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Protein

Basic phospholipase A2 2

Gene
N/A
Organism
Bungarus caeruleus (Indian krait)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom phospholipase A2 (PLA2) that shows anticoagulant and neurotoxic activities.By similarity
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activityi

Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.PROSITE-ProRule annotation

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi47Calcium; via carbonyl oxygenBy similarity1
Binding sitei48Mannose1 Publication1
Metal bindingi49Calcium; via carbonyl oxygenBy similarity1
Active sitei65By similarity1
Metal bindingi66CalciumBy similarity1
Binding sitei66Mannose1 Publication1
Active sitei111By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Toxin
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.4 8193

Names & Taxonomyi

Protein namesi
Recommended name:
Basic phospholipase A2 2 (EC:3.1.1.4)
Short name:
svPLA2
Alternative name(s):
Phosphatidylcholine 2-acylhydrolase
OrganismiBungarus caeruleus (Indian krait)
Taxonomic identifieri132961 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeBungarinaeBungarus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 11Sequence analysisAdd BLAST›11
PropeptideiPRO_000041430412 – 19By similarity8
ChainiPRO_000041430520 – 137Basic phospholipase A2 2Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 89Combined sources1 Publication
Disulfide bondi44 ↔ 136Combined sources1 Publication
Disulfide bondi46 ↔ 62Combined sources1 Publication
Disulfide bondi61 ↔ 117Combined sources1 Publication
Disulfide bondi68 ↔ 110Combined sources1 Publication
Disulfide bondi78 ↔ 103Combined sources1 Publication
Disulfide bondi96 ↔ 108Combined sources1 Publication

Post-translational modificationi

Homodimerization and interaction of the catalytically important Asp-49 (here Asp-111) with mannose molecules may render this protein inactive.

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Homodimer; non-covalently linked.1 Publication

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6SLM1
SMRiQ6SLM1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6SLM1

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG008137

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6SLM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LVAVCVSLLG AANIPPQPLN LKQFKNMIQC AGTRTWTSYI GYGCYCGYGG
60 70 80 90 100
SGTPVDELDR CCYTHDHCYN KAANIPGCNP LIKTYSYTCT KPNITCNDTS
110 120 130
DSCARFICDC DRTAAICFAS APYNINNIMI SASTSCQ
Length:137
Mass (Da):14,827
Last modified:July 5, 2004 - v1
Checksum:i322B123BF4F6BD05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455755 mRNA Translation: AAR19228.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY455755 mRNA Translation: AAR19228.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0ZX-ray2.18A/B20-137[»]
1U4JX-ray2.18A/B20-137[»]
ProteinModelPortaliQ6SLM1
SMRiQ6SLM1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG008137

Enzyme and pathway databases

BRENDAi3.1.1.4 8193

Miscellaneous databases

EvolutionaryTraceiQ6SLM1

Family and domain databases

CDDicd00125 PLA2c, 1 hit
Gene3Di1.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001211 PLipase_A2
IPR033112 PLipase_A2_Asp_AS
IPR016090 PLipase_A2_dom
IPR036444 PLipase_A2_dom_sf
IPR033113 PLipase_A2_His_AS
PANTHERiPTHR11716 PTHR11716, 1 hit
PfamiView protein in Pfam
PF00068 Phospholip_A2_1, 1 hit
PRINTSiPR00389 PHPHLIPASEA2
SMARTiView protein in SMART
SM00085 PA2c, 1 hit
SUPFAMiSSF48619 SSF48619, 1 hit
PROSITEiView protein in PROSITE
PS00119 PA2_ASP, 1 hit
PS00118 PA2_HIS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPA2B5_BUNCE
AccessioniPrimary (citable) accession number: Q6SLM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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