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Protein

Envelope glycoprotein H

Gene

gH

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.UniRule annotation

GO - Biological processi

Keywordsi

Biological processFusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell
LigandSialic acid

Protein family/group databases

TCDBi1.G.22.1.1 the cytomegalovirus (human herpesvirus 5) glycoprotein go (go) family

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein HUniRule annotation
Short name:
gHUniRule annotation
Gene namesi
Name:gHUniRule annotation
Synonyms:UL75
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 719Virion surfaceUniRule annotationAdd BLAST696
Transmembranei720 – 740HelicalUniRule annotationAdd BLAST21
Topological domaini741 – 742IntravirionUniRule annotation2

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23UniRule annotationAdd BLAST23
ChainiPRO_000043665424 – 742Envelope glycoprotein HUniRule annotationAdd BLAST719

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi62N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi67N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi192N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi641N-linked (GlcNAc...) asparagine; by hostUniRule annotation1
Glycosylationi700N-linked (GlcNAc...) asparagine; by hostUniRule annotation1

Post-translational modificationi

N-glycosylated, O-glycosylated, and sialylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6SW67

Interactioni

Subunit structurei

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion.UniRule annotation

Structurei

Secondary structure

1742
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiQ6SW67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni217 – 280Interaction with gLUniRule annotationAdd BLAST64

Sequence similaritiesi

Belongs to the herpesviridae glycoprotein H family.UniRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK22777
OrthoDBiVOG0900004Y

Family and domain databases

Gene3Di2.60.40.3190, 1 hit
HAMAPiMF_04033 HSV_GH, 1 hit
InterProiView protein in InterPro
IPR003493 Herpes_gH
IPR035305 Herpes_glycoH_C
IPR038172 Herpes_glycoH_C_sf
PfamiView protein in Pfam
PF17488 Herpes_glycoH_C, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SW67-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPGLPSYLI ILAVCLFSHL LSSRYGAEAV SEPLDKAFHL LLNTYGRPIR
60 70 80 90 100
FLRENTTQCT YNSSLRNSTV VRENAISFNF FQSYNQYYVF HMPRCLFAGP
110 120 130 140 150
LAEQFLNQVD LTETLERYQQ RLNTYALVSK DLASYRSFSQ QLKAQDSLGE
160 170 180 190 200
QPTTVPPPID LSIPHVWMPP QTTPHGWTES HTTSGLHRPH FNQTCILFDG
210 220 230 240 250
HDLLFSTVTP CLHQGFYLID ELRYVKITLT EDFFVVTVSI DDDTPMLLIF
260 270 280 290 300
GHLPRVLFKA PYQRDNFILR QTEKHELLVL VKKDQLNRHS YLKDPDFLDA
310 320 330 340 350
ALDFNYLDLS ALLRNSFHRY AVDVLKSGRC QMLDRRTVEM AFAYALALFA
360 370 380 390 400
AARQEEAGAQ VSVPRALDRQ AALLQIQEFM ITCLSQTPPR TTLLLYPTAV
410 420 430 440 450
DLAKRALWTP NQITDITSLV RLVYILSKQN QQHLIPQWAL RQIADFALKL
460 470 480 490 500
HKTHLASFLS AFARQELYLM GSLVHSMLVH TTERREIFIV ETGLCSLAEL
510 520 530 540 550
SHFTQLLAHP HHEYLSDLYT PCSSSGRRDH SLERLTRLFP DATVPATVPA
560 570 580 590 600
ALSILSTMQP STLETFPDLF CLPLGESFSA LTVSEHVSYI VTNQYLIKGI
610 620 630 640 650
SYPVSTTVVG QSLIITQTDS QTKCELTRNM HTTHSITVAL NISLENCAFC
660 670 680 690 700
QSALLEYDDT QGVINIMYMH DSDDVLFALD PYNEVVVSSP RTHYLMLLKN
710 720 730 740
GTVLEVTDVV VDATDSRLLM MSVYALSAII GIYLLYRMLK TC
Length:742
Mass (Da):84,321
Last modified:July 5, 2004 - v1
Checksum:iA4E837BA88DFF4DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31627.1
RefSeqiYP_081523.1, NC_006273.2

Genome annotation databases

GeneIDi3077450
KEGGivg:3077450

Similar proteinsi

Entry informationi

Entry nameiGH_HCMVM
AccessioniPrimary (citable) accession number: Q6SW67
Secondary accession number(s): D2K3N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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