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UniProtKB - Q6TH18 (Q6TH18_DANRE)
Protein
Submitted name:
E2F transcription factor 4, p107/p130-binding
Gene
e2f5
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- anatomical structure development Source: UniProt
- regulation of cell cycle Source: InterPro
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: E2F transcription factor 4, p107/p130-bindingImportedSubmitted name: E2F transcription factor 5 |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030828-3, e2f5 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- RNA polymerase II transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSDARG00000038812, Expressed in testis and 27 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 85 | E2F_TDPInterPro annotationAdd BLAST | 67 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 99 – 133 | Sequence analysisAdd BLAST | 35 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_4_3_1 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6TH18-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAESNSASFP HSTPNGSSRH EKSLGLLTVK FVTLLQEAKD GVLDLKVAAD
60 70 80 90 100
SLAVKQKRRI YDITNVLEGI GLIEKKTKNT IQWKGESTGC QPQEVLEQVE
110 120 130 140
LLKANIADLE LQERELDMQK ACLQQSIKQL NEDPYSCRYP YCQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA5WUE8 | A5WUE8_DANRE | E2F transcription factor 5 | e2f5 | 363 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293515 Genomic DNA No translation available. AY398338 mRNA Translation: AAQ97771.1 |
RefSeqi | NP_991178.1, NM_205615.2 |
Genome annotation databases
Ensembli | ENSDART00000126177.3; ENSDARP00000111176.2; ENSDARG00000038812.8 |
GeneIDi | 402908 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR293515 Genomic DNA No translation available. AY398338 mRNA Translation: AAQ97771.1 |
RefSeqi | NP_991178.1, NM_205615.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000126177.3; ENSDARP00000111176.2; ENSDARG00000038812.8 |
GeneIDi | 402908 |
Organism-specific databases
CTDi | 1875 |
ZFINi | ZDB-GENE-030828-3, e2f5 |
Phylogenomic databases
GeneTreei | ENSGT00940000157353 |
HOGENOMi | CLU_032091_4_3_1 |
Gene expression databases
Bgeei | ENSDARG00000038812, Expressed in testis and 27 other tissues |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR015633, E2F IPR037241, E2F-DP_heterodim IPR028316, E2F5 IPR003316, E2F_WHTH_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR12081, PTHR12081, 1 hit PTHR12081:SF35, PTHR12081:SF35, 1 hit |
Pfami | View protein in Pfam PF02319, E2F_TDP, 1 hit |
SMARTi | View protein in SMART SM01372, E2F_TDP, 1 hit |
SUPFAMi | SSF144074, SSF144074, 1 hit SSF46785, SSF46785, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6TH18_DANRE | |
Accessioni | Q6TH18Primary (citable) accession number: Q6TH18 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |