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UniProtKB - Q6TNR1 (RHPN2_DANRE)

Entry version 87 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Rhophilin-2

Gene

rhpn2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds specifically to GTP-Rho.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DRE-5666185, RHO GTPases Activate Rhotekin and Rhophilins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhophilin-2
Alternative name(s):
GTP-Rho-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rhpn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-030131-9927, rhpn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189001 – 683Rhophilin-2Add BLAST683

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6TNR1

PRoteomics IDEntifications database

More...PRIDEi		Q6TNR1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RhoA.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7955.ENSDARP00000024226

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6TNR1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 100REM-1PROSITE-ProRule annotationAdd BLAST75
Domaini111 – 460BRO1PROSITE-ProRule annotationAdd BLAST350
Domaini515 – 593PDZPROSITE-ProRule annotationAdd BLAST79

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RHPN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2220, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6TNR1

Database of Orthologous Groups

More...OrthoDBi		641122at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6TNR1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.280, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004328, BRO1_dom
IPR038499, BRO1_sf
IPR011072, HR1_rho-bd
IPR036274, HR1_rpt_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03097, BRO1, 1 hit
PF02185, HR1, 1 hit
PF17820, PDZ_6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01041, BRO1, 1 hit
SM00742, Hr1, 1 hit
SM00228, PDZ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46585, SSF46585, 1 hit
SSF50156, SSF50156, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51180, BRO1, 1 hit
PS50106, PDZ, 1 hit
PS51860, REM_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6TNR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDTLIPNGC KSNGPVENGY FKKGCNPFAQ TGRSKLQNKR AVLNQKIIKQ 
        60         70         80         90        100
MRMRAGAENL LKATSNNKVR EQVVLELSYV NSDLQLLMEQ LEGLNSSVEV 
       110        120        130        140        150
YQNVQESSSI PLIPLGLKET KDVDFSVPLK DFILEHYSED GSNFQNQIDD 
       160        170        180        190        200
LMDLRQACRT PSRNNSGVDL IANYFSQLSF LETRFFSPTR QIGIFFTWYD 
       210        220        230        240        250
SFTGMPVCQN NISLEKASML FNMAALYSQI GTRADRQTLA GLEDAIAAFQ 
       260        270        280        290        300
KSARVLHFLK ETFTHTPSYD MSPAMLSMLL RLMLAQAHEC LFEQITLPGI 
       310        320        330        340        350
RNEFFCLLKM AQEAAKVAET YAQVHQSMIE TPITKNVPFF WTTMSQLKIN 
       360        370        380        390        400
HYNSLAHYFV STALLDHQLN PSDDEDKQEK ALSQLYDAMP EGRSPLDILK 
       410        420        430        440        450
NKDERRRIGK AHLQRSIMGH EEAIRTHCRC RHLQKLDILS DILRASLNRS 
       460        470        480        490        500
LTKFEQNDKE DEFTDYMLAP DIISKTEKKA EMEIPAATKV KVTDLFQRLG 
       510        520        530        540        550
PLSVFSAKQR WTAPRTIRLI LQDRDLGFTL KGDAPVQIQS LDPLCPAAAG 
       560        570        580        590        600
GLKEGDYLVA VGDTDCKWMG VSDVMKLLKD VDEEGINIRV VSMMDSSSQP 
       610        620        630        640        650
MATKSATYCG GLSKTYSMIC LAHDEDDKNP KSRKVAKKPS FLSFGLKNKK 
       660        670        680 
SSSTLSLPNA DYSRPWNRPS ANYSNSHHES GLY
Length:683
Mass (Da):77,057
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B459E94D9F380AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QEF4F1QEF4_DANRE
Rhophilin-2
rhpn2
683Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1D5NSD7A0A1D5NSD7_DANRE
Rhophilin-2
rhpn2
289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti254R → G in AAH44556 (Ref. 2) Curated1
Sequence conflicti258F → L in AAH44556 (Ref. 2) Curated1
Sequence conflicti280L → F in AAH44556 (Ref. 2) Curated1
Sequence conflicti288H → Q in AAH44556 (Ref. 2) Curated1
Sequence conflicti430C → R in AAH44556 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY391456 mRNA Translation: AAQ91268.1
BC044556 mRNA Translation: AAH44556.1

NCBI Reference Sequences

More...RefSeqi		NP_957472.1, NM_201178.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		321330

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:321330

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY391456 mRNA Translation: AAQ91268.1
BC044556 mRNA Translation: AAH44556.1
RefSeqiNP_957472.1, NM_201178.1

3D structure databases

SMRiQ6TNR1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024226

Proteomic databases

PaxDbiQ6TNR1
PRIDEiQ6TNR1

Genome annotation databases

GeneIDi321330
KEGGidre:321330

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		85415
ZFINiZDB-GENE-030131-9927, rhpn2

Phylogenomic databases

eggNOGiKOG2220, Eukaryota
InParanoidiQ6TNR1
OrthoDBi641122at2759
PhylomeDBiQ6TNR1

Enzyme and pathway databases

ReactomeiR-DRE-5666185, RHO GTPases Activate Rhotekin and Rhophilins

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q6TNR1

Family and domain databases

Gene3Di1.25.40.280, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR004328, BRO1_dom
IPR038499, BRO1_sf
IPR011072, HR1_rho-bd
IPR036274, HR1_rpt_sf
IPR001478, PDZ
IPR041489, PDZ_6
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF03097, BRO1, 1 hit
PF02185, HR1, 1 hit
PF17820, PDZ_6, 1 hit
SMARTiView protein in SMART
SM01041, BRO1, 1 hit
SM00742, Hr1, 1 hit
SM00228, PDZ, 1 hit
SUPFAMiSSF46585, SSF46585, 1 hit
SSF50156, SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51180, BRO1, 1 hit
PS50106, PDZ, 1 hit
PS51860, REM_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHPN2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6TNR1
Secondary accession number(s): Q803B1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 87 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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