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Protein

Methyltransferase N6AMT1

Gene

N6amt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic (PubMed:20606008, PubMed:26797129). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:26797129). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:20606008, PubMed:26797129). Also acts as a N6-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N6-methyladenosine) (By similarity). N6-methyladenosine (m6A) DNA is significantly enriched in exonic regions and is associated with gene transcriptional activation (By similarity). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity).By similarity2 Publications

Caution

Although predicted to act as a DNA methyltransferase, DNA methyltransferase activity has been elusive for many years due to inability to detect N6-methyladenosine (m6A) in vertebrate cells (PubMed:16684535, PubMed:19116772). The development of deep sequencing allowed identification of m6A in mammal cells and identification of N6amt1 as a N6-adenine-specific DNA methyltransferase.By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei77S-adenosyl-L-methionineBy similarity1
Binding sitei122S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.297 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-156581 Methylation
R-MMU-72764 Eukaryotic Translation Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Methyltransferase N6AMT1Curated
Alternative name(s):
HemK methyltransferase family member 21 Publication
Methylarsonite methyltransferase N6AMT1By similarity (EC:2.1.1.-By similarity)
N(6)-adenine-specific DNA methyltransferase 1Curated (EC:2.1.1.72By similarity)
Protein N(5)-glutamine methyltransferaseCurated (EC:2.1.1.-2 Publications)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:N6amt1Imported
Synonyms:Hemk21 PublicationImported, Pred281 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1915018 N6amt1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Early embryonic lethality (PubMed:20606008). The postimplantation development of mutant embryos is impaired, resulting in degeneration around embryonic day 6.5 (PubMed:20606008).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004455561 – 214Methyltransferase N6AMT1Add BLAST214

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6SKR2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6SKR2

PeptideAtlas

More...
PeptideAtlasi
Q6SKR2

PRoteomics IDEntifications database

More...
PRIDEi
Q6SKR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in undifferentiated embryonic stem cells (at protein level) (PubMed:19116772). Also expressed in testis and brain, weakly expressed in differentiated embryonic stem cells and kidney (PubMed:19116772). Not expressed in muscle, heart, placenta, pancreas, lung and stomach (PubMed:19116772).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000044442 Expressed in 239 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6SKR2 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer; heterodimerizes with TRMT112.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000061835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6SKR2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6SKR2

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 57S-adenosyl-L-methionine bindingUniRule annotationBy similarity5
Regioni122 – 125Substrate bindingBy similarity4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3191 Eukaryota
COG2890 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000013073

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000219949

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052569

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6SKR2

KEGG Orthology (KO)

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KOi
K19589

Identification of Orthologs from Complete Genome Data

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OMAi
EWDDWME

Database of Orthologous Groups

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OrthoDBi
EOG091G0XHW

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6SKR2

TreeFam database of animal gene trees

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TreeFami
TF314919

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004557 PrmC-related
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05175 MTS, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53335 SSF53335, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00537 hemK_rel_arch, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00092 N6_MTASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6SKR2-1) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication, mHemk11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAPSVPTPL YGHVGRGAFR DVYEPAEDTF LLLDALEAAA AELAGVEICL
60 70 80 90 100
EVGAGSGVVS AFLASMIGPR ALYMCTDINP EAAACTLETA RCNRVHVQPV
110 120 130 140 150
ITDLVHGLLP RLKGKVDLLV FNPPYVVTPP EEVGSRGIEA AWAGGRNGRE
160 170 180 190 200
VMDRFFPLAP ELLSPRGLFY LVTVKENNPE EIFKTMKTRG LQGTTALCRQ
210
AGQEALSVLR FSKS
Length:214
Mass (Da):22,984
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB8A545E9DABB5F6C
GO
Isoform 2 (identifier: Q6SKR2-2) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication, mHemk21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     133-138: VGSRGI → RKSLKQ
     139-214: Missing.

Show »
Length:138
Mass (Da):14,685
Checksum:i3F7DE6EE486A6C05
GO
Isoform 3 (identifier: Q6SKR2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-150: VGSRGIEAAWAGGRNGRE → VRLTTELSLCSQLFHETK
     151-214: Missing.

Show »
Length:150
Mass (Da):16,032
Checksum:i0D893888F140FC8F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AC140319 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EDK98331 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti75C → Y in AAH98330 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_059900133 – 150VGSRG…RNGRE → VRLTTELSLCSQLFHETK in isoform 3. Add BLAST18
Alternative sequenceiVSP_059901133 – 138VGSRGI → RKSLKQ in isoform 2. 6
Alternative sequenceiVSP_059902139 – 214Missing in isoform 2. Add BLAST76
Alternative sequenceiVSP_059903151 – 214Missing in isoform 3. Add BLAST64

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY583759 mRNA Translation: AAS94315.1
AY536887 mRNA Translation: AAS45233.1
AY456393 mRNA Translation: AAR19227.1
AK145617 mRNA Translation: BAE26543.1
AC140319 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK98330.1
CH466521 Genomic DNA Translation: EDK98331.1 Sequence problems.
CH466521 Genomic DNA Translation: EDK98332.1
BC098330 mRNA Translation: AAH98330.1
BC116393 mRNA Translation: AAI16394.1
BC116394 mRNA Translation: AAI16395.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28289.1 [Q6SKR2-1]
CCDS49889.1 [Q6SKR2-2]

NCBI Reference Sequences

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RefSeqi
NP_001152803.1, NM_001159331.1 [Q6SKR2-2]
NP_080642.1, NM_026366.2 [Q6SKR2-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.296532

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000054442; ENSMUSP00000061835; ENSMUSG00000044442 [Q6SKR2-1]
ENSMUST00000118310; ENSMUSP00000113229; ENSMUSG00000044442 [Q6SKR2-2]
ENSMUST00000120284; ENSMUSP00000112510; ENSMUSG00000044442 [Q6SKR2-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
67768

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:67768

UCSC genome browser

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UCSCi
uc007zuc.1 mouse
uc007zud.1 mouse [Q6SKR2-1]
uc007zue.1 mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY583759 mRNA Translation: AAS94315.1
AY536887 mRNA Translation: AAS45233.1
AY456393 mRNA Translation: AAR19227.1
AK145617 mRNA Translation: BAE26543.1
AC140319 Genomic DNA No translation available.
CH466521 Genomic DNA Translation: EDK98330.1
CH466521 Genomic DNA Translation: EDK98331.1 Sequence problems.
CH466521 Genomic DNA Translation: EDK98332.1
BC098330 mRNA Translation: AAH98330.1
BC116393 mRNA Translation: AAI16394.1
BC116394 mRNA Translation: AAI16395.1
CCDSiCCDS28289.1 [Q6SKR2-1]
CCDS49889.1 [Q6SKR2-2]
RefSeqiNP_001152803.1, NM_001159331.1 [Q6SKR2-2]
NP_080642.1, NM_026366.2 [Q6SKR2-1]
UniGeneiMm.296532

3D structure databases

ProteinModelPortaliQ6SKR2
SMRiQ6SKR2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061835

Proteomic databases

MaxQBiQ6SKR2
PaxDbiQ6SKR2
PeptideAtlasiQ6SKR2
PRIDEiQ6SKR2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054442; ENSMUSP00000061835; ENSMUSG00000044442 [Q6SKR2-1]
ENSMUST00000118310; ENSMUSP00000113229; ENSMUSG00000044442 [Q6SKR2-2]
ENSMUST00000120284; ENSMUSP00000112510; ENSMUSG00000044442 [Q6SKR2-3]
GeneIDi67768
KEGGimmu:67768
UCSCiuc007zuc.1 mouse
uc007zud.1 mouse [Q6SKR2-1]
uc007zue.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29104
MGIiMGI:1915018 N6amt1

Phylogenomic databases

eggNOGiKOG3191 Eukaryota
COG2890 LUCA
GeneTreeiENSGT00390000013073
HOGENOMiHOG000219949
HOVERGENiHBG052569
InParanoidiQ6SKR2
KOiK19589
OMAiEWDDWME
OrthoDBiEOG091G0XHW
PhylomeDBiQ6SKR2
TreeFamiTF314919

Enzyme and pathway databases

BRENDAi2.1.1.297 3474
ReactomeiR-MMU-156581 Methylation
R-MMU-72764 Eukaryotic Translation Termination

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
N6amt1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000044442 Expressed in 239 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ6SKR2 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004557 PrmC-related
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00537 hemK_rel_arch, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiN6MT1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6SKR2
Secondary accession number(s): D3Z6J0
, E9PXT7, Q4KMV5, Q6PRU9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: July 5, 2004
Last modified: December 5, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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