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Entry version 140 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
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Protein

NAD(+) hydrolase SARM1

Gene

SARM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NAD+ hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD+ metabolism (PubMed:25908823, PubMed:27671644, PubMed:28334607). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (PubMed:15123841, PubMed:16964262, PubMed:20306472, PubMed:25908823). Wallerian degeneration is triggered by NAD+ depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD+ into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD+ cleavage promoting cytoskeletal degradation and axon destruction (PubMed:25908823, PubMed:28334607, PubMed:30333228, PubMed:31128467, PubMed:31439793, PubMed:31439792). Also able to hydrolyze NADP+, but not other NAD+-related molecules (PubMed:29395922). Can activate neuronal cell death in response to stress (PubMed:20306472). Regulates dendritic arborization through the MAPK4-JNK pathway (By similarity). Involved in innate immune response: inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38 (PubMed:16964262).By similarity11 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Autoinhibited: in the inactive state, the enzymatic TIR domain is held apart by the autoinhibiting ARM domain (PubMed:27671644, PubMed:31278906). Following activation, possibly by nicotinamide mononucleotide (NMN), auto-inhibitory interactions are released, allowing self-association of the TIR domains and subsequent activation of the NAD+ hydrolase (NADase) activity (PubMed:27671644, PubMed:31128467). Self-association of TIR domains is facilitated by the octamer of SAM domains (PubMed:31278906, PubMed:31439792). NAD+ hydrolase activity is inhibited by nicotinamide (PubMed:28334607).5 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 10.3 min(-1) with NAD+ as substrate.1 Publication
  1. KM=24 µM for NAD+1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei599NAD1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei642PROSITE-ProRule annotation3 Publications1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi569 – 570NAD1 Publication2

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processDifferentiation, Immunity, Innate immunity, Neurogenesis
    LigandNAD

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q6SZW1

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-166166, MyD88-independent TLR4 cascade [Q6SZW1-1]
    R-HSA-168164, Toll Like Receptor 3 (TLR3) Cascade [Q6SZW1-1]
    R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon [Q6SZW1-1]
    R-HSA-937041, IKK complex recruitment mediated by RIP1 [Q6SZW1-1]
    R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex [Q6SZW1-1]

    SIGNOR Signaling Network Open Resource

    More...
    SIGNORi
    Q6SZW1

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    NAD(+) hydrolase SARM1Curated (EC:3.2.2.65 Publications)
    Short name:
    NADase SARM1Curated
    Short name:
    hSARM11 Publication
    Alternative name(s):
    NADP(+) hydrolase SARM1Curated (EC:3.2.2.-1 Publication)
    Sterile alpha and Armadillo repeat protein1 Publication
    Sterile alpha and TIR motif-containing protein 12 Publications
    Sterile alpha motif domain-containing protein 21 Publication
    Short name:
    MyD88-51 Publication
    Short name:
    SAM domain-containing protein 2Imported
    Tir-1 homolog1 Publication
    Short name:
    HsTIR1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SARM12 PublicationsImported
    Synonyms:KIAA05241 Publication, SAMD2Imported, SARM1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000004139.13

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:17074, SARM1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607732, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q6SZW1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cell junction, Cell projection, Cytoplasm, Mitochondrion, Synapse

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11K → A: No effect on mitochondrial localization. 1 Publication1
    Mutagenesisi14R → A: Loss in ability to localize to mitochondria and reduction in apoptotic activity. 1 Publication1
    Mutagenesisi22R → A: No effect on mitochondrial localization. 1 Publication1
    Mutagenesisi27R → A: No effect on mitochondrial localization. 1 Publication1
    Mutagenesisi408S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi411S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi419T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi427S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi432S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi447T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi453T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi454D → K: Reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi461 – 464ITRK → DTRD: Strongly reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication4
    Mutagenesisi461I → D: Reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi462T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi464K → D: Reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi471T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi475T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi480S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi481T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi485S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi493S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi502T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi507S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi513S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi519S → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi531 – 533LGV → DGD: Slightly reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication3
    Mutagenesisi531L → D: Slightly reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi533V → D: Slightly reduced ability to form an octomeric ring and promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi540T → A: Does not affect phosphorylation level. 1 Publication1
    Mutagenesisi548S → A: Decreased phosphorylation, leading to reduced NAD(+) hydrolase activity. 1 Publication1
    Mutagenesisi568Y → A: Loss of NAD(+) hydrolase activity. 1 Publication1
    Mutagenesisi569 – 570RR → AA: Loss of NAD(+) hydrolase activity. 1 Publication2
    Mutagenesisi569R → A: Loss of NAD(+) hydrolase activity. 1 Publication1
    Mutagenesisi579L → A: Reduced NAD(+) hydrolase activity. 1 Publication1
    Mutagenesisi594D → A: Reduced NAD(+) hydrolase activity. 1 Publication1
    Mutagenesisi596E → K: Loss of NAD(+) hydrolase activity. Abolished ability to promote axonal degeneration following injury. 3 Publications1
    Mutagenesisi597K → E: Dominant negative mutant that blocks axon degeneration after axotomy. 1 Publication1
    Mutagenesisi601G → P: Loss of NAD(+) hydrolase activity. Abolished ability to promote axonal degeneration following injury. 3 Publications1
    Mutagenesisi604E → K: Does not affect ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi626L → M: Does not affect ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi627D → K: Abolished ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi628K → D: Abolished ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi629C → S: Abolished ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi632D → K: Does not affect ability to promote axonal degeneration following injury. 1 Publication1
    Mutagenesisi642E → K: Loss of NAD(+) hydrolase activity. 4 Publications1
    Mutagenesisi685H → A: Reduced NAD(+) hydrolase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    23098

    Open Targets

    More...
    OpenTargetsi
    ENSG00000004139

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134971180

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q6SZW1, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SARM1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    83288284

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27Mitochondrion1 PublicationAdd BLAST27
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000009758928 – 724NAD(+) hydrolase SARM1Add BLAST697

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei548Phosphoserine1 Publication1
    Modified residuei558PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylation at Ser-548 by JNK kinases (MAPK8, MAPK9 and /or MAPK10) enhance the NAD+ hydrolase (NADase) activity (PubMed:30333228). Phosphorylation at Ser-548 and subsequent activation takes place in response to oxidative stress conditions and inhibits mitochondrial respiration (PubMed:30333228).1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q6SZW1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q6SZW1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q6SZW1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q6SZW1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q6SZW1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q6SZW1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q6SZW1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    67362 [Q6SZW1-1]
    67363 [Q6SZW1-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q6SZW1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q6SZW1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Predominantly expressed in brain, kidney and liver. Expressed at lower level in placenta.2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated by lipopolysaccharides (LPS).1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000004139, Expressed in stomach and 183 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q6SZW1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q6SZW1, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000004139, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homooctamer; forms an octomeric ring via SAM domains (PubMed:31278906, PubMed:31439792).

    Interacts with TICAM1/TRIF and thereby interferes with TICAM1/TRIF function (PubMed:16964262).

    Interacts with MAPK10/JNK3 and SDC2 (via cytoplasmic domain) (By similarity).

    By similarity3 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Hide details

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    116726, 31 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q6SZW1, 15 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000468032

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q6SZW1, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1724
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q6SZW1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati124 – 186ARMPROSITE-ProRule annotationAdd BLAST63
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini412 – 476SAM 1PROSITE-ProRule annotationAdd BLAST65
    Domaini486 – 548SAM 2PROSITE-ProRule annotationAdd BLAST63
    Domaini560 – 703TIRPROSITE-ProRule annotationAdd BLAST144

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The TIR domain mediates NAD+ hydrolase (NADase) activity (PubMed:28334607). Self-association of TIR domains is required for NADase activity (PubMed:27671644, PubMed:31278906).3 Publications

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SARM1 family.Curated

    Keywords - Domaini

    Repeat, Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3678, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000004155

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_003286_2_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q6SZW1

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    CEVQTWL

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q6SZW1

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.150.50, 2 hits
    1.25.10.10, 1 hit
    3.40.50.10140, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR011989, ARM-like
    IPR016024, ARM-type_fold
    IPR001660, SAM
    IPR013761, SAM/pointed_sf
    IPR039184, SARM1
    IPR000157, TIR_dom
    IPR035897, Toll_tir_struct_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22998, PTHR22998, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF07647, SAM_2, 2 hits
    PF13676, TIR_2, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00454, SAM, 2 hits
    SM00255, TIR, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47769, SSF47769, 2 hits
    SSF48371, SSF48371, 1 hit
    SSF52200, SSF52200, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50105, SAM_DOMAIN, 2 hits
    PS50104, TIR, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q6SZW1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVLTLLLSAY KLCRFFAMSG PRPGAERLAV PGPDGGGGTG PWWAAGGRGP
    60 70 80 90 100
    REVSPGAGTE VQDALERALP ELQQALSALK QAGGARAVGA GLAEVFQLVE
    110 120 130 140 150
    EAWLLPAVGR EVAQGLCDAI RLDGGLDLLL RLLQAPELET RVQAARLLEQ
    160 170 180 190 200
    ILVAENRDRV ARIGLGVILN LAKEREPVEL ARSVAGILEH MFKHSEETCQ
    210 220 230 240 250
    RLVAAGGLDA VLYWCRRTDP ALLRHCALAL GNCALHGGQA VQRRMVEKRA
    260 270 280 290 300
    AEWLFPLAFS KEDELLRLHA CLAVAVLATN KEVEREVERS GTLALVEPLV
    310 320 330 340 350
    ASLDPGRFAR CLVDASDTSQ GRGPDDLQRL VPLLDSNRLE AQCIGAFYLC
    360 370 380 390 400
    AEAAIKSLQG KTKVFSDIGA IQSLKRLVSY STNGTKSALA KRALRLLGEE
    410 420 430 440 450
    VPRPILPSVP SWKEAEVQTW LQQIGFSKYC ESFREQQVDG DLLLRLTEEE
    460 470 480 490 500
    LQTDLGMKSG ITRKRFFREL TELKTFANYS TCDRSNLADW LGSLDPRFRQ
    510 520 530 540 550
    YTYGLVSCGL DRSLLHRVSE QQLLEDCGIH LGVHRARILT AAREMLHSPL
    560 570 580 590 600
    PCTGGKPSGD TPDVFISYRR NSGSQLASLL KVHLQLHGFS VFIDVEKLEA
    610 620 630 640 650
    GKFEDKLIQS VMGARNFVLV LSPGALDKCM QDHDCKDWVH KEIVTALSCG
    660 670 680 690 700
    KNIVPIIDGF EWPEPQVLPE DMQAVLTFNG IKWSHEYQEA TIEKIIRFLQ
    710 720
    GRSSRDSSAG SDTSLEGAAP MGPT
    Length:724
    Mass (Da):79,388
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6391EA4C31EF6604
    GO
    Isoform 2 (identifier: Q6SZW1-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: MVLTLLLSAY...QLVEEAWLLP → MGAVARAHGG...PTGGGGLAAA

    Show »
    Length:690
    Mass (Da):75,337
    Checksum:i18E0005AF7A7B1C5
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    J3KSG7J3KSG7_HUMAN
    NAD(+) hydrolase SARM1
    SARM1
    257Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3KRZ6J3KRZ6_HUMAN
    NAD(+) hydrolase SARM1
    SARM1
    107Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QRE0J3QRE0_HUMAN
    NAD(+) hydrolase SARM1
    SARM1
    118Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06170223P → R. Corresponds to variant dbSNP:rs7212814Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0136031 – 106MVLTL…AWLLP → MGAVARAHGGLRVARARESV AGGRHRGAGRPGARAAGAAA GLVRAEAGGRRAGRGRRPGR GLPTGGGGLAAA in isoform 2. 1 PublicationAdd BLAST106

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ290445 mRNA Translation: CAB90355.1
    AY444166 mRNA Translation: AAR17520.1
    AB011096 mRNA Translation: BAA25450.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11230.2 [Q6SZW1-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_055892.2, NM_015077.3 [Q6SZW1-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000585482; ENSP00000468032; ENSG00000004139 [Q6SZW1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    23098

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:23098

    UCSC genome browser

    More...
    UCSCi
    uc032ezg.2, human [Q6SZW1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ290445 mRNA Translation: CAB90355.1
    AY444166 mRNA Translation: AAR17520.1
    AB011096 mRNA Translation: BAA25450.1
    CCDSiCCDS11230.2 [Q6SZW1-1]
    RefSeqiNP_055892.2, NM_015077.3 [Q6SZW1-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6O0QX-ray1.80A/B560-700[»]
    6O0RX-ray1.80A/B560-700[»]
    6O0SX-ray2.70A/B/C/D/E/F/G/H409-561[»]
    6O0TX-ray2.80A/B/C/D/E/F/G/H409-561[»]
    6O0UX-ray3.03A/B560-700[»]
    6O0VX-ray2.07A/B/C/D560-700[»]
    6O1BX-ray1.67A560-700[»]
    6QWVX-ray2.47A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P387-548[»]
    SMRiQ6SZW1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116726, 31 interactors
    IntActiQ6SZW1, 15 interactors
    STRINGi9606.ENSP00000468032

    PTM databases

    iPTMnetiQ6SZW1
    PhosphoSitePlusiQ6SZW1

    Polymorphism and mutation databases

    BioMutaiSARM1
    DMDMi83288284

    Proteomic databases

    EPDiQ6SZW1
    jPOSTiQ6SZW1
    MassIVEiQ6SZW1
    MaxQBiQ6SZW1
    PaxDbiQ6SZW1
    PeptideAtlasiQ6SZW1
    PRIDEiQ6SZW1
    ProteomicsDBi67362 [Q6SZW1-1]
    67363 [Q6SZW1-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    14061, 197 antibodies

    Genome annotation databases

    EnsembliENST00000585482; ENSP00000468032; ENSG00000004139 [Q6SZW1-1]
    GeneIDi23098
    KEGGihsa:23098
    UCSCiuc032ezg.2, human [Q6SZW1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    23098
    DisGeNETi23098
    EuPathDBiHostDB:ENSG00000004139.13

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SARM1
    HGNCiHGNC:17074, SARM1
    HPAiENSG00000004139, Low tissue specificity
    MIMi607732, gene
    neXtProtiNX_Q6SZW1
    OpenTargetsiENSG00000004139
    PharmGKBiPA134971180

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3678, Eukaryota
    GeneTreeiENSGT00390000004155
    HOGENOMiCLU_003286_2_0_1
    InParanoidiQ6SZW1
    OMAiCEVQTWL
    PhylomeDBiQ6SZW1

    Enzyme and pathway databases

    PathwayCommonsiQ6SZW1
    ReactomeiR-HSA-166166, MyD88-independent TLR4 cascade [Q6SZW1-1]
    R-HSA-168164, Toll Like Receptor 3 (TLR3) Cascade [Q6SZW1-1]
    R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon [Q6SZW1-1]
    R-HSA-937041, IKK complex recruitment mediated by RIP1 [Q6SZW1-1]
    R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex [Q6SZW1-1]
    SIGNORiQ6SZW1

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    23098, 2 hits in 98 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SARM1, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    23098
    PharosiQ6SZW1, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q6SZW1
    RNActiQ6SZW1, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000004139, Expressed in stomach and 183 other tissues
    ExpressionAtlasiQ6SZW1, baseline and differential
    GenevisibleiQ6SZW1, HS

    Family and domain databases

    Gene3Di1.10.150.50, 2 hits
    1.25.10.10, 1 hit
    3.40.50.10140, 1 hit
    InterProiView protein in InterPro
    IPR011989, ARM-like
    IPR016024, ARM-type_fold
    IPR001660, SAM
    IPR013761, SAM/pointed_sf
    IPR039184, SARM1
    IPR000157, TIR_dom
    IPR035897, Toll_tir_struct_dom_sf
    PANTHERiPTHR22998, PTHR22998, 1 hit
    PfamiView protein in Pfam
    PF07647, SAM_2, 2 hits
    PF13676, TIR_2, 1 hit
    SMARTiView protein in SMART
    SM00454, SAM, 2 hits
    SM00255, TIR, 1 hit
    SUPFAMiSSF47769, SSF47769, 2 hits
    SSF48371, SSF48371, 1 hit
    SSF52200, SSF52200, 1 hit
    PROSITEiView protein in PROSITE
    PS50105, SAM_DOMAIN, 2 hits
    PS50104, TIR, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSARM1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6SZW1
    Secondary accession number(s): O60277, Q7LGG3, Q9NXY5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: July 5, 2004
    Last modified: October 7, 2020
    This is version 140 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
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