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Entry version 83 (05 Jun 2019)
Sequence version 2 (16 Aug 2004)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei40For ubiquitin thioesterase activityCurated1
Active sitei151For ubiquitin thioesterase activityCurated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host ISG15 by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Viral immunoevasion, Viral RNA replication
LigandNucleotide-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C87.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 2 domains:
Ubiquitin thioesterase (EC:3.4.19.12)
RNA-directed RNA polymerase (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCrimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri652961 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaNegarnaviricotaPolyploviricotinaEllioviricetesBunyaviralesNairoviridaeOrthonairovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiBos taurus (Bovine) [TaxID: 9913]
Capra hircus (Goat) [TaxID: 9925]
Homo sapiens (Human) [TaxID: 9606]
Hyalomma [TaxID: 34625]
Ovis aries (Sheep) [TaxID: 9940]
Rhipicephalus microplus (Cattle tick) (Boophilus microplus) [TaxID: 6941]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008767 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi40C → A: Loss of deubiquitinating and deISGylase activities. 1 Publication1
Mutagenesisi151H → A: Loss of deubiquitinating and deISGylase activities; when associated with Ala-40. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003960801 – 3945RNA-directed RNA polymerase LAdd BLAST3945

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6TQR6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ISG15P051615EBI-4403908,EBI-746466From Homo sapiens.

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60307N

Protein interaction database and analysis system

More...
IntActi
Q6TQR6, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

13945
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6TQR6

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6TQR6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 158OTUPROSITE-ProRule annotationAdd BLAST130
Domaini2342 – 2551RdRp catalyticPROSITE-ProRule annotationAdd BLAST210

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 186Poly-Ser4
Compositional biasi2698 – 2745Ser-richAdd BLAST48

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The OTU domain is responsible for the deubiquitinating and deISGylation activities of Nsp2.Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nairovirus RNA polymerase family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain-like_cys_pep_sf
IPR015843 RNA-dir_pol_nairovirus
IPR007099 RNA-dir_pol_NSvirus
IPR007322 RNA_pol_bunyavir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF02338 OTU, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036900 RdRPol_NRV, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50802 OTU, 1 hit
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6TQR6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFLRSLDWT QVIAGQYVSN PRFNISDYFE IVRQPGDGNC FYHSIAELTM
60 70 80 90 100
PNKTDHSYHY IKRLTESAAR KYYQEEPEAR LVGLSLEDYL KRMLSDNEWG
110 120 130 140 150
STLEASMLAK EMGITIIIWT VAASDEVEAG IKFGDGDVFT AVNLLHSGQT
160 170 180 190 200
HFDALRILPQ FETDTREALS LMDRVIAVDQ LTSSSSDELQ DYEDLALALT
210 220 230 240 250
SAEESNRRSS LDEVTLSKKQ AEILRQKASQ LSKLVNKSQN IPTRVGRVLD
260 270 280 290 300
CMFNCKLCVE ISADTLILRP ESKEKIGEIM SLRQLGHKLL TRDKQIKQEF
310 320 330 340 350
SRMKLYVTKD LLDHLDVGGL LRAAFPGTGI ERHMQLLHSE MILDICTVSL
360 370 380 390 400
GVMLSTFLYG SNNKNKKKFI TNCLLSTALS GKKVYKVLGN LGNELLYKAP
410 420 430 440 450
RKALATVCSA LFGKQINKLQ NCFRTISPVS LLALRNLDFD CLSVQDYNGM
460 470 480 490 500
IENMSKLDNT DVEFNHREIA DLNQLTSRLI TLRKEKDTDL LKQWFPESDL
510 520 530 540 550
TRRSIRNAAN AEEFVISEFF KKKDIMKFIS TSGRAMSAGK IGNVLSYAHN
560 570 580 590 600
LYLSKSSLNM TSEDISQLLI EIKRLYALQE DSEVEPIAII CDGIESNMKQ
610 620 630 640 650
LFAILPPDCA RECEVLFDDI RNSPTHSTAW KHALRLKGTA YEGLFANCYG
660 670 680 690 700
WQYIPEDIKP SLTMLIQTLF PDKFEDFLDR TQLHPEFRDL TPDFSLTQKV
710 720 730 740 750
HFKRNQIPSV ENVQISIDAT LPESVEAVPV TERKMFPLPE TPLSEVHSIE
760 770 780 790 800
RIMENFTRLM HGGRLSTKKR DGDPAEQGNQ QSITEHESSS ISAFKDYGER
810 820 830 840 850
GIVEENHMKF SGEDQLETRQ LLLVEVGFQT DIDGKIRTDH KKWKDILKLL
860 870 880 890 900
ELLGIKCSFI ACADCSSTPP DRWWITEDRV RVLKNSVSFL FNKLSRNSPT
910 920 930 940 950
EVTDIVVGAI STQKVRSYLK AGTATKTPVS TKDVLETWEK MKEHILNRPT
960 970 980 990 1000
GLTLPTSLEQ AMRKGLVEGV VISKEGSESC INMLKENLDR ITDEFERTKF
1010 1020 1030 1040 1050
KHELTQNITT SEKMLLSWLS EDIKSSRCGE CLSNIKKAVD ETANLSGKIE
1060 1070 1080 1090 1100
LLAYNLQLTN HCSNCHPNGV NISNTSNVCK RCPKIEVVSH CENKGFEDSN
1110 1120 1130 1140 1150
ECLTDLDRLV RLTLPGKTEK ERRVKRNVEY LIKLMMSMSG IDCIKYPTGQ
1160 1170 1180 1190 1200
LITHGRVSAK HNDGNLKDRS DDDQRLAEKI DTVRKELSES KLKDYSTYAR
1210 1220 1230 1240 1250
GVISNSLKNL SRQGKSKCSV PRSWLEKVLF DLKVPTKDEE VLINIRNSLK
1260 1270 1280 1290 1300
ARSEFVRNND KLLIRSKEEL KKCFDVQSFK LKKNKQPVPF QVDCILFKEV
1310 1320 1330 1340 1350
AAECMKRYIG TPYEGIVDTL VSLINVLTRF TWFQEVVLYG KICETFLRCC
1360 1370 1380 1390 1400
TEFNRSGVKL VKIRHCNINL SVKLPSNKKE NMLCCLYSGN MELLQGPFYL
1410 1420 1430 1440 1450
NRRQAVLGSS YLYIVITLYI QVLQQYRCLE VINSVSEKTL QDIENHSMTL
1460 1470 1480 1490 1500
LEDSFREITF ALEGRFEESY KIRTSRCRAS GNFLNRSSRD HFISVVSGLN
1510 1520 1530 1540 1550
LVYGFLIKDN LLANSQQQNK QLQMLRFGML AGLSRLVCPN ELGKKFSTSC
1560 1570 1580 1590 1600
RRIEDNIARL YLQTSIYCSV RDVEDNVKHW KQRDLCPEVT IPCFTVYGTF
1610 1620 1630 1640 1650
VNSDRQLIFD IYNVHIYNKE MDNFDEGCIS VLEETAERHM LWELDLMNSL
1660 1670 1680 1690 1700
CSDEKKDTRP ARLLLGCPNV RKAATREGKK LLKLNSDTST DTQSIASEVS
1710 1720 1730 1740 1750
DRRSYSSSKS RIRSIFGRYN SQKKPFELRS GLEVFNDPFN DYQQAITDIC
1760 1770 1780 1790 1800
QFSEYTPNKE SILKDCLQII RKNPSHTMGS FELIQAISEF GMSKFPPENI
1810 1820 1830 1840 1850
DKARRDPKNW VSISEVTETT SIVASPRTHM MLKDCFKIIL GTENKKIVKM
1860 1870 1880 1890 1900
LRGKLKKLGA ISTNIEIGKR DCLDLLSTVD GLTDQQKENI VNGIFEPSKL
1910 1920 1930 1940 1950
SFYHWKELVK KNIDEVLLTE DGNLIFCWLK TISSSVKGSL KKRLKFMNIH
1960 1970 1980 1990 2000
SPELMPENCL FSSEEFNELI KLKKLLLNEQ QDEQELKQDL LISSWIKCIT
2010 2020 2030 2040 2050
ACKDFASIND KIQKFIYHLS EELYDIRLQH LELSKLKQEH PSVSFTKEEV
2060 2070 2080 2090 2100
LIKRLEKNFL KQHNLEIMET VNLVFFAALS APWCLHYKAL ESYLVRHPEI
2110 2120 2130 2140 2150
LDCGSKEDCK LTLLDLSVSK LLVCLYQKDD EELINSSSLK LGFLVKYVVT
2160 2170 2180 2190 2200
LFTSNGEPFS LSLNDGGLDL DLHKTTDEKL LHQTKIVFAK IGLSGNSYDF
2210 2220 2230 2240 2250
IWTTQMIANS NFNVCKRLTG RSTGERLPRS VRSKVIYEMV KLVGETGMAI
2260 2270 2280 2290 2300
LQQLAFAQAL NYEHRFYAVL APKAQLGGAR DLLVQETGTK VMHATTEMFS
2310 2320 2330 2340 2350
RNLLKTTSDD GLTNPHLKET ILNVGLDCLA NMRNLDGKPI SEGSNLVNFY
2360 2370 2380 2390 2400
KVICISGDNT KWGPIHCCSF FSGMMQQVLK NVPDWCSFYK LTFIKNLCRQ
2410 2420 2430 2440 2450
VEIPAGSIKK ILNVLRYRLC SKGGVEQHSE EDLRRLLTDN LDSWDGNDTV
2460 2470 2480 2490 2500
KFLVTTYISK GLMALNSYNH MGQGIHHATS SVLTSLAAVL FEELAIFYLK
2510 2520 2530 2540 2550
RSLPQTTVHV EHAGSSDDYA KCIVVTGILS KELYSQYDET FWKHACRLKN
2560 2570 2580 2590 2600
FTAAVQRCCQ MKDSAKTLVS DCFLEFYSEF MMGYRVTPAV IKFMFTGLIN
2610 2620 2630 2640 2650
SSVTSPQSLM QACQVSSQQA MYNSVPLVTN TAFTLLRQQI FFNHVEDFIR
2660 2670 2680 2690 2700
RYGILTLGTL SPFGRLFVPT YSGLVSSAVA LEDAEVIARA AQTLQMNSVS
2710 2720 2730 2740 2750
IQSSSLTTLD SLGRSRTSST AEDSSSVSDT TAASHDSGSS SSSFSFELNR
2760 2770 2780 2790 2800
PLSETELQFI KALSSLKSTQ ACEVIQNRIT GLYCNSNEGP LDRHNVIYSS
2810 2820 2830 2840 2850
RMADSCDWLK DGKRRGNLEL ANRIQSVLCI LIAGYYRSFG GEGTEKQVKA
2860 2870 2880 2890 2900
SLNRDDNKII EDPMIQLIPE KLRRELERLG VSRMEVDELM PSISPDDTLA
2910 2920 2930 2940 2950
QLVAKKLISL NVSTEEYSAE VSRLKQTLTA RNVLHGLAGG IKELSLPIYT
2960 2970 2980 2990 3000
IFMKSYFFKD NVFLSLTDRW STKHSTNYRD SCGKQLKGRI ITKYTHWLDT
3010 3020 3030 3040 3050
FLGCSVSINR HTTVKEPSLF NPNIRCVNLI TFEDGLRELS VIQSHLKVFE
3060 3070 3080 3090 3100
NEFTNLNLQF SDPNRQKLRI VESRPAESEL EANRAVIVKT KLFSATEQVR
3110 3120 3130 3140 3150
LSNNPAVVMG YLLDESAISE VKPTKVDFSN LLKDRFKIMQ FFPSVFTLIK
3160 3170 3180 3190 3200
MLTDESSDSE KSGLSPDLQQ VARYSNHLTL LSRMIQQAKP TVTVFYMLKG
3210 3220 3230 3240 3250
NLMNTEPTVA ELVSYGIKEG RFFRLSDTGV DASTYSVKYW KILHCISAIG
3260 3270 3280 3290 3300
CLPLSQADKS SLLMSFLNWR VNMDIRTSDC PLSSHEASIL SEFDGQVIAN
3310 3320 3330 3340 3350
ILASELSSVK RDSEREGLTD LLDYLNSPTE LLKKKPYLGT TCKFNTWGDS
3360 3370 3380 3390 3400
NRSGKFTYSS RSGESIGIFI AGKLHIHLSS ESVALLCETE RQVLSWMSKR
3410 3420 3430 3440 3450
RTEVITKEQH QLFLSLLPQS HECLQKHKDG SALSVIPDSS NPRLLKFVPL
3460 3470 3480 3490 3500
KKGLAVVKIK KQILTVKKQV VFDAESEPRL QWGHGCLSIV YDETDTQTTY
3510 3520 3530 3540 3550
HENLLKVKHL VDCSTDRKKL LPQSVFSDSK VVLSRIKFKT ELLLNSLTLL
3560 3570 3580 3590 3600
HCFLKHAPSD AIMEVESKSS LLHKYLKSGG VRQRNTEVLF REKLNKVVIK
3610 3620 3630 3640 3650
DNLEQGVEEE IEFCNNLTKT VSENPLPLSC WSEVQNYIED IGFNNVLVNI
3660 3670 3680 3690 3700
DRNTVKSELL WKFTLDTNVS TTSTIKDVRT LVSYVSTETI PKFLLAFLLY
3710 3720 3730 3740 3750
EEVLMNLINQ CKAVKELINS TGLSDLELES LLTLCAFYFQ SECSKRDGPR
3760 3770 3780 3790 3800
CSFAALLSLI HEDWQRIGKN ILVRANNELG DVSLKVNIVL VPLKDMSKPK
3810 3820 3830 3840 3850
SERVVMARRS LNHALSLMFL DEMSLPELKS LSVNCKMGNF EGQECFEFTI
3860 3870 3880 3890 3900
LKDNSARLDY NKLIDHCVDM EKKREAVRAV EDLILMLTGR AVKPSAVTQF
3910 3920 3930 3940
VHGDEQCQEQ ISLDDLMAND TVTDFPDREA EALKTGNLGF NWDSD
Length:3,945
Mass (Da):447,851
Last modified:August 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F95F82432B0DBE1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY389361 Genomic DNA Translation: AAR25663.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY389361 Genomic DNA Translation: AAR25663.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PHUX-ray2.20A/B1-217[»]
3PHWX-ray2.00A/C/E/G1-183[»]
3PHXX-ray1.60A1-183[»]
3ZNHX-ray2.30A1-183[»]
5V5GX-ray2.10A/C1-183[»]
5V5HX-ray1.50A1-169[»]
5V5IX-ray2.20A/C1-169[»]
SMRiQ6TQR6
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-60307N
IntActiQ6TQR6, 1 interactor

Protein family/group databases

MEROPSiC87.001

Proteomic databases

PRIDEiQ6TQR6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiQ6TQR6

Protein Ontology

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PROi
PR:Q6TQR6

Family and domain databases

InterProiView protein in InterPro
IPR003323 OTU_dom
IPR038765 Papain-like_cys_pep_sf
IPR015843 RNA-dir_pol_nairovirus
IPR007099 RNA-dir_pol_NSvirus
IPR007322 RNA_pol_bunyavir
PfamiView protein in Pfam
PF04196 Bunya_RdRp, 1 hit
PF02338 OTU, 1 hit
PIRSFiPIRSF036900 RdRPol_NRV, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50802 OTU, 1 hit
PS50525 RDRP_SSRNA_NEG_SEG, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_CCHFI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6TQR6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 16, 2004
Last modified: June 5, 2019
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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