UniProtKB - Q6TA25 (FGOP2_RAT)
Protein
FGFR1 oncogene partner 2 homolog
Gene
Fgfr1op2
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in wound healing pathway underlying the favorable early wound closure characteristics of oral mucosa. Accelerates the collagen gel contraction in vitro.1 Publication
GO - Molecular functioni
- identical protein binding Source: RGD
GO - Biological processi
- response to wounding Source: RGD
- wound healing Source: RGD
Names & Taxonomyi
Protein namesi | Recommended name: FGFR1 oncogene partner 2 homologAlternative name(s): Wound-inducible transcript 3.0 protein Short name: Wit3.0 |
Gene namesi | Name:Fgfr1op2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1303233, Fgfr1op2 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299044 | 1 – 253 | FGFR1 oncogene partner 2 homologAdd BLAST | 253 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 140 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6TA25 |
PRIDEi | Q6TA25 |
PTM databases
iPTMneti | Q6TA25 |
PhosphoSitePlusi | Q6TA25 |
Expressioni
Inductioni
By wound, in oral mucosa undergoing tooth extraction.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000001811, Expressed in brain and 21 other tissues |
Genevisiblei | Q6TA25, RN |
Interactioni
GO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000039568 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 5 – 104 | Sequence analysisAdd BLAST | 100 | |
Coiled coili | 160 – 223 | Sequence analysisAdd BLAST | 64 |
Sequence similaritiesi
Belongs to the SIKE family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QSAD, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q6TA25 |
OMAi | DHENTAD |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q6TA25 |
TreeFami | TF324337 |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q6TA25-1) [UniParc]FASTAAdd to basket
Also known as: Beta
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCTIEKALA DAKALVERLR DHDDAAESLI EQTTALSKRV EAMKQYQEEI
60 70 80 90 100
QELNEVARHR PRSTLVMGIQ QENRQIRELQ QENKELRTSL EEHQSALELI
110 120 130 140 150
MSKYREQMFR LLMASKKDDP GIIMKLKEQH SKIDMVHRNS CEGFFLDASR
160 170 180 190 200
HILEAPQHGL ERRHLEANQN ELQAHVDQIT EMAAVMRKAI EIDEQQGCKE
210 220 230 240 250
QERIFQLEQE NKGLREILQI TRESFLNLRK DDASESTSLS ALVTNSDLSL
RKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 | L → F in AAR20448 (PubMed:12097305).Curated | 1 | |
Sequence conflicti | 79 | L → F in AAR20449 (PubMed:12097305).Curated | 1 | |
Sequence conflicti | 202 | E → Q in AAR20448 (PubMed:12097305).Curated | 1 | |
Sequence conflicti | 202 | E → Q in AAR20449 (PubMed:12097305).Curated | 1 | |
Sequence conflicti | 229 | R → Q in AAR20448 (PubMed:12097305).Curated | 1 | |
Sequence conflicti | 229 | R → Q in AAR20449 (PubMed:12097305).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027542 | 133 – 170 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY426739 mRNA Translation: AAR20448.1 AY426740 mRNA Translation: AAR20449.1 BC087696 mRNA Translation: AAH87696.1 |
RefSeqi | NP_958824.1, NM_201421.1 XP_006237750.1, XM_006237688.2 [Q6TA25-2] |
Genome annotation databases
Ensembli | ENSRNOT00000002476; ENSRNOP00000002476; ENSRNOG00000001811 [Q6TA25-2] ENSRNOT00000042270; ENSRNOP00000039568; ENSRNOG00000001811 [Q6TA25-1] |
GeneIDi | 362463 |
KEGGi | rno:362463 |
UCSCi | RGD:1303233, rat [Q6TA25-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY426739 mRNA Translation: AAR20448.1 AY426740 mRNA Translation: AAR20449.1 BC087696 mRNA Translation: AAH87696.1 |
RefSeqi | NP_958824.1, NM_201421.1 XP_006237750.1, XM_006237688.2 [Q6TA25-2] |
3D structure databases
SMRi | Q6TA25 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000039568 |
PTM databases
iPTMneti | Q6TA25 |
PhosphoSitePlusi | Q6TA25 |
Proteomic databases
PaxDbi | Q6TA25 |
PRIDEi | Q6TA25 |
Genome annotation databases
Ensembli | ENSRNOT00000002476; ENSRNOP00000002476; ENSRNOG00000001811 [Q6TA25-2] ENSRNOT00000042270; ENSRNOP00000039568; ENSRNOG00000001811 [Q6TA25-1] |
GeneIDi | 362463 |
KEGGi | rno:362463 |
UCSCi | RGD:1303233, rat [Q6TA25-1] |
Organism-specific databases
CTDi | 26127 |
RGDi | 1303233, Fgfr1op2 |
Phylogenomic databases
eggNOGi | ENOG502QSAD, Eukaryota |
GeneTreei | ENSGT00390000018003 |
HOGENOMi | CLU_073167_1_0_1 |
InParanoidi | Q6TA25 |
OMAi | DHENTAD |
OrthoDBi | 1368908at2759 |
PhylomeDBi | Q6TA25 |
TreeFami | TF324337 |
Miscellaneous databases
PROi | PR:Q6TA25 |
Gene expression databases
Bgeei | ENSRNOG00000001811, Expressed in brain and 21 other tissues |
Genevisiblei | Q6TA25, RN |
Family and domain databases
InterProi | View protein in InterPro IPR008555, SIKE |
PANTHERi | PTHR12186, PTHR12186, 1 hit |
Pfami | View protein in Pfam PF05769, SIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGOP2_RAT | |
Accessioni | Q6TA25Primary (citable) accession number: Q6TA25 Secondary accession number(s): Q5PPH1, Q6TA26 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | August 21, 2007 | |
Last modified: | October 7, 2020 | |
This is version 90 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families