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Entry version 127 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Sodium-driven chloride bicarbonate exchanger

Gene

SLC4A10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:10993873, PubMed:18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).By similarity2 Publications

Caution

Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed:18319254).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-425381 Bicarbonate transporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.31.2.14 the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium-driven chloride bicarbonate exchanger1 Publication
Alternative name(s):
Solute carrier family 4 member 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A10Imported
Synonyms:NBCN21 Publication, NCBE1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13811 SLC4A10

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605556 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6U841

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 509CytoplasmicSequence analysisAdd BLAST509
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 538ExtracellularSequence analysis8
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 562CytoplasmicSequence analysis3
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 596ExtracellularSequence analysisAdd BLAST13
Transmembranei597 – 617HelicalSequence analysisAdd BLAST21
Topological domaini618 – 626CytoplasmicSequence analysis9
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 720ExtracellularSequence analysisAdd BLAST73
Transmembranei721 – 741HelicalSequence analysisAdd BLAST21
Topological domaini742 – 762CytoplasmicSequence analysisAdd BLAST21
Transmembranei763 – 783HelicalSequence analysisAdd BLAST21
Topological domaini784 – 809ExtracellularSequence analysisAdd BLAST26
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21
Topological domaini831 – 855CytoplasmicSequence analysisAdd BLAST25
Transmembranei856 – 876HelicalSequence analysisAdd BLAST21
Topological domaini877 – 912ExtracellularSequence analysisAdd BLAST36
Transmembranei913 – 933HelicalSequence analysisAdd BLAST21
Topological domaini934 – 935CytoplasmicSequence analysis2
Transmembranei936 – 956HelicalSequence analysisAdd BLAST21
Topological domaini957 – 998ExtracellularSequence analysisAdd BLAST42
Transmembranei999 – 1019HelicalSequence analysisAdd BLAST21
Topological domaini1020 – 1118CytoplasmicSequence analysisAdd BLAST99

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi677N → Q: Reduced glycosylation. Abolishes glycosylation; when associated with Q-687 and Q-697. 1 Publication1
Mutagenesisi687N → Q: Reduced glycosylation. Abolishes glycosylation; when associated with Q-677 and Q-697. 1 Publication1
Mutagenesisi697N → Q: Reduced glycosylation. Abolishes glycosylation; when associated with Q-677 and Q-687. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57282

Open Targets

More...
OpenTargetsi
ENSG00000144290

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37810

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6U841

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB01390 Sodium bicarbonate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC4A10

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74710237

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002452401 – 1118Sodium-driven chloride bicarbonate exchangerAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei89PhosphoserineBy similarity1
Modified residuei94PhosphothreonineBy similarity1
Modified residuei276PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi674N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi677N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi687N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi697N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei1057PhosphoserineBy similarity1
Modified residuei1085PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6U841

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6U841

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6U841

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6U841

PeptideAtlas

More...
PeptideAtlasi
Q6U841

PRoteomics IDEntifications database

More...
PRIDEi
Q6U841

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
29736
6443
67398 [Q6U841-1]
67399 [Q6U841-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6U841

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6U841

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6U841

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144290 Expressed in 60 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6U841 baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034755

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121475, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6U841, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000393066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6U841

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal cytoplasmic domain is likely to have a high level of intrinsic disorder.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1172 Eukaryota
ENOG410XPHD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156972

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000280684

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6U841

KEGG Orthology (KO)

More...
KOi
K13861

Identification of Orthologs from Complete Genome Data

More...
OMAi
LMDFFFT

Database of Orthologous Groups

More...
OrthoDBi
265068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6U841

TreeFam database of animal gene trees

More...
TreeFami
TF313630

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr

The PANTHER Classification System

More...
PANTHERi
PTHR11453 PTHR11453, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55804 SSF55804, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00834 ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6U841-1) [UniParc]FASTAAdd to basket
Also known as: NCBE-B1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIKDQGAQM EPLLPTRNDE EAVVDRGGTR SILKTHFEKE DLEGHRTLFI
60 70 80 90 100
GVHVPLGGRK SHRRHRHRGH KHRKRDRERD SGLEDGRESP SFDTPSQRVQ
110 120 130 140 150
FILGTEDDDE EHIPHDLFTE LDEICWREGE DAEWRETARW LKFEEDVEDG
160 170 180 190 200
GERWSKPYVA TLSLHSLFEL RSCILNGTVL LDMHANTLEE IADMVLDQQV
210 220 230 240 250
SSGQLNEDVR HRVHEALMKQ HHHQNQKKLT NRIPIVRSFA DIGKKQSEPN
260 270 280 290 300
SMDKNAGQVV SPQSAPACVE NKNDVSRENS TVDFSKGLGG QQKGHTSPCG
310 320 330 340 350
MKQRHEKGPP HQQEREVDLH FMKKIPPGAE ASNILVGELE FLDRTVVAFV
360 370 380 390 400
RLSPAVLLQG LAEVPIPTRF LFILLGPLGK GQQYHEIGRS IATLMTDEVF
410 420 430 440 450
HDVAYKAKDR NDLVSGIDEF LDQVTVLPPG EWDPSIRIEP PKNVPSQEKR
460 470 480 490 500
KIPAVPNGTA AHGEAEPHGG HSGPELQRTG RIFGGLILDI KRKAPYFWSD
510 520 530 540 550
FRDAFSLQCL ASFLFLYCAC MSPVITFGGL LGEATEGRIS AIESLFGASM
560 570 580 590 600
TGIAYSLFGG QPLTILGSTG PVLVFEKILF KFCKEYGLSY LSLRASIGLW
610 620 630 640 650
TATLCIILVA TDASSLVCYI TRFTEEAFAS LICIIFIYEA LEKLFELSEA
660 670 680 690 700
YPINMHNDLE LLTQYSCNCV EPHNPSNGTL KEWRESNISA SDIIWENLTV
710 720 730 740 750
SECKSLHGEY VGRACGHDHP YVPDVLFWSV ILFFSTVTLS ATLKQFKTSR
760 770 780 790 800
YFPTKVRSIV SDFAVFLTIL CMVLIDYAIG IPSPKLQVPS VFKPTRDDRG
810 820 830 840 850
WFVTPLGPNP WWTVIAAIIP ALLCTILIFM DQQITAVIIN RKEHKLKKGC
860 870 880 890 900
GYHLDLLMVA VMLGVCSIMG LPWFVAATVL SITHVNSLKL ESECSAPGEQ
910 920 930 940 950
PKFLGIREQR VTGLMIFILM GSSVFMTSIL KFIPMPVLYG VFLYMGASSL
960 970 980 990 1000
KGIQFFDRIK LFWMPAKHQP DFIYLRHVPL RKVHLFTIIQ MSCLGLLWII
1010 1020 1030 1040 1050
KVSRAAIVFP MMVLALVFVR KLMDLLFTKR ELSWLDDLMP ESKKKKLEDA
1060 1070 1080 1090 1100
EKEEEQSMLA MEDEGTVQLP LEGHYRDDPS VINISDEMSK TALWRNLLIT
1110
ADNSKDKESS FPSKSSPS
Length:1,118
Mass (Da):125,946
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2376529C2CBE04E2
GO
Isoform 2 (identifier: Q6U841-2) [UniParc]FASTAAdd to basket
Also known as: NCBE-A1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     287-316: Missing.

Show »
Length:1,088
Mass (Da):122,641
Checksum:i900D304004CC7208
GO
Isoform 3 (identifier: Q6U841-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MEIKDQGAQMEPLLPT → MQSLGVSGNRKVMQSGTCEPFQSLSHQ
     287-316: Missing.

Note: No experimental confirmation available.
Show »
Length:1,099
Mass (Da):123,777
Checksum:iB3A73B8131408E8E
GO
Isoform 4 (identifier: Q6U841-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     370-408: FLFILLGPLG...VFHDVAYKAK → YFMMLPIKLK...LLENGIQAFE
     409-1118: Missing.

Note: No experimental confirmation available.
Show »
Length:408
Mass (Da):46,839
Checksum:i1C70E5B511C6A6CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J240C9J240_HUMAN
Anion exchange protein
SLC4A10
1,106Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW28E7EW28_HUMAN
Anion exchange protein
SLC4A10
1,054Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDX9F8WDX9_HUMAN
Sodium-driven chloride bicarbonate ...
SLC4A10
469Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti336V → L in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti699T → I in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1008V → A in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1009F → S in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1015A → S in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1033S → C in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1048E → G in BAH11596 (PubMed:14702039).Curated1
Sequence conflicti1049D → Y in BAB18301 (PubMed:10993873).Curated1
Sequence conflicti1057 – 1058SM → CV in BAB18301 (PubMed:10993873).Curated2
Sequence conflicti1060A → P in BAB18301 (PubMed:10993873).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449931 – 16MEIKD…PLLPT → MQSLGVSGNRKVMQSGTCEP FQSLSHQ in isoform 3. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_019653287 – 316Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST30
Alternative sequenceiVSP_054471370 – 408FLFIL…AYKAK → YFMMLPIKLKIVMTWYQELM SFWIRLLFSLLENGIQAFE in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_054472409 – 1118Missing in isoform 4. 1 PublicationAdd BLAST710

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB040457 mRNA Translation: BAB18301.1
AY376402 mRNA Translation: AAQ83632.1
AK293793 mRNA Translation: BAH11596.1
AK294767 mRNA Translation: BAH11876.1
AC008063 Genomic DNA No translation available.
AC062022 Genomic DNA No translation available.
AC092841 Genomic DNA No translation available.
AC009487 Genomic DNA No translation available.
AC092654 Genomic DNA No translation available.
AC096654 Genomic DNA Translation: AAX88962.1
CH471058 Genomic DNA Translation: EAX11364.1
BC136269 mRNA Translation: AAI36270.1
BC143714 mRNA Translation: AAI43715.1
AL713680 mRNA Translation: CAD28484.1
AL832525 mRNA Translation: CAD38630.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS46438.1 [Q6U841-2]
CCDS54411.1 [Q6U841-1]
CCDS54412.1 [Q6U841-3]

NCBI Reference Sequences

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RefSeqi
NP_001171486.1, NM_001178015.1 [Q6U841-1]
NP_001171487.1, NM_001178016.1 [Q6U841-3]
NP_071341.2, NM_022058.3 [Q6U841-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375514; ENSP00000364664; ENSG00000144290 [Q6U841-3]
ENST00000415876; ENSP00000395797; ENSG00000144290 [Q6U841-2]
ENST00000446997; ENSP00000393066; ENSG00000144290 [Q6U841-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57282

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57282

UCSC genome browser

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UCSCi
uc002ubx.5 human [Q6U841-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040457 mRNA Translation: BAB18301.1
AY376402 mRNA Translation: AAQ83632.1
AK293793 mRNA Translation: BAH11596.1
AK294767 mRNA Translation: BAH11876.1
AC008063 Genomic DNA No translation available.
AC062022 Genomic DNA No translation available.
AC092841 Genomic DNA No translation available.
AC009487 Genomic DNA No translation available.
AC092654 Genomic DNA No translation available.
AC096654 Genomic DNA Translation: AAX88962.1
CH471058 Genomic DNA Translation: EAX11364.1
BC136269 mRNA Translation: AAI36270.1
BC143714 mRNA Translation: AAI43715.1
AL713680 mRNA Translation: CAD28484.1
AL832525 mRNA Translation: CAD38630.1
CCDSiCCDS46438.1 [Q6U841-2]
CCDS54411.1 [Q6U841-1]
CCDS54412.1 [Q6U841-3]
RefSeqiNP_001171486.1, NM_001178015.1 [Q6U841-1]
NP_001171487.1, NM_001178016.1 [Q6U841-3]
NP_071341.2, NM_022058.3 [Q6U841-2]

3D structure databases

SMRiQ6U841
ModBaseiSearch...

Protein-protein interaction databases

BioGridi121475, 1 interactor
IntActiQ6U841, 3 interactors
STRINGi9606.ENSP00000393066

Chemistry databases

DrugBankiDB01390 Sodium bicarbonate

Protein family/group databases

TCDBi2.A.31.2.14 the anion exchanger (ae) family

PTM databases

iPTMnetiQ6U841
PhosphoSitePlusiQ6U841
SwissPalmiQ6U841

Polymorphism and mutation databases

BioMutaiSLC4A10
DMDMi74710237

Proteomic databases

jPOSTiQ6U841
MassIVEiQ6U841
MaxQBiQ6U841
PaxDbiQ6U841
PeptideAtlasiQ6U841
PRIDEiQ6U841
ProteomicsDBi29736
6443
67398 [Q6U841-1]
67399 [Q6U841-2]

Genome annotation databases

EnsembliENST00000375514; ENSP00000364664; ENSG00000144290 [Q6U841-3]
ENST00000415876; ENSP00000395797; ENSG00000144290 [Q6U841-2]
ENST00000446997; ENSP00000393066; ENSG00000144290 [Q6U841-1]
GeneIDi57282
KEGGihsa:57282
UCSCiuc002ubx.5 human [Q6U841-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57282
DisGeNETi57282

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC4A10
HGNCiHGNC:13811 SLC4A10
HPAiHPA034755
MIMi605556 gene
neXtProtiNX_Q6U841
OpenTargetsiENSG00000144290
PharmGKBiPA37810

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
GeneTreeiENSGT00940000156972
HOGENOMiHOG000280684
InParanoidiQ6U841
KOiK13861
OMAiLMDFFFT
OrthoDBi265068at2759
PhylomeDBiQ6U841
TreeFamiTF313630

Enzyme and pathway databases

ReactomeiR-HSA-425381 Bicarbonate transporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC4A10 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57282
PharosiQ6U841

Protein Ontology

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PROi
PR:Q6U841

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144290 Expressed in 60 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ6U841 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 1 hit
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A10_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6U841
Secondary accession number(s): B7Z1R0
, B7Z2J0, B7ZLC5, B9EG69, F8W675, Q4ZFX6, Q8TCP2, Q9HCQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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