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Protein

Mastermind-like protein 1

Gene

Maml1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processNotch signaling pathway, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-2197563 NOTCH2 intracellular domain regulates transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-8941856 RUNX3 regulates NOTCH signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mastermind-like protein 1
Short name:
Mam-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Maml1Imported
Synonyms:Kiaa0200Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1890504 Maml1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001294941 – 1020Mastermind-like protein 1Add BLAST1020

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei45PhosphoserineBy similarity1
Modified residuei127PhosphoserineCombined sources1
Modified residuei310PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei367PhosphoserineBy similarity1
Modified residuei827N6-acetyllysineBy similarity1
Modified residuei1019PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6T264

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6T264

PRoteomics IDEntifications database

More...
PRIDEi
Q6T264

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6T264

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6T264

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

At E9.5, strongly expressed in the telencephalon, first branchial arch, forelimb buds and somites. By E10.5, continuously expressed in brain and spinal cord. Also expressed in first and second branchial arches and limb buds. By E11.5, expression in CNS is weak but increases in mesodermal tissues. At E14.5, detected in epithelial cells in trachea, esophagus and proximal and distal tubules of the developing lungs.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000050567 Expressed in 253 organ(s), highest expression level in skin of back

CleanEx database of gene expression profiles

More...
CleanExi
MM_MAML1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6T264 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6T264 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via N-terminus) with NOTCH1, NOTCH2, NOTCH3 and NOTCH4 (via ankyrin repeat region). Interacts (via N-terminus) with p53 (via DNA-binding region). Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa/CBF1. Also binds CREBBP/CBP and CDK8. Forms a complex with PRAG1, NOTCH1 and MAML1, in a MAML1-dependent manner (PubMed:25038227).2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
222170, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6T264

Protein interaction database and analysis system

More...
IntActi
Q6T264, 1 interactor

Molecular INTeraction database

More...
MINTi
Q6T264

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000059210

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6T264

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6T264

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 97Required for interaction with NOTCH proteins1 PublicationAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi66 – 102Ala-richSequence analysisAdd BLAST37
Compositional biasi642 – 651Poly-Gln10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal region is required for transcriptional activation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mastermind family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHPP Eukaryota
ENOG4111N9A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153933

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058017

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6T264

KEGG Orthology (KO)

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KOi
K06061

Identification of Orthologs from Complete Genome Data

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OMAi
SEEWMND

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01SE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6T264

TreeFam database of animal gene trees

More...
TreeFami
TF332922

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09596 MamL-1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01275 MamL-1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6T264-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLPTCPMAE FALPRHSAVM ERLRRRIELC RRHHSTCEAR YEAVSPERLE
60 70 80 90 100
LERQHTFALH QRCIQAKAKR AGKHRQPPAA ATAPVAAPAP ASAPAAARLD
110 120 130 140 150
AADGPEHGRP VAHLHDTVKR SLDSAASPQN GDQPNGYGDL FPGHKKTRRE
160 170 180 190 200
APLGVSVSAN GLPPASPLGQ PDKPSGGDTL QTAGKHSLGL DPINKKCLAD
210 220 230 240 250
SGIHLNGGSN SSEPFPLSLS KELKQEPVDD LPCMIAGAGG SVAQSNLMPD
260 270 280 290 300
LNLNEQEWKE LIEELNRSVP DEDMKDLFTE DFEEKKDPEP PGSATQTPLA
310 320 330 340 350
QDINIKTEFS PAAFEQEQLG SPQVRAGSAG QTFLGASSAP VGTDSPSLGS
360 370 380 390 400
SQTLFHTTSQ PGVDNSSPNL MPASAQAQSA QRALTSVVLP SQGPGGASEL
410 420 430 440 450
SSAHQLQQIA AKQKREQMLQ NPQQAAPAPG PGQLATWQQA GPSHSPLDVP
460 470 480 490 500
YPMEKPASPS GYKQDFTNSK LLMMPGVNKS SPRPGGPYLQ PSHSNLLSHQ
510 520 530 540 550
SPSNLNQNPV NNQGSVLDYG NTKPLSHYKA DCGQGGPGSG QNKPALMAYL
560 570 580 590 600
PQQLPHLSNE QNSLFLMKPK SGNMPFRSLV PPGQEQNPSS VPVAAPAASV
610 620 630 640 650
GTQPTVSVAS THNSSPYLSS QQQAAVMKQH QLLLDQQKQR EQQQQQLQQQ
660 670 680 690 700
QFLQRQHLLA EQEKQQFQRH LTRPPPQYQD PTQSTFPQQV GQFTGPSAAV
710 720 730 740 750
PGMNNLGPSN SSCPRVFPQP GTLMSMGPGH APVSSLPSSS GQQDRGVAQF
760 770 780 790 800
TGSQSLPQNS LYGMASGLAQ IVAQPPPQAT STHAHIPRQT NVGQNASTSA
810 820 830 840 850
AYGQNSLGSA SLSQQHSKGT LPPGLTKPQV PRVSAAMGSQ NASWQHQGMP
860 870 880 890 900
NLSSQTSGNS SVNPFTAAPS FHIQQAHLKL AGQQFSQAMP SRPMAPLSSA
910 920 930 940 950
GAAGPMLPPV SAQQRNSAPA SAPPQAAPQQ GLPGLSPSGP ELGAFGQSPT
960 970 980 990 1000
SQMSGRPGLH CAQAYPVRTM GQELPFAYSG QPGSSGLSSV AGHTDLIDSL
1010 1020
LKNRTSEEWI NELDDLLGSQ
Length:1,020
Mass (Da):107,726
Last modified:July 5, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i637132736ECD3A78
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6UY95F6UY95_MOUSE
Mastermind-like protein 1
Maml1
585Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH94599 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC39618 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97898 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti574M → T in AAH58658 (PubMed:15489334).Curated1
Sequence conflicti643 – 646Missing in AAS07633 (PubMed:15019995).Curated4
Sequence conflicti643 – 646Missing in BAC97898 (PubMed:14621295).Curated4
Sequence conflicti675P → S in AAS07633 (PubMed:15019995).Curated1
Sequence conflicti769A → P in BAC39618 (PubMed:16141072).Curated1
Sequence conflicti769A → T in AAS07633 (PubMed:15019995).Curated1
Sequence conflicti770Q → H in BAC39618 (PubMed:16141072).Curated1
Sequence conflicti822P → L in AAS07633 (PubMed:15019995).Curated1
Sequence conflicti861S → C in AAS07633 (PubMed:15019995).Curated1
Sequence conflicti1003N → K in BAC39618 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY442299 mRNA Translation: AAS07633.1
AK129088 mRNA Translation: BAC97898.1 Different initiation.
AL646002 Genomic DNA No translation available.
BC024668 mRNA Translation: AAH24668.1
BC058658 mRNA Translation: AAH58658.1
BC094599 mRNA Translation: AAH94599.2 Different initiation.
AK086146 mRNA Translation: BAC39618.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS24632.2

NCBI Reference Sequences

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RefSeqi
NP_780543.2, NM_175334.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.51116

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000059458; ENSMUSP00000059210; ENSMUSG00000050567

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
103806

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:103806

UCSC genome browser

More...
UCSCi
uc007isd.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY442299 mRNA Translation: AAS07633.1
AK129088 mRNA Translation: BAC97898.1 Different initiation.
AL646002 Genomic DNA No translation available.
BC024668 mRNA Translation: AAH24668.1
BC058658 mRNA Translation: AAH58658.1
BC094599 mRNA Translation: AAH94599.2 Different initiation.
AK086146 mRNA Translation: BAC39618.1 Different initiation.
CCDSiCCDS24632.2
RefSeqiNP_780543.2, NM_175334.3
UniGeneiMm.51116

3D structure databases

ProteinModelPortaliQ6T264
SMRiQ6T264
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222170, 5 interactors
CORUMiQ6T264
IntActiQ6T264, 1 interactor
MINTiQ6T264
STRINGi10090.ENSMUSP00000059210

PTM databases

iPTMnetiQ6T264
PhosphoSitePlusiQ6T264

Proteomic databases

MaxQBiQ6T264
PaxDbiQ6T264
PRIDEiQ6T264

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059458; ENSMUSP00000059210; ENSMUSG00000050567
GeneIDi103806
KEGGimmu:103806
UCSCiuc007isd.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9794
MGIiMGI:1890504 Maml1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IHPP Eukaryota
ENOG4111N9A LUCA
GeneTreeiENSGT00940000153933
HOVERGENiHBG058017
InParanoidiQ6T264
KOiK06061
OMAiSEEWMND
OrthoDBiEOG091G01SE
PhylomeDBiQ6T264
TreeFamiTF332922

Enzyme and pathway databases

ReactomeiR-MMU-2122947 NOTCH1 Intracellular Domain Regulates Transcription
R-MMU-2197563 NOTCH2 intracellular domain regulates transcription
R-MMU-350054 Notch-HLH transcription pathway
R-MMU-8941856 RUNX3 regulates NOTCH signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Maml1 mouse

Protein Ontology

More...
PROi
PR:Q6T264

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000050567 Expressed in 253 organ(s), highest expression level in skin of back
CleanExiMM_MAML1
ExpressionAtlasiQ6T264 baseline and differential
GenevisibleiQ6T264 MM

Family and domain databases

InterProiView protein in InterPro
IPR019082 Neuroggenic_mastermind-like_N
PfamiView protein in Pfam
PF09596 MamL-1, 1 hit
SMARTiView protein in SMART
SM01275 MamL-1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAML1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6T264
Secondary accession number(s): Q505D8
, Q5SUC2, Q6PDK3, Q6ZQG5, Q8BIU5, Q8R3T0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: December 5, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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