SMARCD3

Functionⁱ

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).2 PublicationsBy similarity2 Publications

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
nuclear hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856
nuclear receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17363140
nuclear receptor transcription coactivator activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17363140
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856
transcription coactivator activity
Source: BHF-UCL
Non-traceable author statementⁱ
- 8804307
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cardiac right ventricle formation Source: Ensembl
chromatin remodeling
Source: BHF-UCL
Inferred from direct assayⁱ
- 11726552
muscle cell differentiation Source: Ensembl
neural retina development
Source: BHF-UCL
Inferred from expression patternⁱ
- 18816825
nucleosome disassembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 8895581
positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
positive regulation of neuroblast proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 18816825
positive regulation of smooth muscle cell differentiation Source: Ensembl
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 14701856
regulation of lipid metabolic process Source: Reactome
regulation of protein binding Source: Ensembl
regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17363140
secondary heart field specification Source: Ensembl
transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 14701856

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-3214858 RMTs methylate histone arginines R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400253 Circadian Clock R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORⁱ	Q6STE5

Reactomeⁱ

R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SIGNORⁱ

Q6STE5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 Alternative name(s): 60 kDa BRG-1/Brm-associated factor subunit C BRG1-associated factor 60C Short name: BAF60C
Gene namesⁱ	Name:SMARCD3 Synonyms:BAF60C
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000082014.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11108 SMARCD3
MIMⁱ	601737 gene
neXtProtⁱ	NX_Q6STE5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6604
Open Targets More...OpenTargetsⁱ	ENSG00000082014
PharmGKBⁱ	PA35958

Polymorphism and mutation databases

BioMutaⁱ	SMARCD3
DMDMⁱ	57013057

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000071988	2 – 483	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3Add BLAST		482

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1
Modified residueⁱ	178	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q6STE5
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6STE5
PaxDbⁱ	Q6STE5
PeptideAtlas More...PeptideAtlasⁱ	Q6STE5
PRIDEⁱ	Q6STE5
ProteomicsDBⁱ	67360 67361 [Q6STE5-2]

PTM databases

iPTMnetⁱ	Q6STE5
PhosphoSitePlusⁱ	Q6STE5

Expressionⁱ

Tissue specificityⁱ

Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.

Gene expression databases

Bgeeⁱ	ENSG00000082014 Expressed in 217 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_SMARCD3
ExpressionAtlasⁱ	Q6STE5 baseline and differential
Genevisibleⁱ	Q6STE5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA063955 HPA065517

HPAⁱ

HPA063955
HPA065517

Interactionⁱ

Subunit structureⁱ

Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific (Probable). Component of the BAF complex, which includes at least actin (ACTB), ARID1A/BAF250A, ARID1B/BAF250B, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3 (PubMed:18765789). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity). May be a component of the SWI/SNF-B (PBAF) chromatin remodeling complex, at least composed of SMARCA4/BRG1, SMARCB1/BAF47/SNF5, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PBRM1/BAF180, ARID2/BAF200 and actin (PubMed:22952240, PubMed:26601204). Interacts with SMARCA4/BRG1/BAF190A (PubMed:14701856). Component of SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058). The precise distribution of the related SMARCD1, SMARCD2 and SMARCD3 proteins among these and other SWI/SNF nucleosome-remodeling complexes is not fully known. May allow recruitment of SWI/SNF containing complexes specifically to promoters where these factors are located. Also interacts with several nuclear receptors including PPARG/NR1C3, RXRA/NR1F1, ESR1, NR5A1, NR5A2/LRH1 and other transcriptional activators including the HLH protein SREBF1/SREBP1 and the homeobox protein PBX1 (PubMed:14701856).2 PublicationsBy similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PPARG	P37231	3	EBI-488511,EBI-781384

With

Entry

#Exp.

IntAct

Notes

PPARG

P37231

3

EBI-488511,EBI-781384

GO - Molecular functionⁱ

nuclear hormone receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856
nuclear receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17363140
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856
transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 14701856

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112488, 44 interactors
ComplexPortalⁱ	CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CORUMⁱ	Q6STE5
Database of interacting proteins More...DIPⁱ	DIP-33012N
IntActⁱ	Q6STE5, 19 interactors
STRINGⁱ	9606.ENSP00000262188

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6STE5
SMRⁱ	Q6STE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	259 – 334	SWIBAdd BLAST		76

Sequence similaritiesⁱ

Belongs to the SMARCD family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2570 Eukaryota COG5531 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017809
HOVERGENⁱ	HBG054046
InParanoidⁱ	Q6STE5
KEGG Orthology (KO) More...KOⁱ	K11650
OMAⁱ	METTRKR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06WW
PhylomeDBⁱ	Q6STE5
TreeFamⁱ	TF106486

Family and domain databases

Gene3Dⁱ	1.10.245.10, 1 hit
InterProⁱ	View protein in InterPro IPR038043 SMARCD3 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain
PANTHERⁱ	PTHR13844:SF5 PTHR13844:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02201 SWIB, 1 hit
SMARTⁱ	View protein in SMART SM00151 SWIB, 1 hit
SUPFAMⁱ	SSF47592 SSF47592, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6STE5-1) [UniParc]FASTA Add to basket

Also known as: BAF60C2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAADEVAGGA RKATKSKLFE FLVHGVRPGM PSGARMPHQG APMGPPGSPY 
        60         70         80         90        100
MGSPAVRPGL APAGMEPARK RAAPPPGQSQ AQSQGQPVPT APARSRSAKR 
       110        120        130        140        150
RKMADKILPQ RIRELVPESQ AYMDLLAFER KLDQTIMRKR VDIQEALKRP 
       160        170        180        190        200
MKQKRKLRLY ISNTFNPAKP DAEDSDGSIA SWELRVEGKL LDDPSKQKRK 
       210        220        230        240        250
FSSFFKSLVI ELDKDLYGPD NHLVEWHRTP TTQETDGFQV KRPGDLSVRC 
       260        270        280        290        300
TLLLMLDYQP PQFKLDPRLA RLLGLHTQSR SAIVQALWQY VKTNRLQDSH 
       310        320        330        340        350
DKEYINGDKY FQQIFDCPRL KFSEIPQRLT ALLLPPDPIV INHVISVDPS 
       360        370        380        390        400
DQKKTACYDI DVEVEEPLKG QMSSFLLSTA NQQEISALDS KIHETIESIN 
       410        420        430        440        450
QLKIQRDFML SFSRDPKGYV QDLLRSQSRD LKVMTDVAGN PEEERRAEFY 
       460        470        480 
HQPWSQEAVS RYFYCKIQQR RQELEQSLVV RNT

Length:483

Mass (Da):55,016

Last modified:July 5, 2004 - v1

Checksum:ⁱB7B28DD11DCD0B5C

GO

Isoform 2 (identifier: Q6STE5-2) [UniParc]FASTA Add to basket

Also known as: BAF60C1

The sequence of this isoform differs from the canonical sequence as follows:
1-26: MAADEVAGGARKATKSKLFEFLVHGV → MTPGLQHPPTVVQ

« Hide

        10         20         30         40         50
MTPGLQHPPT VVQRPGMPSG ARMPHQGAPM GPPGSPYMGS PAVRPGLAPA 
        60         70         80         90        100
GMEPARKRAA PPPGQSQAQS QGQPVPTAPA RSRSAKRRKM ADKILPQRIR 
       110        120        130        140        150
ELVPESQAYM DLLAFERKLD QTIMRKRVDI QEALKRPMKQ KRKLRLYISN 
       160        170        180        190        200
TFNPAKPDAE DSDGSIASWE LRVEGKLLDD PSKQKRKFSS FFKSLVIELD 
       210        220        230        240        250
KDLYGPDNHL VEWHRTPTTQ ETDGFQVKRP GDLSVRCTLL LMLDYQPPQF 
       260        270        280        290        300
KLDPRLARLL GLHTQSRSAI VQALWQYVKT NRLQDSHDKE YINGDKYFQQ 
       310        320        330        340        350
IFDCPRLKFS EIPQRLTALL LPPDPIVINH VISVDPSDQK KTACYDIDVE 
       360        370        380        390        400
VEEPLKGQMS SFLLSTANQQ EISALDSKIH ETIESINQLK IQRDFMLSFS 
       410        420        430        440        450
RDPKGYVQDL LRSQSRDLKV MTDVAGNPEE ERRAEFYHQP WSQEAVSRYF 
       460        470
YCKIQQRRQE LEQSLVVRNT

Show »

Length:470

Mass (Da):53,687

Checksum:ⁱDD6C2454B7AC2B04

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JYI7	C9JYI7_HUMAN	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	SMARCD3	139	Annotation score:
H7C4E9	H7C4E9_HUMAN	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	SMARCD3	68	Annotation score:
F8WBJ3	F8WBJ3_HUMAN	SWI/SNF-related matrix-associated a... SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3	SMARCD3	73	Annotation score:

Sequence cautionⁱ

The sequence AAC50697 differs from that shown. Reason: Frameshift at positions 41, 65 and 78.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	88	V → E in AAC50697 (PubMed:8804307).Curated	1
Sequence conflictⁱ	140	R → G in AAC50697 (PubMed:8804307).Curated	1
Sequence conflictⁱ	387	A → P in AAC50697 (PubMed:8804307).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_020884	170	P → S1 PublicationCorresponds to variant dbSNP:rs1050101Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_012498	1 – 26	MAADE…LVHGV → MTPGLQHPPTVVQ in isoform 2. 3 PublicationsAdd BLAST		26

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U66619 mRNA Translation: AAC50697.1 Frameshift. AY450430 mRNA Translation: AAR88510.1 AY450431 mRNA Translation: AAR88511.1 AC021097 Genomic DNA Translation: AAS00380.1 AC005486 Genomic DNA Translation: AAS02031.1 CH471173 Genomic DNA Translation: EAW54005.1 CH471173 Genomic DNA Translation: EAW54007.1 CH471173 Genomic DNA Translation: EAW54008.1 BC002628 mRNA Translation: AAH02628.1 BC110350 mRNA Translation: AAI10351.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34780.1 [Q6STE5-1] CCDS5924.1 [Q6STE5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001003801.1, NM_001003801.1 [Q6STE5-1] NP_001003802.1, NM_001003802.1 [Q6STE5-2] NP_003069.2, NM_003078.3 [Q6STE5-2]
UniGeneⁱ	Hs.647067

Genome annotation databases

Ensemblⁱ	ENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1] ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2] ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2]
GeneIDⁱ	6604
KEGGⁱ	hsa:6604
UCSC genome browser More...UCSCⁱ	uc003wjs.4 human [Q6STE5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6STE5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		MACMU		483	UniRef100_Q6STE5
SMARCD3 isoform 2		PANTR		483
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		CALJA		483
Uncharacterized protein		PROCO		483
Uncharacterized protein		COLAP		483
+9
Q6STE5-2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		HUMAN		470	UniRef100_A0A090N8Z9
SMARCD3 isoform 3		PANTR		470
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		MACMU		470
Macaca fascicularis brain cDNA clone: QorA-10583, similar to human SWI/SNF related, matrix associated, actin dependentregulator of chromatin, subfamily d, member 3 (SMARCD3), mRNA, RefSeq: NM_003078.2		MACFA		470
Uncharacterized protein		PROCO		470
+5

Protein	Similar proteins		Species	Score	Length	Source
Q6STE5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3		MOUSE		483	UniRef90_Q6STE5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		MACMU		483
SMARCD3 isoform 2		PANTR		483
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		CALJA		483
Uncharacterized protein		PROCO		483
+174

Protein	Similar proteins		Species	Score	Length	Source
Q6STE5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3		MOUSE		483	UniRef50_Q6STE5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		MACMU		483
SMARCD3 isoform 2		PANTR		483
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3		CALJA		483
Uncharacterized protein		PROCO		483
+175

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U66619 mRNA Translation: AAC50697.1 Frameshift. AY450430 mRNA Translation: AAR88510.1 AY450431 mRNA Translation: AAR88511.1 AC021097 Genomic DNA Translation: AAS00380.1 AC005486 Genomic DNA Translation: AAS02031.1 CH471173 Genomic DNA Translation: EAW54005.1 CH471173 Genomic DNA Translation: EAW54007.1 CH471173 Genomic DNA Translation: EAW54008.1 BC002628 mRNA Translation: AAH02628.1 BC110350 mRNA Translation: AAI10351.1
CCDSⁱ	CCDS34780.1 [Q6STE5-1] CCDS5924.1 [Q6STE5-2]
RefSeqⁱ	NP_001003801.1, NM_001003801.1 [Q6STE5-1] NP_001003802.1, NM_001003802.1 [Q6STE5-2] NP_003069.2, NM_003078.3 [Q6STE5-2]
UniGeneⁱ	Hs.647067

3D structure databases

ProteinModelPortalⁱ	Q6STE5
SMRⁱ	Q6STE5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112488, 44 interactors
ComplexPortalⁱ	CPX-1164 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1194 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA2 variant CPX-1201 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1202 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA2 variant CPX-1204 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1205 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1206 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1207 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1209 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1210 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1211 SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant CPX-1212 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1213 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1215 Neural progenitor-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1216 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1A-SMARCA4 variant CPX-1217 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA2 variant CPX-1218 Neuron-specific SWI/SNF ATP-dependent chromatin remodeling complex, ARID1B-SMARCA4 variant CPX-1222 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1A-SMARCA4 variant CPX-1223 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA2 variant CPX-1224 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6A-ARID1B-SMARCA4 variant CPX-1225 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA2 variant CPX-1226 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1A-SMARCA4 variant CPX-1227 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA2 variant CPX-1228 Muscle cell-specific SWI/SNF ATP-dependent chromatin remodeling complex, ACTL6B-ARID1B-SMARCA4 variant
CORUMⁱ	Q6STE5
DIPⁱ	DIP-33012N
IntActⁱ	Q6STE5, 19 interactors
STRINGⁱ	9606.ENSP00000262188

PTM databases

iPTMnetⁱ	Q6STE5
PhosphoSitePlusⁱ	Q6STE5

Polymorphism and mutation databases

BioMutaⁱ	SMARCD3
DMDMⁱ	57013057

Proteomic databases

EPDⁱ	Q6STE5
MaxQBⁱ	Q6STE5
PaxDbⁱ	Q6STE5
PeptideAtlasⁱ	Q6STE5
PRIDEⁱ	Q6STE5
ProteomicsDBⁱ	67360 67361 [Q6STE5-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6604
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262188; ENSP00000262188; ENSG00000082014 [Q6STE5-1] ENST00000356800; ENSP00000349254; ENSG00000082014 [Q6STE5-2] ENST00000392811; ENSP00000376558; ENSG00000082014 [Q6STE5-2]
GeneIDⁱ	6604
KEGGⁱ	hsa:6604
UCSCⁱ	uc003wjs.4 human [Q6STE5-1]

Organism-specific databases

CTDⁱ	6604
DisGeNETⁱ	6604
EuPathDBⁱ	HostDB:ENSG00000082014.16
GeneCardsⁱ	SMARCD3
HGNCⁱ	HGNC:11108 SMARCD3
HPAⁱ	HPA063955 HPA065517
MIMⁱ	601737 gene
neXtProtⁱ	NX_Q6STE5
OpenTargetsⁱ	ENSG00000082014
PharmGKBⁱ	PA35958
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2570 Eukaryota COG5531 LUCA
GeneTreeⁱ	ENSGT00390000017809
HOVERGENⁱ	HBG054046
InParanoidⁱ	Q6STE5
KOⁱ	K11650
OMAⁱ	METTRKR
OrthoDBⁱ	EOG091G06WW
PhylomeDBⁱ	Q6STE5
TreeFamⁱ	TF106486

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368082 RORA activates gene expression R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-3214858 RMTs methylate histone arginines R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400253 Circadian Clock R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SIGNORⁱ	Q6STE5

Reactomeⁱ

R-HSA-1368082 RORA activates gene expression
R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
R-HSA-1989781 PPARA activates gene expression
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis
R-HSA-2426168 Activation of gene expression by SREBF (SREBP)
R-HSA-3214858 RMTs methylate histone arginines
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-HSA-400253 Circadian Clock
R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

SIGNORⁱ

Q6STE5

Miscellaneous databases

ChiTaRSⁱ	SMARCD3 human
GeneWikiⁱ	SMARCD3
GenomeRNAiⁱ	6604
Protein Ontology More...PROⁱ	PR:Q6STE5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000082014 Expressed in 217 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_SMARCD3
ExpressionAtlasⁱ	Q6STE5 baseline and differential
Genevisibleⁱ	Q6STE5 HS

Family and domain databases

Gene3Dⁱ	1.10.245.10, 1 hit
InterProⁱ	View protein in InterPro IPR038043 SMARCD3 IPR019835 SWIB_domain IPR036885 SWIB_MDM2_dom_sf IPR003121 SWIB_MDM2_domain
PANTHERⁱ	PTHR13844:SF5 PTHR13844:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF02201 SWIB, 1 hit
SMARTⁱ	View protein in SMART SM00151 SWIB, 1 hit
SUPFAMⁱ	SSF47592 SSF47592, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SMRD3_HUMAN
Accessionⁱ	Q6STE5Primary (citable) accession number: Q6STE5 Secondary accession number(s): D3DX10 , Q2YD86, Q75MJ2, Q75MR8, Q92926, Q9BUH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q6STE5 (SMRD3_HUMAN)

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

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Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ