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Protein

Kelch-like protein 17

Gene

KLHL17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • actin filament binding Source: GO_Central
  • POZ domain binding Source: Ensembl
  • protein-containing complex scaffold activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 17
Alternative name(s):
Actinfilin
Gene namesi
Name:KLHL17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000187961.13
HGNCiHGNC:24023 KLHL17
neXtProtiNX_Q6TDP4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi339451
OpenTargetsiENSG00000187961
PharmGKBiPA134887396

Polymorphism and mutation databases

BioMutaiKLHL17
DMDMi52783052

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191191 – 642Kelch-like protein 17Add BLAST642

Proteomic databases

EPDiQ6TDP4
MaxQBiQ6TDP4
PaxDbiQ6TDP4
PeptideAtlasiQ6TDP4
PRIDEiQ6TDP4
ProteomicsDBi67385

PTM databases

iPTMnetiQ6TDP4
PhosphoSitePlusiQ6TDP4

Expressioni

Gene expression databases

BgeeiENSG00000187961 Expressed in 90 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_KLHL17
ExpressionAtlasiQ6TDP4 baseline and differential
GenevisibleiQ6TDP4 HS

Organism-specific databases

HPAiHPA031251

Interactioni

Subunit structurei

Interacts with F-actin; the interaction disruptes the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi130885, 4 interactors
STRINGi9606.ENSP00000343930

Structurei

3D structure databases

ProteinModelPortaliQ6TDP4
SMRiQ6TDP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 159BTBPROSITE-ProRule annotationAdd BLAST68
Domaini194 – 296BACKAdd BLAST103
Repeati343 – 389Kelch 1Add BLAST47
Repeati390 – 436Kelch 2Add BLAST47
Repeati438 – 483Kelch 3Add BLAST46
Repeati484 – 530Kelch 4Add BLAST47
Repeati532 – 577Kelch 5Add BLAST46
Repeati578 – 624Kelch 6Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni289 – 641Interaction with F-actinBy similarityAdd BLAST353
Regioni640 – 642Interaction with PDZK1By similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 52Pro-richAdd BLAST38

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiQ6TDP4
KOiK10454
OMAiNSWQPEV
OrthoDBiEOG091G04QJ
PhylomeDBiQ6TDP4
TreeFamiTF329218

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR011043 Gal_Oxase/kelch_b-propeller
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030594 KLHL17
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF168 PTHR24412:SF168, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF50965 SSF50965, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6TDP4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQPRSERPAG RTQSPEHGSP GPGPEAPPPP PPQPPAPEAE RTRPRQARPA
60 70 80 90 100
APMEGAVQLL SREGHSVAHN SKRHYHDAFV AMSRMRQRGL LCDIVLHVAA
110 120 130 140 150
KEIRAHKVVL ASCSPYFHAM FTNEMSESRQ THVTLHDIDP QALDQLVQFA
160 170 180 190 200
YTAEIVVGEG NVQTLLPAAS LLQLNGVRDA CCKFLLSQLD PSNCLGIRGF
210 220 230 240 250
ADAHSCSDLL KAAHRYVLQH FVDVAKTEEF MLLPLKQVLE LVSSDSLNVP
260 270 280 290 300
SEEEVYRAVL SWVKHDVDAR RQHVPRLMKC VRLPLLSRDF LLGHVDAESL
310 320 330 340 350
VRHHPDCKDL LIEALKFHLL PEQRGVLGTS RTRPRRCEGA GPVLFAVGGG
360 370 380 390 400
SLFAIHGDCE AYDTRTDRWH VVASMSTRRA RVGVAAVGNR LYAVGGYDGT
410 420 430 440 450
SDLATVESYD PVTNTWQPEV SMGTRRSCLG VAALHGLLYS AGGYDGASCL
460 470 480 490 500
NSAERYDPLT GTWTSVAAMS TRRRYVRVAT LDGNLYAVGG YDSSSHLATV
510 520 530 540 550
EKYEPQVNVW SPVASMLSRR SSAGVAVLEG ALYVAGGNDG TSCLNSVERY
560 570 580 590 600
SPKAGAWESV APMNIRRSTH DLVAMDGWLY AVGGNDGSSS LNSIEKYNPR
610 620 630 640
TNKWVAASCM FTRRSSVGVA VLELLNFPPP SSPTLSVSST SL
Length:642
Mass (Da):69,874
Last modified:July 5, 2004 - v1
Checksum:iFE37BBCCD32131BF
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q0VGE6Q0VGE6_HUMAN
KLHL17 protein
KLHL17 hCG_31732
225Annotation score:
J3QLT4J3QLT4_HUMAN
Kelch-like protein 17
KLHL17
154Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423763 mRNA Translation: AAR03710.1
AL645608 Genomic DNA No translation available.
CCDSiCCDS30550.1
RefSeqiNP_938073.1, NM_198317.2
UniGeneiHs.109212

Genome annotation databases

EnsembliENST00000338591; ENSP00000343930; ENSG00000187961
GeneIDi339451
KEGGihsa:339451
UCSCiuc001aca.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY423763 mRNA Translation: AAR03710.1
AL645608 Genomic DNA No translation available.
CCDSiCCDS30550.1
RefSeqiNP_938073.1, NM_198317.2
UniGeneiHs.109212

3D structure databases

ProteinModelPortaliQ6TDP4
SMRiQ6TDP4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130885, 4 interactors
STRINGi9606.ENSP00000343930

PTM databases

iPTMnetiQ6TDP4
PhosphoSitePlusiQ6TDP4

Polymorphism and mutation databases

BioMutaiKLHL17
DMDMi52783052

Proteomic databases

EPDiQ6TDP4
MaxQBiQ6TDP4
PaxDbiQ6TDP4
PeptideAtlasiQ6TDP4
PRIDEiQ6TDP4
ProteomicsDBi67385

Protocols and materials databases

DNASUi339451
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338591; ENSP00000343930; ENSG00000187961
GeneIDi339451
KEGGihsa:339451
UCSCiuc001aca.3 human

Organism-specific databases

CTDi339451
DisGeNETi339451
EuPathDBiHostDB:ENSG00000187961.13
GeneCardsiKLHL17
HGNCiHGNC:24023 KLHL17
HPAiHPA031251
neXtProtiNX_Q6TDP4
OpenTargetsiENSG00000187961
PharmGKBiPA134887396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00760000118931
HOGENOMiHOG000230814
HOVERGENiHBG014286
InParanoidiQ6TDP4
KOiK10454
OMAiNSWQPEV
OrthoDBiEOG091G04QJ
PhylomeDBiQ6TDP4
TreeFamiTF329218

Enzyme and pathway databases

UniPathwayi
UPA00143

Miscellaneous databases

ChiTaRSiKLHL17 human
GenomeRNAii339451
PROiPR:Q6TDP4

Gene expression databases

BgeeiENSG00000187961 Expressed in 90 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_KLHL17
ExpressionAtlasiQ6TDP4 baseline and differential
GenevisibleiQ6TDP4 HS

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR011043 Gal_Oxase/kelch_b-propeller
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030594 KLHL17
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF168 PTHR24412:SF168, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 6 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 6 hits
SUPFAMiSSF50965 SSF50965, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKLH17_HUMAN
AccessioniPrimary (citable) accession number: Q6TDP4
Secondary accession number(s): Q5SV94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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