UniProtKB - Q6T423 (S22AP_HUMAN)
Protein
Solute carrier family 22 member 25
Gene
SLC22A25
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- organic anion transport Source: GO_Central
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q6T423 |
Protein family/group databases
TCDBi | 2.A.1.19.33, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 22 member 25Alternative name(s): Organic anion transporter UST6 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196600.12 |
HGNCi | HGNC:32935, SLC22A25 |
MIMi | 610792, gene |
neXtProti | NX_Q6T423 |
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 10 – 30 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 145 | ExtracellularSequence analysisAdd BLAST | 115 | |
Transmembranei | 146 – 166 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 167 – 177 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 178 – 198 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 204 | ExtracellularSequence analysis | 6 | |
Transmembranei | 205 – 225 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 226 – 234 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 235 – 255 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 256 – 259 | ExtracellularSequence analysis | 4 | |
Transmembranei | 260 – 280 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 281 – 349 | CytoplasmicSequence analysisAdd BLAST | 69 | |
Transmembranei | 350 – 370 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 371 – 377 | ExtracellularSequence analysis | 7 | |
Transmembranei | 378 – 398 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 399 – 406 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 407 – 427 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 428 – 434 | ExtracellularSequence analysis | 7 | |
Transmembranei | 435 – 455 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 456 – 470 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 471 – 491 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 492 – 494 | ExtracellularSequence analysis | 3 | |
Transmembranei | 495 – 515 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 516 – 547 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 387601 |
OpenTargetsi | ENSG00000196600 |
PharmGKBi | PA162403567 |
Miscellaneous databases
Pharosi | Q6T423, Tdark |
Polymorphism and mutation databases
BioMutai | SLC22A25 |
DMDMi | 296452891 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328926 | 1 – 547 | Solute carrier family 22 member 25Add BLAST | 547 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 56 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | Q6T423 |
PaxDbi | Q6T423 |
PeptideAtlasi | Q6T423 |
PRIDEi | Q6T423 |
ProteomicsDBi | 67366 |
PTM databases
GlyGeni | Q6T423, 2 sites |
iPTMneti | Q6T423 |
PhosphoSitePlusi | Q6T423 |
Expressioni
Tissue specificityi
Expressed exclusively in liver in both embryo and adult.1 Publication
Gene expression databases
Bgeei | ENSG00000196600, Expressed in right lobe of liver and 36 other tissues |
ExpressionAtlasi | Q6T423, baseline and differential |
Organism-specific databases
HPAi | ENSG00000196600, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 132365, 1 interactor |
STRINGi | 9606.ENSP00000307443 |
Miscellaneous databases
RNActi | Q6T423, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000167143 |
HOGENOMi | CLU_001265_33_3_1 |
InParanoidi | Q6T423 |
OMAi | APWALNH |
OrthoDBi | 464838at2759 |
PhylomeDBi | Q6T423 |
TreeFami | TF315847 |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q6T423-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFQDLLDQV GGLGRFQILQ MVFLIMFNVI VYHQTQLENF AAFILDHRCW
60 70 80 90 100
VHILDNDTIP DNDPGTLSQD ALLRISIPFD SNLRPEKCRR FVHPQWKLIH
110 120 130 140 150
LNGTFPNTSE PDTEPCVDGW VYDQSSFPST IVTKWDLVCE SQPLNSVAKF
160 170 180 190 200
LFMAGMMVGG NLYGHLSDRF GRKFVLRWSY LQLAIVGTCA AFAPTILVYC
210 220 230 240 250
SLRFLAGAAT FSIIVNTVLL IVEWITHQFC AMALTLTLCA ASIGHITLGS
260 270 280 290 300
LAFVIRDQCI LQLVMSAPCF VFFLFSRWLA ESARWLIINN KPEEGLKELR
310 320 330 340 350
KAAHRNGMKN AEDILTMEVL KSTMKQELEA AQKKHSLCEL LRIPNICKRI
360 370 380 390 400
CFLSFVRFAS TIPFWGLTLH LQHLGNNVFL LQTLFGAVTL LANCVAPWAL
410 420 430 440 450
NHMSRRLSQM LLMFLLATCL LAIIFVPQEM QTLRVVLATL GVGAASLGIT
460 470 480 490 500
CSTAQENELI PSIIRGRATG ITGNFANIGG ALASLMMILS IYSRPLPWII
510 520 530 540
YGVFAILSGL VVLLLPETRN QPLLDSIQDV ENEGVNSLAA PQRSSVL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCS4 | H0YCS4_HUMAN | Solute carrier family 22 member 25 | SLC22A25 | 399 | Annotation score: | ||
E9PJ86 | E9PJ86_HUMAN | Solute carrier family 22 member 25 | SLC22A25 | 156 | Annotation score: | ||
H0YCA2 | H0YCA2_HUMAN | Solute carrier family 22 member 25 | SLC22A25 | 202 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057783 | 89 | R → C. Corresponds to variant dbSNP:rs35722529Ensembl. | 1 | |
Natural variantiVAR_042576 | 250 | S → G1 PublicationCorresponds to variant dbSNP:rs11231409Ensembl. | 1 | |
Natural variantiVAR_042577 | 300 | R → T1 PublicationCorresponds to variant dbSNP:rs11231397Ensembl. | 1 | |
Natural variantiVAR_057784 | 448 | G → A. Corresponds to variant dbSNP:rs17157907Ensembl. | 1 | |
Natural variantiVAR_060287 | 486 | M → V2 PublicationsCorresponds to variant dbSNP:rs6591771Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY437532 mRNA Translation: AAR84082.1 AP001880 Genomic DNA No translation available. AP003420 Genomic DNA No translation available. BC101316 mRNA Translation: AAI01317.1 |
CCDSi | CCDS31592.1 |
RefSeqi | NP_955384.3, NM_199352.3 XP_016873176.1, XM_017017687.1 |
Genome annotation databases
Ensembli | ENST00000306494; ENSP00000307443; ENSG00000196600 |
GeneIDi | 387601 |
KEGGi | hsa:387601 |
UCSCi | uc001nwr.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY437532 mRNA Translation: AAR84082.1 AP001880 Genomic DNA No translation available. AP003420 Genomic DNA No translation available. BC101316 mRNA Translation: AAI01317.1 |
CCDSi | CCDS31592.1 |
RefSeqi | NP_955384.3, NM_199352.3 XP_016873176.1, XM_017017687.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132365, 1 interactor |
STRINGi | 9606.ENSP00000307443 |
Protein family/group databases
TCDBi | 2.A.1.19.33, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q6T423, 2 sites |
iPTMneti | Q6T423 |
PhosphoSitePlusi | Q6T423 |
Polymorphism and mutation databases
BioMutai | SLC22A25 |
DMDMi | 296452891 |
Proteomic databases
MassIVEi | Q6T423 |
PaxDbi | Q6T423 |
PeptideAtlasi | Q6T423 |
PRIDEi | Q6T423 |
ProteomicsDBi | 67366 |
Protocols and materials databases
Antibodypediai | 51271, 38 antibodies |
DNASUi | 387601 |
Genome annotation databases
Ensembli | ENST00000306494; ENSP00000307443; ENSG00000196600 |
GeneIDi | 387601 |
KEGGi | hsa:387601 |
UCSCi | uc001nwr.2, human |
Organism-specific databases
CTDi | 387601 |
DisGeNETi | 387601 |
EuPathDBi | HostDB:ENSG00000196600.12 |
GeneCardsi | SLC22A25 |
HGNCi | HGNC:32935, SLC22A25 |
HPAi | ENSG00000196600, Tissue enriched (liver) |
MIMi | 610792, gene |
neXtProti | NX_Q6T423 |
OpenTargetsi | ENSG00000196600 |
PharmGKBi | PA162403567 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00940000167143 |
HOGENOMi | CLU_001265_33_3_1 |
InParanoidi | Q6T423 |
OMAi | APWALNH |
OrthoDBi | 464838at2759 |
PhylomeDBi | Q6T423 |
TreeFami | TF315847 |
Enzyme and pathway databases
PathwayCommonsi | Q6T423 |
Miscellaneous databases
BioGRID-ORCSi | 387601, 31 hits in 838 CRISPR screens |
ChiTaRSi | SLC22A25, human |
GeneWikii | SLC22A25 |
GenomeRNAii | 387601 |
Pharosi | Q6T423, Tdark |
PROi | PR:Q6T423 |
RNActi | Q6T423, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196600, Expressed in right lobe of liver and 36 other tissues |
ExpressionAtlasi | Q6T423, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011701, MFS IPR020846, MFS_dom IPR036259, MFS_trans_sf |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit |
SUPFAMi | SSF103473, SSF103473, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S22AP_HUMAN | |
Accessioni | Q6T423Primary (citable) accession number: Q6T423 Secondary accession number(s): A4FU27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations