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Protein

Fasciculation and elongation protein zeta-2

Gene

Fez2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in axonal outgrowth and fasciculation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Fasciculation and elongation protein zeta-2
Alternative name(s):
Zygin II
Zygin-2
Gene namesi
Name:Fez2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2675856 Fez2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001895291 – 348Fasciculation and elongation protein zeta-2Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineBy similarity1
Disulfide bondi148InterchainBy similarity
Modified residuei171PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ6TYB5
MaxQBiQ6TYB5
PaxDbiQ6TYB5
PRIDEiQ6TYB5

PTM databases

iPTMnetiQ6TYB5
PhosphoSitePlusiQ6TYB5

Expressioni

Gene expression databases

BgeeiENSMUSG00000056121 Expressed in 273 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ6TYB5 baseline and differential
GenevisibleiQ6TYB5 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked. May form heterodimers with FEZ1. Interacts with synaptotagmin (By similarity).By similarity

Protein-protein interaction databases

BioGridi230350, 1 interactor
IntActiQ6TYB5, 1 interactor
STRINGi10090.ENSMUSP00000068987

Structurei

3D structure databases

ProteinModelPortaliQ6TYB5
SMRiQ6TYB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili206 – 280Sequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi273 – 279Poly-Lys7

Sequence similaritiesi

Belongs to the zygin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3919 Eukaryota
ENOG410Z11E LUCA
GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ6TYB5
TreeFamiTF313128

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015641 FEZ_2
PANTHERiPTHR12394 PTHR12394, 2 hits
PTHR12394:SF11 PTHR12394:SF11, 2 hits
PfamiView protein in Pfam
PF07763 FEZ, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6TYB5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAADGDWQDF YEFQEPAGSV QEQENCNASP EAGAGAHAGG DSFPALASSL
60 70 80 90 100
EEKLSLCFRP TSEAEPPRAA VRPITECSLL QGDEIWNALT DNYGNVMPVD
110 120 130 140 150
WKSSHTRTLH LLTLNLSEKG MNDGLLFDAS DEEELREQLD MHSIIVSCVN
160 170 180 190 200
EEPLFTADQV IEEIEEMMQE SPDPEDDETP TQSDRLSMLS QEIQTLKRSS
210 220 230 240 250
MSSYEERVKR LSVSELNELL EEIEAAIKQY SEELVQQLAL RDELEFEKEV
260 270 280 290 300
ENSFISALIE VQNKQKEHKE TAKKKKKLKS GSSQNGRSER SHMPGTYLTT
310 320 330 340
VIPYEKKSGP PSVEDLQILT KILHAMKEDS EKVPSLLTDY ILKVLCPT
Length:348
Mass (Da):39,101
Last modified:July 5, 2004 - v1
Checksum:i031D68EF532BB781
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z6D5D3Z6D5_MOUSE
Fasciculation and elongation protei...
Fez2
375Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382580 mRNA Translation: AAR36860.1
BC096619 mRNA Translation: AAH96619.1
CCDSiCCDS28977.1
RefSeqiNP_955519.1, NM_199448.3
UniGeneiMm.236835

Genome annotation databases

EnsembliENSMUST00000070039; ENSMUSP00000068987; ENSMUSG00000056121
GeneIDi225020
KEGGimmu:225020
UCSCiuc008dov.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382580 mRNA Translation: AAR36860.1
BC096619 mRNA Translation: AAH96619.1
CCDSiCCDS28977.1
RefSeqiNP_955519.1, NM_199448.3
UniGeneiMm.236835

3D structure databases

ProteinModelPortaliQ6TYB5
SMRiQ6TYB5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230350, 1 interactor
IntActiQ6TYB5, 1 interactor
STRINGi10090.ENSMUSP00000068987

PTM databases

iPTMnetiQ6TYB5
PhosphoSitePlusiQ6TYB5

Proteomic databases

EPDiQ6TYB5
MaxQBiQ6TYB5
PaxDbiQ6TYB5
PRIDEiQ6TYB5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070039; ENSMUSP00000068987; ENSMUSG00000056121
GeneIDi225020
KEGGimmu:225020
UCSCiuc008dov.2 mouse

Organism-specific databases

CTDi9637
MGIiMGI:2675856 Fez2

Phylogenomic databases

eggNOGiKOG3919 Eukaryota
ENOG410Z11E LUCA
GeneTreeiENSGT00390000017627
HOGENOMiHOG000019494
HOVERGENiHBG005657
InParanoidiQ6TYB5
TreeFamiTF313128

Miscellaneous databases

PROiPR:Q6TYB5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056121 Expressed in 273 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ6TYB5 baseline and differential
GenevisibleiQ6TYB5 MM

Family and domain databases

InterProiView protein in InterPro
IPR011680 FEZ
IPR015641 FEZ_2
PANTHERiPTHR12394 PTHR12394, 2 hits
PTHR12394:SF11 PTHR12394:SF11, 2 hits
PfamiView protein in Pfam
PF07763 FEZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFEZ2_MOUSE
AccessioniPrimary (citable) accession number: Q6TYB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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