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Protein

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

Gene

SMARCD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).2 PublicationsBy similarity2 Publications

GO - Molecular functioni

  • chromatin binding Source: Ensembl
  • nuclear hormone receptor binding Source: UniProtKB
  • nuclear receptor binding Source: BHF-UCL
  • nuclear receptor transcription coactivator activity Source: BHF-UCL
  • signaling receptor binding Source: UniProtKB
  • transcription coactivator activity Source: BHF-UCL
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processNeurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORiQ6STE5

Names & Taxonomyi

Protein namesi
Recommended name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
Alternative name(s):
60 kDa BRG-1/Brm-associated factor subunit C
BRG1-associated factor 60C
Short name:
BAF60C
Gene namesi
Name:SMARCD3
Synonyms:BAF60C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000082014.16
HGNCiHGNC:11108 SMARCD3
MIMi601737 gene
neXtProtiNX_Q6STE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6604
OpenTargetsiENSG00000082014
PharmGKBiPA35958

Polymorphism and mutation databases

BioMutaiSMARCD3
DMDMi57013057

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000719882 – 483SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3Add BLAST482

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6STE5
MaxQBiQ6STE5
PaxDbiQ6STE5
PeptideAtlasiQ6STE5
PRIDEiQ6STE5
ProteomicsDBi67360
67361 [Q6STE5-2]

PTM databases

iPTMnetiQ6STE5
PhosphoSitePlusiQ6STE5

Expressioni

Tissue specificityi

Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.

Gene expression databases

BgeeiENSG00000082014 Expressed in 217 organ(s), highest expression level in nucleus accumbens
CleanExiHS_SMARCD3
ExpressionAtlasiQ6STE5 baseline and differential
GenevisibleiQ6STE5 HS

Organism-specific databases

HPAiHPA063955
HPA065517

Interactioni

Subunit structurei

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). Interacts with SMARCA4/BRG1/BAF190A (PubMed:14701856). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. May allow recruitment of SWI/SNF containing complexes specifically to promoters where these factors are located. Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1 (PubMed:14701856).2 PublicationsBy similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PPARGP372313EBI-488511,EBI-781384

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112488, 44 interactors
ComplexPortaliCPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CORUMiQ6STE5
DIPiDIP-33012N
IntActiQ6STE5, 19 interactors
STRINGi9606.ENSP00000262188

Structurei

3D structure databases

ProteinModelPortaliQ6STE5
SMRiQ6STE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini259 – 334SWIBAdd BLAST76

Sequence similaritiesi

Belongs to the SMARCD family.Curated

Phylogenomic databases

eggNOGiKOG2570 Eukaryota
COG5531 LUCA
GeneTreeiENSGT00390000017809
HOVERGENiHBG054046
InParanoidiQ6STE5
KOiK11650
OMAiMETTRKR
OrthoDBiEOG091G06WW
PhylomeDBiQ6STE5
TreeFamiTF106486

Family and domain databases

Gene3Di1.10.245.10, 1 hit
InterProiView protein in InterPro
IPR038043 SMARCD3
IPR019835 SWIB_domain
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
PANTHERiPTHR13844:SF5 PTHR13844:SF5, 1 hit
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
SMARTiView protein in SMART
SM00151 SWIB, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6STE5-1) [UniParc]FASTAAdd to basket
Also known as: BAF60C2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY
60 70 80 90 100
MGSPAVRPGL APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR
110 120 130 140 150
RKMADKILPQ RIRELVPESQ AYMDLLAFER KLDQTIMRKR VDIQEALKRP
160 170 180 190 200
MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA SWELRVEGKL LDDPSKQKRK
210 220 230 240 250
FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV KRPGDLSVRC
260 270 280 290 300
TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH
310 320 330 340 350
DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS
360 370 380 390 400
DQKKTACYDI DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN
410 420 430 440 450
QLKIQRDFML SFSRDPKGYV QDLLRSQSRD LKVMTDVAGN PEEERRAEFY
460 470 480
HQPWSQEAVS RYFYCKIQQR RQELEQSLVV RNT
Length:483
Mass (Da):55,016
Last modified:July 5, 2004 - v1
Checksum:iB7B28DD11DCD0B5C
GO
Isoform 2 (identifier: Q6STE5-2) [UniParc]FASTAAdd to basket
Also known as: BAF60C1

The sequence of this isoform differs from the canonical sequence as follows:
     1-26: MAADEVAGGARKATKSKLFEFLVHGV → MTPGLQHPPTVVQ

Show »
Length:470
Mass (Da):53,687
Checksum:iDD6C2454B7AC2B04
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JYI7C9JYI7_HUMAN
SWI/SNF-related matrix-associated a...
SMARCD3
139Annotation score:
H7C4E9H7C4E9_HUMAN
SWI/SNF-related matrix-associated a...
SMARCD3
68Annotation score:
F8WBJ3F8WBJ3_HUMAN
SWI/SNF-related matrix-associated a...
SMARCD3
73Annotation score:

Sequence cautioni

The sequence AAC50697 differs from that shown. Reason: Frameshift at positions 41, 65 and 78.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88V → E in AAC50697 (PubMed:8804307).Curated1
Sequence conflicti140R → G in AAC50697 (PubMed:8804307).Curated1
Sequence conflicti387A → P in AAC50697 (PubMed:8804307).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020884170P → S1 PublicationCorresponds to variant dbSNP:rs1050101Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0124981 – 26MAADE…LVHGV → MTPGLQHPPTVVQ in isoform 2. 3 PublicationsAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66619 mRNA Translation: AAC50697.1 Frameshift.
AY450430 mRNA Translation: AAR88510.1
AY450431 mRNA Translation: AAR88511.1
AC021097 Genomic DNA Translation: AAS00380.1
AC005486 Genomic DNA Translation: AAS02031.1
CH471173 Genomic DNA Translation: EAW54005.1
CH471173 Genomic DNA Translation: EAW54007.1
CH471173 Genomic DNA Translation: EAW54008.1
BC002628 mRNA Translation: AAH02628.1
BC110350 mRNA Translation: AAI10351.1
CCDSiCCDS34780.1 [Q6STE5-1]
CCDS5924.1 [Q6STE5-2]
RefSeqiNP_001003801.1, NM_001003801.1 [Q6STE5-1]
NP_001003802.1, NM_001003802.1 [Q6STE5-2]
NP_003069.2, NM_003078.3 [Q6STE5-2]
UniGeneiHs.647067

Genome annotation databases

EnsembliENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1]
ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2]
ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2]
GeneIDi6604
KEGGihsa:6604
UCSCiuc003wjs.4 human [Q6STE5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66619 mRNA Translation: AAC50697.1 Frameshift.
AY450430 mRNA Translation: AAR88510.1
AY450431 mRNA Translation: AAR88511.1
AC021097 Genomic DNA Translation: AAS00380.1
AC005486 Genomic DNA Translation: AAS02031.1
CH471173 Genomic DNA Translation: EAW54005.1
CH471173 Genomic DNA Translation: EAW54007.1
CH471173 Genomic DNA Translation: EAW54008.1
BC002628 mRNA Translation: AAH02628.1
BC110350 mRNA Translation: AAI10351.1
CCDSiCCDS34780.1 [Q6STE5-1]
CCDS5924.1 [Q6STE5-2]
RefSeqiNP_001003801.1, NM_001003801.1 [Q6STE5-1]
NP_001003802.1, NM_001003802.1 [Q6STE5-2]
NP_003069.2, NM_003078.3 [Q6STE5-2]
UniGeneiHs.647067

3D structure databases

ProteinModelPortaliQ6STE5
SMRiQ6STE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112488, 44 interactors
ComplexPortaliCPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant
CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant
CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant
CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant
CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant
CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant
CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant
CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant
CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant
CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant
CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant
CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CORUMiQ6STE5
DIPiDIP-33012N
IntActiQ6STE5, 19 interactors
STRINGi9606.ENSP00000262188

PTM databases

iPTMnetiQ6STE5
PhosphoSitePlusiQ6STE5

Polymorphism and mutation databases

BioMutaiSMARCD3
DMDMi57013057

Proteomic databases

EPDiQ6STE5
MaxQBiQ6STE5
PaxDbiQ6STE5
PeptideAtlasiQ6STE5
PRIDEiQ6STE5
ProteomicsDBi67360
67361 [Q6STE5-2]

Protocols and materials databases

DNASUi6604
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1]
ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2]
ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2]
GeneIDi6604
KEGGihsa:6604
UCSCiuc003wjs.4 human [Q6STE5-1]

Organism-specific databases

CTDi6604
DisGeNETi6604
EuPathDBiHostDB:ENSG00000082014.16
GeneCardsiSMARCD3
HGNCiHGNC:11108 SMARCD3
HPAiHPA063955
HPA065517
MIMi601737 gene
neXtProtiNX_Q6STE5
OpenTargetsiENSG00000082014
PharmGKBiPA35958
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2570 Eukaryota
COG5531 LUCA
GeneTreeiENSGT00390000017809
HOVERGENiHBG054046
InParanoidiQ6STE5
KOiK11650
OMAiMETTRKR
OrthoDBiEOG091G06WW
PhylomeDBiQ6STE5
TreeFamiTF106486

Enzyme and pathway databases

ReactomeiR-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORiQ6STE5

Miscellaneous databases

ChiTaRSiSMARCD3 human
GeneWikiiSMARCD3
GenomeRNAii6604
PROiPR:Q6STE5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082014 Expressed in 217 organ(s), highest expression level in nucleus accumbens
CleanExiHS_SMARCD3
ExpressionAtlasiQ6STE5 baseline and differential
GenevisibleiQ6STE5 HS

Family and domain databases

Gene3Di1.10.245.10, 1 hit
InterProiView protein in InterPro
IPR038043 SMARCD3
IPR019835 SWIB_domain
IPR036885 SWIB_MDM2_dom_sf
IPR003121 SWIB_MDM2_domain
PANTHERiPTHR13844:SF5 PTHR13844:SF5, 1 hit
PfamiView protein in Pfam
PF02201 SWIB, 1 hit
SMARTiView protein in SMART
SM00151 SWIB, 1 hit
SUPFAMiSSF47592 SSF47592, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSMRD3_HUMAN
AccessioniPrimary (citable) accession number: Q6STE5
Secondary accession number(s): D3DX10
, Q2YD86, Q75MJ2, Q75MR8, Q92926, Q9BUH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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