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Protein

Protein UL27

Gene

UL27

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes a cell cycle arrest in G0/G1 by inducing the proteasomal degradation of host histone acetyltransferase KAT5/Tip60.1 Publication

GO - Biological processi

Keywordsi

Biological processG0/G1 host cell cycle checkpoint dysregulation by virus, Host-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL27
Gene namesi
Name:UL27
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182811 – 608Protein UL27Add BLAST608

Proteomic databases

PRIDEiQ6SWA4

Interactioni

Subunit structurei

Interacts with host KAT5, PSME3 and EP400.1 Publication

Protein-protein interaction databases

BioGridi1678002, 27 interactors

Structurei

3D structure databases

SMRiQ6SWA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi7 – 11Poly-Pro5

Sequence similaritiesi

Belongs to the herpesviridae U4 family.Curated

Phylogenomic databases

OrthoDBiVOG0900005K

Family and domain databases

InterProiView protein in InterPro
IPR010302 U5-like_protein_herpesevirus
PfamiView protein in Pfam
PF05999 Herpes_U5, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SWA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPVDQPPPP PLTQQPEEQA KEDHDDGDER LFRDPLTTYE YLDDCRDDEE
60 70 80 90 100
FCHQFLRAYL TPIRNRQEAV RAGLLCRTPE DLAAAGGQKR KTPAPKHPKH
110 120 130 140 150
AMVYIRRSCL VHSACATAHG KYDIRGLTLE SDLAVWAALR GVPLPPDPQH
160 170 180 190 200
FRWLNAGAFR RLVHEAQYLP EISRAAKRIA LAVATGQYVV CTLLDYKTFG
210 220 230 240 250
TRTHYLRQLC SMTEELYLRL DGTLCLFLEP EERELIGRCL PAALCRGLPV
260 270 280 290 300
KYRTHRAAVF FHATFMARAE AALKDLYAAF CECGDGRDDG GNHNGNYGGG
310 320 330 340 350
DHSSLSPSAV ASHHSRLEHA ELRLERNRHL GAFHLPAIRH LTAGDVARVQ
360 370 380 390 400
DSVSRDLGFA DWSQTLVDDY FLLPAGWACA NPRRGYAMYL ASNAVLALRI
410 420 430 440 450
IRLLRASIRH EYTACIRMLS GDVQRLIRLF KGEAALLRKG LAQNPVQRRE
460 470 480 490 500
LSRFRKHVHD LKRIRFTEDT FVETFCDFLE LVQRIPDYRS VSLRIKRELL
510 520 530 540 550
CLHVFKLRRG CRAPPTPEAV RVQRLLWHSL RHGDAPQDRT RLPQFSSALS
560 570 580 590 600
DAELSNHANR CRRKAPLELG PAVVAAPGPS VRYRAHIQKF ERLHVRRFRP

HEVGGHAT
Length:608
Mass (Da):69,143
Last modified:July 5, 2004 - v1
Checksum:i81CB97B6FDCF3F31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31592.1
RefSeqiYP_081486.1, NC_006273.2

Genome annotation databases

GeneIDi3077449
KEGGivg:3077449

Similar proteinsi

Entry informationi

Entry nameiUL27_HCMVM
AccessioniPrimary (citable) accession number: Q6SWA4
Secondary accession number(s): D2K3J6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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