Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Disintegrin gabonin-1

Gene
N/A
Organism
Bitis gabonica (Gaboon adder) (Gaboon viper)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The heterodimer bitisgabonin-1 is a potent inhibitor of the adhesion of the RGD-dependent integrin alpha-5/beta-1 (ITGA5/ITGB1) to immobilized fibronectin.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin gabonin-1
Alternative name(s):
Bitisgabonin-1
OrganismiBitis gabonica (Gaboon adder) (Gaboon viper)
Taxonomic identifieri8694 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeBitis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000032188021 – 471 PublicationAdd BLAST27
ChainiPRO_000032188148 – 128Disintegrin gabonin-1Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 76PROSITE-ProRule annotation
Disulfide bondi54Interchain (with C-265 in bitisgabonin)PROSITE-ProRule annotation
Disulfide bondi59Interchain (with C-270 in bitisgabonin)PROSITE-ProRule annotation
Disulfide bondi67 ↔ 73PROSITE-ProRule annotation
Disulfide bondi72 ↔ 97PROSITE-ProRule annotation
Disulfide bondi85 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Interactioni

Subunit structurei

Heterodimer with bitisgabonin (bitisgabonin-1 is the name of the heterodimer); disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6T6T3
SMRiQ6T6T3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 112DisintegrinPROSITE-ProRule annotationAdd BLAST66

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi89 – 91Cell attachment site3

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG051359

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6T6T3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQVLLVIIC LAVFPYQGSS IILESGNVND YEIVYPKKVT VLPTGAMNSA
60 70 80 90 100
HPCCDPVTCK PKRGEHCISG PCCRNCKFLN AGTICKRGRG DSLHDYCTGV
110 120
TPDCPRNPNK GESDELEWSA AATGSVLM
Length:128
Mass (Da):13,792
Last modified:July 5, 2004 - v1
Checksum:iD283972AA0FB58EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY430404 mRNA Translation: AAR24528.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY430404 mRNA Translation: AAR24528.1

3D structure databases

ProteinModelPortaliQ6T6T3
SMRiQ6T6T3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051359

Family and domain databases

Gene3Di4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
PfamiView protein in Pfam
PF00200 Disintegrin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDID1_BITGA
AccessioniPrimary (citable) accession number: Q6T6T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again