Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-arginine deiminase type-6

Gene

PADI6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • protein-arginine deiminase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandCalcium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:G66-31585-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.3.15 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3247509 Chromatin modifying enzymes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein-arginine deiminase type-6 (EC:3.5.3.15)
Alternative name(s):
Peptidyl arginine deiminase-like protein
Peptidylarginine deiminase VI
Short name:
hPADVI
Protein-arginine deiminase type VI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PADI6
Synonyms:PAD6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000276747.1

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20449 PADI6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610363 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6TGC4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Preimplantation embryonic lethality 2 (PREMBL2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare cause of female primary infertility. In affected women, ovulation and fertilization proceed normally but embryos are arrested at early stages of development. Inheritance is autosomal recessive.
See also OMIM:617234
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078106211H → Q in PREMBL2. 1 PublicationCorresponds to variant dbSNP:rs775156958EnsemblClinVar.1
Natural variantiVAR_078107540G → R in PREMBL2. 1 PublicationCorresponds to variant dbSNP:rs1057517684Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
353238

MalaCards human disease database

More...
MalaCardsi
PADI6
MIMi617234 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000276747

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134975206

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3638347

Drug and drug target database

More...
DrugBanki
DB00155 L-Citrulline

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PADI6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
408360253

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002200361 – 694Protein-arginine deiminase type-6Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10Phosphoserine1 Publication1
Modified residuei446Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6TGC4

PRoteomics IDEntifications database

More...
PRIDEi
Q6TGC4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
67394

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6TGC4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6TGC4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in oocytes and weakly expressed in other somatic tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000276747 Expressed in 5 organ(s), highest expression level in right ovary

CleanEx database of gene expression profiles

More...
CleanExi
HS_PADI6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434634EBI-10892722,EBI-349968

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6TGC4

Protein interaction database and analysis system

More...
IntActi
Q6TGC4, 5 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6TGC4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DATX-ray1.40B441-449[»]
4DAUX-ray2.00B1-13[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6TGC4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6TGC4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi501 – 504Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein arginine deiminase family.Curated

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154565

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG053016

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6TGC4

KEGG Orthology (KO)

More...
KOi
K01481

Identification of Orthologs from Complete Genome Data

More...
OMAi
YKDTVVF

Database of Orthologous Groups

More...
OrthoDBi
787070at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6TGC4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1700, 1 hit
2.60.40.1860, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10837 PTHR10837, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001247 Protein-arginine_deiminase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6TGC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVEGRAMS FQSIIHLSLD SPVHAVCVLG TEICLDLSGC APQKCQCFTI
60 70 80 90 100
HGSGRVLIDV ANTVISEKED ATIWWPLSDP TYATVKMTSP SPSVDADKVS
110 120 130 140 150
VTYYGPNEDA PVGTAVLYLT GIEVSLEVDI YRNGQVEMSS DKQAKKKWIW
160 170 180 190 200
GPSGWGAILL VNCNPADVGQ QLEDKKTKKV IFSEEITNLS QMTLNVQGPS
210 220 230 240 250
CILKKYRLVL HTSKEESKKA RVYWPQKDNS STFELVLGPD QHAYTLALLG
260 270 280 290 300
NHLKETFYVE AIAFPSAEFS GLISYSVSLV EESQDPSIPE TVLYKDTVVF
310 320 330 340 350
RVAPCVFIPC TQVPLEVYLC RELQLQGFVD TVTKLSEKSN SQVASVYEDP
360 370 380 390 400
NRLGRWLQDE MAFCYTQAPH KTTSLILDTP QAADLDEFPM KYSLSPGIGY
410 420 430 440 450
MIQDTEDHKV ASMDSIGNLM VSPPVKVQGK EYPLGRVLIG SSFYPSAEGR
460 470 480 490 500
AMSKTLRDFL YAQQVQAPVE LYSDWLMTGH VDEFMCFIPT DDKNEGKKGF
510 520 530 540 550
LLLLASPSAC YKLFREKQKE GYGDALLFDE LRADQLLSNG REAKTIDQLL
560 570 580 590 600
ADESLKKQNE YVEKCIHLNR DILKTELGLV EQDIIEIPQL FCLEKLTNIP
610 620 630 640 650
SDQQPKRSFA RPYFPDLLRM IVMGKNLGIP KPFGPQIKGT CCLEEKICCL
660 670 680 690
LEPLGFKCTF INDFDCYLTE VGDICACANI RRVPFAFKWW KMVP
Length:694
Mass (Da):77,727
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5D56D6AFF5CE36AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti487F → S in AAS07634 (PubMed:15625577).Curated1
Sequence conflicti517K → N in AAS07634 (PubMed:15625577).Curated1
Sequence conflicti623M → I in AAR38850 (PubMed:15087120).Curated1
Sequence conflicti686A → T in AAR38850 (PubMed:15087120).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078106211H → Q in PREMBL2. 1 PublicationCorresponds to variant dbSNP:rs775156958EnsemblClinVar.1
Natural variantiVAR_078107540G → R in PREMBL2. 1 PublicationCorresponds to variant dbSNP:rs1057517684Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY443100 mRNA Translation: AAS07634.1
AY422079 mRNA Translation: AAR38850.1
AJ549502 Genomic DNA Translation: CAD70706.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS72715.1

NCBI Reference Sequences

More...
RefSeqi
NP_997304.3, NM_207421.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.531598

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000619609; ENSP00000483125; ENSG00000276747
ENST00000625380; ENSP00000485805; ENSG00000280949

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
353238

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:353238

UCSC genome browser

More...
UCSCi
uc031trf.2 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY443100 mRNA Translation: AAS07634.1
AY422079 mRNA Translation: AAR38850.1
AJ549502 Genomic DNA Translation: CAD70706.1
CCDSiCCDS72715.1
RefSeqiNP_997304.3, NM_207421.4
UniGeneiHs.531598

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4DATX-ray1.40B441-449[»]
4DAUX-ray2.00B1-13[»]
ProteinModelPortaliQ6TGC4
SMRiQ6TGC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ6TGC4
IntActiQ6TGC4, 5 interactors

Chemistry databases

BindingDBiQ6TGC4
ChEMBLiCHEMBL3638347
DrugBankiDB00155 L-Citrulline

PTM databases

iPTMnetiQ6TGC4
PhosphoSitePlusiQ6TGC4

Polymorphism and mutation databases

BioMutaiPADI6
DMDMi408360253

Proteomic databases

PeptideAtlasiQ6TGC4
PRIDEiQ6TGC4
ProteomicsDBi67394

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
353238
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619609; ENSP00000483125; ENSG00000276747
ENST00000625380; ENSP00000485805; ENSG00000280949
GeneIDi353238
KEGGihsa:353238
UCSCiuc031trf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
353238
DisGeNETi353238
EuPathDBiHostDB:ENSG00000276747.1

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PADI6

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0028688
HGNCiHGNC:20449 PADI6
MalaCardsiPADI6
MIMi610363 gene
617234 phenotype
neXtProtiNX_Q6TGC4
OpenTargetsiENSG00000276747
PharmGKBiPA134975206

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154565
HOVERGENiHBG053016
InParanoidiQ6TGC4
KOiK01481
OMAiYKDTVVF
OrthoDBi787070at2759
PhylomeDBiQ6TGC4

Enzyme and pathway databases

BioCyciMetaCyc:G66-31585-MONOMER
BRENDAi3.5.3.15 2681
ReactomeiR-HSA-3247509 Chromatin modifying enzymes

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
353238

Protein Ontology

More...
PROi
PR:Q6TGC4

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000276747 Expressed in 5 organ(s), highest expression level in right ovary
CleanExiHS_PADI6

Family and domain databases

Gene3Di2.60.40.1700, 1 hit
2.60.40.1860, 1 hit
InterProiView protein in InterPro
IPR008972 Cupredoxin
IPR004303 PAD
IPR013530 PAD_C
IPR036556 PAD_central_sf
IPR013732 PAD_N
IPR038685 PAD_N_sf
IPR013733 Prot_Arg_deaminase_cen_dom
PANTHERiPTHR10837 PTHR10837, 1 hit
PfamiView protein in Pfam
PF03068 PAD, 1 hit
PF08527 PAD_M, 1 hit
PF08526 PAD_N, 1 hit
PIRSFiPIRSF001247 Protein-arginine_deiminase, 1 hit
SUPFAMiSSF110083 SSF110083, 1 hit
SSF49503 SSF49503, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPADI6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6TGC4
Secondary accession number(s): Q330K5, Q70SX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 3, 2012
Last modified: January 16, 2019
This is version 123 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again