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Protein

Membrane progestin receptor delta

Gene

Paqr6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progestin receptor deltaBy similarity
Short name:
mPR deltaBy similarity
Alternative name(s):
Membrane progesterone P4 receptor deltaBy similarity
Membrane progesterone receptor deltaBy similarity
Progesterone and adipoQ receptor family member 6
Progestin and adipoQ receptor family member 6
Progestin and adipoQ receptor family member VIBy similarity
Gene namesi
Name:Paqr6Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1916207 Paqr6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49CytoplasmicSequence analysisAdd BLAST49
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 79ExtracellularSequence analysis9
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 112CytoplasmicSequence analysisAdd BLAST12
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 146ExtracellularSequence analysisAdd BLAST13
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 216CytoplasmicSequence analysisAdd BLAST49
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 257ExtracellularSequence analysisAdd BLAST20
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 291CytoplasmicSequence analysisAdd BLAST13
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 343ExtracellularSequence analysisAdd BLAST31

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188511 – 343Membrane progestin receptor deltaAdd BLAST343

Proteomic databases

PaxDbiQ6TCG5
PRIDEiQ6TCG5

PTM databases

iPTMnetiQ6TCG5
PhosphoSitePlusiQ6TCG5

Expressioni

Gene expression databases

BgeeiENSMUSG00000041423 Expressed in 25 organ(s), highest expression level in cerebellum
CleanExiMM_PAQR6
ExpressionAtlasiQ6TCG5 baseline and differential
GenevisibleiQ6TCG5 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114166

Structurei

3D structure databases

ProteinModelPortaliQ6TCG5
SMRiQ6TCG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000067790
HOVERGENiHBG052505
InParanoidiQ6TCG5
OMAiFDIHQVP
OrthoDBiEOG091G0NO8
PhylomeDBiQ6TCG5
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6TCG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSLKMPQLL RVHQVPRVFW EEGIMSGYRC PTSSALDCVL SSFQMTNETV
60 70 80 90 100
NIWTHFLPTW YFLWRLLALG SPGFRADPYH LPLLVFLLPA CLYPFASCCA
110 120 130 140 150
HTFSSMSPRA RHICYFLDYG ALSLYSLGCA FPYAAYSMPA SWLHSRLHQL
160 170 180 190 200
FVPAAALNSF LCTGLSCYSR FPELEYPGFS KALRTAAFAY PFLFDNLPLF
210 220 230 240 250
YRLRLCWGGA HSCGRDALSS NHGYHLLCAL LSGFLFAARL PERLAPGRFD
260 270 280 290 300
YIGHSHQLFH ICAVLGTHFQ LEAVLADMGS RRAWLAVQEP TLGLGATVAT
310 320 330 340
LSLAVIGNLF IIAAFTASLL RMPGPCPLLQ GSPLEEGLQA KQQ
Length:343
Mass (Da):38,176
Last modified:July 5, 2004 - v1
Checksum:i9B7BBCEAADA02FC2
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z1S5D3Z1S5_MOUSE
MCG8849, isoform CRA_b
Paqr6 mCG_8849
233Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424295 mRNA Translation: AAR08383.1
AK139144 mRNA Translation: BAE23900.1
CCDSiCCDS17471.1
RefSeqiNP_001297526.1, NM_001310597.1
NP_940802.1, NM_198410.3
UniGeneiMm.441486

Genome annotation databases

EnsembliENSMUST00000147991; ENSMUSP00000114166; ENSMUSG00000041423
GeneIDi68957
KEGGimmu:68957
UCSCiuc012crs.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424295 mRNA Translation: AAR08383.1
AK139144 mRNA Translation: BAE23900.1
CCDSiCCDS17471.1
RefSeqiNP_001297526.1, NM_001310597.1
NP_940802.1, NM_198410.3
UniGeneiMm.441486

3D structure databases

ProteinModelPortaliQ6TCG5
SMRiQ6TCG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000114166

PTM databases

iPTMnetiQ6TCG5
PhosphoSitePlusiQ6TCG5

Proteomic databases

PaxDbiQ6TCG5
PRIDEiQ6TCG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000147991; ENSMUSP00000114166; ENSMUSG00000041423
GeneIDi68957
KEGGimmu:68957
UCSCiuc012crs.1 mouse

Organism-specific databases

CTDi79957
MGIiMGI:1916207 Paqr6

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000067790
HOVERGENiHBG052505
InParanoidiQ6TCG5
OMAiFDIHQVP
OrthoDBiEOG091G0NO8
PhylomeDBiQ6TCG5
TreeFamiTF319738

Miscellaneous databases

ChiTaRSiPaqr6 mouse
PROiPR:Q6TCG5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041423 Expressed in 25 organ(s), highest expression level in cerebellum
CleanExiMM_PAQR6
ExpressionAtlasiQ6TCG5 baseline and differential
GenevisibleiQ6TCG5 MM

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR6_MOUSE
AccessioniPrimary (citable) accession number: Q6TCG5
Secondary accession number(s): Q3UTT0, Q8CF56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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