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Entry version 123 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

TATA box-binding protein-like 2

Gene

Tbpl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TATA box-binding protein-like 2
Short name:
TBP-like 2
Alternative name(s):
TATA box-binding protein-related factor 3
Short name:
TBP-related factor 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tbpl2Imported
Synonyms:Tbp2, Trf3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2684058, Tbpl2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181191 – 350TATA box-binding protein-like 2Add BLAST350

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6SJ95

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6SJ95

PRoteomics IDEntifications database

More...
PRIDEi
Q6SJ95

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254832

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6SJ95

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in myotubes and myofibers (at protein level). Expressed in a wide variety of tissues with highest levels in heart, lung, liver, uterus and placenta and especially the gonads. Expression is higher in the ovary than the testis, and within the ovary expression is localized to the oocytes.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000061809, Expressed in zygote and 10 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6SJ95, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TAF3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6SJ95, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000079309

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6SJ95, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6SJ95

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TBP family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3302, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159561

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6SJ95

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEQEETY

Database of Orthologous Groups

More...
OrthoDBi
1219067at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6SJ95

TreeFam database of animal gene trees

More...
TreeFami
TF300102

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04516, TBP_eukaryotes, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.310.10, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00408, TATA_bind_prot_arch, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000814, TBP
IPR030491, TBP_CS
IPR012295, TBP_dom_sf
IPR033710, TBP_eukaryotic

The PANTHER Classification System

More...
PANTHERi
PTHR10126, PTHR10126, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00352, TBP, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00686, TIFACTORIID

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00351, TFIID, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6SJ95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGSLIMEED IYLDLFLDPY TIQDDFPPAM SQLFSPGVPL DMHSLPSNPE
60 70 80 90 100
TVFHPHLGGV KKASTDFSSV DLSFLPDELT QENRDQTVTG NKLASEESCR
110 120 130 140 150
TRDRQSQLQL PDEHGSELNL NSNSSPDPQS CLCFDDAHSN QPSPETPNSN
160 170 180 190 200
ALPVALIASM MPMNPVPGFS GIVPQLQNVV STANLACKLD LRKIALNAKN
210 220 230 240 250
TEYNPKRFAA VIMRIREPRT TALIFSSGKV VCTGAKSEEE SRLAARKYAR
260 270 280 290 300
VVQKLGFPVR FFNFKIQNMV GSCDVKFPIR LEILALTHRQ FSSSYEPELF
310 320 330 340 350
PGLIYKMVKP QVVLLIFASG KVVLTGAKER SEIYEAFENM YPILESFKKV
Length:350
Mass (Da):38,967
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA436F5AE830B5CCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YMT0Z4YMT0_MOUSE
TATA box-binding protein-like 2
Tbpl2
348Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti294Missing in DAA06033 (PubMed:17570761).Curated1
Sequence conflicti294Missing in CAM19021 (PubMed:19468303).Curated1
Sequence conflicti294Missing in AAI00306 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY457924 mRNA Translation: AAR24282.1
BK005773 mRNA Translation: DAA06033.1
AL844838 Genomic DNA Translation: CAM19020.1
AL844838 Genomic DNA Translation: CAM19021.1
BC100305 mRNA Translation: AAI00306.1
BC119160 mRNA Translation: AAI19161.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS15732.1

NCBI Reference Sequences

More...
RefSeqi
NP_001276618.1, NM_001289689.1
NP_951014.1, NM_199059.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000080453; ENSMUSP00000079309; ENSMUSG00000061809

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
227606

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:227606

UCSC genome browser

More...
UCSCi
uc008iol.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457924 mRNA Translation: AAR24282.1
BK005773 mRNA Translation: DAA06033.1
AL844838 Genomic DNA Translation: CAM19020.1
AL844838 Genomic DNA Translation: CAM19021.1
BC100305 mRNA Translation: AAI00306.1
BC119160 mRNA Translation: AAI19161.1
CCDSiCCDS15732.1
RefSeqiNP_001276618.1, NM_001289689.1
NP_951014.1, NM_199059.2

3D structure databases

SMRiQ6SJ95
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6SJ95, 1 interactor
STRINGi10090.ENSMUSP00000079309

PTM databases

PhosphoSitePlusiQ6SJ95

Proteomic databases

MaxQBiQ6SJ95
PaxDbiQ6SJ95
PRIDEiQ6SJ95
ProteomicsDBi254832

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
61077, 122 antibodies

Genome annotation databases

EnsembliENSMUST00000080453; ENSMUSP00000079309; ENSMUSG00000061809
GeneIDi227606
KEGGimmu:227606
UCSCiuc008iol.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387332
MGIiMGI:2684058, Tbpl2

Phylogenomic databases

eggNOGiKOG3302, Eukaryota
GeneTreeiENSGT00940000159561
InParanoidiQ6SJ95
OMAiMEQEETY
OrthoDBi1219067at2759
PhylomeDBiQ6SJ95
TreeFamiTF300102

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
227606, 0 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q6SJ95
RNActiQ6SJ95, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000061809, Expressed in zygote and 10 other tissues
ExpressionAtlasiQ6SJ95, baseline and differential

Family and domain databases

CDDicd04516, TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408, TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814, TBP
IPR030491, TBP_CS
IPR012295, TBP_dom_sf
IPR033710, TBP_eukaryotic
PANTHERiPTHR10126, PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352, TBP, 2 hits
PRINTSiPR00686, TIFACTORIID
PROSITEiView protein in PROSITE
PS00351, TFIID, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBPL2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6SJ95
Secondary accession number(s): A2AQK6, Q498A1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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