UniProtKB - Q6STE5 (SMRD3_HUMAN)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
SMARCD3
Functioni
GO - Molecular functioni
- chromatin binding Source: Ensembl
- nuclear hormone receptor binding Source: UniProtKB
- nuclear receptor binding Source: BHF-UCL
- nuclear receptor coactivator activity Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
- transcription coactivator activity Source: BHF-UCL
- transcription factor binding Source: UniProtKB
GO - Biological processi
- cardiac right ventricle formation Source: Ensembl
- chromatin remodeling Source: BHF-UCL
- muscle cell differentiation Source: Ensembl
- neural retina development Source: BHF-UCL
- nucleosome disassembly Source: BHF-UCL
- positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
- positive regulation of neuroblast proliferation Source: BHF-UCL
- positive regulation of smooth muscle cell differentiation Source: Ensembl
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of lipid metabolic process Source: Reactome
- regulation of protein binding Source: Ensembl
- regulation of transcription by RNA polymerase II Source: BHF-UCL
- secondary heart field specification Source: Ensembl
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Neurogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6STE5 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214858, RMTs methylate histone arginines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
SIGNORi | Q6STE5 |
Names & Taxonomyi
Protein namesi | Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3Alternative name(s): 60 kDa BRG-1/Brm-associated factor subunit C BRG1-associated factor 60C Short name: BAF60C |
Gene namesi | Name:SMARCD3 Synonyms:BAF60C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11108, SMARCD3 |
MIMi | 601737, gene |
neXtProti | NX_Q6STE5 |
VEuPathDBi | HostDB:ENSG00000082014.16 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nBAF complex Source: UniProtKB
- npBAF complex Source: BHF-UCL
- nucleoplasm Source: HPA
- nucleus Source: BHF-UCL
- SWI/SNF complex Source: UniProtKB
Other locations
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6604 |
OpenTargetsi | ENSG00000082014 |
PharmGKBi | PA35958 |
Miscellaneous databases
Pharosi | Q6STE5, Tbio |
Genetic variation databases
BioMutai | SMARCD3 |
DMDMi | 57013057 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000071988 | 2 – 483 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3Add BLAST | 482 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 178 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q6STE5 |
jPOSTi | Q6STE5 |
MassIVEi | Q6STE5 |
MaxQBi | Q6STE5 |
PaxDbi | Q6STE5 |
PeptideAtlasi | Q6STE5 |
PRIDEi | Q6STE5 |
ProteomicsDBi | 67360 [Q6STE5-1] 67361 [Q6STE5-2] |
PTM databases
iPTMneti | Q6STE5 |
MetOSitei | Q6STE5 |
PhosphoSitePlusi | Q6STE5 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000082014, Expressed in subventricular zone (inner) (primate) and 230 other tissues |
ExpressionAtlasi | Q6STE5, baseline and differential |
Genevisiblei | Q6STE5, HS |
Organism-specific databases
HPAi | ENSG00000082014, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable).
Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789).
Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin.
Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204).
Interacts with SMARCA4/BRG1/BAF190A (PubMed:14701856).
Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. May allow recruitment of SWI/SNF containing complexes specifically to promoters where these factors are located.
Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1 (PubMed:14701856).
Interacts with PRDM1/BLIMP1 (PubMed:32417234).
2 PublicationsBy similarity4 PublicationsBinary interactionsi
Hide detailsIsoform 1 [Q6STE5-1]
With | #Exp. | IntAct |
---|---|---|
PPARG [P37231] | 3 | EBI-488506,EBI-781384 |
Isoform 2 [Q6STE5-2]
With | #Exp. | IntAct |
---|---|---|
PPARG [P37231] | 3 | EBI-488511,EBI-781384 |
GO - Molecular functioni
- nuclear hormone receptor binding Source: UniProtKB
- nuclear receptor binding Source: BHF-UCL
- signaling receptor binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112488, 56 interactors |
ComplexPortali | CPX-1164, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1201, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant |
CORUMi | Q6STE5 |
DIPi | DIP-33012N |
IntActi | Q6STE5, 26 interactors |
STRINGi | 9606.ENSP00000262188 |
Miscellaneous databases
RNActi | Q6STE5, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 258 – 335 | SWIB/MDM2PROSITE-ProRule annotationAdd BLAST | 78 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2570, Eukaryota |
GeneTreei | ENSGT00940000158945 |
HOGENOMi | CLU_023529_0_2_1 |
InParanoidi | Q6STE5 |
OMAi | WENSRSS |
OrthoDBi | 1027566at2759 |
PhylomeDBi | Q6STE5 |
TreeFami | TF106486 |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR038043, SMARCD3 IPR019835, SWIB_domain IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF5, PTHR13844:SF5, 1 hit |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit |
SMARTi | View protein in SMART SM00151, SWIB, 1 hit |
SUPFAMi | SSF47592, SSF47592, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY
60 70 80 90 100
MGSPAVRPGL APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR
110 120 130 140 150
RKMADKILPQ RIRELVPESQ AYMDLLAFER KLDQTIMRKR VDIQEALKRP
160 170 180 190 200
MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA SWELRVEGKL LDDPSKQKRK
210 220 230 240 250
FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV KRPGDLSVRC
260 270 280 290 300
TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH
310 320 330 340 350
DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS
360 370 380 390 400
DQKKTACYDI DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN
410 420 430 440 450
QLKIQRDFML SFSRDPKGYV QDLLRSQSRD LKVMTDVAGN PEEERRAEFY
460 470 480
HQPWSQEAVS RYFYCKIQQR RQELEQSLVV RNT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JYI7 | C9JYI7_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD3 | 139 | Annotation score: | ||
F8WBJ3 | F8WBJ3_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD3 | 73 | Annotation score: | ||
H7C4E9 | H7C4E9_HUMAN | SWI/SNF-related matrix-associated a... | SMARCD3 | 68 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 88 | V → E in AAC50697 (PubMed:8804307).Curated | 1 | |
Sequence conflicti | 140 | R → G in AAC50697 (PubMed:8804307).Curated | 1 | |
Sequence conflicti | 387 | A → P in AAC50697 (PubMed:8804307).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020884 | 170 | P → S1 PublicationCorresponds to variant dbSNP:rs1050101Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012498 | 1 – 26 | MAADE…LVHGV → MTPGLQHPPTVVQ in isoform 2. 3 PublicationsAdd BLAST | 26 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66619 mRNA Translation: AAC50697.1 Frameshift. AY450430 mRNA Translation: AAR88510.1 AY450431 mRNA Translation: AAR88511.1 AC021097 Genomic DNA Translation: AAS00380.1 AC005486 Genomic DNA Translation: AAS02031.1 CH471173 Genomic DNA Translation: EAW54005.1 CH471173 Genomic DNA Translation: EAW54007.1 CH471173 Genomic DNA Translation: EAW54008.1 BC002628 mRNA Translation: AAH02628.1 BC110350 mRNA Translation: AAI10351.1 |
CCDSi | CCDS34780.1 [Q6STE5-1] CCDS5924.1 [Q6STE5-2] |
RefSeqi | NP_001003801.1, NM_001003801.1 [Q6STE5-1] NP_001003802.1, NM_001003802.1 [Q6STE5-2] NP_003069.2, NM_003078.3 [Q6STE5-2] |
Genome annotation databases
Ensembli | ENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1] ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2] ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2] |
GeneIDi | 6604 |
KEGGi | hsa:6604 |
UCSCi | uc003wjs.4, human [Q6STE5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66619 mRNA Translation: AAC50697.1 Frameshift. AY450430 mRNA Translation: AAR88510.1 AY450431 mRNA Translation: AAR88511.1 AC021097 Genomic DNA Translation: AAS00380.1 AC005486 Genomic DNA Translation: AAS02031.1 CH471173 Genomic DNA Translation: EAW54005.1 CH471173 Genomic DNA Translation: EAW54007.1 CH471173 Genomic DNA Translation: EAW54008.1 BC002628 mRNA Translation: AAH02628.1 BC110350 mRNA Translation: AAI10351.1 |
CCDSi | CCDS34780.1 [Q6STE5-1] CCDS5924.1 [Q6STE5-2] |
RefSeqi | NP_001003801.1, NM_001003801.1 [Q6STE5-1] NP_001003802.1, NM_001003802.1 [Q6STE5-2] NP_003069.2, NM_003078.3 [Q6STE5-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112488, 56 interactors |
ComplexPortali | CPX-1164, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1201, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211, SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215, Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218, Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228, Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant |
CORUMi | Q6STE5 |
DIPi | DIP-33012N |
IntActi | Q6STE5, 26 interactors |
STRINGi | 9606.ENSP00000262188 |
PTM databases
iPTMneti | Q6STE5 |
MetOSitei | Q6STE5 |
PhosphoSitePlusi | Q6STE5 |
Genetic variation databases
BioMutai | SMARCD3 |
DMDMi | 57013057 |
Proteomic databases
EPDi | Q6STE5 |
jPOSTi | Q6STE5 |
MassIVEi | Q6STE5 |
MaxQBi | Q6STE5 |
PaxDbi | Q6STE5 |
PeptideAtlasi | Q6STE5 |
PRIDEi | Q6STE5 |
ProteomicsDBi | 67360 [Q6STE5-1] 67361 [Q6STE5-2] |
Protocols and materials databases
Antibodypediai | 18748, 248 antibodies |
DNASUi | 6604 |
Genome annotation databases
Ensembli | ENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1] ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2] ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2] |
GeneIDi | 6604 |
KEGGi | hsa:6604 |
UCSCi | uc003wjs.4, human [Q6STE5-1] |
Organism-specific databases
CTDi | 6604 |
DisGeNETi | 6604 |
GeneCardsi | SMARCD3 |
HGNCi | HGNC:11108, SMARCD3 |
HPAi | ENSG00000082014, Tissue enhanced (skeletal) |
MIMi | 601737, gene |
neXtProti | NX_Q6STE5 |
OpenTargetsi | ENSG00000082014 |
PharmGKBi | PA35958 |
VEuPathDBi | HostDB:ENSG00000082014.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2570, Eukaryota |
GeneTreei | ENSGT00940000158945 |
HOGENOMi | CLU_023529_0_2_1 |
InParanoidi | Q6STE5 |
OMAi | WENSRSS |
OrthoDBi | 1027566at2759 |
PhylomeDBi | Q6STE5 |
TreeFami | TF106486 |
Enzyme and pathway databases
PathwayCommonsi | Q6STE5 |
Reactomei | R-HSA-1368082, RORA activates gene expression R-HSA-1368108, BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781, PPARA activates gene expression R-HSA-2151201, Transcriptional activation of mitochondrial biogenesis R-HSA-2426168, Activation of gene expression by SREBF (SREBP) R-HSA-3214858, RMTs methylate histone arginines R-HSA-381340, Transcriptional regulation of white adipocyte differentiation R-HSA-400206, Regulation of lipid metabolism by PPARalpha R-HSA-400253, Circadian Clock R-HSA-8939243, RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
SIGNORi | Q6STE5 |
Miscellaneous databases
BioGRID-ORCSi | 6604, 7 hits in 996 CRISPR screens |
ChiTaRSi | SMARCD3, human |
GeneWikii | SMARCD3 |
GenomeRNAii | 6604 |
Pharosi | Q6STE5, Tbio |
PROi | PR:Q6STE5 |
RNActi | Q6STE5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000082014, Expressed in subventricular zone (inner) (primate) and 230 other tissues |
ExpressionAtlasi | Q6STE5, baseline and differential |
Genevisiblei | Q6STE5, HS |
Family and domain databases
Gene3Di | 1.10.245.10, 1 hit |
InterProi | View protein in InterPro IPR038043, SMARCD3 IPR019835, SWIB_domain IPR036885, SWIB_MDM2_dom_sf IPR003121, SWIB_MDM2_domain |
PANTHERi | PTHR13844:SF5, PTHR13844:SF5, 1 hit |
Pfami | View protein in Pfam PF02201, SWIB, 1 hit |
SMARTi | View protein in SMART SM00151, SWIB, 1 hit |
SUPFAMi | SSF47592, SSF47592, 1 hit |
PROSITEi | View protein in PROSITE PS51925, SWIB_MDM2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMRD3_HUMAN | |
Accessioni | Q6STE5Primary (citable) accession number: Q6STE5 Secondary accession number(s): D3DX10 Q9BUH1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 172 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families