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Entry version 126 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

LRRGT00098

Gene

Arhgap5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LRRGT00098Imported
Submitted name:
Rho GTPase-activating protein 5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Rat genome database

More...
RGDi
1308507, Arhgap5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000004696, Expressed in jejunum and 19 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000047384

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6TUE6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 324FFInterPro annotationAdd BLAST59
Domaini365 – 419FFInterPro annotationAdd BLAST55
Domaini426 – 480FFInterPro annotationAdd BLAST55
Domaini481 – 547FFInterPro annotationAdd BLAST67
Domaini589 – 762PG1 pseudoGTPaseInterPro annotationAdd BLAST174
Domaini778 – 943PG2 pseudoGTPaseInterPro annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni974 – 1003DisorderedSequence analysisAdd BLAST30
Regioni1021 – 1049DisorderedSequence analysisAdd BLAST29
Regioni1068 – 1088DisorderedSequence analysisAdd BLAST21
Regioni1128 – 1156DisorderedSequence analysisAdd BLAST29
Regioni1168 – 1245DisorderedSequence analysisAdd BLAST78

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili308 – 328Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1023 – 1037PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1168 – 1199PolyampholyteSequence analysisAdd BLAST32
Compositional biasi1218 – 1245PolyampholyteSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4271, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154553

KEGG Orthology (KO)

More...
KOi
K13709

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.440, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR027417, P-loop_NTPase
IPR039007, pG1
IPR032835, RhoGAP-FF1
IPR039006, RhoGAP_pG2
IPR001806, Small_GTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01846, FF, 1 hit
PF00071, Ras, 1 hit
PF16512, RhoGAP-FF1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00441, FF, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF81698, SSF81698, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51676, FF, 4 hits
PS51852, PG1, 1 hit
PS51853, PG2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6TUE6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKNKEPRPP SYTVSVVGLS GTEKDKGNCG VGKSCLCNRF VRSKADEYYP
60 70 80 90 100
EHTSVLSTID FGGRVVNNDH FLYWGDITQN GEDGVECKIH VIEQTEFIDD
110 120 130 140 150
QTFLPHRSTN LQPYIKRAAA SKLQSAEKLM YICTDQLGLE QDFEQKQMPE
160 170 180 190 200
GKLNVDGFLL CIDVSQGCNR KFDDQLKFVN NLFVQLSKSK KPVIIAATKC
210 220 230 240 250
DECVDHYLRE VQAFASNKKN LLVVETSARF NVNIETCFTA LVQMLDKTRG
260 270 280 290 300
KPKIIPYLDA YKTQRQLVVT ATDKFEKLVQ TVRDYHATWK TVSNKLKNHP
310 320 330 340 350
DYEEYINLEG TRKARNTFSK HIEQLKQEHI RKRREEYIST LPRAFNTLLP
360 370 380 390 400
DLEEIEHLNW LEALKLMEKR ADFQLCFVVL EKTPWDETDH IDKINDRRIP
410 420 430 440 450
FDLLSTLEAE KVYQNHVQHL ISEKRRIEMK EKFKKTLEKI QFISPGQPWE
460 470 480 490 500
EVMCFVMEDE AFKYITEADS KEVYGRHQRE IVEKAKEEFQ EMLFEHSELF
510 520 530 540 550
YDLDLNATPS SDKMSEIHTV LSEEPRYKAL QKLAPDRESL LLKHIGFVYH
560 570 580 590 600
PTKETCLSGQ YCTDIKVENL LANSLLHSDH NRSRLYHDST NIDKVNLFIL
610 620 630 640 650
GKDGLAQELA NEIRTQSTDD EYALDGKIYE LDLRPVDAKS PYILSQLWTA
660 670 680 690 700
AFKPHGCFCV FNSIESLSFI GEFIGKIRTE ASQIRKDKYM ANLPFTLILA
710 720 730 740 750
NQRDSISKNL PILRHQGQQL ANKLQCPFVD VPAGTYPRKF NESQIKQALR
760 770 780 790 800
GVLESVKHNL DVVSPVPINK DVSEADLRIV MCAMCGDPFS VDIILSPFLD
810 820 830 840 850
SHSCSAAQAG QNNSLMLDKI IGEKRRRIQI TILSYHSSIG VRKDELVHGY
860 870 880 890 900
ILVYSAKRKA SMGMLRAFLS EVQDTIPVQL VAVTDSQADF FENEAIKELM
910 920 930 940 950
TEGEHIATEI TAKFTALYSL SQYHRQTEVF TLFFSDVLEK KNMIENSYLS
960 970 980 990 1000
DNTRESTHQS EDVFLPSPRD CFPYNNYPDS DDDTEAPPPY SPIGDDVQLL
1010 1020 1030 1040 1050
PTPSDRSRYR LDLEGNEYPV HSTPNCHDHE RNHKVPPPIK PKPVVPKTNV
1060 1070 1080 1090 1100
KKLDPNLLKT IEAGIGKNPR KQTSRVPLAH PEDMDSSDNY AEPLDTIFKQ
1110 1120 1130 1140 1150
KGYPDEIYVV PDDSQNRIIK IRNSFVNNTQ GDEENGFSDR TSKGHGERRP
1160 1170 1180 1190 1200
SKYKYKSKTL FSKAKSYYRR THSDASDDEA FPTSKTKRKG RHRGSEEDPL
1210 1220 1230 1240
LSPVETWKGG IDNPAITSDQ EVDDKKIKKK PHKVKEDKKG FVSKG
Length:1,245
Mass (Da):142,758
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i40728811B86B2E31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2K7N9A0A0G2K7N9_RAT
Rho GTPase-activating protein 5
Arhgap5 rCG_61384
1,503Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07064283 Genomic DNA No translation available.
AY387084 mRNA Translation: AAQ91054.1

NCBI Reference Sequences

More...
RefSeqi
NP_001041334.1, NM_001047869.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000041373; ENSRNOP00000047384; ENSRNOG00000004696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
299012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:299012

UCSC genome browser

More...
UCSCi
RGD:1308507, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07064283 Genomic DNA No translation available.
AY387084 mRNA Translation: AAQ91054.1
RefSeqiNP_001041334.1, NM_001047869.1

3D structure databases

SMRiQ6TUE6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047384

Genome annotation databases

EnsembliENSRNOT00000041373; ENSRNOP00000047384; ENSRNOG00000004696
GeneIDi299012
KEGGirno:299012
UCSCiRGD:1308507, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
394
RGDi1308507, Arhgap5

Phylogenomic databases

eggNOGiKOG4271, Eukaryota
GeneTreeiENSGT00940000154553
KOiK13709

Gene expression databases

BgeeiENSRNOG00000004696, Expressed in jejunum and 19 other tissues

Family and domain databases

Gene3Di1.10.10.440, 3 hits
InterProiView protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR027417, P-loop_NTPase
IPR039007, pG1
IPR032835, RhoGAP-FF1
IPR039006, RhoGAP_pG2
IPR001806, Small_GTPase
PfamiView protein in Pfam
PF01846, FF, 1 hit
PF00071, Ras, 1 hit
PF16512, RhoGAP-FF1, 1 hit
SMARTiView protein in SMART
SM00441, FF, 4 hits
SUPFAMiSSF52540, SSF52540, 1 hit
SSF81698, SSF81698, 1 hit
PROSITEiView protein in PROSITE
PS51676, FF, 4 hits
PS51852, PG1, 1 hit
PS51853, PG2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6TUE6_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6TUE6
Secondary accession number(s): E9PTJ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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