UniProtKB - Q6TXE9 (Q6TXE9_RAT)
Protein
Prolyl-tRNA synthetase
Gene
Eprs
Organism
Rattus norvegicus (Rat)
Status
Functioni
Catalytic activityi
- EC:6.1.1.15ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- GTPase binding Source: RGD
- identical protein binding Source: RGD
- proline-tRNA ligase activity Source: RGD
- protein homodimerization activity Source: RGD
- RNA stem-loop binding Source: RGD
- zinc ion binding Source: RGD
GO - Biological processi
- cellular response to insulin stimulus Source: RGD
- cellular response to interferon-gamma Source: RGD
- negative regulation of translation Source: RGD
- prolyl-tRNA aminoacylation Source: RGD
- regulation of long-chain fatty acid import into cell Source: RGD
Keywordsi
Molecular function | Aminoacyl-tRNA synthetaseARBA annotation, Ligase |
Biological process | Protein biosynthesisARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:EprsImported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1310952, Eprs |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- aminoacyl-tRNA synthetase multienzyme complex Source: RGD
- cytoplasm Source: RGD
- GAIT complex Source: RGD
- ribonucleoprotein complex Source: RGD
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002393, Expressed in liver and 20 other tissues |
Interactioni
GO - Molecular functioni
- GTPase binding Source: RGD
- identical protein binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000033323 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 723 – 779 | WHEP-TRSInterPro annotationAdd BLAST | 57 | |
Domaini | 796 – 852 | WHEP-TRSInterPro annotationAdd BLAST | 57 | |
Domaini | 874 – 930 | WHEP-TRSInterPro annotationAdd BLAST | 57 | |
Domaini | 1030 – 1270 | AA_TRNA_LIGASE_IIInterPro annotationAdd BLAST | 241 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 683 – 710 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 769 – 794 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 847 – 871 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 930 – 985 | DisorderedSequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 684 – 706 | PolyampholyteSequence analysisAdd BLAST | 23 | |
Compositional biasi | 778 – 794 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 849 – 867 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 930 – 955 | PolyampholyteSequence analysisAdd BLAST | 26 | |
Compositional biasi | 956 – 974 | PolarSequence analysisAdd BLAST | 19 |
Phylogenomic databases
eggNOGi | KOG1147, Eukaryota KOG4163, Eukaryota |
GeneTreei | ENSGT00550000074815 |
OrthoDBi | 809861at2759 |
Family and domain databases
CDDi | cd00778, ProRS_core_arch_euk, 1 hit |
Gene3Di | 2.40.240.10, 2 hits 3.30.110.30, 1 hit 3.40.50.620, 1 hit 3.40.50.800, 1 hit |
HAMAPi | MF_01571, Pro_tRNA_synth_type3, 1 hit |
InterProi | View protein in InterPro IPR002314, aa-tRNA-synt_IIb IPR001412, aa-tRNA-synth_I_CS IPR006195, aa-tRNA-synth_II IPR004154, Anticodon-bd IPR036621, Anticodon-bd_dom_sf IPR000924, Glu/Gln-tRNA-synth IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd IPR036282, Glutathione-S-Trfase_C_sf IPR004499, Pro-tRNA-ligase_IIa_arc-type IPR016061, Pro-tRNA_ligase_II_C IPR017449, Pro-tRNA_synth_II IPR033721, ProRS_core_arch_euk IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR014729, Rossmann-like_a/b/a_fold IPR009068, S15_NS1_RNA-bd IPR000738, WHEP-TRS_dom |
Pfami | View protein in Pfam PF03129, HGTP_anticodon, 1 hit PF09180, ProRS-C_1, 1 hit PF00749, tRNA-synt_1c, 1 hit PF03950, tRNA-synt_1c_C, 1 hit PF00587, tRNA-synt_2b, 1 hit PF00458, WHEP-TRS, 3 hits |
PRINTSi | PR00987, TRNASYNTHGLU |
SMARTi | View protein in SMART SM00946, ProRS-C_1, 1 hit SM00991, WHEP-TRS, 3 hits |
SUPFAMi | SSF47060, SSF47060, 3 hits SSF47616, SSF47616, 1 hit SSF50715, SSF50715, 1 hit SSF64586, SSF64586, 1 hit |
TIGRFAMsi | TIGR00408, proS_fam_I, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50862, AA_TRNA_LIGASE_II, 1 hit PS00762, WHEP_TRS_1, 3 hits PS51185, WHEP_TRS_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6TXE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAALCLTVNA GNPPLGCRVK VNKRNKSFML SFLEALLAVE HVKGDVSISV
60 70 80 90 100
EEGKENLLRV SESVVFTDTN SILRYLARVA ATSGLYGSNL MEHTEIDHWL
110 120 130 140 150
EFSATKLSSC DVLTSAIKEL NHCLSLRTYL VGNSLTLADL CVWATLKGNA
160 170 180 190 200
ACQEHLRQSK TLVHVNRWYG FLEAQQAFRS VGTKWDASAN KATGAPDRKQ
210 220 230 240 250
DIGKFVELPG AEMGKVTVRF PPEASGYLHI GHAKAALLNQ HYQVNFKGKL
260 270 280 290 300
IMRFDDTNPE KEKEDFEKVI LEDVAMLHIK PDQFTYTSDH FETIMKYAEK
310 320 330 340 350
LIEEGKAYVD DTPADEMKAE PVEKNLQMWE EMKRGSQFGQ SCCLRAKIDM
360 370 380 390 400
SSNNGCMRDP TLYRCKIQPH PRTGNKYNVY PTYDFACPIV DSIEGVTHAL
410 420 430 440 450
RTTEYHDRDE QFYWIIEALG IRKPYIWEYS RLNLNNTVLS KRKLTWFVNE
460 470 480 490 500
GLGSSRSVVN MEWDKIWAFN KKVIDPVAPR YVALLKKEVI PVNILDAQEE
510 520 530 540 550
MKEVARHPKN PDVGLKPVWY SPKVFIEGAD AETFSEGEMV TFINWGNINI
560 570 580 590 600
TKIHKNPDGK ITSLDAKLNL ENKDYKKTTK ITWLAETTQA LPVPAVCVTY
610 620 630 640 650
EHLITKPVLG KDEDFKQYVN KDSKHEELML GDPCLKDLKK GDIIQLQRRG
660 670 680 690 700
FFICDQPYEP VSPYSCKEAP CILIYIPDGH TKEMPTSGSK EKTKVEISKK
710 720 730 740 750
ETGSAPKERP AAAVSAPCAA AEDAAILYSR VAVQGDAVRD LKAKKAPKED
760 770 780 790 800
IDAAVKQLLT LKAEYKEKTG QEYRPGNPPT AAVQTVSTKS PSNTGEYTSL
810 820 830 840 850
YNKVAAQGEL VRKLKAEKAP KAKINDAVEC LLSLKAEYKE KTGKEYVPGQ
860 870 880 890 900
LPASQNSHSS PVSNAKPVGS ETPEAKLLFD RVACQGEVVR KLKAEKASKD
910 920 930 940 950
QVDSAVQELL QLKAQYKSLT GIEYKPVSAT GAEDKDKKKK EKENKSEKQN
960 970 980 990 1000
KPQKQNDGQG KDSSKSQGSG LSSGGAGEGQ GPKKQTRLGL EAKKEENLAE
1010 1020 1030 1040 1050
WYSQVITKSE MIEYYDVSGC YILRPWSYSI WESIKDFFDA EIKKLGVENC
1060 1070 1080 1090 1100
YFPIFVSQGA LEKEKNHIAD FAPEVAWVTR SGKTELAEPI AIRPTSETVM
1110 1120 1130 1140 1150
YPAYAKWVQS HRDLPIRLNQ WCNVVRWEFK HPQPFLRTRE FLWQEGHSAF
1160 1170 1180 1190 1200
ATFEEAADEV LQILELYARV YEELLAIPVV RGRKTEKEKF AGGDYTTTLE
1210 1220 1230 1240 1250
AFISASGRAI QGATSHHLGQ NFSKMCEIVF EDPKTPGEKQ FAYQCSWGLT
1260 1270 1280 1290 1300
TRTIGVMIMV HGDNMGLVLP PRVASVQVVV IPCGITNTLS EEDREALMAK
1310 1320 1330 1340 1350
CNEYRRRLLG ADIRARVDLR DNYSPGWKFN HWELKGVPVR LEVGPRDMKS
1360 1370 1380 1390 1400
CQFVAVRRDT GEKLTIAEKE AESKLKGVLE DIQLNLFTRA SEDLKSHMVV
1410 1420 1430 1440 1450
SDTLEDFQKV LDSGKVAQIP FCGEIDCEDW IKKTTARDQD VEPGAPSMGA
1460 1470 1480
KSLCIPFNPL CELQPGAMCV CGKNPAKFYT LFGRSY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JZI2 | A0A0G2JZI2_RAT | Glutamyl-tRNA synthetase | Eprs | 1,512 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07022023 Genomic DNA No translation available. AY383705 mRNA Translation: AAQ96263.1 |
RefSeqi | NP_001019409.1, NM_001024238.1 |
Genome annotation databases
Ensembli | ENSRNOT00000038264; ENSRNOP00000033323; ENSRNOG00000002393 |
GeneIDi | 289352 |
KEGGi | rno:289352 |
UCSCi | RGD:1310952, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AABR07022023 Genomic DNA No translation available. AY383705 mRNA Translation: AAQ96263.1 |
RefSeqi | NP_001019409.1, NM_001024238.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000033323 |
Genome annotation databases
Ensembli | ENSRNOT00000038264; ENSRNOP00000033323; ENSRNOG00000002393 |
GeneIDi | 289352 |
KEGGi | rno:289352 |
UCSCi | RGD:1310952, rat |
Organism-specific databases
CTDi | 107508 |
RGDi | 1310952, Eprs |
Phylogenomic databases
eggNOGi | KOG1147, Eukaryota KOG4163, Eukaryota |
GeneTreei | ENSGT00550000074815 |
OrthoDBi | 809861at2759 |
Gene expression databases
Bgeei | ENSRNOG00000002393, Expressed in liver and 20 other tissues |
Family and domain databases
CDDi | cd00778, ProRS_core_arch_euk, 1 hit |
Gene3Di | 2.40.240.10, 2 hits 3.30.110.30, 1 hit 3.40.50.620, 1 hit 3.40.50.800, 1 hit |
HAMAPi | MF_01571, Pro_tRNA_synth_type3, 1 hit |
InterProi | View protein in InterPro IPR002314, aa-tRNA-synt_IIb IPR001412, aa-tRNA-synth_I_CS IPR006195, aa-tRNA-synth_II IPR004154, Anticodon-bd IPR036621, Anticodon-bd_dom_sf IPR000924, Glu/Gln-tRNA-synth IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd IPR036282, Glutathione-S-Trfase_C_sf IPR004499, Pro-tRNA-ligase_IIa_arc-type IPR016061, Pro-tRNA_ligase_II_C IPR017449, Pro-tRNA_synth_II IPR033721, ProRS_core_arch_euk IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR014729, Rossmann-like_a/b/a_fold IPR009068, S15_NS1_RNA-bd IPR000738, WHEP-TRS_dom |
Pfami | View protein in Pfam PF03129, HGTP_anticodon, 1 hit PF09180, ProRS-C_1, 1 hit PF00749, tRNA-synt_1c, 1 hit PF03950, tRNA-synt_1c_C, 1 hit PF00587, tRNA-synt_2b, 1 hit PF00458, WHEP-TRS, 3 hits |
PRINTSi | PR00987, TRNASYNTHGLU |
SMARTi | View protein in SMART SM00946, ProRS-C_1, 1 hit SM00991, WHEP-TRS, 3 hits |
SUPFAMi | SSF47060, SSF47060, 3 hits SSF47616, SSF47616, 1 hit SSF50715, SSF50715, 1 hit SSF64586, SSF64586, 1 hit |
TIGRFAMsi | TIGR00408, proS_fam_I, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit PS50862, AA_TRNA_LIGASE_II, 1 hit PS00762, WHEP_TRS_1, 3 hits PS51185, WHEP_TRS_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6TXE9_RAT | |
Accessioni | Q6TXE9Primary (citable) accession number: Q6TXE9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |