC:3.4.11.18

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Co2+UniRule annotation, Zn2+UniRule annotation, Mn2+UniRule annotation, Fe2+UniRule annotationNote: Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=573 µM for Met-pro-p-nitroanilide (at pH 8)1 Publication

    pH dependencei

    Optimum pH is 7.5-8.0.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei161SubstrateUniRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi178Divalent metal cation 1UniRule annotation1
    Metal bindingi189Divalent metal cation 1UniRule annotation1
    Metal bindingi189Divalent metal cation 2; catalyticUniRule annotation1
    Metal bindingi252Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation1
    Binding sitei259SubstrateUniRule annotation1
    Metal bindingi284Divalent metal cation 2; catalyticUniRule annotation1
    Metal bindingi315Divalent metal cation 1UniRule annotation1
    Metal bindingi315Divalent metal cation 2; catalyticUniRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAminopeptidase, Hydrolase, Protease
    LigandMetal-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.11.18, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q6UB28

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q6UB28

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M24.001

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Methionine aminopeptidase 1D, mitochondrialUniRule annotation (EC:3.4.11.18UniRule annotation)
    Short name:
    MAP 1DUniRule annotation
    Short name:
    MetAP 1DUniRule annotation
    Alternative name(s):
    Methionyl aminopeptidase type 1D, mitochondrial
    Peptidase M 1DUniRule annotation
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:METAP1D
    Synonyms:MAP1D
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000172878.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:32583, METAP1D

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    610267, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6UB28

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    254042

    Open Targets

    More...
    OpenTargetsi
    ENSG00000172878

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6UB28, Tbio

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3831223

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    METAP1D

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74710242

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 19MitochondrionUniRule annotationAdd BLAST19
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031412620 – 335Methionine aminopeptidase 1D, mitochondrialAdd BLAST316

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6UB28

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6UB28

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6UB28

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6UB28

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6UB28

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6UB28

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6UB28

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    67401

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6UB28

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6UB28

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000172878, Expressed in oviduct epithelium and 189 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6UB28, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000172878, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    129008, 8 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6UB28, 6 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000315152

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q6UB28, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6UB28

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.UniRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2738, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000157735

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_015857_1_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6UB28

    KEGG Orthology (KO)

    More...
    KOi
    K01265

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SYFHGPP

    Database of Orthologous Groups

    More...
    OrthoDBi
    1002357at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6UB28

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325318

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd01086, MetAP1, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.230.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_01974, MetAP_1, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036005, Creatinase/aminopeptidase-like
    IPR000994, Pept_M24
    IPR001714, Pept_M24_MAP
    IPR002467, Pept_M24A_MAP1

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00557, Peptidase_M24, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00599, MAPEPTIDASE

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF55920, SSF55920, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00500, met_pdase_I, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00680, MAP_1, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6UB28-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAAPSGVHLL VRRGSHRIFS SPLNHIYLHK QSSSQQRRNF FFRRQRDISH
    60 70 80 90 100
    SIVLPAAVSS AHPVPKHIKK PDYVTTGIVP DWGDSIEVKN EDQIQGLHQA
    110 120 130 140 150
    CQLARHVLLL AGKSLKVDMT TEEIDALVHR EIISHNAYPS PLGYGGFPKS
    160 170 180 190 200
    VCTSVNNVLC HGIPDSRPLQ DGDIINIDVT VYYNGYHGDT SETFLVGNVD
    210 220 230 240 250
    ECGKKLVEVA RRCRDEAIAA CRAGAPFSVI GNTISHITHQ NGFQVCPHFV
    260 270 280 290 300
    GHGIGSYFHG HPEIWHHAND SDLPMEEGMA FTIEPIITEG SPEFKVLEDA
    310 320 330
    WTVVSLDNQR SAQFEHTVLI TSRGAQILTK LPHEA
    Length:335
    Mass (Da):37,088
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2EB90946DC983D7B
    GO

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAY55948 differs from that shown. Reason: Erroneous initiation.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05027314G → V1 PublicationCorresponds to variant dbSNP:rs10497377Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AY374142 mRNA Translation: AAR27795.1
    DQ005576 mRNA Translation: AAY55948.1 Different initiation.
    CH471058 Genomic DNA Translation: EAX11190.1
    BC113644 mRNA Translation: AAI13645.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS2246.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001309207.1, NM_001322278.1
    NP_001309208.1, NM_001322279.1
    NP_954697.1, NM_199227.2

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000315796; ENSP00000315152; ENSG00000172878

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    254042

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:254042

    UCSC genome browser

    More...
    UCSCi
    uc002uhk.4, human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AY374142 mRNA Translation: AAR27795.1
    DQ005576 mRNA Translation: AAY55948.1 Different initiation.
    CH471058 Genomic DNA Translation: EAX11190.1
    BC113644 mRNA Translation: AAI13645.1
    CCDSiCCDS2246.1
    RefSeqiNP_001309207.1, NM_001322278.1
    NP_001309208.1, NM_001322279.1
    NP_954697.1, NM_199227.2

    3D structure databases

    SMRiQ6UB28
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi129008, 8 interactors
    IntActiQ6UB28, 6 interactors
    STRINGi9606.ENSP00000315152

    Chemistry databases

    ChEMBLiCHEMBL3831223

    Protein family/group databases

    MEROPSiM24.001

    PTM databases

    iPTMnetiQ6UB28
    PhosphoSitePlusiQ6UB28

    Polymorphism and mutation databases

    BioMutaiMETAP1D
    DMDMi74710242

    Proteomic databases

    EPDiQ6UB28
    jPOSTiQ6UB28
    MassIVEiQ6UB28
    MaxQBiQ6UB28
    PaxDbiQ6UB28
    PeptideAtlasiQ6UB28
    PRIDEiQ6UB28
    ProteomicsDBi67401

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    33857, 117 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    254042

    Genome annotation databases

    EnsembliENST00000315796; ENSP00000315152; ENSG00000172878
    GeneIDi254042
    KEGGihsa:254042
    UCSCiuc002uhk.4, human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    254042
    DisGeNETi254042
    EuPathDBiHostDB:ENSG00000172878.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    METAP1D
    HGNCiHGNC:32583, METAP1D
    HPAiENSG00000172878, Low tissue specificity
    MIMi610267, gene
    neXtProtiNX_Q6UB28
    OpenTargetsiENSG00000172878

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2738, Eukaryota
    GeneTreeiENSGT00940000157735
    HOGENOMiCLU_015857_1_1_1
    InParanoidiQ6UB28
    KOiK01265
    OMAiSYFHGPP
    OrthoDBi1002357at2759
    PhylomeDBiQ6UB28
    TreeFamiTF325318

    Enzyme and pathway databases

    BRENDAi3.4.11.18, 2681
    PathwayCommonsiQ6UB28
    SABIO-RKiQ6UB28

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    254042, 8 hits in 873 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    METAP1D, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    254042
    PharosiQ6UB28, Tbio

    Protein Ontology

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    PROi
    PR:Q6UB28
    RNActiQ6UB28, protein

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
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    Gene expression databases

    BgeeiENSG00000172878, Expressed in oviduct epithelium and 189 other tissues
    GenevisibleiQ6UB28, HS

    Family and domain databases

    CDDicd01086, MetAP1, 1 hit
    Gene3Di3.90.230.10, 1 hit
    HAMAPiMF_01974, MetAP_1, 1 hit
    InterProiView protein in InterPro
    IPR036005, Creatinase/aminopeptidase-like
    IPR000994, Pept_M24
    IPR001714, Pept_M24_MAP
    IPR002467, Pept_M24A_MAP1
    PfamiView protein in Pfam
    PF00557, Peptidase_M24, 1 hit
    PRINTSiPR00599, MAPEPTIDASE
    SUPFAMiSSF55920, SSF55920, 1 hit
    TIGRFAMsiTIGR00500, met_pdase_I, 1 hit
    PROSITEiView protein in PROSITE
    PS00680, MAP_1, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAP12_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6UB28
    Secondary accession number(s): Q1WNX3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 5, 2004
    Last modified: August 12, 2020
    This is version 132 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families
    5. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    6. Peptidase families
      Classification of peptidase families and list of entries
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