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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes dUMP from dCTP (dUTP route).
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyuridine 5'-triphosphate nucleotidohydrolase (DUT)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00666

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL72
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004167081 – 388Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST388

Proteomic databases

PRIDEiQ6SW70

Structurei

3D structure databases

ProteinModelPortaliQ6SW70
SMRiQ6SW70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000AY

Family and domain databases

HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR036157 dUTPase-like_sf
IPR006882 Herpes_Orf11
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF04797 Herpes_ORF11, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SW70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMLTDRID SQLVLSRLPR SRFQRFWETP TLIMKEESAP SSGSIILAEK
60 70 80 90 100
SVNMRYCVRF ASDSDFQTTF TLPQSTEEKY DKEQHPGEDE ASSPLPSPLK
110 120 130 140 150
VPYKWMPSSF IVKQCHTQLA FYNKHIIWLS RERKVPTSLG VSLYIPEGFF
160 170 180 190 200
GITFYKCLDA QFVCMPELLE SGLQVPQLDV VNLNDTFQSI FPGTIEGDIG
210 220 230 240 250
VFPCFVPEPW QLMNLPPPNE HRFFSLRTRQ TLVIGPGHTQ TVYFDAAYVH
260 270 280 290 300
APGICALIVG VRQFSQSDLI IRPTIWLPGT AAGVTVVNTS HTTVCISPHT
310 320 330 340 350
TVAKAVFTTH RFTYLPVGSH PLGQMIVPPT PDIGFTHTPE HALLQRTPSP
360 370 380
VDDDVDETEE DEKSSDAESP VNTSDVIFDV GPKPPRHP
Length:388
Mass (Da):43,459
Last modified:July 5, 2004 - v1
Checksum:i4B04A9E1909D9882
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31625.1
RefSeqiYP_081520.1, NC_006273.2

Genome annotation databases

GeneIDi3077454
KEGGivg:3077454

Similar proteinsi

Entry informationi

Entry nameiDUT_HCMVM
AccessioniPrimary (citable) accession number: Q6SW70
Secondary accession number(s): D2K3M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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