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Protein

Membrane progesterone receptor epsilon

Gene

Paqr9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone.By similarity

Miscellaneous

Non-classical progesterone receptors involved in extranuclear signaling are classified in 2 groups: the class II progestin and adipoQ receptor (PAQR) family (also called mPRs) (PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like heme/steroid-binding protein family (also called MAPRs) (PGRMC1, PGRMC2, NENF and CYB5D2).By similarity

GO - Molecular functioni

  • signaling receptor activity Source: GO_Central
  • steroid binding Source: UniProtKB-KW

Keywordsi

Molecular functionReceptor
LigandLipid-binding, Steroid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane progesterone receptor epsilonBy similarity
Short name:
mPR epsilonBy similarity
Alternative name(s):
Membrane progesterone P4 receptor epsilonBy similarity
Membrane progestin receptor epsilonBy similarity
Progesterone and adipoQ receptor family member 9
Progestin and adipoQ receptor family member 9By similarity
Progestin and adipoQ receptor family member IX
Gene namesi
Name:Paqr9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1922802 Paqr9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 84CytoplasmicSequence analysisAdd BLAST84
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 114ExtracellularSequence analysis9
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 160CytoplasmicSequence analysisAdd BLAST25
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Topological domaini182 – 203ExtracellularSequence analysisAdd BLAST22
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 241CytoplasmicSequence analysisAdd BLAST17
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 299ExtracellularSequence analysisAdd BLAST37
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Topological domaini321 – 341CytoplasmicSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 375ExtracellularSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002188531 – 375Membrane progesterone receptor epsilonAdd BLAST375

Proteomic databases

MaxQBiQ6TCG2
PaxDbiQ6TCG2
PRIDEiQ6TCG2

PTM databases

iPTMnetiQ6TCG2
PhosphoSitePlusiQ6TCG2
SwissPalmiQ6TCG2

Expressioni

Gene expression databases

BgeeiENSMUSG00000064225 Expressed in 163 organ(s), highest expression level in liver
CleanExiMM_PAQR9
GenevisibleiQ6TCG2 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078547

Structurei

3D structure databases

ProteinModelPortaliQ6TCG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ADIPOR family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000115439
HOVERGENiHBG053506
InParanoidiQ6TCG2
OMAiCSYPFAL
OrthoDBiEOG091G0949
TreeFamiTF319738

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit

Sequencei

Sequence statusi: Complete.

Q6TCG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRRLQQRGA GVKGPPASTS RRSHPASASA PRSPPAATTK PLLRWDEVPD
60 70 80 90 100
DFVECFILSG YRRLPCTAQE CLASVLKPTN ETLNFWTHFI PLLLFLSKFC
110 120 130 140 150
RLFFLGGSDV PFHHPWLLPL WCYASGVLLT FAMSCTAHVF SCLSLRLRAA
160 170 180 190 200
FFYLDYASIS YYGFGSTVAY YYYLLPSLSL LDARVMTPYV QQRLGWHVDC
210 220 230 240 250
TRLIAVYRAL VLPVAFVLAV ACTVACCKSR TDWCSYPFAL RTFVFVMPLS
260 270 280 290 300
MACPIMLESW LFDLRGENPT LFVHFYRRYF WLVVAAFFNV SKIPERIQPG
310 320 330 340 350
LFDIIGHSHQ LFHIFTFLSI YDQVYYVEEG LRQFLQAPPA APTFSGTVGY
360 370
MLLLVVCLGL VIRKFLNSTE FCSKK
Length:375
Mass (Da):42,741
Last modified:June 28, 2011 - v2
Checksum:i673047F8770A3D02
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35P → S in AAR08386 (PubMed:16044242).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424298 mRNA Translation: AAR08386.1
AK133021 mRNA Translation: BAE21473.1
CCDSiCCDS23409.1
RefSeqiNP_940806.2, NM_198414.2
UniGeneiMm.151485

Genome annotation databases

EnsembliENSMUST00000079597; ENSMUSP00000078547; ENSMUSG00000064225
GeneIDi75552
KEGGimmu:75552
UCSCiuc009rbf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY424298 mRNA Translation: AAR08386.1
AK133021 mRNA Translation: BAE21473.1
CCDSiCCDS23409.1
RefSeqiNP_940806.2, NM_198414.2
UniGeneiMm.151485

3D structure databases

ProteinModelPortaliQ6TCG2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078547

PTM databases

iPTMnetiQ6TCG2
PhosphoSitePlusiQ6TCG2
SwissPalmiQ6TCG2

Proteomic databases

MaxQBiQ6TCG2
PaxDbiQ6TCG2
PRIDEiQ6TCG2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079597; ENSMUSP00000078547; ENSMUSG00000064225
GeneIDi75552
KEGGimmu:75552
UCSCiuc009rbf.1 mouse

Organism-specific databases

CTDi344838
MGIiMGI:1922802 Paqr9

Phylogenomic databases

eggNOGiKOG0748 Eukaryota
COG1272 LUCA
GeneTreeiENSGT00530000062965
HOGENOMiHOG000115439
HOVERGENiHBG053506
InParanoidiQ6TCG2
OMAiCSYPFAL
OrthoDBiEOG091G0949
TreeFamiTF319738

Miscellaneous databases

PROiPR:Q6TCG2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064225 Expressed in 163 organ(s), highest expression level in liver
CleanExiMM_PAQR9
GenevisibleiQ6TCG2 MM

Family and domain databases

InterProiView protein in InterPro
IPR004254 AdipoR/HlyIII-related
PANTHERiPTHR20855 PTHR20855, 1 hit
PfamiView protein in Pfam
PF03006 HlyIII, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAQR9_MOUSE
AccessioniPrimary (citable) accession number: Q6TCG2
Secondary accession number(s): Q3V0N1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: June 28, 2011
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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