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Protein

Myogenic factor 6

Gene

myf6

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Myogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Myogenic factor 6
Short name:
Myf-6
Alternative name(s):
Muscle-specific regulatory factor 4
Gene namesi
Name:myf6
Synonyms:mrf4
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273571 – 239Myogenic factor 6Add BLAST239

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000027392

Structurei

3D structure databases

ProteinModelPortaliQ6SYV5
SMRiQ6SYV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 147bHLHPROSITE-ProRule annotationAdd BLAST52

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
InParanoidiQ6SYV5
KOiK18485

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SYV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMDLFETNTY LFNDLRYLEE GDHGPLQHLD MSGVSPLYNG NDSPLSPGQD
60 70 80 90 100
NVPSETGGES SGDEHVLAPP GLRSHCEGQC LMWACKICKR KSAPTDRRKA
110 120 130 140 150
ATLRERRRLK KINEAFDALK RKTVANPNQR LPKVEILRSA ISYIERLQDL
160 170 180 190 200
LQTLDEQERS QSGASDTRND KEQNRPSGGD YRWKKASNTW PTSADHSAII
210 220 230
NQRDGNCESS ATSSLLCLSS IVSSISDDKT NLRQGVQED
Length:239
Mass (Da):26,694
Last modified:July 5, 2004 - v1
Checksum:i7AB2333774279835
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16R → G in CAC39207 (Ref. 2) Curated1
Sequence conflicti43S → R in CAC39207 (Ref. 2) Curated1
Sequence conflicti179G → V in CAC39207 (Ref. 2) Curated1
Sequence conflicti239D → N in CAC39207 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY445320 mRNA Translation: AAR20812.1
AJ308546 Genomic DNA Translation: CAC39207.1
RefSeqiNP_001027943.1, NM_001032771.1
UniGeneiTru.1967

Genome annotation databases

GeneIDi446039
KEGGitru:446039

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY445320 mRNA Translation: AAR20812.1
AJ308546 Genomic DNA Translation: CAC39207.1
RefSeqiNP_001027943.1, NM_001032771.1
UniGeneiTru.1967

3D structure databases

ProteinModelPortaliQ6SYV5
SMRiQ6SYV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000027392

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi446039
KEGGitru:446039

Organism-specific databases

CTDi4618

Phylogenomic databases

eggNOGiKOG3960 Eukaryota
ENOG4111SED LUCA
InParanoidiQ6SYV5
KOiK18485

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR002546 Basic
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR039704 Myogenic_factor
PANTHERiPTHR11534 PTHR11534, 1 hit
PfamiView protein in Pfam
PF01586 Basic, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00520 BASIC, 1 hit
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYF6_TAKRU
AccessioniPrimary (citable) accession number: Q6SYV5
Secondary accession number(s): Q90ZL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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