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UniProtKB - Q6SJ96 (TBPL2_HUMAN)
Protein
TATA box-binding protein-like 2
Gene
TBPL2
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- general transcription initiation factor activity Source: GO_Central
- RNA polymerase II general transcription initiation factor activity Source: GO_Central
GO - Biological processi
- DNA-templated transcription, initiation Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q6SJ96 |
SignaLinki | Q6SJ96 |
SIGNORi | Q6SJ96 |
Names & Taxonomyi
Protein namesi | Recommended name: TATA box-binding protein-like 2Short name: TBP-like 2 Alternative name(s): TATA box-binding protein-related factor 3 Short name: TBP-related factor 3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19841, TBPL2 |
MIMi | 608964, gene |
neXtProti | NX_Q6SJ96 |
VEuPathDBi | HostDB:ENSG00000182521 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 387332 |
OpenTargetsi | ENSG00000182521 |
PharmGKBi | PA134990291 |
Miscellaneous databases
Pharosi | Q6SJ96, Tbio |
Genetic variation databases
BioMutai | TBPL2 |
DMDMi | 74749326 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318118 | 1 – 375 | TATA box-binding protein-like 2Add BLAST | 375 |
Proteomic databases
EPDi | Q6SJ96 |
jPOSTi | Q6SJ96 |
MassIVEi | Q6SJ96 |
MaxQBi | Q6SJ96 |
PaxDbi | Q6SJ96 |
PeptideAtlasi | Q6SJ96 |
PRIDEi | Q6SJ96 |
ProteomicsDBi | 67358 |
PTM databases
iPTMneti | Q6SJ96 |
PhosphoSitePlusi | Q6SJ96 |
Expressioni
Tissue specificityi
Ubiquitously expressed in all tissues examined with highest levels in heart, lung, ovary, spleen and testes.2 Publications
Gene expression databases
Bgeei | ENSG00000182521, Expressed in sural nerve and 27 other tissues |
ExpressionAtlasi | Q6SJ96, baseline and differential |
Organism-specific databases
HPAi | ENSG00000182521, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Interacts with TAF3.
By similarityProtein-protein interaction databases
BioGRIDi | 132286, 10 interactors |
STRINGi | 9606.ENSP00000247219 |
Miscellaneous databases
RNActi | Q6SJ96, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 103 – 184 | DisorderedSequence analysisAdd BLAST | 82 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 111 – 126 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 127 – 184 | Polar residuesSequence analysisAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the TBP family.Sequence analysis
Phylogenomic databases
eggNOGi | KOG3302, Eukaryota |
GeneTreei | ENSGT00940000159561 |
HOGENOMi | CLU_060161_1_2_1 |
InParanoidi | Q6SJ96 |
OMAi | MEQEETY |
OrthoDBi | 1219067at2759 |
PhylomeDBi | Q6SJ96 |
TreeFami | TF300102 |
Family and domain databases
CDDi | cd04516, TBP_eukaryotes, 1 hit |
Gene3Di | 3.30.310.10, 2 hits |
HAMAPi | MF_00408, TATA_bind_prot_arch, 1 hit |
InterProi | View protein in InterPro IPR000814, TBP IPR030491, TBP_CS IPR012295, TBP_dom_sf IPR033710, TBP_eukaryotic |
PANTHERi | PTHR10126, PTHR10126, 1 hit |
Pfami | View protein in Pfam PF00352, TBP, 2 hits |
PRINTSi | PR00686, TIFACTORIID |
PROSITEi | View protein in PROSITE PS00351, TFIID, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6SJ96-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASAPWPERV PRLLAPRLPS YPPPPPTVGL RSMEQEETYL ELYLDQCAAQ
60 70 80 90 100
DGLAPPRSPL FSPVVPYDMY ILNASNPDTA FNSNPEVKET SGDFSSVDLS
110 120 130 140 150
FLPDEVTQEN KDQPVISKHE TEENSESQSP QSRLPSPSEQ DVGLGLNSSS
160 170 180 190 200
LSNSHSQLHP GDTDSVQPSP EKPNSDSLSL ASITPMTPMT PISECCGIVP
210 220 230 240 250
QLQNIVSTVN LACKLDLKKI ALHAKNAEYN PKRFAAVIMR IREPRTTALI
260 270 280 290 300
FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPARFLDF KIQNMVGSCD
310 320 330 340 350
VRFPIRLEGL VLTHQQFSSY EPELFPGLIY RMVKPRIVLL IFVSGKVVLT
360 370
GAKERSEIYE AFENIYPILK GFKKA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V454 | G3V454_HUMAN | TATA box-binding protein-like 2 | TBPL2 | 22 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038692 | 31 | R → P1 PublicationCorresponds to variant dbSNP:rs8019270Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY457923 mRNA Translation: AAR24281.1 DQ448593 mRNA Translation: ABD93323.1 BC117159 mRNA Translation: AAI17160.1 BC117185 mRNA Translation: AAI17186.1 |
RefSeqi | NP_950248.1, NM_199047.2 |
Genome annotation databases
Ensembli | ENST00000247219.5; ENSP00000247219.5; ENSG00000182521.5 |
GeneIDi | 387332 |
KEGGi | hsa:387332 |
UCSCi | uc001xby.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY457923 mRNA Translation: AAR24281.1 DQ448593 mRNA Translation: ABD93323.1 BC117159 mRNA Translation: AAI17160.1 BC117185 mRNA Translation: AAI17186.1 |
RefSeqi | NP_950248.1, NM_199047.2 |
3D structure databases
AlphaFoldDBi | Q6SJ96 |
SMRi | Q6SJ96 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 132286, 10 interactors |
STRINGi | 9606.ENSP00000247219 |
PTM databases
iPTMneti | Q6SJ96 |
PhosphoSitePlusi | Q6SJ96 |
Genetic variation databases
BioMutai | TBPL2 |
DMDMi | 74749326 |
Proteomic databases
EPDi | Q6SJ96 |
jPOSTi | Q6SJ96 |
MassIVEi | Q6SJ96 |
MaxQBi | Q6SJ96 |
PaxDbi | Q6SJ96 |
PeptideAtlasi | Q6SJ96 |
PRIDEi | Q6SJ96 |
ProteomicsDBi | 67358 |
Protocols and materials databases
Antibodypediai | 61077, 125 antibodies from 22 providers |
DNASUi | 387332 |
Genome annotation databases
Ensembli | ENST00000247219.5; ENSP00000247219.5; ENSG00000182521.5 |
GeneIDi | 387332 |
KEGGi | hsa:387332 |
UCSCi | uc001xby.5, human |
Organism-specific databases
CTDi | 387332 |
DisGeNETi | 387332 |
GeneCardsi | TBPL2 |
HGNCi | HGNC:19841, TBPL2 |
HPAi | ENSG00000182521, Tissue enhanced (skeletal) |
MIMi | 608964, gene |
neXtProti | NX_Q6SJ96 |
OpenTargetsi | ENSG00000182521 |
PharmGKBi | PA134990291 |
VEuPathDBi | HostDB:ENSG00000182521 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3302, Eukaryota |
GeneTreei | ENSGT00940000159561 |
HOGENOMi | CLU_060161_1_2_1 |
InParanoidi | Q6SJ96 |
OMAi | MEQEETY |
OrthoDBi | 1219067at2759 |
PhylomeDBi | Q6SJ96 |
TreeFami | TF300102 |
Enzyme and pathway databases
PathwayCommonsi | Q6SJ96 |
SignaLinki | Q6SJ96 |
SIGNORi | Q6SJ96 |
Miscellaneous databases
BioGRID-ORCSi | 387332, 12 hits in 1067 CRISPR screens |
ChiTaRSi | TBPL2, human |
GenomeRNAii | 387332 |
Pharosi | Q6SJ96, Tbio |
PROi | PR:Q6SJ96 |
RNActi | Q6SJ96, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182521, Expressed in sural nerve and 27 other tissues |
ExpressionAtlasi | Q6SJ96, baseline and differential |
Family and domain databases
CDDi | cd04516, TBP_eukaryotes, 1 hit |
Gene3Di | 3.30.310.10, 2 hits |
HAMAPi | MF_00408, TATA_bind_prot_arch, 1 hit |
InterProi | View protein in InterPro IPR000814, TBP IPR030491, TBP_CS IPR012295, TBP_dom_sf IPR033710, TBP_eukaryotic |
PANTHERi | PTHR10126, PTHR10126, 1 hit |
Pfami | View protein in Pfam PF00352, TBP, 2 hits |
PRINTSi | PR00686, TIFACTORIID |
PROSITEi | View protein in PROSITE PS00351, TFIID, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | TBPL2_HUMAN | |
Accessioni | Q6SJ96Primary (citable) accession number: Q6SJ96 Secondary accession number(s): Q17RU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families