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Protein

Membrane glycoprotein US11

Gene

US11

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Participates in the inhibition of the host immune response. Redirects newly synthesized MHC class I heavy chains via the SEC61 translocon to the cytosol where they undergo proteasome-dependent destruction. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host adaptive immune response by virus, Inhibition of host MHC class I molecule presentation by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane glycoprotein US11
Gene namesi
Name:US11
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 182LumenalSequence analysisAdd BLAST165
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 215CytoplasmicSequence analysisAdd BLAST12

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000041832018 – 215Membrane glycoprotein US11Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 142By similarity
Glycosylationi73N-linked (GlcNAc...) asparagine; by hostBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
A fraction of newly synthesized molecules retain the signal peptide after the N-linked glycan has been attached and translation of the polypeptide has been completed. Delayed cleavage of the signal peptide is determined by the first four residues, as well as by the transmembrane region (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6SVZ5

Expressioni

Developmental stagei

Expressed at early and late period of virus infection.

Keywords - Developmental stagei

Early protein, Late protein

Interactioni

Protein-protein interaction databases

BioGridi1678043, 1 interactor

Structurei

3D structure databases

SMRiQ6SVZ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 146Ig-like H-typeAdd BLAST100

Sequence similaritiesi

Belongs to the cytomegalovirus US6 family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK22786
OrthoDBiVOG090000QI

Family and domain databases

InterProiView protein in InterPro
IPR012536 CMV_US
PfamiView protein in Pfam
PF08001 CMV_US, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SVZ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLVMLILAL WAPVAGSMPE LSLTLFDEPP PLVETEPLPP LPDVSEYRVE
60 70 80 90 100
YSEARCVLRS GGRLEALWTL RGNLSVPTPT PRVYYQTLEG YADRVPTPVE
110 120 130 140 150
DISESLVAKR YWLRDYRVPQ RTKLVLFYFS PCHQCQTYYV ECEPRCLVPW
160 170 180 190 200
VPLWSSLEDI ERLLFEDRRL MAYYALTIKS AQYTLMMVAV IQVFWGLYVK
210
GWLHRHFPWM FSDQW
Length:215
Mass (Da):25,288
Last modified:July 5, 2004 - v1
Checksum:i6872C1A2B7C1D21F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31700.1
RefSeqiYP_081596.1, NC_006273.2

Genome annotation databases

GeneIDi3077490
KEGGivg:3077490

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31700.1
RefSeqiYP_081596.1, NC_006273.2

3D structure databases

SMRiQ6SVZ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1678043, 1 interactor

Proteomic databases

PRIDEiQ6SVZ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077490
KEGGivg:3077490

Phylogenomic databases

KOiK22786
OrthoDBiVOG090000QI

Family and domain databases

InterProiView protein in InterPro
IPR012536 CMV_US
PfamiView protein in Pfam
PF08001 CMV_US, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUS11_HCMVM
AccessioniPrimary (citable) accession number: Q6SVZ5
Secondary accession number(s): D2K3V6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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