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Protein

Inner tegument protein

Gene

UL47

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an essential role in cytoplasmic secondary envelopment during viral egress. Interacts with the capsid via the large tegument protein/LTP and participates in its transport to the host trans-Golgi network (TGN) where secondary envelopment occurs. Modulates tegumentation and capsid accumulation at the viral assembly complex.UniRule annotation

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Inner tegument proteinUniRule annotation
Gene namesi
Name:UL47
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004182961 – 983Inner tegument proteinAdd BLAST983

Proteomic databases

PRIDEiQ6SW85

Interactioni

Subunit structurei

Interacts (via C-teminus) with the large tegument protein/LTP (via N-terminus).UniRule annotation

Structurei

3D structure databases

SMRiQ6SW85
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni474 – 983Interaction with large tegument proteinUniRule annotationAdd BLAST510

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi147 – 150Poly-Ala4
Compositional biasi886 – 891Poly-Ala6

Sequence similaritiesi

Belongs to the herpesviridae inner tegument protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900001A

Family and domain databases

HAMAPiMF_04043 HSV_ITP, 1 hit
InterProiView protein in InterPro
IPR007611 Herpes_U30
IPR034738 HSV_ITP
PfamiView protein in Pfam
PF04523 Herpes_U30, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SW85-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMARRTVDFK KLIEQLRARA TDKAEALNTV SQLEIGAVDA QDVTASAVRA
60 70 80 90 100
FVGALPSSGY HFGFVRQNVV FYLLSHATVQ TARDPLYAAE QLHEQLDRFL
110 120 130 140 150
RHQHDGGGDE DRLPFYHNGA TLTAFQKLLQ TLREIQTVIA EQSGGTAAAA
160 170 180 190 200
DLIASNNAST ERRGKKGGSS SGGQQPLVRR VITQLETAAT EARPYVNCRA
210 220 230 240 250
VAELLDLTYQ RLIYWACTLM PYVLFRRDTD TELDTVLLMH FFYTHYRSVN
260 270 280 290 300
GDLAVEFQNY VKNSVRHMSS FVSSDIDGDQ KPGAEHMRDV SYKLFVGNLQ
310 320 330 340 350
ARDASGLMFP IISTRISTVN LYLSPERMFF HPGLISRLLS EEVSPRANLD
360 370 380 390 400
AYARVCDRVL EDHLHTPRRV QRLLDLTQMV MRLVELGFNH DTCAAYAQMA
410 420 430 440 450
LIQPASQKSS LFVSEIREKL IQIIYNFYTF FMCLYVYSPT FLFDHRRRLI
460 470 480 490 500
LEQHRSTLIG SKEELQHVWS NVTLNVNTHF AVQYTEEDFE AHTKGATEAE
510 520 530 540 550
REYLYRDLHS KWGVHLFTLR PSRGAAGAAS PLPPLDGVTR SDILRECALV
560 570 580 590 600
NLNEGRVNYA SLLAFSHHPE FPSIFAQLVV VTEFSEIFGI PQGLFQAVGS
610 620 630 640 650
PRLFALIQLC RVLLPEQVTL YQNLVSIYNL TTFVKHIDAA VFKTVRDCVF
660 670 680 690 700
DIATTLEHLS GVPVTPNVDL LAELMARSVA HNLYTTVNPL IEDVMRSSAG
710 720 730 740 750
SLRNYLRHTR LCFGLARGRA RLSEDGVTVY VEVQGQYGLR VPTTRFVEQL
760 770 780 790 800
RELVRRDRLL AENLRGLNER LLSVRVRVRQ ISSDTEEVSR HAKGHRTVAQ
810 820 830 840 850
MSKALKKTAS KIKMLETRVT LALEQAQRSN GAVVTAVQRA LAVFDVLSRE
860 870 880 890 900
NLERRGAQLC LTEATSLLHR HRALAPMTWP AGTGVAAAAE ADGALREFLE
910 920 930 940 950
APWESAPQPP RLRMTPDTDH EESTAGATSV PEVLGARYEP AHLAASDLLN
960 970 980
WYIVPVSQAQ QDILSSIDPP AGSTSVSLPP ASP
Length:983
Mass (Da):110,024
Last modified:July 5, 2004 - v1
Checksum:i8227D02C0056A636
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31611.1
RefSeqiYP_081505.1, NC_006273.2

Genome annotation databases

GeneIDi3077521
KEGGivg:3077521

Similar proteinsi

Entry informationi

Entry nameiITP_HCMVM
AccessioniPrimary (citable) accession number: Q6SW85
Secondary accession number(s): D2K3L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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