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Entry version 73 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Breast cancer-associated antigen SGA-56M

Gene

SGA56M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Breast cancer-associated antigen SGA-56MImported
Submitted name:
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans), isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SGA56MImported
Synonyms:SMG7Imported
ORF Names:hCG_39862Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25605

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6TV06

PRoteomics IDEntifications database

More...
PRIDEi
Q6TV06

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 95EST1_DNA_bindInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni285 – 311DisorderedSequence analysisAdd BLAST27
Regioni361 – 459DisorderedSequence analysisAdd BLAST99
Regioni555 – 576DisorderedSequence analysisAdd BLAST22
Regioni653 – 720DisorderedSequence analysisAdd BLAST68
Regioni734 – 754DisorderedSequence analysisAdd BLAST21
Regioni769 – 802DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi294 – 311PolarSequence analysisAdd BLAST18
Compositional biasi361 – 440PolarSequence analysisAdd BLAST80
Compositional biasi653 – 695PolarSequence analysisAdd BLAST43
Compositional biasi734 – 752PolarSequence analysisAdd BLAST19

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000049052

KEGG Orthology (KO)

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KOi
K14409

Database of Orthologous Groups

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OrthoDBi
556396at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10373 EST1_DNA_bind, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48452 SSF48452, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6TV06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLGILCKC PLQNESQEES YNAYPLPAVK VSMDWLRLRP RVFQEAVVDE
60 70 80 90 100
RQYIWPWLIS LLNSFHPHEE DLSSISATPL PEEFELQGFL ALRPSFRNLD
110 120 130 140 150
FSKGHQGITG DKEGQQRRIR QQRLISIGKW IADNQPRLIQ CENEVGKLLF
160 170 180 190 200
ITEIPELILE DPSEAKENLI LQETSVIESL AADGSPGLKS VLSTSRNLSN
210 220 230 240 250
NCDTGEKPVV TFKENIKTRE VNRDQGRSFP PKEVRRDYSK GITVTKNDGK
260 270 280 290 300
KDNNKRKTET KKCTLEKLQE TGKQNVAVQV KSQTELRKTP VSEARKTPVT
310 320 330 340 350
QTPTQASNSQ FIPIHHPGAF PPLPSRPGFP PPTYVIPPPV AFSMGSGYTF
360 370 380 390 400
PAGVSVPGTF LQPTAHSPAG NQVQAGKQSH IPYSQQRPSG PGPMNQGPQQ
410 420 430 440 450
SQPPSQQPLT SLPAQPTAQS TSQLQVQALT QQQQSPTKAV PALGKSPPHH
460 470 480 490 500
SGFQQYQQAD ASKQLWNPPQ VQGPLGKIMP VKQPYYLQTQ DPIKLFEPSL
510 520 530 540 550
QPPVMQQQPL EKKMKPFPME PYNHNPSEVK VPEFYWDSSY SMADNRSVMA
560 570 580 590 600
QQANIDRRGK RSPGVFRPEQ DPVPRMPFEK SLLEKPSELM SHSSSFLSLT
610 620 630 640 650
GFSLNQERYP NNSMFNEVYG KNLTSSSKAE LSPSMAPQET SLYSLFEGTP
660 670 680 690 700
WSPSLPASSD HSTPASQSPH SSNPSSLPSS PPTHNHNSVP FSNFGPIGTP
710 720 730 740 750
DNRDRRTADR WKTDKPAMGG FGIDYLSATS SSESSWHQAS TPSGTWTGHG
760 770 780 790 800
PSMEDSSAVL MESLKSIWSS SMMHPGPSAL EQLLMQQKQK QQRGQGTMNP

PH
Length:802
Mass (Da):88,984
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAEBB71BC7A12876B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY386363 mRNA Translation: AAR25620.1
CH471067 Genomic DNA Translation: EAW91154.1
CH471067 Genomic DNA Translation: EAW91158.1

NCBI Reference Sequences

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RefSeqi
NP_775179.1, NM_173156.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
9887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9887

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY386363 mRNA Translation: AAR25620.1
CH471067 Genomic DNA Translation: EAW91154.1
CH471067 Genomic DNA Translation: EAW91158.1
RefSeqiNP_775179.1, NM_173156.2

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ6TV06
PRIDEiQ6TV06

Genome annotation databases

GeneIDi9887
KEGGihsa:9887

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9887
PharmGKBiPA25605

Phylogenomic databases

HOGENOMiHOG000049052
KOiK14409
OrthoDBi556396at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SMG7 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9887

Family and domain databases

InterProiView protein in InterPro
IPR018834 DNA/RNA-bd_Est1-type
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF10373 EST1_DNA_bind, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6TV06_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6TV06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 73 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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