Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 108 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein FAM111B

Gene

FAM111B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM111B
Alternative name(s):
Cancer-associated nucleoprotein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM111B
Synonyms:CANP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000189057.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24200 FAM111B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615584 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6SJ93

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis (POIKTMP)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant form of hereditary poikiloderma, a genodermatosis characterized by mottled pigmentation, telangiectasia, and epidermal atrophy. POIKTMP features include tendon contracture, myopathy, and progressive pulmonary fibrosis. It manifests from early childhood with telangiectasia and pigmentary anomalies especially on the face and sun-exposed areas, tendon contractures that particularly involve the ankles and feet causing gait disturbance, and development of pulmonary fibrosis during the second decade of life resulting in progressive dyspnea and restrictive impairment of lung function.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070953621Y → D in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777236EnsemblClinVar.1
Natural variantiVAR_070954627R → G in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777237EnsemblClinVar.1
Natural variantiVAR_070955628S → N in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777238EnsemblClinVar.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
374393

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
FAM111B

MalaCards human disease database

More...
MalaCardsi
FAM111B
MIMi615704 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000189057

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
221043 Hereditary fibrosing poikiloderma-tendon contractures-myopathy-pulmonary fibrosis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485469

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6SJ93 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM111B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758524

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002744091 – 734Protein FAM111BAdd BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki284Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6SJ93

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6SJ93

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6SJ93

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6SJ93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6SJ93

PeptideAtlas

More...
PeptideAtlasi
Q6SJ93

PRoteomics IDEntifications database

More...
PRIDEi
Q6SJ93

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
67356 [Q6SJ93-1]
67357 [Q6SJ93-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6SJ93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6SJ93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000189057 Expressed in 84 organ(s), highest expression level in intestine

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6SJ93 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6SJ93 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038637

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q011053EBI-6309082,EBI-1053182

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131897, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q6SJ93, 11 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000341565

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6SJ93 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM111 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHAZ Eukaryota
ENOG4112AWX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005182

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112429

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6SJ93

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYIFTCR

Database of Orthologous Groups

More...
OrthoDBi
470902at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6SJ93

TreeFam database of animal gene trees

More...
TreeFami
TF332538

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009003 Peptidase_S1_PA

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6SJ93-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSMKTEENK SFSAMEDDQR TRPEVSKDTV MKQTHADTPV DHCLSGIRKC
60 70 80 90 100
SSTFKLKSEV NKHETALEMQ NPNLNNKECC FTFTLNGNSR KLDRSVFTAY
110 120 130 140 150
GKPSESIYSA LSANDYFSER IKNQFNKNII VYEEKTIDGH INLGMPLKCL
160 170 180 190 200
PSDSHFKITF GQRKSSKEDG HILRQCENPN MECILFHVVA IGRTRKKIVK
210 220 230 240 250
INELHEKGSK LCIYALKGET IEGALCKDGR FRSDIGEFEW KLKEGHKKIY
260 270 280 290 300
GKQSMVDEVS GKVLEMDISK KKALQQKDIH KKIKQNESAT DEINHQSLIQ
310 320 330 340 350
SKKKVHKPKK DGETKDVEHS REQILPPQDL SHYIKDKTRQ TIPRIRNYYF
360 370 380 390 400
CSLPRKYRQI NSQVRRRPHL GRRYAINLDV QKEAINLLKN YQTLNEAIMH
410 420 430 440 450
QYPNFKEEAQ WVRKYFREEQ KRMNLSPAKQ FNIYKKDFGK MTANSVSVAT
460 470 480 490 500
CEQLTYYSKS VGFMQWDNNG NTGNATCFVF NGGYIFTCRH VVHLMVGKNT
510 520 530 540 550
HPSLWPDIIS KCAKVTFTYT EFCPTPDNWF SIEPWLKVSN ENLDYAILKL
560 570 580 590 600
KENGNAFPPG LWRQISPQPS TGLIYLIGHP EGQIKKIDGC TVIPLNERLK
610 620 630 640 650
KYPNDCQDGL VDLYDTTSNV YCMFTQRSFL SEVWNTHTLS YDTCFSDGSS
660 670 680 690 700
GSPVFNASGK LVALHTFGLF YQRGFNVHAL IEFGYSMDSI LCDIKKTNES
710 720 730
LYKSLNDEKL ETYDEEKGKQ ESSLQDHQIE PMEC
Length:734
Mass (Da):84,674
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5CDDF963849CE433
GO
Isoform 2 (identifier: Q6SJ93-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-30: Missing.

Show »
Length:704
Mass (Da):81,201
Checksum:i2D47981D619449C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PS27E9PS27_HUMAN
Protein FAM111B
FAM111B
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH62456 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104S → G in AAH62456 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053821218G → D. Corresponds to variant dbSNP:rs1060428Ensembl.1
Natural variantiVAR_070953621Y → D in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777236EnsemblClinVar.1
Natural variantiVAR_070954627R → G in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777237EnsemblClinVar.1
Natural variantiVAR_070955628S → N in POIKTMP. 1 PublicationCorresponds to variant dbSNP:rs587777238EnsemblClinVar.1
Natural variantiVAR_030282731P → A. Corresponds to variant dbSNP:rs17153376Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0227391 – 30Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY457926 mRNA Translation: AAR20839.1
AK304258 mRNA Translation: BAG65124.1
BC062456 mRNA Translation: AAH62456.1 Sequence problems.
BC130513 mRNA Translation: AAI30514.1
BC130539 mRNA Translation: AAI30540.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44611.1 [Q6SJ93-2]
CCDS7972.1 [Q6SJ93-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001136175.1, NM_001142703.1 [Q6SJ93-2]
NP_001136176.1, NM_001142704.1 [Q6SJ93-2]
NP_945185.1, NM_198947.3 [Q6SJ93-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000343597; ENSP00000341565; ENSG00000189057 [Q6SJ93-1]
ENST00000411426; ENSP00000393855; ENSG00000189057 [Q6SJ93-2]
ENST00000529618; ENSP00000432875; ENSG00000189057 [Q6SJ93-2]
ENST00000620384; ENSP00000483456; ENSG00000189057 [Q6SJ93-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
374393

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:374393

UCSC genome browser

More...
UCSCi
uc001nnl.5 human [Q6SJ93-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457926 mRNA Translation: AAR20839.1
AK304258 mRNA Translation: BAG65124.1
BC062456 mRNA Translation: AAH62456.1 Sequence problems.
BC130513 mRNA Translation: AAI30514.1
BC130539 mRNA Translation: AAI30540.1
CCDSiCCDS44611.1 [Q6SJ93-2]
CCDS7972.1 [Q6SJ93-1]
RefSeqiNP_001136175.1, NM_001142703.1 [Q6SJ93-2]
NP_001136176.1, NM_001142704.1 [Q6SJ93-2]
NP_945185.1, NM_198947.3 [Q6SJ93-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi131897, 14 interactors
IntActiQ6SJ93, 11 interactors
STRINGi9606.ENSP00000341565

PTM databases

iPTMnetiQ6SJ93
PhosphoSitePlusiQ6SJ93

Polymorphism and mutation databases

BioMutaiFAM111B
DMDMi74758524

Proteomic databases

EPDiQ6SJ93
jPOSTiQ6SJ93
MassIVEiQ6SJ93
MaxQBiQ6SJ93
PaxDbiQ6SJ93
PeptideAtlasiQ6SJ93
PRIDEiQ6SJ93
ProteomicsDBi67356 [Q6SJ93-1]
67357 [Q6SJ93-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
374393

Genome annotation databases

EnsembliENST00000343597; ENSP00000341565; ENSG00000189057 [Q6SJ93-1]
ENST00000411426; ENSP00000393855; ENSG00000189057 [Q6SJ93-2]
ENST00000529618; ENSP00000432875; ENSG00000189057 [Q6SJ93-2]
ENST00000620384; ENSP00000483456; ENSG00000189057 [Q6SJ93-1]
GeneIDi374393
KEGGihsa:374393
UCSCiuc001nnl.5 human [Q6SJ93-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
374393
DisGeNETi374393
EuPathDBiHostDB:ENSG00000189057.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM111B
GeneReviewsiFAM111B
HGNCiHGNC:24200 FAM111B
HPAiHPA038637
MalaCardsiFAM111B
MIMi615584 gene
615704 phenotype
neXtProtiNX_Q6SJ93
OpenTargetsiENSG00000189057
Orphaneti221043 Hereditary fibrosing poikiloderma-tendon contractures-myopathy-pulmonary fibrosis syndrome
PharmGKBiPA143485469

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IHAZ Eukaryota
ENOG4112AWX LUCA
GeneTreeiENSGT00390000005182
HOGENOMiHOG000112429
InParanoidiQ6SJ93
OMAiGYIFTCR
OrthoDBi470902at2759
PhylomeDBiQ6SJ93
TreeFamiTF332538

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
374393
PharosiQ6SJ93 Tdark

Protein Ontology

More...
PROi
PR:Q6SJ93
RNActiQ6SJ93 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000189057 Expressed in 84 organ(s), highest expression level in intestine
ExpressionAtlasiQ6SJ93 baseline and differential
GenevisibleiQ6SJ93 HS

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
SUPFAMiSSF50494 SSF50494, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF111B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6SJ93
Secondary accession number(s): B4E2G2, Q6P661
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again