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Protein

Protein UL76

Gene

UL76

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May participate in nuclear egress of viral particles. Plays a role in the dispersal of several host nucleolar proteins including NCL/nucleolin and NPM1. Since deletion of host NCL/nucleolin negatively impact on nuclear egress, UL76 supposedly acts on this process through its effect on host nucleoli (By similarity). Induces cell cycle arrest in host cells at the G2/M phase following by apoptosis. The mechanism involves the inhibition of host mitotic complex cyclinB/CDK1.By similarity1 Publication

GO - Biological processi

Keywordsi

Biological processHost G2/M cell cycle arrest by virus, Host-virus interaction, Modulation of host cell cycle by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL76
Gene namesi
Name:UL76
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host Golgi apparatus, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004167201 – 325Protein UL76Add BLAST325

Proteomic databases

PRIDEiQ6SW66

Expressioni

Inductioni

Expressed late in the infection cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Protein-protein interaction databases

BioGridi1677989, 2 interactors

Structurei

3D structure databases

SMRiQ6SW66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae UL24 family.Curated

Phylogenomic databases

OrthoDBiVOG090000JH

Family and domain databases

InterProiView protein in InterPro
IPR002580 Herpes_UL24
PfamiView protein in Pfam
PF01646 Herpes_UL24, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SW66-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSGCGDDAD STGNALRRLP HVRKRIGKRK HLDIYRRLLR VFPSFVALNR
60 70 80 90 100
LLGGLFPPEL QKYRRRLFIE VRLSRRIPDC VLVFLPPDSG SRGIVYCYVI
110 120 130 140 150
EFKTTYSDAD DQSVRWHATH SLQYAEGLRQ LKGALVDFDF LRLPRGGGQV
160 170 180 190 200
WSVVPSLVFF QQKADRPSFY RAFRSGRFDL CTDSVLDYLG RRQDESVAHL
210 220 230 240 250
LAATRRRLLR AARGKRAALP RARASAVAGG RGGGNARRGL ARGRAHGPGA
260 270 280 290 300
QTVSASGAEG SGSQGTDLLR GSRRARVRGG GAVEPAVRAR RRTVAADAAT
310 320
TTVSSAFVVP RDRRGRSFRR PTRSL
Length:325
Mass (Da):35,964
Last modified:July 5, 2004 - v1
Checksum:iAAFCDBFB0D97ACA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31628.1
RefSeqiYP_081524.1, NC_006273.2

Genome annotation databases

GeneIDi3077435
KEGGivg:3077435

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31628.1
RefSeqiYP_081524.1, NC_006273.2

3D structure databases

SMRiQ6SW66
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1677989, 2 interactors

Proteomic databases

PRIDEiQ6SW66

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077435
KEGGivg:3077435

Phylogenomic databases

OrthoDBiVOG090000JH

Family and domain databases

InterProiView protein in InterPro
IPR002580 Herpes_UL24
PfamiView protein in Pfam
PF01646 Herpes_UL24, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUL76_HCMVM
AccessioniPrimary (citable) accession number: Q6SW66
Secondary accession number(s): D2K3N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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