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Protein

Enkurin

Gene

Enkur

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.1 Publication

GO - Molecular functioni

  • calmodulin binding Source: MGI
  • SH3 domain binding Source: UniProtKB-KW

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enkurin
Gene namesi
Name:Enkur
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1918483 Enkur

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869761 – 255EnkurinAdd BLAST255

Proteomic databases

MaxQBiQ6SP97
PaxDbiQ6SP97
PRIDEiQ6SP97

PTM databases

PhosphoSitePlusiQ6SP97

Expressioni

Tissue specificityi

High expression in testis and vomeronasal organ and lower expression in ovary, heart, lung, and brain. Not expressed in other tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000026679 Expressed in 102 organ(s), highest expression level in seminiferous tubule of testis
CleanExiMM_4933434I06RIK
ExpressionAtlasiQ6SP97 baseline and differential
GenevisibleiQ6SP97 MM

Interactioni

Subunit structurei

Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027992

Structurei

3D structure databases

ProteinModelPortaliQ6SP97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 252EnkurinPROSITE-ProRule annotationAdd BLAST93
Domaini176 – 187IQAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 89SH3-bindingSequence analysis7

Domaini

Residues 160-255 contains the TRPC2 binding site.
The IQ motif is involved in calmodulin binding.

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiENOG410IET1 Eukaryota
ENOG410ZNA7 LUCA
GeneTreeiENSGT00390000009461
HOGENOMiHOG000007231
HOVERGENiHBG056756
InParanoidiQ6SP97
OMAiHPVMGIQ
OrthoDBiEOG091G0MPU
PhylomeDBiQ6SP97
TreeFamiTF323892

Family and domain databases

InterProiView protein in InterPro
IPR026150 Enkur
IPR027012 Enkurin_dom
PANTHERiPTHR21490:SF0 PTHR21490:SF0, 1 hit
PfamiView protein in Pfam
PF13864 Enkurin, 1 hit
PROSITEiView protein in PROSITE
PS51665 ENKURIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6SP97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSPCTSESI YNLIPSDLKE PPQHPRYTSL FRATIKNDMK KFKTAMKTMG
60 70 80 90 100
PAKVEIPSPK DFLKKHSKEK TLPPKKKFNR CSPKKPAVPL RTDHPVMGIQ
110 120 130 140 150
SGKNFINTNA ADVIMGVAKK PKPIYVDKRT GDKHDLETSG LFPKYINKKD
160 170 180 190 200
YGITPEYICK RNEDVKKAQE EYDNYIQENL KKAAMKRLSD EEREAVLQGL
210 220 230 240 250
KKNWEEVHKE FQSLSVFIDS VPKKIRKQKL EKEMKQLEHD ISVIEKHKII

YIANK
Length:255
Mass (Da):29,527
Last modified:July 5, 2004 - v1
Checksum:i325389264E2701EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454124 mRNA Translation: AAS45167.1
CCDSiCCDS38055.1
RefSeqiNP_082004.1, NM_027728.2
UniGeneiMm.27658

Genome annotation databases

EnsembliENSMUST00000027992; ENSMUSP00000027992; ENSMUSG00000026679
GeneIDi71233
KEGGimmu:71233
UCSCiuc008ina.1 mouse

Similar proteinsi

Entry informationi

Entry nameiENKUR_MOUSE
AccessioniPrimary (citable) accession number: Q6SP97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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